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EGFR mutation--a commonly neglected mutation in squamous cell lung carcinoma

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 253-254页

作者： Rajeev saini Ullas Batra Akhil Jain Chaturbhuj Agrawal Department of Medical Oncology Rajiv Gandhi Cancer Institute and Research CentreSector 5RohiniNew Delhi 110085India

Lung cancer is the leading cause of cancer-related death *** in molecular biology have unveiled various targetable mutations with epidermal growth factor receptor(EGFR)being most *** testing is recommended for all locally advanced or metastatic adenocarcinoma lungs but recommendation in squamous histology is ***,just on the basis of histology,EGFR testing should not be withheld in patients diagnosed as squamous cell cancer on small biopsy,in females,never smokers and *** report two cases with squamous cell lung cancer diagnosed on small biopsy,in non smoker females with EGFR mutations emphasizing the importance of testing in such population.

关键词： Epidermal growth factor receptor mutation squamous cell lung carcinoma never smoker small biopsy

Studies of Surfactant in Photogalvanic Cell for Solar Energy Conversion and Storage

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Advances in Chemical Engineering and Science 2017年第2期7卷 125-136页

作者： Shiv Ram saini Shankar Lal Meena Ramesh Chand Meena Department of Chemistry JNVU Jodhpur India

The photogalvanic effect was studied in photogalvanic cell containing orange G as Photosensitizer, sodium lauryl sulphate and EDTA as reducing agent. The photo-outputs with EDTA are higher for Solar Energy Conversion and Storage. The current-voltage relations of the cell have been measured in the dark and light under both forward and reverse direction. The photo potential and photocurrent generated was found to be 960.0 mV and 350.0 μA, respectively. The observed conversion efficiency was 1.52% fill factor and the maximum power of cell was 0.47 μA and 158.9 μW. The storage capacity of the cell was 80.0 minutes in dark. A mechanism was proposed for the generation of photocurrent in photo galvanic cell.

关键词： Orange-G NaLS (Surfactant) Photopotential Photocurrent Conversion Efficiency

Role of Active Principles of Podophyllum hexandrum in Amelioration of Radiation Mediated Lung Injuries by Reactive Oxygen/Nitrogen Species Reduction

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CellBio 2013年第3期2卷 105-116页

作者： Rashmi saini Savita Verma Abhinav Singh Manju Lata Gupta Institute of Nuclear Medicine and Allied Sciences (INMAS) Defence Research and Development Organization (DRDO) New Delhi India

Radiation induced reactive oxygen/nitrogen species (ROS/RNS) are reported to cause lung injuries such as pneumonitis and fibrosis which may be fatal at times. Current study is designed to analyse the radioprotective efficacy of P. hexandrum active principles (G-002M) on lungs of mice exposed to high dose of gamma irradiation (7 Gy). Cellular profiles and inflammatory cell infiltrates of irradiated bronchoalveolar lavage fluid (BALF) have shown correlations with lung pathology. Cell counts were determined in BALF of control, 7 Gy radiation exposed and radiation with G-002M pretreated mice. ROS/Nitric Oxide (NO) production was measured by 2,7?dichlorodihydrofluorescein diacetate (DCF-DA) and diaminofluorescein diacetate (DAF-2DA) through microscopy and flow cytometry respectively. Immunostaining of inducible nitric oxide synthase (iNOS) in BALF cells and lung sections was also observed microscopically. iNOS ex- pression was observed in lungs by western blotting. BALF was also processed to estimate total protein, LDH, and phospholipids content. Catalase, reduced Glutathione (GSH), Glutathione reductase (GR) and lipid peroxidation were estimated in lung tissues. Pre-administration of G-002M significantly decreased radiation mediated neutrophils count in BALF of irradiated mice. ROS generation, iNOS expression, total protein, LDH and phospholipids were found less affected in G-002M pretreated group in comparison to radiation alone group. Radiation exposure to mice was found apparently leading to parenchymal fibrosis, an architectural distortion of the lung tissue with edema, infiltration of inflammatory blood cells with increased immunolabeling of iNOS. G-002M pretreatment significantly countered radiation mediated increased lipid peroxidation and decreased GR, catalase and GSH in mice. Current study demonstrates possible role of P. hexandrum (G-002M) in minimizing lung damage induced by radiation mediated ROS/RNS generation.

关键词： Bronchoalveolar Lavage Fluid Lung Injury Reactive Nitrogen Species Podophyllum hexandrum Radiation

Reconstruction of chronic acromioclavicular joint disruption with artificial ligament prosthesis

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Chinese Journal of Traumatology 2013年第4期16卷 216-220页

作者： Devendra Kumar Chouhan Uttam Chand saini Mandeep Singh Dhillon Department of Orthopaedics Post Graduate Instituteof Medical Education & Research Sector 12 Chandigarh160012 India

Objective： Management of Rockwood type 3 acromioclavicular disruptions is a matter of debate. Should we adopt conservative or operative measures at first presentation？ It is not clear but most of the evidences are in favour of conservative management. We present our expe- rience in managing these patients surgically. Methods： We present a prospective series of eight cases of chronic Rockwood type 3 acromioclavicular joint disruptions treated surgically. Anatomical reconstruction of the coracoclavicular ligament was done by artificial braided polyester ligament prosthesis： Results： All the patients were able to perform daily activities from an average of the 14th postoperative day. All patients felt an improvement in pain, with decrease in ave- rage visual analogue scale from preoperative 6.5 points （range 3-9 points） to 2.0 points （range 0-5 points）, Constant score from 59% to 91% and American Shoulder and Elbow Surgeons shoulder score from 65 to 93 points postoperatively. These results improved or at least remained stationary on midterm follow-up, and no deterioration was recorded at an average follow-up of 46 months. Conclusion： This midterm outcome analysis of the artificial ligament prosthesis is the first such follow-up study with prosthesis. Our results are encouraging and justify the further use and evaluation of this relatively new and easily reproducible technique.

关键词： Acromioclavicularjoint Prostheses and implants Reconstructive surgical procedures Ligaments

A Comprehensive Review of High Throughput Phenotyping and Machine Learning for Plant Stress Phenotyping

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Phenomics 2022年第3期2卷 156-183页

作者： Taqdeer Gill Simranveer K.Gill Dinesh K.saini Yuvraj Chopra Jason P.de Koff Karansher S.Sandhu Department of Agricultural and Environmental Sciences Tennessee State UniversityNashvilleTN 37209USA College of Agriculture Punjab Agricultural UniversityLudhianaPunjab 141004India Department of Plant Breeding and Genetics Punjab Agricultural UniversityLudhianaPunjab 141004India Department of Crop and Soil Sciences Washington State UniversityPullmanWA 99163USA

During the last decade,there has been rapid adoption of ground and aerial platforms with multiple sensors for phenotyping various biotic and abiotic stresses throughout the developmental stages of the crop *** throughput phenotyping(HTP)involves the application of these tools to phenotype the plants and can vary from ground-based imaging to aerial phenotyping to remote *** of these HTP tools has tried to reduce the phenotyping bottleneck in breeding programs and help to increase the pace of genetic *** specifically,several root phenotyping tools are discussed to study the plant’s hidden half and an area long ***,the use of these HTP technologies produces big data sets that impede the inference from those *** learning and deep learning provide an alternative opportunity for the extraction of useful information for making *** are interdisciplinary approaches for data analysis using probability,statistics,classification,regression,decision theory,data visualization,and neural networks to relate information extracted with the phenotypes *** techniques use feature extraction,identification,classification,and prediction criteria to identify pertinent data for use in plant breeding and pathology *** review focuses on the recent findings where machine learning and deep learning approaches have been used for plant stress phenotyping with data being collected using various HTP *** have provided a comprehensive overview of different machine learning and deep learning tools available with their potential advantages and ***,this review provides an avenue for studying various HTP platforms with particular emphasis on using the machine learning and deep learning tools for drawing legitimate ***,we propose the conceptual challenges being faced and provide insights on future perspectives for managing those issues.

关键词： Biotic and abiotic stresses Deep learning Ground-based imaging High throughput phenotyping Machine learning Unmanned aerial vehicle

Complete oxidation of 1,4-dioxane over zeolite-13X-supported Fe catalysts in the presence of air

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Chinese Journal of Catalysis 2016年第2期37卷 240-249页

作者： C.Ramakrishna R.Krishna T.Gopi G.Swetha Bijendra saini S.Chandra Shekar Anchal Srivastava 国防研发局、防化装备评估设备(CDEF) 印度那格浦尔MH-441108

Zeolite-13X-supported Fe（Fe/zeolite-13X） catalysts with various Fe contents were prepared by the wet impregnation *** catalysts were characterized by N2 adsorption-desorption isotherms to estimate the Brunauer-Emmett-Teller surface areas and Barrett-Joyner-Hanlenda pore size distributions.X-ray diffraction,scanning electron microscopy,temperature-programmed reduction,and temperature-programmed desorption of NH3 were used to investigate the textural properties of the Fe/zeolite-13 X *** catalytic activities were determined for the complete oxidation of1,4-dioxane using air as the oxidant in a fixed-bed flow reactor in the temperature range 100-400℃.The influences of various process parameters,such as reaction temperature,metal loading,and gas hourly space velocity（GHSV）,on the dioxane removal efficiency by catalytic oxidation were *** stability of the catalyst was tested at 400℃ by performing time-on-stream analysis for 50 *** Fe/zeolite-13 X catalyst with 6 wt%Fe exhibited the best catalytic activity among the Fe/zeolite-13 X catalysts at 400℃ and a GHSV of 24000 h^（-1）,with 97%dioxane conversion and95%selectivity for the formation of carbon oxides（CO and CO2）.Trace amounts（ 3%） of acetaldehyde,ethylene glycol monoformate,ethylene glycol diformate,1,4-dioxane-2-ol,1,4-dioxane-2-one,and 2-methoxy-1,3-dioxalane were also formed as degradation products.A plausible degradation mechanism is proposed based on the products identified by GC-MS analysis.

关键词： Iron Zeolite-13X 1 4-Dioxane Catalytic degradation Complete oxidation Degradation mechanism

Detection of Leptospirosis Bacteria in Rodent Urine by Surface Plasmon Resonance Sensor Using Graphene

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Photonic Sensors 2021年第3期11卷 305-313页

作者： Surjeet Raikwar Y.K.Prajapati D.K.Srivastava J.B.Maurya J.P.saini Department of Electronics and Communication Engineering Bundelkhand Institute of Engineering and TechnologyJhansiUttar Pradesh284128India Department of Electronics and Communication Engineering Motilal Nehru National Institute of Technology AllahabadPrayagrajUttar Pradesh211004India Netaji Subhas University of Technology DwarkaNew Delhi110078India

In this paper, a graphene-coated surface plasmon resonance sensor is designed for the examination of Rodent urine which is responsible for Leptospirosis bacteria. Rodent urine is considered as sensing medium. Graphene surface is activated by phosphate-buffered saline solution for better attachment of Leptospirosis bacteria on its surface. Oliguria and Polyuria are the Rodent urine with high and low concentrations of Leptospirosis bacteria, respectively. The transfer matrix method is used for the formulation of reflection intensity of p-polarized light. The reflectance curves for angular interrogation are plotted and the results are obtained in terms of sensitivity, detection accuracy, and quality factor. The significantly high sensitivity and detection accuracy for Oliguria distinguishes it from Polyuria having lower sensitivity.

关键词： Surface plasmon resonance sensor active metal layer Leptospirosis bacteria

CFOA Based Low Pass and High Pass Ladder Filter—A New Configuration

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Circuits and Systems 2014年第12期5卷 293-300页

作者： Praween K. Sinha Akshay saini Pranav Kumar Sumit Mishra Electronics and Communication Department Maharaja Agrasen Institute of Technology New Delhi India Electronics and Communication Department University School of Information and Communication Technology New Delhi India Techno Scientific Inc. Concord Canada

A new technique using signal flow graph for conversion of ladder based filter into CFOA based filter has been proposed. The proposed technique converts the existing LC ladder based filter into CFOA in low pass and high pass configuration. The design of low pass filter and high pass filter has been realized using the proposed technique. The proposed configuration is implemented using CFOA as an active device and all the capacitors are grounded. Simulation has been carried out using simulation software I-cap. The simulation results have been demonstrated and discussed.

关键词： CFOA-Current Feedback Operational Amplifier Ladder Filter Signal Flow Graph Current Mode Voltage Mode High Pass Filter Low Pass Filter

Impact Analysis of Genetically Modified (Bt) Cotton Genotypes on Economically Important Natural Enemies under Field Conditions

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Advances in Entomology 2016年第2期4卷 61-74页

作者： Dalip Kumar Surender Singh Yadav Vivek Kumar saini Krishan Kumar Dahiya Department of Entomology College of Agriculture CCS HAU Hisar India Government College Hisar India Cotton Section Department of Plant Breeding and Genetics CCS HAU Hisar India

Field studies were conducted at Hisar during Kharif, 2009-2010 and 2010-2011 under natural and unsprayed condition. RCH 134 Bt, HS 6 (non Bt), H 1117 and Ganganagar Ageti (non Bt) were selected for the studies. The experiment was laid down in Randomized Block Design replicated thrice having plant spacing 67.5 × 60 cm. Among the bollworms, Erias spp. exhibited positive correlation with rainfall, minimum temperature and relative humidity morning hours significantly at 5 percent level whereas Helicoverpa and Pectinophora displayed positive relations only with evening hours relative humidity significantly while Spodoptera were significantly positive correlated with relative humidity of morning and evening hours. Bollworm complex was negatively correlated with all the weather parameters employed to study although being non-significant in case of rainfall, maximum and minimum of temperature, morning and evening hours of relative humidity. Among the sucking pests, leafhoppers, whitefly, thrips and aphids population showed significantly negative correlation with weather parameters. The comparison of natural bio-agents in cotton hybrids under study revealed that overall mean population of natural enemies were higher in Bt cotton hybrid as compared to non-Bt. These results confirm that use of genetically modified (Bt) cotton in lieu of conventional genotypes could positively impact non-target and beneficial insect species by preserving their host populations.

关键词： Bt Cotton Natural Enemies Sucking Pests Bollworm Complex Population Dynamics Correlation Co-Efficient Abiotic Factors