检索结果-南通市图书馆

Pattern of hepatitis C virus genotypes and subtypes circulating in war-stricken Khyber Pakhtunkhwa,Pakistan:Review of published literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1037-1042页

作者： Abdul Waheed Khan sadia Nawab Zeeshan Nasim Abdul Haleem Khan Syed Ishfaq Ahmad Fazli Zahir Israr Ud Din Institute of Information Sciences Academia SinicaTaiwan Center for Biotechnology and Microbiology University of SwatPakistan Institute of Biotechnology and Genetic Engineering The University of AgriculturePeshawarPakistan 4Department of ZoologyIslamia College PeshawarPakistan

Infection due to hepatitis C virus(HCV) is a major cause of fibrosis and hepatocellular carcinoma in Pakistan. In the current review, pattern of HCV genotypes and subtypes in Khyber Pakhtunkhwa province was ascertained in light of the available literature. After thorough analysis, genotype 3(58.27%) was determined to be the leading HCV genotype,followed by genotypes 2(12.39%), 1(9.54%) and 4(0.86%). The proportions of genotypes 5 and 6 were recorded as 0.09% and 0.22% respectively. Subtype wise, 3 a accounted for 48.67%, followed by subtype 2 a(10.91%), 3 b(9.43%), 1 a(5.84%), 1 b(3.66%), 2 b(1.45%) and genotype 4 with its undefined subtypes contributed a portion of0.86%. The cumulative share of subtypes 1 c, 2 c, 3 c, 5 a and 6 a was less than 1%. In11.51% cases, the subtype was untypeable while in 7.17% cases mixed subtypes were recorded. Gender wise, proportions of most HCV subtypes were marginally higher among males as compared to females. On the basis of studied groups, 3 a was pervasive among all groups except in intravenous drug users where 2 a was the major HCV ***, based on various geographical locations(provincial divisions), subtype 3 a revealed a ubiquitous distribution. Conclusively, HCV 3 a persists to be the principal subtype across the province of Khyber Pakhtunkhwa. The considerable number of untypeable subtypes in most studies urges for an improved genotyping system on the basis of local sequence data and practice of sequencing for determination of underlying subtype in untypeable cases. Further, studies on identification of subtypes transmission pattern are imperative for assessment of transmission origin and reinforcement of efficient control strategies. In addition, the current review emphasizes the need of attention toward HCV risk groups and ignored southern side of Khyber Pakhtunkhwa province for better holistic understanding of HCV genotype distribution pattern in the province.

关键词： Hepatitis C Hepatitis C virus Genotype Subtype

Curcumin:reclaiming the lost ground against cancer resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2021年第2期4卷 298-320页

作者： Siraj Shaikh Javed Shaikh Yusufi sadia Naba Kailas Doke Khursheed Ahmed Mujahid Yusufi Post-Graduate Department of Chemistry and Research Center Abeda Inamdar Senior College of ArtsScience and Commerce(Affiliated to SPPU)Pune 411001India Advanced Scientific Research Laboratory Azam CampusPune 411001India.

Curcumin, a polyphenol, has a wide range of biological properties such as anticancer, antibacterial, antitubercular, cardioprotective and neuroprotective. Moreover, the anti-proliferative activities of Curcumin have been widely studied against several types of cancers due to its ability to target multiple pathways in cancer. Although Curcumin exhibited potent anticancer activity, its clinical use is limited due to its poor water solubility and faster metabolism. Hence, there is an immense interest among researchers to develop potent, water-soluble, and metabolically stable Curcumin analogs for cancer treatment. While drug resistance remains a major problem in cancer therapy that renders current chemotherapy ineffective, curcumin has shown promise to overcome the resistance and re-sensitize cancer to chemotherapeutic drugs in many studies. In the present review, we are summarizing the role of curcumin in controlling the proliferation of drug-resistant cancers and development of curcumin-based therapeutic applications from cell culture studies up to clinical trials.

关键词： Curcumin drug-resistant cancer signaling pathways clinical trials

Morpholine hydrazone scaffold： Synthesis, anticancer activity and docking studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2017年第3期28卷 607-611页

作者： Muhammad Taha Syed Adnan Ali Shah Muhammad Afifi Manar Zulkeflee sadia Sultan Abdul Wadood Fazal Rahim Nor Hadiani Ismail Atta-ur-Rahman Institute for Natural Product Discovery (AuRlns) Universiti Teknologi MARA Puncak Alam Campus 42300 Bandar Puncak Alam SelangorD. E. Malaysia Faculty of Applied Science UiTM Shah Alam 40450 Shah Alam Selangor D.E. Malaysia Faculty of Pharrnacy Universiti Teknologi MARA Puncat~ Alam Campus 42300 Baadar Puncak Alam Selangor D.E. Malaysia Department of Biochemistry Abdul Wali Khan University Mardan 23200 Pakistan Department of Chemistry Hazara University Mansehra 21300 Pakistan

In this paper, synthesis and anticancer activities of morpholine hydrazones scaffold（1-17） thoroughly studied. Small series of morpholine hydrazones synthesized by treating 5-morpholinothiophene-2-carbaldehyde with different aryl hydrazides to form morpholine hydrazones scaffold（1-17）. The in vitro anticancer potential of all these compounds was checked against human cancer cell lines like Hep G2（human hepatocellular liver carcinoma） and MCF-7（human breast adenocarcinoma）. Analogs 13 had similar substantial cytotoxic effects towards Hep G2 with IC_（50） value 6.31±1.03μmmol/L when compared with the standard Doxorubicin（IC_（50）value 6.00±0.80μmmol/L）; while compounds 5,8 and 9 showed potent cytotoxicity against MCF-7 with IC_（50） value 7.08±0.42μmmol/L, 1.26±0.34μmmol/L and11.22±0.22μmmol/L respectively when compared with the standard Tamoxifen（IC_（50）= 11.00±0.40μmol/L）. Molecular docking studies also performed to understand the binding interaction.

关键词： Morpholine hydrazones Synthesis HepG2 MCF-7 Molecular docking

Evolution and Fate of Haloacetic Acids before and after Chlorination within the Treatment Plant Using SPE-GC-MS

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

American Journal of Analytical Chemistry 2011年第5期2卷 522-532页

作者： sadia Waseem Ijaz Ul Mohsin 不详

The previous research on the occurrence of disinfection by-products (DBPs) in drinking water has focused on trihalomethane (THMs) formation and evolution, in particular within distribution systems. In this study, the variability of occurrence of haloacetic acids (HAAs) before and after treatment was investigated. The investigation focused on point–to-point fluctuations of HAAs in different treatment stages within the treatment plant. The research was also carried out to find out the possible sources for the presence of HAAs before chlorination in the raw water. The results showed that the presence of HAAs from the raw water point until the filtered water occurred due to industrial waste and sewages. Subsequent formation of HAAs from treated point until service reservoir due to disinfection. The HAAs concentration was the highest and most variable in the plant where level of DBP precursor indicators and the chlorine dose were both higher. However, HAAs level and in particular dichloroacetic acids (DCAA) (the preponderant HAAs species in the waters under study), trichloroacetic acids (TCAA) decreased dramatically during filtration, very probably because of the biodegradation within the filter. An ANNOVA test was used to evaluate the level of significance of HAAs between treated water and service reservoir outlet water.

关键词： Haloacetic Acids Disinfection by-Products Drinking Water

Functional Genomics Approaches to Study At5g24290 Gene in Arabidopsis thaliana and Its Homologous in Brassica Species

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Functional Genomics Approaches to Study At5g24290 Gene in Ar...

SARS-CoV-2 infection and diabetes:Pathophysiological mechanism of multi-system organ failure

第十二届全国植物基因组学大会

作者： sadia Tehrim Oil Crops Research Institute of The CAAS

The angiosperm family,Brassicaceae(mustard family) contains several key research and agricultural species,the foremost being the model species Arabidopsis thaliana and the Brassica crops including diverse agronomically crops such as oilseed rape,cabbage,broccoli and other leafy vegetables.A pattern of segmental chromosome co linearity has been well known in Brassica species and *** of the Arabidopsis genome sequence is the culmination of a remarkable decade of world-wide growth and collaboration in developing Arabidopsis as a model genetic and genomic *** the immense progress in functional characterization of plant genomes,over 30%Arabidopsis genes have not been functionally charac-

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Virology 2022年第5期11卷 252-274页

作者： Bipradas Roy sadia Afrin Runa Department of Physiology Wayne State UniversityDetroitMI 48201United States Division of Hypertension and Vascular Research Department of Internal MedicineHenry Ford Health SystemDetroitMI 48202United States Department of Biotechnology and Genetic Engineering Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityGopalganj 8100Bangladesh

Since the discovery of the coronavirus disease 2019 outbreak,a vast majority of studies have been carried out that confirmed the worst outcome of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in people with preexisting health conditions,including diabetes,obesity,hypertension,cancer,and cardiovascular ***,diabetes itself is one of the leading causes of global public health concerns that impose a heavy global burden on public health as well as socio-economic *** diabetes and SARS-CoV-2 infection have their independent ability to induce the pathogenesis and severity of multi-system organ failure,while the co-existence of these two culprits can accelerate the rate of disease progression and magnify the severity of the ***,the exact pathophysiology of multi-system organ failure in diabetic patients after SARS-CoV-2 infection is still *** review summarized the organ-specific possible molecular mechanisms of SARS-CoV-2 and diabetesinduced pathophysiology of several diseases of multiple organs,including the lungs,heart,kidneys,brain,eyes,gastrointestinal system,and bones,and subsequent manifestation of multi-system organ failure.

关键词： SARS-CoV-2 Diabetes Neurological dysfunction Cardiovascular complications Renal dysfunction Bone loss

Combination of mesenchymal stem cells and three-dimensional collagen scaffold preserves ventricular remodeling in rat myocardial infarction model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2022年第8期14卷 633-657页

作者： Rida-e-Maria Qazi Irfan Khan Kanwal Haneef Tuba Shakil Malick Nadia Naeem Waqas Ahmad Asmat Salim sadia Mohsin Stem Cell Laboratory Dr.Panjwani Center for Molecular Medicine and Drug ResearchICCBSUniversity of KarachiKarachi 75270SindhPakistan Dr.Zafar H.Zaidi Center for Proteomics University of KarachiKarachi 75270SindhPakistan Dow Research Institute of Biotechnology and Biomedical Sciences(DRIBBS) Dow University of Health and SciencesOjha CampusKarachi 74200SindhPakistan Cardiovascular Research Center Lewis Katz School of MedicineTemple UniversityPhiladelphiaPA 19140United States

BACKGROUND Cardiovascular diseases are the major cause of mortality *** of the damaged myocardium remains a challenge due to mechanical constraints and limited healing ability of the adult heart *** tissue engineering using biomaterial scaffolds combined with stem cells and bioactive molecules could be a highly promising approach for cardiac *** of biomaterials can provide suitable microenvironment to the cells and can solve cell engraftment problems associated with cell transplantation *** stem cells(MSCs)are potential candidates in cardiac tissue engineering because of their multilineage differentiation potential and ease of *** of DNA methyl transferase inhibitor,such as zebularine,in combination with three-dimensional(3D)scaffold can promote efficient MSC differentiation into cardiac lineage,as epigenetic modifications play a fundamental role in determining cell fate and lineage specific gene *** To investigate the role of collagen scaffold and zebularine in the differentiation of rat bone marrow(BM)-MSCs and their subsequent in vivo *** MSCs were isolated from rat BM and characterized morphologically,immunophenotypically and by multilineage differentiation *** were seeded in collagen scaffold and treated with 3μmol/L zebularine in three different *** analysis was done and cardiac differentiation was analyzed at the gene and protein *** and untreated MSC-seeded scaffolds were transplanted in the rat myocardial infarction(MI)model and cardiac function was assessed by *** tracking was performed by DiI dye labeling,while regeneration and neovascularization were evaluated by histological and immunohistochemical analysis,*** MSCs were successfully isolated and seeded in collagen *** analysis revealed that zebularine was not cytotoxic in any of the treatment *** differentiation analysis

关键词： Mesenchymal stem cells Myocardial infarction Cardiac tissue engineering Demethylating agent Collagen scaffold Zebularine

Assessment of genetic diversity, detection of strain-specific single nucleotide polymorphisms and identification of the Bangladesh and Vietnam strain of Channa striata by PCR-RFLP analysis of the mitochondrial COI gene fragment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2022年第3期7卷 287-295页

作者： Md Samsul Alam Foyjunnesa Projna Mst.sadia Zafrin Rituparna Das Mohd Golam Quader Khan Department of Fisheries Biology and Genetics Bangladesh Agricultural UniversityMymensingh2202Bangladesh

Striped snakehead(Channa striata)has enormous fisheries and aquaculture importance due to its high market demand and food ***,Vietnam strain of the species has been introduced to Bangladesh for ***,it is essential to develop a reliable molecular technique that can distinguish the Bangladesh strain from the Vietnam ones as biological invasion by feral exotic fish to the wild may cause enduring damage to ecosystem and species *** clips from snakehead samples were collected from six locations and total DNA was *** cytochrome oxidase c 1(COI)gene fragment was amplified by PCR using the Fish F1/R1 primer set and sequenced for analysis of intra-and inter-strain genetic diversity and detection of single nucleotide polymorphism to distinguish the Vietnam strain from Bangladesh ones.A total of 15 haplotypes were identified with an overall haplotype diversity of *** median-joining network created based on COI gene sequences clearly differentiated the Bangladesh strain from the strain of Vietnamese origin by a total of 18 single nucleotide *** In silico restriction analysis revealed AluI was the most suitable restriction enzyme that produced diagnostic restriction profiles of the two strains of ***-RFLP analysis by the restriction enzyme AluI created distinguishing restriction profile similar to that in the In silico *** work illustrates a simple,reliable and inexpensive molecular tool for the identification of the Bangladesh and Vietnam strains of *** by one-step PCR and restriction of the COI gene fragment.

关键词： COI Channa striata snakehead Genetic diversity SNP PCR-RFLP

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国和巴基斯坦手机银行的采用：跨文化研究

中国和巴基斯坦手机银行的采用：跨文化研究

作者： sadia Akhtar 中国科学技术大学

学位级别：硕士

手机的不断发展掀起了一场人与人之间沟通以及交易方式革命。它重新定义了沟通过程,并重新设计了服务提供方式。手机带来了无数的变化,影响着人们的生活以及商业环境。手机变得越来越复杂,它能提供越来越多功能并且变得小巧纤薄,它改变... 详细信息

手机的不断发展掀起了一场人与人之间沟通以及交易方式革命。它重新定义了沟通过程,并重新设计了服务提供方式。手机带来了无数的变化,影响着人们的生活以及商业环境。手机变得越来越复杂,它能提供越来越多功能并且变得小巧纤薄,它改变了全世界许多人的生活。手机银行是移动技术的最佳服务之一,现在这项业务在金融和商业环境中稳步发展并不断取得进步。之前的一些研究分析了用户使用手机银行的意图,但这些研究存在一些局限性。为了突破这些局限性,我做了本篇论文的研究,研究目前是在中国和巴基斯这两个亚洲文化国家之间进行的,主要研究用户对手机银行的接受程度。目前的研究基于两个著名的理论,技术接受模型(TAM)和霍夫斯泰德的文化维度理论(CDT)。技术接受模型(TAM)的研究扩展了社会影响因子,,并且在模型上增加了文化的影响。该研究假设感知的有用性、感知的易用性和社会影响显著影响个人在巴基斯坦和中国接受手机银行的意愿。该研究还假设文化影响了感知有用性、感知易用性,并且作用于与个人使用手机银行的意图。通过对两国数据的分析,对该模型进行了实证研究。整体样本数为570人,包括300人(52.63%)来自中国受访者和270人(47.36%)来自巴基斯坦受访者。为了检验模型中的假设,本研究使用了 IBM SPSS软件进行多层次回归分析。结果表明,感知的易用性、感知的有用性和社会影响对个人在巴基斯坦接受手机银行业务的意愿有显著和积极的影响。另一方面,感知有用性是影响中国用户使用手机银行的一个重要预测因素,而社会影响力和感知易用性对促进中国用户使用手机银行没有影响。此外,文化被认为是社会影响力与个人意图之间正相关关系的抑制因素。该研究指出了理论和管理两方面的意义。目前研究是在两种不同的文化(巴基斯坦文化和中国文化)中进行的,其新颖的研究方法为学术和工业研究开辟了新的途径。此外,它还为监管机构、服务提供商、银行家、政府、决策者、新客户和老客户提供了一些建议,有助于改善两国公众的手机银行服务。

关键词：手机银行社交影响个人意图跨文化文化维度理论技术采用模型