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Acta Mechanica Solida Sinica 2008年第1期21卷 34-43页

作者： yong-Dong Li Wei Tan Kang yong lee Department of Mechanical Engineering Academy of Armored Force Engineering No.21 Du Jia Kan Chang Xin Dian Beijing 100072 China School of Mechanical Engineering Yonsei University Seoul 120-749 South Korea

The problem considered is a mode Ⅲ crack lying parallel to the interface of an exponential-type functional graded material （FGM） strip bonded to a linear-type FGM substrate with infinite thickness. By applying the Fourier integral transform, the problem was reduced as a Cauchy singular integral equation with an unknown dislocation density function. The collocation method based on Chebyshev polynomials proposed by Erdogan and Gupta was used to solve the singular integral equation numerically. With the numerical solution, the effects of the geometrical and physical parameters on the stress intensity factor （SIF） were analyzed and the following conclusions were drawn：（a） The region affected by the interface or free surface varies with the material rigidity, and higher material rigidity will lead to bigger affected region. （b） The SIF of the crack in the affected region and parallel to the micro-discontinuous interface is lower than those of the weak discontinuous cases. Reducing the weak-discontinuity of the interface will be beneficial to decrease the SIF of the interface-parallel crack in the region affected by the interface. （c） The effect of the free surface on SIF is more remarkable than that of the interface, and the latter is still more notable than that of the material rigidity. When the effects of the interface and free surface are fixed, increase of the material rigidity will enhance the value of SIF.

关键词： bi-FGM composite mode Ⅲ crack stress intensity factor weak/mico discontinuity,the Cauchy singular integral equation

Clinical characteristics of incidental or unsuspected gallbladder cancers diagnosed during or after cholecystectomy: A systematic review and meta-analysis

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World Journal of Gastroenterology 2015年第4期21卷 1315-1323页

作者： Kui Sun Choi sae Byeol Choi Pyoungjae Park Wan Bae Kim Sang yong Choi Department of Surgery Korea University College of MedicineSeoul 152-703South Korea

AIM: To perform a systematic review of incidental or unsuspected gallbladder(GB) cancer diagnosed during or after cholecystectomy. METHODS: Data in Pub Med, EMBASE, and CochraneLibrary were reviewed and 26 publications were included in the meta-analysis. The inclusion criterion for incidental GB cancer was GB cancer diagnosed during or after cholecystectomy that was not suspected at a preoperative stage. Pooled proportions of the incidence, distribution of T stage, and revisional surgery of incidental GB cancer were ***: The final pooled population comprised 2145 patients with incidental GB cancers. Incidental GB cancers were found in 0.7% of cholecystectomies p e r f o r m e d f o r b e n i g n g a l l b l a d d e r d i s e a s e s o n preoperative diagnosis(95%CI: 0.004-0.012). Nearly 50% of the incidental GB cancers were stage T2 with a pooled proportion of 47.0%(95%CI: 0.421-0.519). T1 and T3 GB cancers were found at a similar frequency, with pooled proportions of 23.0%(95%CI: 0.178-0.291) and 25.1%(95%CI: 0.195-0.317), respectively. The pooled proportion that completed revisional surgery for curative intent was 40.9%(95%CI: 0.329-0.494). The proportion of patients with unresectable disease upon revisional surgery was 23.0%(95%CI: 0.177-0.294). CONCLUSION: A large proportion of incidental GB cancers were T2 and T3 lesions. Revisional surgery for radical cholecystectomy is warranted in T2 and more advanced cancers.

关键词： Gallbladder cancer Laparoscopic surgery Cholecyste

Optical Properties of Zinc-Blende InGaN/GaN Quantum Well Structures and Comparison with Experiment

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Chinese Physics Letters 2010年第4期27卷 136-139页

作者： PARK Seoung-Hwan lee yong-Tak Department of Electronics Engineering Catholic University of Daegu Hayang Kyeongsan Kyeongbuk 712- 702 Republic of Korea Department of Information and Communications Gwangju Institute of Science and Technology 1 Oryong-dong Buk-gu Gwangju 500-712 Republic of Korea

Optical properties of zinc-blende InGaN/GaN Q W structures are investigated using the multiband effective-mass theory. The transition wavelength values at 300 K ranged from 440 to 570nm in the investigated range of the In composition and the well width. The theoretical wavelengths show reasonable agreement with the experimental results. The optical gain decreases with the increasing well width. This is mainly due to the reduction in the quasi-Fermi-level separation because the optical matrix element increases with the well width.

关键词： Condensed matter: electrical magnetic and optical Surfaces interfaces and thin films Nanoscale science and low-D systems

A global multiplicity result for two-point boundary value problems of p-Laplacian systems

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Science China Mathematics 2010年第4期53卷 967-984页

作者： lee Eun Kyoung lee yong-Hoon Department of Mathematics Pusan National University

In this paper,we consider the existence,nonexistence and multiplicity of positive solutions for two-point boundary value problems of p-Laplacian systems which have a singular indefinite weight and real *** proofs,we mainly make use of the upper and lower solution method and the fixed point index *** obtain a global multiplicity result,we construct a weighted space to benefit richer topology of the solution space than C 0-space.

关键词： p-Laplacian system singular indefinite weight multiparameters upper solution and lower solution fixed point index theorem weighted space

Investigation of acoustic attributes based on preference and perceptional acoustics of Korean traditional halls for optimal design solutions

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Building Simulation 2024年第5期17卷 723-738页

作者： Beta Bayu Santika Haram lee Jin yong Jeon Department of Architectural Engineering Hanyang UniversitySeoul 04763R.O.Korea

Immersed in the rich tapestry of traditional culture,Gugak,the traditional Korean music stands as a captivating embodiment of artistic *** study embarked on a comprehensive evaluation of a Gugak hall,employing acoustic measurements,computer simulations,and subjective perception *** evaluation focused on the reverberance,clarity,spatial impression,and preference,unravelling the secrets that shape the immersive Gugak *** intricate computer simulations and auralization,the experience of Gugak performances was meticulously brought to life,allowing exploration under diverse conditions by adjusting stage volume ratios from -20% to+20% and modifying the interior materials,including the walls,ceiling,and lateral *** Gugak halls exhibited relatively low values of reverberation time(RT),early decay time(EDT),and binaural quality index(BQI)the dominant factor influencing the acoustic environment was the effect of sound strength(G).Musical clarity(C80)value did not show an inverse proportionality to the reverberation ***,genre differences between traditional Korean and Western classical music did not significantly affect listeners’perception and satisfaction with regards to reverberance,clarity,and spatial *** a result,Gugak halls can adhere to the same acoustic design criteria as Western orchestra halls,since this study found that people perceived them the same *** this study,sound strength was found to be strongly correlated with perception *** was possible to enhance listeners’perception and preference regarding the acoustic environment through material and structural changes to the sidewalls and *** changes improved the reinforcement of low frequencies and simultaneously enhanced the relative effect of side ***,enhancing the reflection and spatial characteristics of the materials effectively improved listener *** on these findings,an optimal des

关键词： Korean traditional hall acoustical parameters perceptual evaluation acoustic preference stage volume ratio

Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy

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Nano-Micro Letters 2020年第7期12卷 156-174页

作者： Wenquan Ou Kang Sik Nam Dae Hoon Park Jungho Hwang sae Kwang Ku Chul Soon yong Jong Oh Kim Jeong Hoon Byeon College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea College of Korean Medicine Daegu Haany UniversityGyeongsan 38610Republic of Korea School of Mechanical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea

Because of enhanced e cacy and lower side e ects,cancer immunotherapies have recently been extensively investigated in clinical trials to overcome the limitations of conventional cancer *** engineering attempts have been made to build nanosystems even including stimulus nanomaterials for the e cient delivery of antigens,adjuvants,or anticancer drugs to improve immunogenic cancer cell death,this requires huge R&D e orts and investment for clinically relevant findings to be approved for translation of the *** this end,in this study,an air–liquid two-phase electrospray was developed for stable bubble pressing under a balance between mechanical and electrical parameters of the spray to continuously produce biomimetic nanosystems consisting of only clinically relevant compounds[paclitaxel-loaded fake blood cell Eudragit particle(Eu-FBCP/PTX)]to provide a conceptual leap for the timely development of translatable chemo-immunotherapeutic *** was pursued as the e cacy of systems for delivering anticancer agents that has been mainly influenced by nanosystem shape because of its relevance to transporting behavior to organs,blood circulation,and cell–membrane *** resulting Eu-FBCP/PTX nanosystems exhibiting phagocytic and micropinocytic uptake behaviors can confer better e cacy in chemo-immunotherapeutics in the absence and presence of anti-PD-L1 antibodies than similar sized PTX-loaded spherical Eu particles(Eu-s/PTX).

关键词： Cancer immunotherapies Air–liquid two-phase electrospray Paclitaxel-loaded fake blood cell Eudragit particle Translatable chemo-immunotherapeutic nanosystems Anti-PD-L1 antibodies

Inverse relationship between bioavailable testosterone and subclinical coronary artery calcification in non-obese Korean men

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Asian Journal of Andrology 2012年第4期14卷 612-615页

作者： Byoung-Jin Park Jae-yong Shim yong-Jae lee Jung-Hyun lee Hye-Ree lee Department of Family Medicine Yonsei University College of Medicine Seou1135-720 Korea Department of Health Promotion Center Gangnam Severance Hospita Yonsei University College of Medicine Seou1135-720 Korea

Although low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with apparently low cardiometabolic risk. This study was performed to investigate the association between male sex hormones and subclinical coronary artery calcification measured as coronary calcium score in non-obese Korean men. We examined the relationship of total testosterone, sex hormone-binding globulin, bioavai lable testosterone and free testosterone with coronary calcium score in 291 non-obese Korean men （mean age： 52.8--- 9.3 years） not having a history of cardiovascular disease. Using multiple linear regression, we evaluated associations between log （sex hormone） levels and log （coronary calcium score） after adjusting for confounding variables in 105 men with some degree of coronary calcification defined as coronary calcium score ~〉 1. In multiple linear regression analysis, bioavailable testosterone was inversely associated with coronary calcium score （P=0.046） after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, mean blood pressure, resting heart rate, C-reactive protein, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein （HDL） cholesterol, hypertension medication and hyperlipidernia medication, whereas total testosterone, sex hormone-binding globulin and free testosterone were not （P=0.674, P=O. 121 and P=O. 102, respectively）. Our findings indicate that bioavailable testosterone is inversely associated with the degree of subclinical coronary artery calcification in non-obese men.

关键词： bioavailable testosterone cardiovascular disease coronary calcium score male sex hormone subclinical coronary arterydisease testosterone

Gate-versus defect-induced voltage drop and negative differential resistance in vertical graphene heterostructures

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npj Computational Materials 2022年第1期8卷 480-488页

作者： Tae Hyung Kim Juho lee Ryong-Gyu lee yong-Hoon Kim School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon34141Korea

To enable the computer-aided design of vertically stacked two-dimensional(2D)van der Waals(vdW)heterostructure devices,we here introduce a non-equilibrium first-principles simulation method based on the multi-space constrained-search density functional *** it to graphene/few-layer hBN/graphene field-effect transistors,we show that the negative differential resistance(NDR)characteristics can be produced not only from the gating-induced mismatch between two graphene Dirac cones in energy-momentum space but from the bias-dependent energetic shift of defect ***,for a carbon atom substituted for a nitrogen atom(C_(N))within inner hBN layers,the increase of bias voltage is found to induce a self-consistent electron filling of in-gap C_(N)states,which in turn changes voltage drop profiles and produces symmetric NDR *** the CN placed on outer hBN layers,however,the pinning of C_(N)states to nearby graphene significantly modifies device characteristics,demonstrating the critical impact of atomic details for 2D vdW devices.

关键词： defect resistance details

A Lightweight Certificate-Based Aggregate Signature Scheme Providing Key Insulation

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Computers, Materials & Continua 2021年第11期69卷 1747-1764页

作者： yong-Woon Hwang Im-Yeong lee Department of Software Convergence in Soonchunhyang University Asan-si31538Korea

Recently,with the advancement of Information and Communications Technology(ICT),Internet of Things(IoT)has been connected to the cloud and used in industrial sectors,medical environments,and smart ***,if data is transmitted in plain text when collecting data in an IoTcloud environment,it can be exposed to various security threats such as replay attacks and data ***,digital signatures are *** integrity is ensured when a user(or a device)transmits data using a *** addition,the concept of data aggregation is important to efficiently collect data transmitted from multiple users(or a devices)in an industrial IoT ***,signatures based on pairing during aggregation compromise efficiency as the number of signatories *** signature methods(e.g.,identity-based and certificateless cryptography)have been *** methods pose key escrow and key distribution *** order to solve these problems,the use of aggregate signatures in certificate-based cryptography is being studied,and studies to satisfy the prevention of forgery of signatures and other security problems are being *** this paper,we propose a new lightweight signature scheme that uses a certificate-based aggregate signature and can generate and verify signed messages from IoT devices in an IoT-cloud *** this proposed method,by providing key insulation,security threats that occur when keys are exposed due to physical attacks such as side channels can be *** can be applied to create an environment in which data is collected safely and efficiently in IoT-cloud is environments.

关键词： Internet of things certificate-based aggregate signature key insulation cloud lightweight physical attack

Molecular Sensors of Temperature,Pressure,and Pain with Special Focus on TRPV1,TRPM8,and PIEZO2 Ion Channels

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Neuroscience Bulletin 2021年第12期37卷 1745-1749页

作者： Ru-Rong Ji Seok-yong lee Department of Anesthesissology Center for Translation Pain MedicineDuke University Medical CenterDurhamNC 27710USA Departments of Neurobiology and Cell Biology Duke University Medical CenterDurhamNC 27710USA Department of Biochemistry Duke University Medical CenterDurhamNC 27710USA

The 2021 Nobel Prize in Physiology or Medicine was awarded to two sensory neurobiologists and pain researchers,*** at the University of California in San Francisco and Ardem Patapoutian at Scripps Research in San Diego,for their discoveries of thermal and mechanical transducers[1](https://***/prizes/medicine/2021/advanced-infor mation/).As the Nobel Committee stated,“the question of how we sense the physical world through somatic sensation has fascinated humankind for millennia,however,the identity of the molecular transducers responsible for detecting and converting heat.

关键词： Sensors Focus stated