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Diagnostically untypable hepatitis C virus variants:It is time to resolve the problem

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World Journal of Gastroenterology 2014年第46期20卷 17690-17692页

作者： Muhammad Sohail Afzal Muhammad Yousaf Khan Muhammad Ammar sadia Anjum Najm us Sahar Sadaf Zaidi Atta Ur Rahman School of Applied Biosciences National University of Science and TechnologyIslamabad 44000Pakistan Genomic Research Labs and Diagnostics Center Rawalpindi 46000Pakistan

Pakistan is a low income country with more than 10 million hepatitis C virus (HCV) infections and the burden is on continuous raise. Accurate viral genotyping is very critical for proper treatment of the infected individuals as the sustained virological response of the standard antiviral interferon therapy is genotype dependent. We observed at our diagnostic center that 15.6% of HCV patient’s samples were not genotype-able by using Ohno et al method. The genotyped samples showed that 3a (68.3%) is the major prevalent genotype in Pakistan followed by 2a (10.3%), 3b (2.6%), 1b (1.5%), 2b (1.2%) and 1a (0.5%). Presence of large number of untypable HCV variants in the current study highlights an important issue of health care setup in Pakistan. Untypable HCV cases create difficulties in treatment of these patients. The problem of routine diagnostics setup of Pakistan should be addressed on priority basis to facilitate the medical professionals in patient’s treatment and to help in achieving the maximum sustained virological response.

关键词： Hepatitis C virus Genotypes Diagnostics Untypable variants Antiviral interferon therapy Pakistan

A New Record of Aspergillus vadensis (Ascomycota) Isolated from Soil in Yunnan Province,China

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Phyton-International Journal of Experimental Botany 2021年第3期90卷 1031-1039页

作者： sadia Nadir Sehroon Khan Dhanushka N.Wanasinghe Saowaluck Tibpromma Shahid Iqbal Jianchu Xu Peter Mortimer CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Centre for Mountain Futures Kunming Institute of BotanyKunming654400China Department of Chemistry University of Science and TechnologyBannu28100Pakistan

During a survey of soil fungi in Yunnan Province,several isolates of Aspergillus were *** on morphology and molecular analyses of internal transcribed spacer regions and intervening 5.8S nrRNA gene(ITS),β-tubulin and calmodulin(CaM)genes sequences,two isolates were identified as Aspergillus vadensis(section Nigri).A phylogenetic tree,detailed descriptions,illustrations and scanned electron microscopy morphology are provided for the new *** is the first record of *** from China.

关键词： Morphology phylogeny section Nigri soil fungi

Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study

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World Journal of Diabetes 2017年第6期8卷 304-310页

作者： Syeda sadia Fatima Zehra Jamil Syed Hani Abidi Daniyal Nadeem Zara Bashir Ahmed Ansari Depart-ment- of Biological and Biomedical Sciences Aga Khan Universit-y Medical College Aga Khan Universit-y

AIMTo assess circulatory levels of interleukin-18 (IL-18) and determine whether the presence of IL-18 promoter polymorphism influences metabolic syndrome phenotypes. METHODSThis study recruited one hundred and eighty individuals divided into three groups with sixty subjects each as: Normal weight (18.0-22.9 kg/m2), overweight (23.0-25.9 kg/m2) and obese (> 26.0 kg/m2) according to South Asian criteria of BMI. Fasting blood glucose (FBG), Lipid profile, insulin, IL-18 and tumor necrosis factor (TNF)α were measured using ELISA kits, whereas low density lipoprotein (LDL)-cholesterol, insulin resistance (HOMA-IR) and insulin sensitivity (QUICKI) were calculated. The body fat percentage (BF) was measured through bioelectrical impedance analysis; waist and hip circumference were measured. Genotyping of IL-18 -607 C/A polymorphism was performed by using tetra-primer amplification refractory mutation system. Student t test, One-way analysis of variance, Hardy-Weinberg equilibrium, Pearson’s χ2 test and Pearson’s correlation were used, where a P value < 0.05 was considered significant. RESULTSIn an aged matched study, obese subjects showed higher levels of FBG, cholesterol, triglycerides and LDL levels as compared to normal weight (P < 0.001). Highest levels of IL-18 and TNF levels were also seen in obese subjects (IL-18: 58.87 ± 8.59 ng/L) (TNF: 4581.93 ± 2132.05 pg/mL). The percentage of IL-18 -607 A/A polymorphism was higher in overweight and obese subjects vs normal weight subjects (P < 0.001). Moreover, subjects with AA genotype had a higher BF, insulin resistance, TNFα and IL-18 levels when compared with subjects with AC (heterozygous) or CC (wild type) genotypes. However, we did not find any difference in the lipid profile between three subgroups. CONCLUSIONThis preliminary data suggests that IL-18 polymorphism affects IL-18 levels that might cause low grade inflammation, further exacerbated by increased TNFα. All these incr

关键词： Metabolic syndrome Interleukin-18 Polymorphism Obesity Body fat High density lipoprotein Low density lipoprotein Insulin

Potential medicinal plants involved in inhibiting 3CL^(pro) activity:A practical alternate approach to combating COVID-19

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Journal of Integrative Medicine 2022年第6期20卷 488-496页

作者： Fan Yang Xiao-lan Jiang Akash Tariq Sehrish sadia Zeeshan Ahmed Jordi Sardans Muhammad Aleem Riaz Ullah Rainer W.Bussmann The Medical Center of General Practice Sichuan Academy of Medical Science and Sichuan Provincial People’s HospitalChengdu 610041Sichuan ProvinceChina Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830041Xinjiang Uygur Autonomous RegionChina Department of Biological Sciences University of Veterinary and Animal SciencesRavi CampusPattoki 55300Pakistan Consejo Superior de Investigaciones Científicas Global Ecology UnitCentre for Ecological Research and Forestry Applications-Consejo Superior de Investigaciones Científicas-Universitat Autònoma de BarcelonaBellaterra08193 BarcelonaCataloniaSpain Centre for Ecological Research and Forestry Applications Cerdanyola del Vallès 08193CataloniaSpain Department of Pharmacognosy College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia Department of Ethnobotany Institute of Botanyllia State UniversityTbilisi 0105Georgia

At present,a variety of vaccines have been approved,and existing antiviral drugs are being tested to find an effective treatment for coronavirus disease 2019(COVID-19).However,no standardized treatment has yet been approved by the World Health *** virally encoded chymotrypsin-like protease(3CL^(pro))from severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which facilitates the replication of SARS-CoV in the host cells,is one potential pharmacological target for the development of antiSARS *** search engines,such as Web of Science,Google Scholar,Scopus and PubMed,were used to retrieve data on the traditional uses of medicinal plants and their inhibitory effects against the SARS-CoV 3CL^(pro).Various pure compounds,including polyphenols,terpenoids,chalcones,alkaloids,biflavonoids,flavanones,anthraquinones and glycosides,have shown potent inhibition of SARS-CoV-2 3CL^(pro) activity with 50% inhibitory concentration(IC_(50))values ranging from 2-44μg/***,most of these active compounds,including xanthoangelol E(isolated from Angelica keiskei),dieckol 1(isolated from Ecklonia cava),amentoflavone(isolated from Torreya nucifera),celastrol,pristimerin,tingenone and iguesterin(isolated from Tripterygium regelii),tannic acid(isolated from Camellia sinensis),and theaflavin-3,3’-digallate,3-isotheaflav1in-3 gallate and dihydrotanshinone I(isolated from Salvia miltiorrhiza),had IC_(50)values of less than 15μg/*** mechanistic studies of several active compounds revealed that their mode of inhibition was dose-dependent and competitive,with K_(i)values ranging from 2.4-43.8μmol/*** the significance of plant-based compounds and the many promising results obtained,there is still need to explore the phytochemical and mechanistic potentials of plants and their *** medicinal plants could serve as an effective inexpensive nutraceutical for the general public to help manage COVID-19.

关键词： COVID-19 SARS-CoV-2 Coronavirus 3C proteases Medicinal plants Plant-derived compounds Drug development

Multi-Layered Deep Learning Features Fusion for Human Action Recognition

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Computers, Materials & Continua 2021年第12期69卷 4061-4075页

作者： sadia Kiran Muhammad Attique Khan Muhammad Younus Javed Majed Alhaisoni Usman Tariq Yunyoung Nam Robertas Damaševicius Muhammad Sharif Department of Computer Science HITEC University TaxilaTaxilaPakistan College of Computer Science and Engineering University of Ha’ilHa’ilSaudi Arabia College of Computer Engineering and Sciences Prince Sattam Bin Abdulaziz UniversityAl-KhrajSaudi Arabia Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea Faculty of Applied Mathematics Silesian University of TechnologyGliwicePoland Department of Computer Science COMSATS University IslamabadWah CampusPakistan

Human Action Recognition(HAR)is an active research topic in machine learning for the last few *** surveillance,robotics,and pedestrian detection are the main applications for action *** vision researchers have introduced many HAR techniques,but they still face challenges such as redundant features and the cost of *** this article,we proposed a new method for the use of deep learning for *** the proposed method,video frames are initially pre-processed using a global contrast approach and later used to train a deep learning model using domain transfer *** Resnet-50 Pre-Trained Model is used as a deep learning model in this *** are extracted from two layers:Global Average Pool(GAP)and Fully Connected(FC).The features of both layers are fused by the Canonical Correlation Analysis(CCA).Then features are selected using the Shanon Entropy-based threshold *** selected features are finally passed to multiple classifiers for final *** are conducted on five publicly available datasets as IXMAS,UCF Sports,YouTube,UT-Interaction,and *** accuracy of these data sets was 89.6%,99.7%,100%,96.7%and 96.6%,*** with existing techniques has shown that the proposed method provides improved accuracy for ***,the proposed method is computationally fast based on the time of execution.

关键词： Action recognition transfer learning features fusion features selection classification

On global behavior for complex soliton solutions of the perturbed nonlinear Schrödinger equation in nonlinear optical fibers

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Journal of Ocean Engineering and Science 2022年第5期7卷 431-443页

作者： M.S.Osman Hassan Almusawa Kalim U.Tariq sadia Anwar Sachin Kumar Muhammad Younis Wen-Xiu Ma Department of Mathematics Faculty of ScienceCairo UniversityGiza 12613Egypt Department of Mathematics Faculty of Applied ScienceUmm Alqurah UniversityMakkah 21955Saudi Arabia Department of Mathematics College of SciencesJazan UniversityJazan 45142Saudi Arabia Department of Mathematics Mirpur University of Science and TechnologyMirpur-10250(AJK)Pakistan Department of Mathematics Faculty of Mathematical SciencesUniversity of DelhiDelhi 110007India Centre for Undergraduate Studies University of the PunjabLahore 54590Pakistan Department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina Department of Mathematics King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Mathematics and Statistics University of South FloridaTampaFL 33620USA School of Mathematical and Statistical Sciences North-West UniversityMafikeng CampusPrivate Bag X2046Mmabatho 2735South Africa

In this research article,the perturbed nonlinear Schrödinger equation(P-NLSE)is examined by utilizing two analytical methods,namely the extended modified auxiliary equation mapping and the generalized Riccati equation mapping ***,we establish several sorts of new families of complex soliton wave solutions such as hyperbolic functions,trigonometric functions,dark and bright solitons,periodic solitons,singular solitons,and kink-type solitons wave solutions of the *** the mentioned methods,the results are displayed in 3D and 2D contours for specific values of the open *** obtained findings demonstrate that the implemented techniques are capable of identifying the exact solutions of the other complex nonlinear evolution equations(C-NLEEs)that arise in a range of applied disciplines.

关键词： P-NLSE Optical solitons The AEM method The REM method

Recommender System for Configuration Management Process of Entrepreneurial Software Designing Firms

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Computers, Materials & Continua 2021年第5期67卷 2373-2391页

作者： Muhammad Wajeeh Uz Zaman Yaser Hafeez Shariq Hussain Haris Anwaar Shunkun Yang sadia Ali Aaqif Afzaal Abbasi Oh-Young Song University Institute of Information Technology Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindi46000Pakistan Department of Software Engineering Foundation University IslamabadIslamabad44000Pakistan Department of Electrical Electronics and Telecommunication EngineeringUniversity of Engineering and TechnologyLahore54000Pakistan School of Reliability and Systems Engineering Beihang UniversityBeijing100191China Department of Software Sejong UniversitySeoul05006South Korea

The rapid growth in software demand incentivizes software development organizations to develop exclusive software for their customers *** problem is addressed by the software development industry by software product line(SPL)practices that employ feature ***,optimal feature selection based on user requirements is a challenging ***,there is a requirement to resolve the challenges of software development,to increase satisfaction and maintain high product quality,for massive customer needs within limited *** this work,we propose a recommender system for the development team and clients to increase productivity and quality by utilizing historical information and prior experiences of similar developers and *** proposed system recommends features with their estimated cost concerning new software requirements,from all over the globe according to similar developers’and clients’needs and *** system guides and facilitates the development team by suggesting a list of features,code snippets,libraries,cheat sheets of programming languages,and coding references from a cloud-based knowledge management ***,a list of features is suggested to the client according to their needs and *** experimental results revealed that the proposed recommender system is feasible and effective,providing better recommendations to developers and *** provides proper and reasonably well-estimated costs to perform development tasks effectively as well as increase the client’s satisfaction *** results indicate that there is an increase in productivity,performance,and quality of products and a reduction in effort,complexity,and system ***,our proposed system facilitates developers and clients during development by providing better recommendations in terms of solutions and anticipated ***,the increase in productivity and satisfaction level maximizes the benefits and usability of SPL in the

关键词： Feature selection recommender system software reuse configuration management

JA-mediated transcriptional regulation of secondary metabolism in medicinal plants

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Science Bulletin 2015年第12期60卷 1062-1072,I0002页

作者： sadia Afrin Jing-Jia Huang Zhi-Yong Luo Molecular Biology Research Center State Key Laboratory of Medical Genetics School of Life Sciences Central SouthUniversity Changsha 410078 China

Plants produce a wide spectrum of secondary metabolites that play critical roles in plant-environment interactions and against biotic and abiotic stresses. Moreover, many secondary metabolites have pharmaceu- tical efficacy for a wide range of diseases （cancer, malaria, etc.）. Controlled transcription of biosynthetic genes is one of the major mechanisms regulating sec- ondary metabolism in plants. Several transcription factor families such as MYC, MYB, WRKY and AP2/ERF have been found to be involved in the regulation of secondary metabolism in different medicinal plants. In addition, the biosynthesis and proper accumulation of secondary metabolites are also induced by signaling molecule jasmonic acid （JA）. This review provides an insight into JA signaling pathway and JA-mediated transcriptional regu- lation of secondary metabolism （vinblastine, nicotine, artemisinin, taxol and ginsenoside） in a range of medicinal plant species.

关键词： Jasmonic acid Medicinal plant Secondary metabolite Transcription factor

A Study on Heat Transfer Enhancement through Various Nanofluids in a Square Cavity with Localized Heating

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Energy Engineering 2021年第6期118卷 1659-1679页

作者： Sheikh Hassan Didarul Ahasan Redwan Md.Mamun Molla Sharaban Thohura M.Abu Taher sadia Siddiqa Department of Mathematics and Physics North South UniversityDhakaBangladesh Center for Applied and Scientific Computing(CASC) North South UniversityDhakaBangladesh Department of Mathematics Jagannath UniversityDhakaBangladesh Department of Mathematics Dhaka University of Engineering and TechnologyGazipurBangladesh Department of Mathematics COMSAT University IslamabadAttock CampusAttockPakistan

A two-dimensional(2D)laminar flow of nanofluids confined within a square cavity having localized heat source at the bottom wall has been *** governing Navier–Stokes and energy equations have been non dimensionalized using the appropriate non dimensional variables and then numerically solved using finite volume *** flow was controlled by a range of parameters such as Rayleigh number,length of heat source and nanoparticle volume *** numerical results are represented in terms of isotherms,streamlines,velocity and temperature distribution as well as the local and average rate of heat transfer.A comparative study has been conducted for two different base fluids,ethylene glycol and water as well as for two different solids Cu and Al_(2)O_(3).It is found that the ethylene glycol-based nanofluid is superior to the water-based nanofluid for heat transfer enhancement.

关键词： Nanofluids finite volume method heat transfer enhancement localized heating