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Proposal for pathogenesis-based treatment options to reduce calcium oxalate stone recurrence

Asian Journal of Urology 2023年第3期10卷 246-257页

作者： saeed r.khan Benjamin K.Canales Department of Pathology Immunologyand Laboratory MedicineUniversity of FloridaGainesvilleFLUSA Department of Urology University of FloridaGainesvilleFLUSA

Objective:Prevalence of kidney stone disease continues to increase globally with recurrence rates between 30%and 50%despite technological and scientific *** in recurrence would improve patient outcomes and reduce cost and stone *** objective was to review results of experimental studies performed to determine the efficacy of readily available compounds that can be used to prevent ***: All relevant literature up to October 2020,listed in PubMed is ***: Clinical guidelines endorse the use of evidence-based medications,such as alkaline agents and thiazides,to reduce urinary mineral supersaturation and ***,there may be additional steps during stone pathogenesis where medications could moderate stone *** calcium oxalate stones grow attached to randall’s plaques or *** of clinical and experimental studies suggest involvement of reactive oxygen species and oxidative stress in the formation of both the plaques and *** renin-angiotensin-aldosterone system(rAAS),nicotinamide adenine dinucleotide phosphate(NADPH)oxidase,mitochondria,and NOD-like receptor pyrin domain containing-3(NLrP3)inflammasome have all been implicated at specific steps during stone pathogenesis in animal ***: In addition to supersaturation-reducing therapies,the use of anti-oxidants,free radical scavengers,and inhibitors of NADPH oxidase,NLrP3 inflammasome,and rAAS may prove beneficial for stone *** such as statins and angiotensin converting enzyme inhibitors are already in use as therapeutics for hypertension and cardio-vascular disease and have previously shown to reduce calcium oxalate nephrolithiasis in *** clinical evidence for their use in stone prevention in humans is limited,experimental data support they be considered along with standard evidence-based medications and clinical expertise when patients are being counselled for stone prevention.

关键词： Kidney stones Calcium oxalate Inflammation Inflammasome Supersaturation reactive oxygen species Oxidative stress

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Electronic and thermoelectric properties of YbMg_(2)X_(2)(X=P,As,Sb,Bi)zintl compounds by first-principles method

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Journal of rare Earths 2024年第1期42卷 147-154,I0006页

作者： Sajid khan Dil Faraz khan r.Neffati Tariq Usman Muhammad Waqar Ahsraf Shamim khan saeed Ullah Jan G.Murtaza Department of Physics University of Science&Technology BannuBannu28100Pakistan Department of Physics Faculty of ScienceKing Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Laboratoire de Physique de La Matiere Condensee Departement de PhysiqueFaculte des Sciences de TunisUniversite Tunis El ManarCampus Universitaire1060TunisTunisia Department of Physics Shaoxing UniversityShaoxing312000China Department of Mathematics&Natural Sciences Prince Mohammad Bin Fahd UniversityAlkhobar31952Saudi Arabia Materials Modeling Lab Department of PhysicsIslamia College Peshawar25120KhyberPakhtunkhwaPakistan

In this work the structural,electronic and thermoelectric properties of YbMg_(2)X_(2)(X=P,As,Sb,Bi)zintl compounds were investigated comprehensively using first principles *** electronic properties were studied using PBE GGA,TB-mBJ and hybrid(YS-PBE0)*** the structural parameters of optimized structures are in harmonious agreement to the available *** band structure study illustrates that the titled materials manifest metallic and semi metallic nature using PBE and TB-mBJ potentials while they show wide band gap semiconducting behavior by following hybrid(YS-PBE0)*** density of states(TDOS)and partial density of states(PDOS)were also calculated to glimpse the contribution of orbitals of atoms in the formation of *** properties were studied by using BoltzTraP2 code employed to *** get enormous values of Seebeck coefficient(S),power factor(PF)and thermoelectric figure of merit(ZT)for all the samples YbMg_(2)X_(2)(X=P,As,Sb,Bi),Moreover,the overwhelming transport properties for the titled compounds indicate the optimum level of carriers’concentration which pinpoints these materials to be better thermoelectrics in the 1-2-2 zintl family.

关键词： Zintl compounds Hybrid functional Band structure Thermoelectrics rare earths

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A Hybrid and Lightweight Device-to-Server Authentication Technique for the Internet of Things

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Computers, Materials & Continua 2024年第3期78卷 3805-3823页

作者： Shaha Al-Otaibi rahim khan Hashim Ali Aftab Ahmed khan Amir saeed Jehad Ali Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science Abdul Wali Khan University MardanMardan23200Pakistan Department of Computer Science and IT UET PeshawarJalozai Campus PeshawarPeshawar24240Pakistan Department of AI Convergence Network Ajou UniversitySuwon16499South Korea

The Internet of Things(IoT)is a smart networking infrastructure of physical devices,i.e.,things,that are embedded with sensors,actuators,software,and other technologies,to connect and share data with the respective server *** IoTs are cornerstones in different application domains,the device’s authenticity,i.e.,of server(s)and ordinary devices,is the most crucial issue and must be resolved on a priority ***,various field-proven methodologies were presented to streamline the verification process of the communicating devices;however,location-aware authentication has not been reported as per our knowledge,which is a crucial metric,especially in scenarios where devices are *** paper presents a lightweight and location-aware device-to-server authentication technique where the device’s membership with the nearest server is subjected to its location information along with other ***,Media Access Control(MAC)address and Advance Encryption Scheme(AES)along with a secret shared key,i.e.,λ_(i) of 128 bits,have been utilized by Trusted Authority(TA)to generate MaskIDs,which are used instead of the original ID,for every device,i.e.,server and member,and are shared in the offline ***,TA shares a list of authentic devices,i.e.,server S_(j) and members C_(i),with every device in the IoT for the onward verification process,which is required to be executed before the initialization of the actual communication ***,every device should be located such that it lies within the coverage area of a server,and this location information is used in the authentication process.A thorough analytical analysis was carried out to check the susceptibility of the proposed and existing authentication approaches against well-known intruder attacks,i.e.,man-in-the-middle,masquerading,device,and server impersonations,etc.,especially in the IoT ***,proposed authentication and existing state-of-the-art approaches have been s

关键词： Internet of things authenticity security location communication

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Development and Application of a Validated UHPLC Method for the Determination of Atropine and Its Major Impurities in Antidote Treatment Nerve Agent Auto-Injectors (ATNAA) Stored in the Strategic National Stockpiles

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Pharmacology & Pharmacy 2017年第1期8卷 15-31页

作者： Cheng H.Yen Adil Mohammad Miah Schneider Salwa K.Poole Bryan Lowry Brenda W.Mc Curdy Patrick J.Faustino saeed r.khan Office of regulatory Affairs Detroit LaboratoryFood and Drug AdministrationDetroitMIUSA Division of Product Quality research Office of Testing and ResearchOffice of Pharmaceutical QualityCenter for Drug Evaluation and ResearchFood and Drug AdministrationSilver SpringMDUSA

The development and implementation of advanced analytical technologies is essential for extending the expiry for complex drug products stored in the Strategic National Stockpiles. Consequently, a novel Ultra High-Performance Liquid Chromatographic (UHPLC) method has been developed for the analysis of atropine and its respective impurities to support the analytical research platform for auto-injectors. This study is part of a larger research effort to improve the efficiency and broaden the applicability of advanced analytical methods for medical counter-measure medications. The current HPLC compendial methodology for atropine sulfate injection requires an analysis time of 40 minutes for atropine. In comparison, the novel gradient UHPLC method required only 8 minutes to evaluate both atropine and its major pharmaceutical impurities. Improved separation was achieved on a Waters Acquity UHPLC BEH C18 1.7 μm, 2.1 × 100 mm column employing gradient elution of mobile phase solvent A (0.1% H3PO4) and solvent B (0.1% H3PO4, 90% ACN, and 10% H2O). The method was validated according to USP Category I requirements for assay. The daily standard calibration curves were linear over a concentration range from 50 μg/mL to 250 μg/mL with a correlation coefficient of >0.999. The detection limit (LOD) and quantitation limit (LOQ) were 3.9 μg/ml and 13.1 μg/ml, respectively. resolution results indicate that atropine and the following impurities, degradants and a preservative can also be separated and analyzed using this proposed method: noratropine, 4,4’-di-hy-droxydiphenyl ether, 2,4’-dihydroxydiphenyl ether, 4-bromophenol, 4-hydro-xyatropine, tropic acid, apoatropine HCl, atropic acid, hydroquinone, nitroethane, phenol and catechol. The UHPLC method demonstrated enhanced selectivity and significantly reduced the analysis time when compared with the traditional USP compendial HPLC method. The method was successfully applied to the evaluation of atropine in ATNAA auto-injectors lots fro

关键词： Atropine Sulfate Atropine ATNAA SLEP UHPLC Impurities

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Mechanism of Thermally radiative Prandtl Nanofluids and Double-Diffusive Convection in Tapered Channel on Peristaltic Flow with Viscous Dissipation and Induced Magnetic Field

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1501-1520页

作者： Yasir.khan Safia Akram Maria Athar Khalid saeed Alia razia A.Alameer Department of Mathematics University of Hafr Al-BatinHafr Al-Batin31991Saudi Arabia MCS National University of Sciences and TechnologyIslamabadPakistan SEECS National University of Sciences and TechnologyIslamabadPakistan College of Aeronautical Engineering National University of Sciences and TechnologyIslamabadPakistan

The application of mathematical modeling to biological fluids is of utmost importance, as it has diverse applicationsin medicine. The peristaltic mechanism plays a crucial role in understanding numerous biological flows. In thispaper, we present a theoretical investigation of the double diffusion convection in the peristaltic transport of aPrandtl nanofluid through an asymmetric tapered channel under the combined action of thermal radiation andan induced magnetic field. The equations for the current flow scenario are developed, incorporating relevantassumptions, and considering the effect of viscous dissipation. The impact of thermal radiation and doublediffusion on public health is of particular interest. For instance, infrared radiation techniques have been used totreat various skin-related diseases and can also be employed as a measure of thermotherapy for some bones toenhance blood circulation, with radiation increasing blood flow by approximately 80%. To solve the governingequations, we employ a numerical method with the aid of symbolic software such as Mathematica and *** velocity, magnetic force function, pressure rise, temperature, solute (species) concentration, and nanoparticlevolume fraction profiles are analytically derived and graphically displayed. The results outcomes are compared withthe findings of limiting situations for verification.

关键词： Double diffusion convection thermal radiation induced magnetic field peristaltic flow tapered asymmetric channel viscous dissipation Prandtl nanofluid

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Experimental study on the dynamic response of a 3-D wedge under asymmetric impact

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Journal of Hydrodynamics 2024年第2期36卷 263-274页

作者： saeed Hosseinzadeh Kristjan Tabri Maritime Engineering research Group School of EngineeringUniversity of SouthamptonSouthamptonUK Department of Civil Engineering and Architecture Tallinn University of TechnologyTallinnEstonia Marine Technology Competence Center Tallinn University of TechnologyKuressaareEstonia

Water entry problems represent complex multiphase flows involving air,water,and structure interaction,occurring rapidly in rough seas,and potentially effecting structural integrity of floating *** paper experimentally investigates asymmetric slamming loads acting on a 3-D elastic wedge *** specimen,featuring two different bottom plates(stiffened and unstiffened),each 4 mm thick,aims to assess the effect of structural stiffness on dynamic *** experiments are conducted at different drop heights of 25 cm and 50 cm and varying heel angles from 5°to 25°.The paper describes the experimental conditions,including wedge geometry,material properties,and the test *** study explores the influence of heel angle on impact acceleration,revealing an increase in peak acceleration with a higher inclination angle,particularly in the vertical ***,the hydrodynamic pressure resulting from asymmetric slamming is *** pressure results analyzed and compared at different locations along the length of the *** experimental findings indicate that,despite the leeward side(stiffened)experiencing a smaller hydrodynamic load,the heel angle significantly affects pressure results on the windward side(unstiffened),leading to a more pronounced dynamic *** time history of pressure results emphasizes the effect of elastic vibrations,particularly noticeable on the unstiffened bottom *** study contributes to a deeper understanding of asymmetric slamming on aluminum structures,facilitating the enhancement of mathematical models and the validation of numerical simulations.

关键词： Flexible fluid structure interactions(FFSI) experimental study asymmetric impact hydrodynamic pressure slamming loads

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Coupling of rANS and BEM Solvers for Simulation of Propeller Behind the Hull in Full Appended Model

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China Ocean Engineering 2024年第3期38卷 424-438页

作者： saeed NAJAFI Mehdi POUrMOSTAFA LIU Peng-fei Iranian National Institute for Oceanography and Atmospheric Science(INIOAS) Tehran 14155-4781Iran Department of Maritime Engineering Amir Kabir University of TechnologyTehran 15875-4413Iran Marine Offshore and Subsea TechnologySchool of EngineeringNewcastle UniversityNewcastle upon TyneNE17RUUK

To design a propeller for ship power plant,the interaction between ship hull and propeller must be taken into *** main concern is to apply the wake effect of ship stern on the propeller *** this paper,a coupled BEM(Boundary Element Method)/rANS(renolds-Averaged Navier−Stokes)solver is used to simulate propeller behind the hull in the self-propulsion *** motivation of this work is to develop a practical tool to design marine propulsion system without suffering long computational *** unsteady boundary element method which is also known as panel method is chosen to estimate the propeller *** wakes are treated using a time marching wake alignment ***,a rANS code coupled with VoF equation is developed to consider the ship motions and wake field effects in the problem.A coupling algorithm is developed to interchange ship wake field to the potential flow solver and propeller thrust to the rANS *** on the difference between hull resistance and the propeller thrust,a PI controller is developed to compute the propeller rPM in every time *** of the solver is carried out using the towing tank test report of a 50 m oceanography research *** factor and trust deduction coefficient are estimated ***,the wake rollup pattern of the propeller in open water is compared with the propeller in real wake field.

关键词： rANS BEM coupled method ship propeller self-propulsion wake sheet pattern

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Quantum dense coding with gravitational cat states

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Communications in Theoretical Physics 2024年第3期76卷 84-90页

作者： saeed Haddadi Mehrdad Ghominejad Artur Czerwinski Faculty of Physics Semnan UniversityP.O.Box 35195-363SemnanIran Centre for Quantum Optical Technologies Centre of New TechnologiesUniversity of WarsawBanacha 2c02-097 WarszawaPoland

A protocol of quantum dense coding with gravitational cat states is *** explore the effects of temperature and system parameters on dense coding capacity and provide an efficient strategy to preserve the quantum advantage of dense coding for these *** results may open new opportunities for secure communication and insights into the fundamental nature of gravity in the context of quantum information processing.

关键词： quantum dense coding gravitational cat states quantum advantage

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Effect of PKD1L1 Mutation on its Interaction with PKD2 to Cause Situs Inversus Totalis

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Journal of Clinical and Nursing research 2024年第8期8卷 183-206页

作者： Fatima Haroon Salma saeed khan Assad Ullah Institute of Molecular Biology and Biotechnology(IMBB) the University of LahorePakistan Biomedical and Life Sciences Kohsar University MurreeMurree 47150PunjabPakistan Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan

Situs inversus totalis(SIT)is a rare homozygous recessive disease caused by the mutation in PKD1L1,which is required for normal interaction with PKD2 and leads to different complications such as respiratory disorders,brain disorders and even *** present study was designed to find out the mutational effect on the binding of PKD2 with mutated PKD1L1,which leads to *** three-dimensional(3D)structure of wild type and mutated PKD1L1 was predicted with>90%confidence using different online *** different online tools that were employed were SWISS-MODEL,Phyre2(normal&intensive)and *** compute the physiochemical properties of PKD1L1(wild&mutated)and PKD2 in silico approaches were employed using the ExPASy ProtParam *** properties such as molecular weight,isoelectric point,the total number of negatively and positively charged residues,extinction coefficient,half-life,instability and aliphatic index,grand average of hydropathicity,and amino acid percentage were calculated.A lot of variability was observed in these parameters among PKD1L1 and PKD2,which accounted for diversification in their functional *** theoretical pI points showed that PKD1L1(whole)is more basic with 6.64 pI compared to its first chain TOPO_DOM(amino acids from 1–1748)has a pI of 5.62 which means it is basic while PKD2 have the lowest pI point of *** was performed using the PatchDock and ClusPro online tools.

关键词： SIT PKD1L1 PKD2 SWISS-MODEL ClusPro

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Quantum speedup and non-Markovianity of an atom in structured reservoirs:pseudomodes as a good description of environmental memory

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Communications in Theoretical Physics 2024年第8期76卷 60-66页

作者： Maryam Hadipour Soroush Haseli saeed Haddadi Faculty of Physics Urmia University of TechnologyUrmiaIran School of Physics Institute for Research in Fundamental Sciences(IPM)PO Box 19395-5531TehranIran Faculty of Physics Semnan UniversityPO Box 35195-363SemnanIran

Following the recent paper(Teittinen et al 2019 New J. Phys. 21 123041), one can see that in general there is no simple relation between non-Markovianity and quantum speed limit. Here, we investigate the connection between quantum speed limit time and non-Markovianity of an atom in structured environments(reservoirs) whose dynamics is governed by an exact pseudomode master equation(Garraway 1997 Phys. rev. A 55 2290). In particular, we find an inverse relation between them, which means that the non-Markovian feature of the quantum process leads to speedup of evolution. Thus, there is a link between quantum speedup and memory effects for specific cases of dynamical evolution. Our results might shed light on the relationship between the speedup of quantum evolution and the backflow of information from the environment to the system.

关键词： quantum speed limit non-Markovianity pseudomode method structured environments

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