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Helicobacter pylori outer membrane protein Q genotypes and their susceptibility to antiadhesive phytotherapeutic agents

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Journal of Integrative Medicine 2017年第5期15卷 398-406页

作者： Javed Yakoob Zaigham Abbas Malik Hassan Mehmood Kanwal Tariq Saima Azhar Saleem safia Awan Abdul Malik Saeed Hamid Rustam Khan Wasim Jafri Department of Medicine Aga Khan UniversityKarachi 74800Pakistan Department of Biological Biomedical Sciences Aga Khan UniversityKarachi 74800Pakistan

OBJECTIVE： Helicobacter pylori is a Gram-negative organism. Its outer membrane protein Q（Hop Q） mediates host-pathogen interactions; Hop Q genotypes 1 and 2 are found associating with gastroduodenal pathologies. The authors measured the anti-adhesion effects of the extracts of Abelmoschus esculentus, Zingiber officinale, Trachyspermum ammi, Glycyrrhiza glabra, Curcuma longa and Capsicum annum against Hop Q genotypes and H. pylori cytotoxin-associated gene A（Cag A）.METHODS： DNA was extracted by polymerase chain reaction of the Hop Q genotypes（i.e., type 1, type 2 and Cag A） from 115 H. pylori strains. The effect of the extracts from selected dietary ingredients was determined using a gastric adenocarcinoma cell line and a quantitative DNA fragmentation assay. The anti-adhesive effect of these extracts on H. pylori was tested using an anti-adhesion ***： C. annum, C. longa and A. esculentus showed prominent anti-adhesion effects with resultant values of 17.3% ± 2.9%, 14.6% ± 3.7%, 13.8% ± 3.6%, respectively, against Hop Q type 1 and 13.1% ± 1.7%, 12.1% ± 2%, 11.1% ± 1.6%, respectively, against Hop Q type 2. C. longa（93%）, C. annum（89%） and A. esculentus（75%） had better anti-adhesive activity against H. pylori with Hop Q type 1 compared to Hop Q type 2 with respective values of 70%, 64% and 51%. Extracts of C. annum（14.7% ± 4.1%）, A. esculentus（12.3% ± 4.1%） and Z. officinale（8.4% ± 2.8%） had an anti-adhesion effect against Cag A-positive H. pylori strains compared to Cag A-negative strains.

关键词： outer membrane protein Q Helicobacter pylori anti-adhesion Abelmoschus esculentus Capsicum annum Curcuma Ionga

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Pakistan-China Friendly Relations Are Deep Rooted

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Voice of Friendship 2011年第2期 30-31页

作者： Syed Ali Nawaz gilani

On the eve of the 60th anniversary celebrations of the establishment of Pakistan-China Diplomatic Relations,a special function was jointly organized in March

关键词： Pakistan jointly headed delegation organized anniv

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55 Years of Pak-China Relations

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Voice of Friendship 2006年第4期 16-19页

作者： Syed Ali Nawaz gilani secretary-general of the Pak-ChinaFriendship Association NWFP Pakistan

“The bedrock of our bilateral bonds is a strong faith and trust in each other that we have nurtured with care and devotion”, Presi- dent General Pervez Musharraf’s words reflect the importance of Pak-China relation... 详细信息

关键词： diplomatic Pakistan delegation visit bilateral inv

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HCV-discovery to elimination, 'myth or reality'

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Hepatoma Research 2018年第9期4卷 37-44页

作者： Wasim Jafri Basit Siddiqui safia Awan Aga Khan University Department of Medicine Section of GastroenterologyKarachi 75500Pakistan

Hepatitis C virus (HCV) was discovered in 1989, before that it was commonly known as transfusion associated non A non B hepatitis. It rapidly assumed the role of leading cause of cirrhosis and liver cancer and a leading indication for liver transplant globally. For over two decades the treatment was suboptimal with the use of pegylated interferon and ribavirin combination across all genotypes. The vaccine development also failed for over two decades. However a major breakthrough happened in December 2013 when the Food and Drug Administration (FDA) approved the first pan genotypic oral directly acting drug Sofosbuvir. Since then many new directly acing drugs have been approved through fast track by the FDA. Today we have directly acting antiviral agents for all HCV patients providing cure rates of over 90%. Looking into this success the World Health Organization has set targets for 2030 for HCV elimination. There are several countries which have formed strategies to achieve this goal and others are still thinking to develop their own strategies. The availability of generics have reduced the prices substantially, however the problem is so gigantic that unless proper operational strategies for elimination are developed by the developing world especially by China and Pakistan, the two counties having the largest existing pool of HCV patients, the goals of elimination may not come true.

关键词： Hepatitis C virus elimination directly acting antiviral agents Pakistan

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60 Golden Years of Pak-China Relations

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Voice of Friendship 2011年第3期 14-17页

作者： Syed Ali Nawaz gilani

Since establishment of diplomatic ties between the two countries in May 1951,China and Pakistan have developed an all-season friendship which is based on equality,brotherhood and overall *** the past 60 years,the two countries have carried out multi-dimensional cooperation in varied *** unstable international situation,the China-Pakistan friendship remained strong and *** is only because both the countries enjoy high respect and trust over each *** years have witnessed a frequent exchange of visits between the leadership of the two countries which further promoted and bonded cooperation in almost every area of the relationship.

关键词： diplomatic cooperation Pakistan leadership Golden

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Welcome, President Mr. Xi Jinping

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Voice of Friendship 2015年第2期 49-50页

作者： Syed Ali Nawaz gilani Pakistan-China Friendship Association Khyber Chapter

The Chinese President His Excellency *** Jinping is arriving today on state visit to Pakistan after taking over the office of President of the People’s Republic of China on March 14,*** visit is taking place in the b... 详细信息

关键词： political apart Pakistan today boosting visit curr

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Gallbladder endometriosis as a cause of occult bleeding

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World Journal of Gastroenterology 2007年第33期13卷 4517-4519页

作者： K Saadat-gilani L Bechmann A Frilling G Gerken A Canbay Division of Gastroenterology and Hepatology University Hospital Essen Germany Department of General Visceral and Transplantation Surgery University Hospital Essen Germany

A 17-year-old girl with colicky abdominal pain andchronic anemia presented to the gastrointestinal serviceof the University Hospital of Essen. In the routineworkup, there were no pathological findings despitethe anemia. Because of the fluctuation of symptomswith a climax at the time of menstruation, consecutiveultrasound studies were performed revealing a visiblemass inside the gallbladder. This finding was confirmedby a magnetic resonance imaging (MRI) study performedat the same time. Because of the severe anemia by thattime, a cholecystectomy was performed, and histologyreconfirmed the diagnosis of isolated gallbladderendometriosis. The patient recovered well and has hadno recurrence of the disease to date.

关键词： Gallbladder Endometriosis Bleeding Menstrual cycle Abdominal pain

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Measurements of Natural Radioactivity of Industrial Raw Materials from the West of Saudi Arabia (Arabian Shield)

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Journal of Modern Physics 2015年第4期6卷 510-520页

作者： safia H. Q. Hamidalddin Physics Department Girls Faculty of Science King Abdulaziz University Jeddah Saudi Arabia

Rock samples of industrial raw materials that are used in the building, from the West of Saudi Arabia (Arabian Shield), have been investigated using X-ray diffraction to identify the mineral chemical composition. The concentrations of Al%, Bi, Pb, Th, U, and K in ppm were measured by atomic absorption analysis. The activity concentrations in Bq/kg dry weight of 226Ra, 232Th and 40K were measured using gamma-ray spectrometry where the range and average were found to be (03.04 - 10.91) 07.90, (03.19 - 13.31) 09.14 and (95.59 - 361.52) 234.81 in Basalt, for Granite (33.81 - 89.13) 80.85, (28.42 - 112.77) 68.50 and (1260.13 - 1629.21) 1376.69, for Gold (00.78 - 11.84) 04.73, (01.48 - 4.69) 02.69 and (13.76 - 445.09) 197.58, for Andesite 05.72, 03.73 and 471.93, and for Marble 01.56, 01.38 and 10.15 respectively. Most results existing within the given values in building materials by UNSCEAR 1993 included Raeq (Bq/kg), D (nGy/h), Deff (mSv/y), Hex and Hin, which meant that it was safe for humans.

关键词： Arabian Shield Industrial Raw Materials Harrat

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Value of multi-disciplinary input into laparoscopic management of rectal cancer-An observational study

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World Journal of Gastrointestinal Surgery 2017年第6期9卷 153-160页

作者： Pawan Kumar Dhruva Rao Sooriyaratchige Pradeep Manjula Peiris Seema safia Arif Rhodri A Davies Ashraf Gergies Masoud Puthucode Narayanan Haray Department of Colorectal Surgery Prince Charles Hospital Velindre Cancer Centre University of South Wales Pontypridd

AIMTo assess the impact of multi-disciplinary teams (MDTs) management in optimising the outcome for rectal cancers. METHODSWe undertook a retrospective review of a prospectively maintained database of patients with rectal cancers (defined as tumours ≤ 15 cm from anal verge) discussed at our MDT between Jan 2008 and Jan 2011. The data was validated against the national database to ensure completeness of dataset. The clinical course and follow-up data was validated using the institution’s electronic patient records. The data was analysed in terms of frequencies and percentages. Significance of any differences were analysed using χ2 test. A Kaplan-Meier analysis was performed for overall survival and disease free survival. RESULTSFollowing appropriate staging, one hundred and thirty-three patients were suitable for potentially curative resections. Seventy two (54%) were upper rectal cancer (URC) - tumour was > 6 cm from the anal verge and 61 (46%) were lower rectal cancers (LRC) - lower extent of the tumour was palpable ≤ 6 cm. Circumferential resection margin (CRM) appeared threatened on pre-operative MRI in 19/61 (31%) patients with LRC requiring neo-adjuvant therapy (NAT). Of the 133 resections, 118 (89%) were attempted laparoscopically (5% conversion rate). CRM was positive in 9 (6.7%) patients; Median lymph node harvest was 12 (2-37). Major complications occurred in 8 (6%) patients. Median follow-up was 53 mo (0-82). The 90-d mortality was 2 (1.5%). Over the follow-up period, disease related mortality was 11 (8.2%) and overall mortality was 39 (29.3%). Four (3%) patients had local recurrence and 22 (16.5%) patients had distant metastases. CONCLUSIONManagement of rectal cancers can be optimized with multi-disciplinary input to attain acceptable long-term oncological outcomes even when incorporating a laparoscopic approach to rectal cancer resection.

关键词： Rectal cancer Multi-disciplinary management Laparoscopic rectal resection outcomes

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Influence of monovalent alkaline metal cations on binder-free nano-zeolite X inpara-xylene separation

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Chinese Journal of Chemical Engineering 2015年第1期23卷 64-70页

作者： Milad Rasouli Nakisa Yaghobi Seyedeh Zahra Movassaghi gilani Hossein Atashi Majid Rasouli Department of Chemical Engineering Faculty of Engineering University of Sistan and Baluchestan Petrochemical Department Iran Polymer and Petrochemical Institute Chemical Engineering Department Amirkabir University of Technology

The adsorption process was studied for separating para-xylene from xylene mixture on modified nano-zeolite X in a breakthrough system. Nano-zeolitic adsorbent with different ratios of Si O2/Al2O3 was synthesized through hydrothermal process and ion-exchanged with alkaline metal cations like lithium, sodium and potassium. The product was characterized by X-ray diffraction, scanning electron microscopy(SEM), nitrogen adsorption,transform electron microscopy(TEM) and in situ Fourier transform infrared(FTIR) spectroscopy. The influence of nano-zeolite water content and desorbent type on the selectivity of para-xylene toward other C8 aromatic isomers was studied. The optimization of adsorption process was also investigated under variable operation conditions. The isotherm for each isomer of C8 aromatics and the desorbents possess the adsorption characteristics of Langmuir type. The selectivity factor of para-xylene relative to each of meta-xylene, ortho-xylene and ethylbenzene under the optimum conditions obtained to be 5.36, 2.43 and 3.22, in the order given.

关键词： Nano-zeolite X Adsorption C8aromatics Isotherm

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