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Primary intestinal lymphangiectasia: Minireview

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World Journal of Clinical Cases 2014年第10期2卷 528-533页

作者： sachin B ingle Chitra R Hinge(ingle) Department of Pathology MIMSR Medical College Latur Maharashtra 4132512 India Department of Physiology MIMSR Medical College Latur Maharashtra 4132512 India

Primary idiopathic intestinal lymphangiectasia is an unusual disease featured by the presence of dilated lymphatic channels which are located in the mucosa, submucosa or subserosa leading to protein loosing *** often affected were children and generally diagnosed before third year of life but may be rarely seen in adults too. Bilateral pitting oedema of lower limb is the main clinical manifestation mimicking the systemic disease and posing a real diagnostic dilemma to the clinicians to differentiate it from other common systemic diseases like Congestive cardiac failure, Nephrotic Syndrome, Protein Energy Malnutrition, etc. Diagnosis can be made on capsule endoscopy which can localise the lesion but unable to take biopsy samples. Thus, recently double-balloon enteroscopy and biopsy in combination can be used as an effective diagnostic tool to hit the correct diagnosis. Patients respond dramatically to diet constituting low long chain triglycerides and high protein content with supplements of medium chain triglyceride. So early diagnosis is important to prevent untoward complications related to disease or treatment for the sake of accurate pathological diagnosis.

关键词： Primary idiopathic intestinal lymphangiectasia Mucosa-submucosa Protein loosing enteropathy Double balloon endoscopy Biopsy

Splenic lymphoma with massive splenomegaly: Case report with review of literature

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World Journal of Clinical Cases 2014年第9期2卷 478-481页

作者： sachin B ingle Chitra R Hinge ingle Department of Pathology MIMSR Medical CollegeLatur Maharashtra 4132512 India Department of Physiology MIMSR Medical CollegeLatur Maharashtra 4132512 India

As per strict criteria of Das Gupta et al, primary splenic lymphoma is very rare. Herein, we are reporting an unusual case of primary large cell splenic lymphoma of B lineage in a middle aged female presenting with massive splenomegaly(3.8 kg) and hypersplenism. After performing therapeutic splenectomy for hypersplenism, a precise diagnosis of diffuse large B cell lymphoma was made on histopathology and confirmed by immunohistochemistry. The patient responded well to standard(Cyclophosphamide, Hydroxydaunorubicin, Oncovin(vincristine), Prednisone or prednisolone) regimen last year and is now in full remission. The splenectomy thereby has prevented the potential grave complications related to hypersplenism and splenic rupture. Our aim behind highlighting the topic is to specify that emergency splenectomy followed by anticoagulation therapy is an effective plan of management to prevent untoward complications related to disease and treatment.

关键词： Huge splenic lymphoma Pancytopenia Splenectomy Anticoagulation

Primary splenic lymphoma:Current diagnostic trends

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World Journal of Clinical Cases 2016年第12期4卷 385-389页

作者： sachin B ingle Chitra R Hinge(ingle) Department of Pathology MIMSR Medical College Department of Physiology MIMSR Medical College

The primary splenic lymphoma is extremely uncommon, can present with grave complications like hypersplenismand splenic rupture. In view of vague clinical presentation, it is difficult to arrive at the diagnosis. In such circumstances, histopathological diagnosis is very important. A precise diagnosis can only be made on histopathology and confirmed on *** splenectomy is preferred as an effective therapeutic and diagnostic tool in cases with giant splenomegaly. Core biopsy is usually not advised due to a high risk of post-core biopsy complications in view of its high vascularity and fragility. Aim behind highlighting the topic is to specify that core biopsy/ fine needle aspiration cytology can be used as an effective diagnostic tool to arrive at correct diagnosis to prevent untoward complications related to disease and treatment. Anticoagulation therapy is vital after splenectomy to avoid portal splenic vein thrombosis.

关键词： Splenic lymphoma Biopsy Immunohistochemistry

Epithelial cysts of the spleen:A minireview

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World Journal of Gastroenterology 2014年第38期20卷 13899-13903页

作者： sachin B ingle Chitra R Hinge (ingle) Swapna Patrike Department of Pathology MIMSR Medical College Department of Physiology MIMSR Medical College

Primary splenic epithelial cyst is an unusual event in everyday surgical practice with about 800 cases reported until date in the English literature. Splenic cysts may be parasitic or non-parasitic in origin. Nonparasitic cysts are either primary or secondary. Primary cysts are also called true,congenital,epidermoid or epithelial cysts. Primary splenic cysts account for 10% of all benign non-parasitic splenic cysts and are the most frequent type of splenic cysts in children. Usually,splenic cysts are asymptomatic and can be found incidentally during imaging techniques or on laprotomy. The symptoms are related to the size of cysts. When they assume large sizes,they may present with fullness in the left abdomen,local or referred pain,symptoms due to compression of adjacent structures(like nausea,vomiting,flatulence,diarrhoea) or rarely thrombocytopenia,and occasionally complications such as infection,rupture and/or haemorrhage. The preoperative diagnosis of primary splenic cysts can be ascertained by ultrasonography(USG),computed tomography or magnetic resonance imaging,although the wide use of USG today has led to an increase in the incidence of splenic cysts by 1%. However,careful histopathological evaluation along with immunostaining for presence of epithelial lining is mandatory to arrive at the diagnosis. The treatment has changed drastically from total splenectomy in the past to splenic preservation methods recently.

关键词： Epithelial cyst Spleen Diagnosis Splenectomy Laporoscopy

Papillary carcinoma of breast: Minireview

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World Journal of Clinical Cases 2016年第1期4卷 20-24页

作者： sachin B ingle Hemant G Murdeshwar Saleha Siddiqui Department of Pathology MIMSR Medical College Department of Pathology Dr.V.M.Government Medical College

The term "intracystic papillary ductal carcinoma in situ " constitutes only 0.5% to 1% of all breast *** is usually seen in postmenopausal age ***,we are presenting a minireview about this unusual breast malignancy us... 详细信息

关键词： Papillary carcinoma breast Intracystic Solid Diagnosis and management

Unusual case of insitu(intracystic) papillary carcinoma of breast

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World Journal of Clinical Cases 2013年第7期1卷 227-229页

作者： sachin B ingle Chitra R Hinge(ingle) Hemant G Murdeshwar Baban D Adgaonkar Department of Pathology MIMSR Medical College Vishwanathpuram Latur 413512 India Department of Physiology MIMSR Medical College Vishwanathpuram Latur 413512 India Department of Pathology Dr V M Government Medical College Solapur Maharashtra 413001 India

The term "intracystic papillary ductal carcinoma in situ ", has recently changed and is now more appropriately referred to as "intracystic papillary carcinoma'' constituting only 0.5% to 1% of all breast cancers. Herein, we discuss an unusual case of intracystic insitu papillary carcinoma of breast in a postmenopausal woman, the diagnosis of which was made on histopathology and confirmed by immunohistochemistry. Patient responded well to postoperative adjuvant radiotherapy without any recurrence, thereby preventing further morbidity and mortality related to invasion or tumor progression. So careful histopathological evaluation is the mainstay to arrive at the correct diagnosis to avoid untoward complications related to under diagnosis and /over diagnosis.

关键词： Insitu papillary carcinoma Histopathology

Primary signet ring cell carcinoma of the appendix: A rare case report

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World Journal of Clinical Cases 2015年第6期3卷 538-541页

作者： Ram V Kulkarni sachin B ingle Saleha Siddiqui Department of Pathology MIMSR Medical College

Primary adenocarcinoma of the appendix is a rare malignancythat constitutes < 0.5% of all gastroin-testinalneoplasms. Moreover, primary signet ring cell carcinomaof the appendix is an exceedingly rare entity. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastasesand unresectable peritoneal dissemination occurring in a 45-year-old female patient. She was clinically misdiagnosed as torsion of ovarian cyst. She underwent appendicectomy and unilateral *** revealed signet ring cell carcinoma and a right hemicolectomy was done. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-fluorouracil, and leucovorin(FOLFOX-4). The patient is doing well till today on follow up without progression of disease 10 mo after beginning chemotherapy.

关键词： Appendix Primary Signet ring cell carcinoma Ovarian metastasis

Isolated gastric Crohn's disease

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World Journal of Clinical Cases 2013年第2期1卷 71-73页

作者： sachin B ingle Chitra R Hinge Sarita Dakhure Smita S Bhosale Department of Pathology and Anaesthesia MIMSR Medical College

Crohn's disease(CD) is a chronic idiopathic inflammatory disease of gastrointestinal tract characterized by segmental and transmural involvement of gastrointestinal tract. Ileocolonic and colonic/anorectal is a most common and account for 40% of cases and involvement of small intestine in about 30%. The stomach is rarely the sole or predominant site of CD. To date there are only a few documented case reports of adults with isolated gastric CD and no reports in the pediatric population. Isolated stomach involvement is very unusual presentation accounting for less than 0.07% of all gastrointestinal CD. The diagnosis is difficult to establish in cases of atypical presentation as in isolated gastroduodenal disease. In the absence of any other source of disease and in the presence of nonspecific upper GI endoscopy and histological findings, serological testing can play a vital role in the diagnosis of atypical CD. Recent stud-ies have suggested that perinuclear anti-neutrophil cytoplasmic antibody and anti-Saccharomycescervisia antibody may be used as additional diagnostic tools. The effectiveness of infliximab in isolated gastric CD is limited to only a few case reports of adult patients and the long-term outcome is unknown.

关键词： Gastrointestinal tract Crohn’s disease Perinuclear anti-neutrophil cytoplasmic antibody Anti-Saccharomycescervisia antibody

Unusual histological variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation

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World Journal of Clinical Cases 2015年第4期3卷 389-392页

作者： Smita Shete Saroj Bolde Gopal Pandit Pushkar Matkari sachin B ingle Department of Pathology Dr. Vaishampayan Memorial Government Medical College Department of Pathology MIMSR Medical College

Malignant peripheral nerve sheath tumor(MPNST)with rhabdomyoblastic differentiation is called as malignant triton tumor(MTT). It is highly aggressive soft tissue tumor with higher local recurrence rate. MTT has poor prognosis than MPNST. MTT seems to be more aggressive in patients with neurofibromatosis(NF-1). We herein, reporting an interesting case of 55 years male with multiple neurofibromas all over the body since 30 years and multiple café-au-lait spots, diagnosed as NF-1. Since 6 years, he had an enlarged mass in left thigh. Wide excision of mass was done. On histopathological examination revealed the diagnosis of MTT and diagnosis of which was confirmed on immunohistochemistry.

关键词： Malignant triton tumor Neurofibromatosis-1 Desmin S-100 protein