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World Journal of Radiology 2012年第4期4卷 128-134页

作者： saeed Mirsadraee Dilip Oswal Yalda Alizadeh Andrea Caulo Edwin JR van Beek Clinical Research Imaging Centre University of EdinburghEdinburgh EH16 4TJUnited Kingdom Department of Radiology Mid Yorkshire NHS TrustWakefield WF1 4DGUnited Kingdom Department of Pathology Leeds Teaching HospitalsLeeds LS9 7TFUnited Kingdom

Lung cancer is the most common cause of death from cancer in males,accounting for more than 1.4 million deaths in *** is a growing concern in China,Asia and Africa as *** staging of the disease is an important part of the management as it provides estimation of patient’s prognosis and identifies treatment *** also helps to build a database for future staging projects.A major revision of lung cancer staging has been announced with effect from January *** new classification is based on a larger surgical and non-surgical cohort of patients,and thus more accurate in terms of outcome prediction compared to the previous *** are several original papers regarding this new classification which give comprehensive description of the methodology,the changes in the staging and the statistical *** overview is a simplified description of the changes in the new classification and their potential impact on patients’ treatment and prognosis.

关键词： Lung neoplasms Neoplasm staging Lung cancer staging

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在 7T 的多原子的磁性的回声光谱学的应用

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World Journal of Radiology 2011年第4期3卷 105-113页

作者： Mary C stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem saeed William Vennart susan T Francis Peter G Morris The sir Peter Mansfield Magnetic Resonance Centre School of Physics and AstronomyUniversity of Nottingham school of Biomedical sciences University of Nottingham Medical School Academic Radiology University of Nottingham Molecular Medicine PfizerSandwich

AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRs) studies of *** at both 3 and 7T using 1H MRs. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRs respectively. REsULTs: In the brain, increased signal-to-noise ratio (sNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. sNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P scle, the increased sNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUsION: The demonstrated improvements in brain and muscle MRs measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies.

关键词： Magnetic resonance spectroscopy 13C 1H 7 Tesla Glutamate Glutamine γ-aminobutyric acid

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