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北京市某公共建筑综合节能改造与能效评估

建筑节能（中英文） 2024年第4期52卷 88-94页

作者：褚赛魏俊辉刘启明孙林娜许抗吾北京市勘察设计研究院有限公司北京100038

以北京市东城区某综合园区为例,根据园区现状对其围护结构热工性能、供暖空调、建筑照明及用水器具进行节能诊断及能耗分析。结果显示:建筑供暖耗热量及照明耗电量占比分别为58.96%和10.24%,为挖掘改造潜力并确定基准能耗提供了依据;通... 详细信息

以北京市东城区某综合园区为例,根据园区现状对其围护结构热工性能、供暖空调、建筑照明及用水器具进行节能诊断及能耗分析。结果显示:建筑供暖耗热量及照明耗电量占比分别为58.96%和10.24%,为挖掘改造潜力并确定基准能耗提供了依据;通过围护结构保温层加装、门窗更换、高效空调设备更换、照明灯具更换及节水器具更换等节能技改措施进行综合节能改造,计算改造后能耗;将不同能源类型能耗归一化为标煤,经测算,改造后项目节能量约为71.0 tce,综合节能率35.52%,减少向大气排放二氧化碳175.38 t,节能减排效果显著,为类似地区公建节能改造提供了借鉴和参考。本次能评估多采用理论模拟计算方法,还需改造后实际运行数据对比支撑。

关键词：公共建筑节能诊断节能改造节能率

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持续葡萄糖监测技术在糖尿病患者中的应用

中外医学研究 2024年第19期22卷 96-99页

作者：鄢赛高榕六盘水市人民医院贵州六盘水553000

目的:探究持续葡萄糖监测技术在糖尿病患者中的应用。方法:回顾性分析2023年1—12月六盘水市人民医院内分泌科住院及门诊就诊的180例糖尿病患者的临床资料。根据血糖监测方法的不同将其分为对照组和观察组,各90例。对照组实施指尖血糖监... 详细信息

目的:探究持续葡萄糖监测技术在糖尿病患者中的应用。方法:回顾性分析2023年1—12月六盘水市人民医院内分泌科住院及门诊就诊的180例糖尿病患者的临床资料。根据血糖监测方法的不同将其分为对照组和观察组,各90例。对照组实施指尖血糖监测,观察组实施持续葡萄糖监测技术。比较两组血糖水平,血糖达标情况,血糖波动情况,胰岛素用量,低血糖情况。结果:观察组午餐、晚餐前后血糖值均低于对照组,差异有统计学意义(PtIR)高于对照组,差异有统计学意义(P0.05);观察组四分位区间(IQR)、十分位数区间(IDR)均小于对照组,差异有统计学意义(Pt=4.849,P<0.001)。观察组低血糖发生率为18.89%,低于对照组的42.22%,差异有统计学意义(P<0.05)。结论:糖尿病患者实施持续葡萄糖监测的效果优于指尖血糖监测,血糖波动减少,胰岛素用量降低。

关键词：糖尿病指尖血糖监测持续葡萄糖监测血糖管理

中国EtF期权Delta对冲收益的日夜特征研究

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管理科学学报 2024年第2期27卷 136-158页

作者：刘彦初汤昊文钱潮阳中山大学岭南学院广州510275 华宝基金管理有限公司上海200120

期权市场是现代金融市场的重要组成部分,研究期权市场Delta对冲收益的日夜特征,对于理解期权市场运行机制以及降低金融市场风险具有重要意义.本文使用我国2015年—2021年股票EtF期权数据,研究了期权Delta对冲收益的日夜特征.研究结果表... 详细信息

期权市场是现代金融市场的重要组成部分,研究期权市场Delta对冲收益的日夜特征,对于理解期权市场运行机制以及降低金融市场风险具有重要意义.本文使用我国2015年—2021年股票EtF期权数据,研究了期权Delta对冲收益的日夜特征.研究结果表明,总体上Delta对冲的隔夜收益为负、日内收益不显著;认购期权和认沽期权的Delta对冲收益具有非对称性,即认购期权日内为负、隔夜为正,而认沽期权恰好相反.即使替换为基于波动率和标的资产价格关系的对冲模型,非对称性异象仍然存在.这些发现不同于美国期权市场的Delta对冲收益日内为正、隔夜为负的特征.本文进一步探讨了可能的成因:从风险溢价看,波动率风险溢价可以解释总体上负的隔夜对冲收益,但是不能解释Delta对冲收益的非对称性;从模型误差看,模型误差与标的资产收益共同作用影响了Delta对冲收益;从交易制度看,t+1交易制度约束造成了标的资产日夜收益反转,进而导致了对冲收益的非对称性,并且t+1交易制度约束越强,对冲收益的非对称性越明显.本文将丰富我国期权市场Delta对冲效率、交易制度对金融市场影响的相关研究,有利于提高投资者的风险管理水平、增进监管者对市场行为的理解,从而推动中国多层次资本市场的高质量发展.

关键词： EtF期权 Delta对冲收益日内和隔夜风险溢价模型误差 t+1交易制度

Dawn of CAR-t cell therapy in autoimmune diseases

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Chinese Medical Journal 2024年第10期137卷 1140-1150页

作者： Yuxin Liu Minghao Dong Yunhui chu Luoqi Zhou Yunfan You Xiaowei Pang Sheng Yang Luyang Zhang Lian Chen Lifang Zhu Jun Xiao Wei Wang chuan Qin Daishi tian Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and TechnologyWuhanHubei 430030China

Chimeric antigen receptor(CAR)-t cell therapy has achieved remarkable success in the treatment of hematological *** on the immunomodulatory capability of CAR-t cells,efforts have turned toward exploring their potential in treating autoimmune *** analysis of 210 records from 128 academic journals published by 372 institutions in 40 countries/regions indicates a growing number of publications on CAR-t therapy for autoimmune diseases,covering a range of subtypes such as systemic lupus erythematosus,multiple sclerosis,among ***-t therapy holds promise in mitigating several shortcomings,including the indiscriminate suppression of the immune system by traditional immunosuppressants,and non-sustaining therapeutic levels of monoclonal antibodies due to inherent pharmacokinetic *** persisting and proliferating in vivo,CAR-t cells can offer a tailored and precise *** paper reviewed preclinical experiments and clinical trials involving CAR-t and CAR-related therapies in various autoimmune diseases,incorporating innovations well-studied in the field of hematological tumors,aiming to explore a safe and effective therapeutic option for relapsed/refractory autoimmune diseases.

关键词： CAR-t cell therapy Autoimmune disease Immunotherapy Multiple sclerosis Neuromyelitis optica spectrum disorder Systemic lupus erythematosus

Analysis of formation and slope stability in Caofeidian Channel in Bohai Bay

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China Geology 2019年第2期2卷 189-197页

作者： Hong-xian chu sai Mei Xiao-hui Gao Zhong-hua Fang Jing Feng Key Laboratory of Coastal Wetland Biogeosciences Qingdao Institute of Marine GeologyChina Geological SurveyMinistry of Natural ResourcesQingdao 266071China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

In this paper, by studying bathymetric survey and shallow seismic detection data over multiple periods of history, the authors outline the geomorphic features of the Caofeidian Channel. the results of our studies indicate that the channel at the front end is dominated by erosion. the maximum water depth reaches 42.2 m, which sets the highest record for the water depth in Bohai Bay;the authors preliminarily conclude that the formation of the early channel occurred because the subsidence rate of the deep structure is slightly smaller than the deposition rate of the upper strata, and the Caofeidian Channel has existed for a long time, over 20 ka. the trending of the channel experienced a transition from the NS to the NE and then NW direction;the authors conclude that endogenic and exogenic processes, such as geological structures, the evolution of the ancient Luanhe River Delta, marine hydrodynamics, and human activity, jointly control the development and evolution of the geographic system in the Caofeidian sea area. the slope stabilities under the extreme conditions of a heavy storm and an earthquake are analyzed by performing simulations.

关键词： Caofeidian Channel tidal current Deposition Erosion Stability

Gene mutations in newly diagnosed multiple myeloma patients detected by next-generation sequencing technology

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Cancer Pathogenesis and therapy 2024年第3期2卷 205-211页

作者： Yutong Wang Mengzhen Wang Bin chu Minqiu Lu Lei Shi Shan Gao Yuan Chen Qin Yan Na Ji Li Bao Department of Hematology Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China

Background:Multiple myeloma(MM)is a heterogeneous plasma-derived hematopoietic malignancy with complex genetic mutation contributing to the *** gene sequencing has been applied in MM,genetic features from Chinese MM patients are reported *** investigated the genetic mutation of newly diagnosed multiple myeloma(NDMM)patients and explore its correlation with cytogenetic abnormalities detected by fluorescence in situ hybridization(FISH).Methods:A total of 206 patients with NDMM were *** enriching plasma cells with CD138 magnetic beads,92 MM-related target gene mutations were detected by the Illumina sequencing platform,and six common genetic abnormalities were detected by ***:162 cases(78.6%)had at least one gene mutation detected by *** top 5 mutated genes were KRAS,NRAS,tRAF3,BRAF,and *** abnormalities detected by FISH have a certain correlation with gene mutations,t(11;14)translocations are often accompanied by CCND1 and tP53 mutations,KLHL6 in t(4;14),SP140,CDKN1B and PRKD2 in t(14;16)and t(14;20)*** mutation ratio was higher for EGR1,while lower of CCND1 in patients with gain *** tP53 mutation was more likely in patients with 17p *** gene mutation affects the pathway of the RNA process is more frequently occurring in males and age less than 70 years *** International Staging System(ISS)Stage Ⅲ correlated with gene mutations in the NK-κB pathway while Revised ISS(R-ISS)Stage Ⅲ correlated with the DNA damage repair ***:there are various gene mutations in NDMM patients,mainly RAS/MAPK and NF-κB pathway gene pathways.

关键词： Multiple myeloma Next-generation sequencing Genetics mutation

Ru@RuO2 Core-Shell Nanorods: A Highly Active and Stable Bifunctional Catalyst for Oxygen Evolution and Hydrogen Evolution Reactions

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Energy & Environmental Materials 2019年第3期2卷 201-208页

作者： Rongzhong Jiang Dat t.tran Jiangtian Li Deryn chu Sensors and Electron Devices Directorate U.S.Army Research Laboratory2800 Powder Mill RoadAdelphiMD 20783-1197USA

Ru@RuO2 core-shell nanorods were successfully synthesized by heat-treating Ru nanorods with air oxidation through an accurate control of the temperature and time. the structure, composition, dimension, and adsorption property of the core-shell nanorods were well characterized with XRD and tEM. the catalytic activity and stability were electrochemically evaluated with a rotating disk electrode, a rotating ring-disk electrode, and chronopotentiometric methods. the Ru@RuO2 nanorods reveal excellent bifunctional catalytic activity and robust stability for both oxygen evolution reaction(OER) and hydrogen evolution reaction(HER). the overpotentials for OER and HER are 320 m V and 137 m V at the current density of10 m A cm-2, respectively. the catalytic activity of Ru@RuO2 nanorods for OER is 6.5 times higher than that of the state-of-the-art catalyst IrO2 according to the catalytic current density measured at 1.60 V(versus RHE).the catalytic activity of Ru@RuO2 nanorods for HER is comparable to 40%Pt/C by comparing the catalytic current densities at à0.2 V.

关键词： bifunctional catalyst core-shell hydrogen evolution reaction oxygen evolution reaction Ru@RuO2

基于合同能源管理模式的云机房节能改造方案设计及经济性分析

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建筑节能（中英文） 2024年第5期52卷 124-127,135页

作者：褚赛刘启明魏俊辉鲍超许抗吾刘嘉北京市勘察设计研究院有限公司北京100038

以北京市朝阳区某云机房为例,调研机房现状空调情况,分析电量电费数据。针对系统存在的制冷能效低、运行费用高、通风散热差等问题,提出加装6个制冷量为50kW的风冷氟泵冷却模块及采用高压雾化喷淋系统两项改造措施,并基于15年期合同能... 详细信息

以北京市朝阳区某云机房为例,调研机房现状空调情况,分析电量电费数据。针对系统存在的制冷能效低、运行费用高、通风散热差等问题,提出加装6个制冷量为50kW的风冷氟泵冷却模块及采用高压雾化喷淋系统两项改造措施,并基于15年期合同能源管理模式,计算项目动态投资回收期,评判项目投资回收风险。测算结果表明,机房年均节电量306.55 MWh,节能率35.25%,减排二氧化碳93.06t,改造后机房PUE值由1.82降至1.58;工程投资额151.8万元,年均节约费用26.98万元,税后内部收益率13.18%,动态投资回收期7.22年;节能环保效益及经济效益较好,以期为园区乃至北京市类似机房升级改造提供参考和借鉴。

关键词：合同能源管理机房节能改造自然冷源动态投资回收期

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风速时间序列模拟的模型有效性验证及代表性风场实例分析

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振动与冲击 2019年第15期38卷 73-79页

作者：马赛褚福磊清华大学机械工程系

在风力发电场的合理选址以及风力发电机组的结构设计阶段,能量谱与功率谱模型对于风力发电机组的系统方案有着直接的影响,特别是在具体结构设计阶段选取恰当的功率谱模型是至关重要的,但目前对具体模型的选择依据尚不明确。针对能量谱... 详细信息

在风力发电场的合理选址以及风力发电机组的结构设计阶段,能量谱与功率谱模型对于风力发电机组的系统方案有着直接的影响,特别是在具体结构设计阶段选取恰当的功率谱模型是至关重要的,但目前对具体模型的选择依据尚不明确。针对能量谱与功率谱两种重要的风速数据分析模型,以国内五处地区代表性风场的全年风速测试数据为基础,进行了能量谱与功率谱的分析,从分析结果中得出了如下两个结论:①我国东南沿海地区风场的风力资源最为丰富,其有效风能密度区(200~400 W/m^2)持续时间最长;北部地区风场的风力资源也较为丰富,且在高风能密度区(>500 W/m^2)具有一定优势;对于主要风力资源集中在低风能密度区(<200 W/m^2)的部分地区风场,在风力发电设备选型时应该有针对性的进行结构设计,实现低速风力资源的高效利用。②对于具体风场的风速模型选择准则给出了实例验证与建议:Mann功率谱模型表现出与各风场实测数据良好的一致性,应该在进行结构设计时作为主要备选。

关键词：风速时间序列能量谱模型功率谱模型模型选择依据