检索结果-南通市图书馆

维普期刊数据库

Characteristics and Risk Factors for Pediatric Sepsis

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2024年第3期44卷 648-656页

作者： Yong-bing ZHU Tong-lin LIU Qi DAI Shu-fan LIU Peng XIONG Hao HUANG Yi yuan Tian-nan ZHANG Yu CHEN Department of Pediatric Intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Sepsis is considered a major cause of health loss in children and had high mortality and ***,there is no reliable model for predicting the prognosis of pediatric patients with *** study aimed to analyze the clinical characteristics of sepsis in children and assess the risk factors associated with poor prognosis in pediatric sepsis patients to identify timely interventions and improve their *** This study analyzed the clinical indicators and laboratory results of septic patients hospitalized in the Pediatric Intensive Care Unit of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,China,from January 1,2019,to December 31,*** factors for sepsis were identified by logistic regression *** A total of 355 children with sepsis were enrolled,with 333 children(93.8%)in the good prognosis group,and 22 children(6.2%)in the poor prognosis *** them,there were 255 patients(71.8%)in the sepsis group,and 100 patients(28.2%)in the severe sepsis *** length of hospital stay in the poor prognosis group was longer than that in the good prognosis group(P0.05),and the platelet(PLT),albumin(ALB),and hemoglobin(Hb)levels were lower in the poor prognosis group(P<0.01).The IL-8 levels in the severe sepsis group were higher than those in the sepsis group(P<0.05).Multiple logistic regression analysis suggested that lower Hb levels,ALB levels,peak PLT counts,and higher IL-1βlevels were independent risk factors for poor prognosis in children with *** Lower Hb,ALB,and PLT counts and elevated IL-1βare independent risk factors for poor prognosis in children with sepsis.

关键词： pediatric sepsis inflammation severity prognosis risk factors

Extended survival with metastatic pancreatic cancer under fruquintinib treatment after failed chemotherapy:Two case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第7期12卷 1296-1304页

作者： Dan Wu Qiong Wang Shuai Yan Xia Sun Ya Qin Ming yuan nan-Yao Wang Xian-Ting Huang Department of Oncology Jiangyin People's HospitalWuxi 214400Jiangsu ProvinceChina

BACKGROUND Pancreatic cancer is a highly malignant *** decades of treatment progress,the current five-year survival rate for patients is still less than 10%.For later-line treatment,the treatment options are even more ***-angiogenic drugs can improve progression-free survival in patients with advanced pancreatic *** data show that fruquintinib might improve the prognosis of advanced pancreatic cancer by targeting angiogenesis and lymphopoiesis,improving the abnormal vascular structure,and modulating the tumour immune *** SUMMARY We present two cases of third-line fruquintinib monotherapy that brought an extraprolonged progress-free survival(PFS)of 10 *** 1 took adjuvant gemcitabine-based and first-line nab-paclitaxel-based chemotherapy and then used local radiotherapy combined with programmed cell death 1 receptor(PD-1).Each line lasted approximately 7 ***,the patient took third-line fruquintinib,which was followed by stable disease for 10 months,during which no additional adverse effect was *** patient later refused to take fruquintinib due to difficulty urinating and lower abdominal pain after the coronavirus disease 2019(COVID-19)*** patient died in February *** 2 also took two prior lines of chemotherapy and then local radiotherapy combined with *** confirmed disease progression,the patient experienced a continuous partial response after using fruquintinib monotherapy in the third *** the patient had COVID-19 in December 2022,fruquintinib was *** patient died in January 2023 due to disease *** Both cases achieved a PFS benefit from later-line single-agent fruquintinib *** its better safety profile,fruquintinib may be worth exploring and studying in more depth as a later-line treatment for pancreatic cancer patients.

关键词： Pancreatic cancer Anti-vascular endothelial growth factor receptor Fruquintinib Case report

Mushroom Poisoning Outbreaks—China,2023

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2024年第4期6卷 64-68,I0001-I0005页

作者： Haijiao Li Yizhe Zhang Hongshun Zhang Jing Zhou Zuohong Chen Jiaqi Liang Yu Yin Qian He Shaofeng Jiang Yutao Zhang yuan yuan nan Lang Bowen Cheng Jiaju Zhong Zhongfeng Li Chengye Sun National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina College of Life Sciences Hunan Normal UniversityChangsha CityHunan ProvinceChina

What is already known about this topic?Mushroom poisoning poses a significant food safety concern in China,with a total of 196 species identified in poisoning incidents by the end of *** is added by this report?In 2023,the China CDC conducted an investigation into 505 cases of mushroom poisoning spanning 24 provincial-level administrative *** investigation resulted in 1,303 patients and 16 deaths,yielding a case fatality rate of 1.23%.A total of 97 mushrooms were identified as the cause of 6 distinct clinical disease types,with 12 species newly documented as poisonous mushrooms in *** are the implications for public health practice?Close collaboration among CDC staff,physicians,and mycologists remains crucial for the control and prevention of mushroom poisoning in the future.

关键词： prevention yielding poisoning

Identification of an Aux/IAA regulator for flesh firmness using combined GWAS and bulked segregant RNA-Seq analysis in watermelon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticultural Plant Journal 2024年第5期10卷 1198-1213页

作者： Muhammad Anees Hongju Zhu Muhammad Jawad Umer Chengsheng Gong Pingli yuan Xuqiang Lu nan He Mohamed Omar Kaseb Dongdong Yang Yong Zhao Wenge Liu Henan Joint International Research Laboratory of South Asian Fruits and Cucurbits Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China Henan Key Laboratory of Fruit and Cucurbit Biology Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural Science(ICRCAAS)AnyangHenan 455000China National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China

Watermelon is a highly cultivated fruit crop renowned for its quality properties of fruit *** various quality factors,fruit flesh firmness is a crucial quality parameter influencing the fruit texture,shelf life and its commercial *** auxin/indole-3-acetic acid(Aux/IAA)plays a significant role in fruit development and ripening of non-climacteric ***,the regulatory mechanism of Aux/IAA in controlling fruit flesh firmness and ripening in watermelon remains *** this study,we employed an integrative approach combining genome-wide association study(GWAS)and bulked segregant RNA-Seq analysis(BSR-Seq)to identify an overlapping candidate region between 12776310 and 12968331 bp on chromosome 6,underlying an auxin-responsive gene(Aux/IAA)associated with flesh firmness in *** analysis,followed by real-time quantitative reverse transcription PCR(qRT-PCR),confirmed that the expression of Aux/IAA was consistently higher in fruits with high flesh *** sequence alignment revealed a single base mutation in the coding region of Aux/***,the concomitant Kompetitive/Competitive allele-specific PCR(KASP)genotyping data sets for F2 population and germplasm accessions identified Aux/IAA as a strong candidate gene associated with flesh ***/IAA was enriched in the plant hormone signal transduction pathway,involving cell enlargement and leading to low flesh *** determined the higher accumulation of abscisic acid(ABA)in fruits with low flesh firmness than hard ***,overexpression of Aux/IAA induced higher flesh firmness with an increased number of fruit flesh cells while reducing ABA content and flesh cell ***,the allelic variation in Aux/IAA for soft flesh firmness was found to exist in Citrullus mucosospermus and gradually fixed into Citrullus lanatus during domestication,indicating that soft flesh firmness was a domesticated *** findings significantly enhanced our unders

关键词： Watermelon Flesh firmness GWAS BSR-Seq KASP marker analysis Transient overexpression

Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第1期16卷 30-50页

作者： Yu-Hua Du Jian-Jun Zhao Xia Li Shi-Cong Huang Na Ning Guo-Qing Chen Yi Yang Yi nan Ling yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Ningxia Chinese Medicine Research Center Manufacturing LaboratoryYinchuan 750004Ningxia Hui Autonomous RegionChina College of Foundation Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Pachymic acid(PA)is derived from Poria *** has a variety of pharmacological and inhibitory effects on various ***,the mechanism of action of PA in gastric cancer(GC)remains *** To investigate the mechanism of PA in treating GC via the combination of network pharmacology and experimental *** The GeneCards and OMIM databases were used to derive the GC targets,while the Pharm Mapper database provided the PA *** the STRING database,a protein-protein interaction network was constructed and core targets were *** analyses of Gene Ontology,Kyoto Encyclopedia of Genes and Genomes(KEGG),and gene set enrichment analysis were conducted,and molecular docking and clinical correlation analyses were performed on the core ***,the network pharmacology findings were validated through in vitro cell assays,encompassing assessments of cell viability,apoptosis,cell cycle,cloning,and western blot *** According to network pharmacology analysis,the core targets were screened,and the PI3K/AKT signaling pathway is likely to be the mechanism by which PA effectively treats GC,according to KEGG enrichment *** experimental findings showed that PA could control PI3K/AKT signaling to prevent GC cell proliferation,induce apoptosis,and pause the cell *** Network pharmacology demonstrated that PA could treat GC by controlling a variety of signaling pathways and acting on a variety of *** has also been supported by in vitro cell studies,which serve as benchmarks for further research.

关键词： Pachymic acid Gastric cancer Network pharmacology Enrichment analysis Cell proliferation

Multitap RF Canceller with Single LMS Loop for Adaptive Co-Site Broadband Interference Cancellation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2024年第9期 179-197页

作者： Jiang Yunhao Liu Zhipeng yuan Lei Xu Anfei Wang Hang Zhao nan Wu Minghu Hubei Key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of Technology Hubei Collaborative Innovation Center for High-Efficiency Utilization of Solar Energy Hubei University of Technology

With the development of wireless communication technology,an urgent problem to be solved is co-site broadband interference on independent communication platforms such as satellites,space stations,aircrafts and ***,the problem of strong selfinterference rejection should be solved in the co-time co-frequency full duplex mode which realizes spectrum multiplication in 5G communication *** the research of such interference rejection,interference cancellation technology has been *** order to reject multipath interference,multitap double LMS(Least Mean Square) loop interference cancellation system is often used for cancelling RF(Radio Frequency) domain interference ***,more taps will lead to a more complex structure of the cancellation system.A novel tap single LMS loop adaptive interference cancellation system was proposed to improve the system compactness and reduce the *** addition,a mathematical model was built for the proposed cancellation system,the correlation function of CP2FSK(Continuous Phase Binary Frequency Shift Keying) signal was derived,and the quantitative relationship was established between the correlation function and the interference signal bandwidth and tap delay *** steadystate weights and the expression of the average interference cancellation ratio(ICR) were deduced in the scenes of LOS(Line of Sight) interference with antenna swaying on an independent communication platform and indoor multipath *** quantitative relationship was deeply analyzed between the interference cancellation performance and the parameters such as antenna swing,LMS loop gain,and interference signal bandwidth,which was verified by simulation *** the performance of the proposed interference cancellation system was compared with that of the traditional double LMS loop cancellation *** results showed that the compact single LMS loop cancellation system can achieve an average interference rejecti

关键词：

Robustness of the octupole collectivity in 144Ba within the cranking covariant density functional theory in 3D lattice

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第8期35卷 124-131页

作者： Ze‑Kai Li yuan‑yuan Wang Mathematics and Physics Department North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071000China

The octupole deformation and collectivity in octupole double-magic nucleus 144Ba are investigated using the Cranking covariant density functional theory in a three-dimensional lattice *** reduced B(E3)transition probability is implemented for the first time in semiclassical approximation based on the microscopically calculated electric octupole *** available data,including the I-ωrelation and electric transitional probabilities B(E2)and B(E3)are well ***,it is shown that the ground state of 144Ba exhibits axial octupole and quadrupole deformations that persist up to high spins(I≈24h).

关键词： Octupole collectivity Cranking covariant density functional theory Rotational spectrum Electric transitional probabilities

维普期刊数据库

Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第2期30卷 171-180页

作者： ZHAO Wen-xiao WANG Tong ZHANG Ya-nan CHEN Qian WANG yuan XING Yan-qing ZHENG Jun DUAN Chen-chen CHEN Lijun ZHAO Hai-jun WANG Shijun School of Nursing Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula Shandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan(250355)China

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver *** extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and *** alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides *** addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut *** review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关键词： Chinese medicine polysaccharides gut microbiota short-chain fatty acids lipopolysaccharides gut-organaxis synergistic actions

维普期刊数据库

Impact of baseline hepatitis B virus viral load on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2504-2519页

作者： Di Pan Hao-nan Liu Zhi-yuan Yao Xiao-Xiao Chen Yu-Qi Li Jing-Jing Zhu Zheng-Xiang Han Xiao-Bing Qin Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Although the combination of lenvatinib and PD-1 inhibitors has become the standard regimen for the treatment of advanced hepatocellular carcinoma(HCC),real data on the impact of baseline hepatitis B virus(HBV)-DNA levels on the clinical efficacy of this regimen is still *** To evaluate the effectiveness of camrelizumab combined with lenvatinib in patients with HCC at varying levels of *** One hundred and twenty patients with HCC who received camrelizumab and lenvatinib treatment were categorized into two cohorts:HBV-DNA≤2000(n=66)and HBV-DNA>2000(n=54).The main outcomes measured were overall survival(OS)and progression-free survival(PFS),while additional outcomes included the rate of objective response rate(ORR),disease control rate(DCR),and any negative *** proportional hazards regression analysis revealed independent predictors of OS,leading to the creation of a nomogram incorporating these *** The median PFS was 8.32 months for the HBV-DNA≤2000 group,which was similar to the 7.80 months observed for the HBV DNA>2000 group(P=0.88).Likewise,there was no notable variation in the median OS between the two groups,with durations of 13.30 and 14.20 months respectively(P=0.14).The ORR and DCR were compared between the two groups,showing ORR of 19.70%vs 33.33%(P=0.09)and DCR of 72.73%vs 74.07%(P=0.87).The nomogram emphasized the importance of antiviral treatment as the main predictor of patient results,with portal vein tumor thrombus and Barcelona Clinic Liver Cancer staging following closely *** The clinical outcomes of patients with HBV-associated HCC treated with camrelizumab in combination with lenvatinib are not significantly affected by HBV viral load.

关键词： Hepatitis B virus Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy