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A Rare Association of Giant Cell Arteritis with Recurrent Corneal Ulcer

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Open Journal of Ophthalmology 2016年第3期6卷 144-149页

作者： sailaja Bondalapati Kay Khine Maya Bitar David Chesnutt Richard M. Davis University of North Carolina School of Medicine Chapel Hill NC USA Department of Ophthalmology University of North Carolina Hospitals Chapel Hill NC USA

We report a rare case of association of temporal arteritis with recurrent central corneal ulcer. A 91-year-old male with a remote history of clinically diagnosed giant cell arteritis (GCA) and penetrating keratoplasty (PK) for corneal edema in 1990’s in the left eye presented with irritation and severe dry eye. He progressively developed central corneal ulcer regardless of treatment with aggressive lubrication and patching. The clinical course, blood tests and temporal artery biopsy results yielded the diagnosis of recurrent GCA. The clinical course improved after starting oral steroids. The case report illustrates the importance of ruling out GCA in patients with recurrent corneal ulcers and history of GCA. It also highlights the significance of shared understanding between primary care physicians and specialists to handle common and chronic diseases to make efficient diagnoses and plan treatment regimens. This is the first plausible case of reported GCA association with central corneal ulcer in the United States.

关键词： Giant Cell Arteritis Temporal Arteritis Central Corneal Ulcer Sterile Ulcer

A Rare Case of Reparative Granuloma of Nasal Cavity

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第5期3卷 293-297页

作者： Jadi Lingaiah Laxminath Ganji sailaja Yella Kranthi Raj Thatikonda Department of Otorhinolaryngology—Head & Neck Surgery Chalmeda Anand Rao Institute of Medical Sciences Karimnagar India

Giant cell reparative granuloma (GCRG) is a rare, benign tumour that mostly involves the maxilla and mandible. It is rare in the nasal cavity and paranasal sinuses. Here we report a case of GCRG of nasal cavity in 24-year-old man who came with unilateral nasal obstruction, epistaxis and proptosis. CT scan showed soft tissue hypodensity lesion of left nasal cavity. Endoscopic surgical excision and biopsy were done. The pathology was consistent with GCRG. There was no recurrence seen on follow-up for 2 years. A short literature review about diagnosis, clinical behavior, radiological findings and treatment of this tumor entity are given.

关键词： Reparative Granuloma Giant Cell Tumour Aneurysmal Bone Cyst

Contribution of technology in language learning： A focus

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Sino-US English Teaching 2010年第1期7卷 1-5页

作者： G. V. S. Ananta Lakshmi S. Sunila sailaja Department of English Godavari Institute of Engineering ＆ Technology Rajahmundry 533294 lndia

The emerging technologies in various fields are affecting all walks of life including learning, teaching, education, etc.. The present learning in engineering colleges in the Indian scenario and their effect on general language proficiency is discussed. In the present era of job-oriented education how the accurate language learning and strengthening of skills facilitate one＇s career building is discussed here. The present paper focuses on independent, collaborative and supportive learning environment in the class to mould the reluctant learners. It also brings out the differences between conventional learning and technology assisted learning. In the midst of thousands of soft ware available, it is difficult for one to choose which is most suitable, to use friendly English learning process and which will be specific, more and more learners center and the need for such soft wares is given specific high light here. How the assessment should be carried through language modules is discussed here with a special attention to the learners and product assessment separately.

关键词： language learning technology engineering classroom learner assessment

Prediction and Expression Analysis of miRNAs Associated with Heat Stress in Oryza sativa

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Rice science 2014年第1期21卷 3-12页

作者： B.sailaja S.R.VOLETI D.SUBRAHMANYAM N.SARLA V.VISHNU PRASANTH V.P.BHADANA S.K.MANGRAUTHIA Biotechnology Section Directorate of Rice Research Rajendranagar

Computational prediction of potential microRNAs （miRNAs） and their target genes was performed to identify the miRNAs and genes associated with temperature response in rice. The data of temperature-responsive miRNAs of Arabidopsis, and miRNAs and the whole genome data of rice were used to predict potential miRNAs in Oryza sativa involved in temperature response. A total of 55 miRNAs were common in both the species, and 27 miRNAs were predicted at the first time in rice. Target genes were searched for these 27 miRNAs in rice genome following stringent criteria. Real time PCR based on expression analysis of nine miRNAs showed that majority of the miRNAs were down regulated under heat stress for rice cultivar Nagina 22. Furthermore, miR169, miR1884 and miR160 showed differential expression in root and shoot tissues of rice. Identification and expression studies of miRNAs during heat stress will advance the understanding of gene regulation under stress in rice.

关键词： miRNA Oryza sativa Arabidopsis target mRNA regulation

Microwave Assisted Synthesis of Guar Gum Grafted Acrylic Acid/Nanoclay Superabsorbent Composites and Its Use in Crystal Violet Dye Absorption

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Green and Sustainable Chemistry 2016年第1期6卷 11-25页

作者： S. B. Shruthi Chandan Bhat S. P. Bhaskar G. Preethi R. R. N. sailaja Chemical Engineering Department Dayananda Sagar College of Engineering Kumaraswamy Layout Bengaluru India Resource Efficient Process Technology Application The Energy and Resources Institute Bengaluru India

Natural gums can be tailored and used for the removal of toxic dyes like crystal violet via grafting techniques. However, grafting via microwave irradiation showed both higher yield and fast reaction kinetics as compared to conventional grafting. Silane modified nanoclay has been used to prepare acrylic acid grafted guar gum nanocomposites via microwave irradiation technique. The grafting was confirmed via infrared spectroscopy while XRD diffractograms suggested exfoliation of modified nanoclay in guar gum grafted acrylic acid. The reaction kinetic parameters have been optimized. The effect of nanoclay on swelling characteristics has been examined. The sensitivity of pH on swelling capabilities has also been assessed. The efficiency of the superabsorbent nanocomposite on the absorption of crystal violet dye has been studied. The superabsorbent nanocomposite loaded with 1.75% modified nanocaly was found to be optimal concentration for the removal of crystal violet dye.

关键词： Microwave Guar Gum Superabsorbent Nanocomposites Dye Absorption

Increasing thirty-day readmissions of Crohn’s disease and ulcerative colitis in the United States:A national dilemma

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World Journal of Gastrointestinal Pathophysiology 2022年第3期13卷 85-95页

作者： Dushyant Singh Dahiya Abhilash Perisetti Asim Kichloo Amandeep Singh Hemant Goyal Laura Rotundo Madhu Vennikandam Hafeez Shaka Gurdeep Singh Jagmeet Singh sailaja Pisipati Mohammad Al-Haddad Madhusudhan R Sanaka Sumant Inamdar Department of Internal Medicine Central Michigan University College of MedicineSaginawMI 48601United States Division of Gastroenterology Parkview Cancer InstituteFort WayneIN 46845United States Division of Gastroenterology and Hepatology Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine The Wright Center for Graduate Medical EducationScrantonPA 18505United States Department of Internal Medicine Mercer University School of MedicineMaconGA 31207United States Department of Gastroenterology and Hepatology Sparrow Hospital/Michigan State University College of Human MedicineLansingMI 48912United States Department of Internal Medicine John H.StrogerJr.Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine Our Lady of Lourdes Memorial HospitalBinghamtonNY 13905United States Department of Internal Medicine Guthrie Robert Packer HospitalSayrePA 18840United States Division of Gastroenterology and Hepatology Mayo ClinicScottsdaleAZ 85259United States Division of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN 46202United States Division of Gastroenterology and Hepatology University of Arkansas for Medical SciencesLittle RockAR 72205United States

BACKGROUND The prevalence of Crohn’s disease(CD)and ulcerative colitis(UC)is on the rise *** rising prevalence is concerning as patients with CD and UC may frequently relapse leading to recurrent hospitalizations and increased healthcare *** To identify trends and adverse outcomes for 30 d readmissions for CD and *** This was a retrospective,interrupted trends study involving all adult(≥18 years)30 d readmissions of CD and UC from the National Readmission Database(NRD)between 2008 and ***<18 years,elective,and traumatic hospitalizations were excluded from this *** identified hospitalization characteristics and readmission rates for each calendar *** of inpatient mortality,mean length of hospital stay(LOS)and mean total hospital cost(THC)were calculated using a multivariate logistic trend analysis adjusting for age,gender,insurance status,comorbidity burden and hospital ***,trends between CD and UC readmissions were compared using regression of the interaction coefficient after adjusting for age and gender to determine relative trends between the two ***®Version 16 software(StataCorp,TX,United States)was used for statistical analysis and P value≤0.05 were considered statistically *** Total number of 30 d readmissions increased from 6202 in 2010 to 7672 in 2018 for CD and from 3272 in 2010 to 4234 in 2018 for *** noted increasing trends for 30-day all-cause readmission rate of CD from 14.9%in 2010 to 17.6%in 2018(P-trend<0.001),CD specific readmission rate from 7.1%in 2010 to 8.2%in 2018(P-trend<0.001),30-day all-cause readmission rate of UC from 14.1%in 2010 to 15.7%in 2018(P-trend=0.003),and UC specific readmission rate from 5.2%in 2010 to 5.6%in 2018(P-trend=0.029).There was no change in the risk adjusted trends of inpatient mortality and mean LOS for CD and UC ***,we found an increasing trend of mean THC for UC *** comparison,there w

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Readmissions Trends