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Correlation between Fibroscan and laboratory tests in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis patients for assessing liver fibrosis

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World Journal of Hepatology 2022年第4期14卷 744-753页

作者： Layal Al Nanaf Mohammed Hussein Kamareddine Emilie Fayad Aniqa Hussain said farhat Department of Radiological Science American University of Science and TechnologyFaculty of Health SciencesBeirut 1100Lebanon Department of Internal Medicine Lankenau Medical CenterPhiladelphiaPA 19131United States Department of Radiology Saint George Hospital University Medical CenterBeirut 1100Lebanon Faculty of Medicine University of New South WalesSydney 2052Australia Department of Gastroenterology Saint George Hospital University Medical CenterBeirut 1100Lebanon

BACKGROUND Non-alcoholic fatty liver disease(NAFLD) is a spectrum of disease ranging from simple steatosis to non-alcoholic steatohepatitis(NASH), through to advanced fibrosis and cirrhosis. Many patients with NAFLD remain undiagnosed and recognizing those at risk is very crucial. Although liver biopsy is the gold standard method for diagnosing and staging NAFLD, non-invasive imaging and lab modalities are also very promising in diagnosing these *** To explore some of these non-invasive modalities in this context and assess how they hold up in terms of making a diagnosis while avoiding an invasive procedure like a liver *** This study was conducted on NAFLD/NASH patients(n = 73) who underwent Fibroscan examinations at Saint George Hospital University Medical Center over 17 mo in order to assess liver fibrosis. Obtained Fibroscan results were correlated to laboratory tests and calculated aspartate transaminase(AST)/alanine transaminase(ALT) ratio, AST platelet ratio index(APRI) score and Fibrosis-4 *** A significant age difference was observed across fibrosis stages of investigated patients. The mean stiffness score was 9.48 ± 11.77 KPa. A significant negative correlation was observed between ALT, AST, Albumin, gamma-glutamyl transferase, cholesterol, LDL, HDL, triglycerides, and ALP when compared across fibrosis stages. On the other hand, a significant positive correlation was found between Bilirubin, PT INR, partial thromboplastin time, glucose, and Platelet count when compared across fibrosis stages, in addition to AST/ALT ratio, APRI, and Fib-4 *** This study showed that Ultrasound alone is not efficient in the assessment of advancement of liver disease. Furthermore, the high positive relation between AST/ALT ratio, APRI and Fib-4 scores with fibrosis stages in NAFLD patients suggests that they could be used clinically in combination with Fibroscan to predict significant fibrosis and cirrhosis and to avoid liver biopsy.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Fibroscan Cirrhosis Hepatology

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Facial Image-Based Autism Detection:A Comparative Study of Deep Neural Network Classifiers

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Computers, Materials & Continua 2024年第1期78卷 105-126页

作者： Tayyaba farhat Sheeraz Akram Hatoon SAlSagri Zulfiqar Ali Awais Ahmad Arfan Jaffar Faculty of Computer Science and Information Technology The Superior UniversityLahore54600Pakistan Intelligent Data Visual Computing Research(IDVCR) Faculty of Computer Science and Information TechnologyThe Superior UniversityLahore54600Pakistan Information Systems Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh12571Saudi Arabia School of Computer Science and Electronic Engineering(CSEE) University of EssexWivenhoe ParkColchesterCO43SQUK

Autism Spectrum Disorder(ASD)is a neurodevelopmental condition characterized by significant challenges in social interaction,communication,and repetitive *** and precise ASD detection is crucial,particularly in regions with limited diagnostic resources like *** study aims to conduct an extensive comparative analysis of various machine learning classifiers for ASD detection using facial images to identify an accurate and cost-effective solution tailored to the local *** research involves experimentation with VGG16 and MobileNet models,exploring different batch sizes,optimizers,and learning rate *** addition,the“Orange”machine learning tool is employed to evaluate classifier performance and automated image processing capabilities are utilized within the *** findings unequivocally establish VGG16 as the most effective classifier with a 5-fold cross-validation ***,VGG16,with a batch size of 2 and the Adam optimizer,trained for 100 epochs,achieves a remarkable validation accuracy of 99% and a testing accuracy of 87%.Furthermore,the model achieves an F1 score of 88%,precision of 85%,and recall of 90% on test *** validate the practical applicability of the VGG16 model with 5-fold cross-validation,the study conducts further testing on a dataset sourced fromautism centers in Pakistan,resulting in an accuracy rate of 85%.This reaffirms the model’s suitability for real-world ASD *** research offers valuable insights into classifier performance,emphasizing the potential of machine learning to deliver precise and accessible ASD diagnoses via facial image analysis.

关键词： Autism Autism Spectrum Disorder(ASD) disease segmentation features optimization deep learning models facial images classification

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Myxedema ascites with high CA-125:Case and a review of literature

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World Journal of Hepatology 2013年第2期5卷 86-89页

作者： Bou Khalil Roula El Rassi Patrick Chammas Nizar Obeid Jean Ghabach Maroun Sakr Charles Itani Tarek farhat said Quarantaine Governmental University Medical Hospital Beirut 961Lebanon Saint Georges University Medical Center University of BalamandBeirut 961Lebanon Department of Surgery Lebanese UniversityBeirut 961Lebanon Chairman of Anesthesia Department Rosary HospitalBeirut 961Lebanon

Ascites appearing in a previously healthy female patient is usually ascribed to a variety of causes,among which,is a cancerous process,especially if it comes with a raised CA-125 *** the CA-125 antigen is present on more than 80% of malignant epithelial ovarian tissue of non-mucinous type,it is also found on both healthy and malignant cells of mesothelial and non-mesothelial *** ascites which is caused by hypothyroidism is a rare entity,but on the other hand is easy to *** is one of the differential diagnoses when the ascites is refractory to treatment and no other obvious cause can be *** the diagnosis is delayed,patients will frequently receive unnecessary procedures,while treatment has very good response rates and ascites resolve with serum CA-125 normalization after adequate hormonal treatment.

关键词： Hypothyroidism Refractory ascites High CA-125 Hormonal therapy Abdominal paracentesis

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Calculation and application of partition coefficients of light hydrocarbons in oil-based mud system

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Petroleum Exploration and Development 2022年第4期49卷 906-918页

作者： BEN ABDALLAH Bacem Rabie AHMADI Riadh LYNEN Frederic REKHISS farhat Laboratoire LR3E.Ecole Nationale d’Ingénieurs de Sfax Rte Soukra km 3SfaxTunisia Separation Science Group Department of Organic and Macromolecular ChemistryGhent UniversityKrijgslaan 281-S4B-9000 GhentBelgium

To find out the relationship between the oil-based mud,the formation fluid and the extracted gas,we use a thermodynamic approach based on static headspace gas chromatography technique to calculate the partition coefficients of 47 kinds of light hydrocarbons compounds between nC5 and nC8 in two kinds of oil-based mud-air systems,and reconstruct the original formation fluid composition under thermodynamic *** oil-based drilling mud has little effect on the formation fluid compositions in the range of nC5-nC8(less than 1%for low-toxicity oil-based mud and less than 10%for oil-based mud).For most light hydrocarbon compositions,the partition coefficients obtained by vapor phase calibration and the direct quantitative methods have errors of less than 10%,and the partition coefficients obtained by direct quantitative method are more *** reconstructed compositions of the two kinds of crude oil have match degrees of 91%and 89%with their real compositions,proving the feasibility and accuracy of reconstructing the composition of original formation fluid by using partition coefficients of light hydrocarbon compositions between nC5 and nC8.

关键词： oil-based mud drilling mud gas light hydrocarbon compositions partition coefficients reservoir fluid

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Antioxidant and anti-diabetic activities in commercial and homemade pomegranate molasses in Lebanon

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Food Bioscience 2022年第2期46卷 338-345页

作者： Mira Bou Dargham Jocelyne Matar Boumosleh Antoine farhat Salwa Abdelkhalek Elias Bou-Maroun Leina El Hosry Department of Nursing and Health Sciences Notre Dame University-LouaizeZouk MosbehLebanon Department of Rehabilitation and Health Services University of North TexasDentonTexasUSA Department of Health and Medical Sciences Khawarizmi International College Univ.Bourgogne Franche-Comt´e AgroSup DijonUMR A 02.102Proc´ed´es Alimentaires et MicrobiologiquesF-21000DijonFrance

Pomegranate fruit and its derived products are rich sources of bioactive *** have many biological *** molasses(PM)is a thick,traditional Middle Eastern syrup used in many recipes for Lebanese and international *** is a highly nutritious product which makes it of great *** purpose of this study was to assess the phytochemical composition,antioxidant and anti-diabetic properties of homemade and commercial PM consumed in Lebanon using samples collected from households in rural areas(n=4)and the market(n=28).The objectives of this study were to determine their total phenolic content using the Follin-Ciocalteu method,their total flavonoid content using aluminum chloride method,their antioxidant activity using DPPH radical scavenging as well as ferrous ion chelating assays and their anti-diabetic activity usingα-amylase andα-glucosidase inhibitory activities with acarbose,a known anti-diabetic drug,used as the standard *** PM samples exhibited a higher antioxidant activity than commercial samples,with the most active homemade PM sample having IC_(50)values of 0.09 mg/mL(DPPH radical scavenging assay)and 46.78%ferrous ion chelating assay).Homemade PM samples also showed higher anti-diabetic activity than commercial samples,with the most active homemade PM sample having an IC_(50)values of 0.63 mg/mL(α-amylase inhibitory activity)and of 0.41 mg/mL(α-glucosidase inhibitory activity)and being almost as active as acarbose with both enzymes(1.5 times).Significant inverse strong/moderate correlations were observed between total phenolic content/total flavonoid content and the IC_(50)value of DPPH radical scavenging assay,indicating positive associations between total phenolic and flavonoid contents and antioxidant *** addition,significant negative moderate correlations were observed between total phenolic/flavonoid contents andα-amylase inhibitory activity,indicating positive associations between total phenoli

关键词： Pomegranate molasses Antioxidant activity Ferrous ion chelating assay Anti-diabetic activity α-amylase inhibitory assay α-glucosidase inhibitory assay

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Impact of Drain Effluent on Surficial Sediments in the Mediterranean Coastal Wetland: Sedimentological Characteristics and Metal Pollution Status at Lake Manzala, Egypt

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Journal of Ocean University of China 2019年第4期18卷 834-848页

作者： farhat Hassan I. Geology Department Faculty of Science Suez University

Surface sediments were collected from Lake Manzala, the Mediterranean coastal wetland located to the east of the Nile Delta, Egypt, to assess the effect of drain effluent on the spatial variations of sedimentary characteristics and heavy metal pollution. Grain-size compositions, textures, and heavy metal distribution patterns in sediments are presented using GIS technique. Results of the analysis of the sediment showed a clear effect of drain effluent, with an increase in fine fractions and homogeneous suspensions in transportation mode. Lake sediments were dominated by sandy mud textures, and mode of transportation was homogeneous sus- pension and rolling. Spatial distribution of heavy metals (Fe, Mn, Zn, Cu, Ni, Cr, and Pb) was studied in the lake’s surficial sediments, along with their relationship to drain effluent and their contamination status in the ecological system. Heavy metal pollution status was assessed by means of accepted sediment quality guidelines and contamination assessment methods (contamination factor, con- tamination degree, modified contamination degree, geo-accumulation, and enrichment factor). Among the determined heavy metals, Pb had the most ecological risk. Generally, the heavy metals in the surface sediments indicated pollution risk ranging from moderate to considerable, particularly, in those sites facing drains and inlets that had the highest toxic effluent. The results were interpreted by statistical means. A cluster analysis defined areas facing drain discharge and inlets as separated groups. ANOVA indicated that most of the sedimentation and studied metals directed this clustering.

关键词： Lake Manzala Mediterranean wetland metal pollution sedimentological characteristics

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Candida endocarditis: Update on management considerations

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World Journal of Cardiology 2023年第10期15卷 469-478页

作者： Yasser Jamil Akintayo Akinleye Mojtaba Mirzaei Matthew Lempel Kassem farhat Samuel Pan Department of Internal Medicine Yale School of MedicineWaterburyCT 06708United States Department of Rheumatology Yale School of MedicineNew HavenCT 06510United States Department of Infectious Disease Yale School of MedicineWaterburyCT 06708United States

The rise in incidence rates of invasive candidiasis warrants an increase in atten-tion and efforts toward preventing and treating this virulent *** involvement is one of the most feared sequelae and has a poor *** the introduction of several novel antifungal agents over the past quarter century,complications and mortality rates due to Candida endocarditis have remained *** fungal endocarditis has a mechanism similar to bacterial endocar-ditis,no specific diagnostic criteria or algorithm exists to help guide its ***,recent data has questioned the current guidelines recommen-ding a combined approach of antifungal agents with surgical valve or indwelling prostheses *** the emergence of multidrug-resistant Candida auris,a focus on improved prophylactic measures and management strategies is nece-ssary.

关键词： Candida Candida endocarditis Fungal endocarditis Invasive fungal infection

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油基钻井液体系轻烃组分分配系数计算及应用

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石油勘探与开发 2022年第4期49卷 787-797页

作者： ABDALLAH Bacem Rabie Ben AHMADI Riadh LYNEN Frederic REKHISS farhat 突尼斯斯法克斯国家工程学院LR3E实验室斯法克斯3000突尼斯比利时根特大学有机与高分子化学系根特9000比利时

采用一种基于静态顶空气相色谱技术的热力学方法研究了油基钻井液、地层流体和钻井液气体之间的关系,计算了两种油基钻井液-空气体系nC_(5)—nC_(8)范围内47种轻烃组分的分配系数,在热力学平衡条件下开展原始地层流体组分重构。研究表明... 详细信息

采用一种基于静态顶空气相色谱技术的热力学方法研究了油基钻井液、地层流体和钻井液气体之间的关系,计算了两种油基钻井液-空气体系nC_(5)—nC_(8)范围内47种轻烃组分的分配系数,在热力学平衡条件下开展原始地层流体组分重构。研究表明,油基钻井液对钻井液气体中nC_(5)—nC_(8)范围内的地层流体组分的影响很小,对于低毒性合成油基钻井液,影响小于1%,对于柴油基钻井液,影响小于10%。对于多数轻烃组分,采用气相校准法和直接定量法确定的分配系数的误差小于10%,直接定量法计算的分配系数更准确。两种原油样品重构组分与真实组分之间的匹配度分别为91%和89%,证明利用nC_(5)—nC_(8)范围内轻烃组分分配系数通过静态顶空分析重构原始地层流体组分的可行性和准确性较高。

关键词：油基钻井液钻井液气体轻烃组分分配系数地层流体

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Recent progress in structural modulation of metal nanomaterials for electrocatalytic CO_(2) reduction

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Rare Metals 2021年第6期40卷 1412-1430页

作者： Chen-Huai Yang farhat Nosheen Zhi-Cheng Zhang Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin University&Collaborative Innovation Center of Chemical Science and EngineeringTianjin 300072China Department of Chemistry Division of Science and TechnologyUniversity of EducationLahore 54660Pakistan

The electrochemical CO_(2) reduction(ECR)into value-added products presents an appealing approach to mitigate CO_(2) emission caused by excess consumption of fossil *** obtain high catalytic activity and selectivity toward target product in ECR,designing and developing a stable and efficient electrocatalyst is of significant *** date,metal nanomaterials have been widely applied as electrocatalysts for ECR due to their unique physicochemical *** structural modulation of metal nanomaterials is an attractive strategy to improve the catalytic *** this review,the recent progress of structural modulation,including size,facet,grain boundary,composition,interface,ligand modification,and crystal phase,is systematically summarized from both theoretical and experimental ***,the opportunities and perspectives of structural modulation of metal nanomaterials for ECR are proposed.

关键词： CO_(2)reduction Structural modulation Electrocatalysis Metal nanomaterial Crystal phase

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相干完美吸收-激光器的最新进展及其未来应用展望

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Journal of Central South University 2022年第10期29卷 3203-3216页

作者： YANG Min-ye YE Zhi-lu ZHU Liang farhat Mohamed CHEN Pai-Yen Department of Electrical and Computer Engineering University of Illinois at ChicagoChicagoIL 60607United States Computer Electricaland Mathematical Science and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

近年来,非厄米系统,特别是宇称-时间(PT)对称系统引起的特殊物理现象吸引了许多科研人员。具有光谱退化性质的异常点(EP)和特征值分别为无限大及零的相干完美吸收-激光(CPAL)点是其中最为热门的研究课题。迄今为止,对于作为PT对称系统... 详细信息

近年来,非厄米系统,特别是宇称-时间(PT)对称系统引起的特殊物理现象吸引了许多科研人员。具有光谱退化性质的异常点(EP)和特征值分别为无限大及零的相干完美吸收-激光(CPAL)点是其中最为热门的研究课题。迄今为止,对于作为PT对称系统的破缺相和确定相边界的EP讨论已经有了非常多的成果。然而,针对CPAL点的理论分析和实验验证,相对于EP来说,仍有不足。与EP不同,CPAL点作为PT对称系统中破缺相中的一个特殊解,可能会表现出更加违反直觉的物理特征,而这些表现可能对研究非厄米物理学有着重要的意义。本文回顾了在不同物理子学科中关于CPAL现象的一些研究,包括光学、电子和电磁学、以及声学。此外,对于CPAL系统未来可能的发展方向及应用给出了一些设想。

关键词：宇称-时间对称性相干完美吸收-激光器光谱奇点非厄米物理学

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