检索结果-南通市图书馆

Association of ABCB1 gene polymorphisms rs1128503, rs2032582, rs4148738 with anemia in patients receiving dabigatran after total knee arthroplasty

引用

Chinese Journal of Traumatology 2024年第1期27卷 27-33页

作者： Alina Kasimova Dmitry Labutin anton Gvozdetsky Svetlana Bozhkova Division of Wound Infection Prevention and Treatment Vreden National Medical Research Center of Traumatology and OrthopaedicsSt.PetersburgRussian Federation Department of Clinical Pharmacology and Evidence-based Medicine Pavlov First Saint Petersburg State Medical UniversitySt.PetersburgRussian Federation Department of Psychiatry and Addictology North-Western State Medical University named after I.I.MechnikovSt.PetersburgRussian Federation

Purpose:Dabigatran is usually prescribed in recommended doses without monitoring of the blood coagulation for the prevention of venous thromboembolism after joint ***1 is a key gene in the metabolism of dabigatran *** allele variants are likely to play a pivotal role in the occurrence of hemorrhagic ***:The prospective study included 127 patients with primary knee osteoarthritis undergoing total knee *** with anemia and coagulation disorders,elevated transaminase and creatinine levels as well as already receiving anticoagulant and antiplatelet therapy were excluded from the *** association of ABCB1 gene polymorphisms rs1128503,rs2032582,rs4148738 with anemia as the outcome of dabigatran therapy was evaluated by single-nucleotide polymorphism analysis with a realtime polymerase chain reaction assay and laboratory blood *** beta regression model was used to predict the effect of polymorphisms on the studied laboratory *** probability of the type 1 error(p)was less than 0.05 was considered statistically *** was used to correct for significance levels in multiple hypothesis *** calculations were performed using Rprogramming language ***:For all polymorphisms there was no association with the level of platelets,protein,creatinine,alanine transaminase,prothrombin,international normalized ratio,activated partial thromboplastin time and *** of rs1128503(TT)had a significant decrease of hematocrit(p=0.001),red blood count and hemoglobin(p=0.015)while receiving dabigatran therapy during the postoperative period compared to the CC,*** of rs2032582(TT)had a significant decrease of hematocrit(p=0.001),red blood count and hemoglobin(p=0.006)while receiving dabigatran therapy during the postoperative period compared to the GG,GT *** differences were not observed in carriers of ***:It might be necessary to r

关键词： Thromboprophylaxis P-glycoprotein Dabigatran Anemia SNPs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

3D micro-devices for enhancing the lateral resolution in optical microscopy

引用

Light(Advanced Manufacturing) 2024年第2期5卷 50-63页

作者： Gordon Zyla Goran Maconi anton Nolvi Jan Marx Dimitra Ladika Ari Salmi Vasileia Melissinaki Ivan Kassamakov Maria Farsari Institute of Electronic Structure and Laser Foundation for Research and Technology-HellasHeraklionGreece Electronics Research Laboratory Department of PhysicsUniversity of HelsinkiHelsinkiFinland Applied Laser Technologies Ruhr University BochumBochumGermany

Although optical microscopy is a widely used technique across various multidisciplinary fields for inspecting small-scale objects,surfaces or organisms,it faces a significant limitation:the lateral resolution of optical microscopes is fundamentally constrained by light *** micro-spheres,however,offer a promising solution to this issue as they are capable of significantly enhancing lateral resolution through extraordinary phenomena,such as a photonic *** upon the potential of dielectric micro-spheres,this paper introduces a novel approach for fabricating 3D micro-devices designed to enhance lateral resolution in optical *** proposed 3D micro-device comprises a modified coverslip and a micro-sphere,facilitating easy handling and integration into any existing optical *** manufacture the device,two advanced femtosecond laser techniques are employed:femtosecond laser ablation and multi-photon *** laser ablation was employed to create a micro-hole in the coverslip,which allows light to be focused through this ***-photon lithography was used to fabricate a micro-sphere with a diameter of 20μm,along with a cantilever that positions the above the processed micro-hole and connect it with the *** this context,advanced processing strategies for multi-photon lithography to produce a micro-sphere with superior surface roughness and almost perfect geometry(λ/8)from a Zr-based hybrid photoresist are *** performance of the micro-device was evaluated using Mirau-type coherence scanning interferometry in conjunction with white light illumination at a central wavelength of 600 nm and a calibration grid(Λ=0.28μm,h>50 nm).Here,the 3D micro-device proved to be capable of enhancing lateral resolution beyond the limits achievable with conventional lenses or microscope objectives when used in ***,it maintained the high axial resolution characteristic of Mirau-type coherenc

关键词： Photonic nanojet Multi-photon lithography Optical microscopy Micro-optics Multi-photon grayscale lithography Extreme manufacturing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimal transcorneal electrical stimulation parameters for preserving photoreceptors in a mouse model of retinitis pigmentosa

引用

Neural Regeneration Research 2024年第11期19卷 2543-2552页

作者： Sam Enayati Karen Chang anton Lennikov Menglu Yang Cherin Lee Ajay Ashok Farris Elzaridi Christina Yen Kasim Gunes Jia Xie Kin-Sang Cho Tor Paaske Utheim Dong Feng Chen Schepens Eye Research Institute of Massachusetts Eye and Ear Department of OphthalmologyHarvard Medical SchoolBostonMAUSA Institute of clinical medicine Faculty of MedicineUniversity of OsloOsloNorway Department of Medical Biochemistry Oslo University HospitalUniversity of OsloOsloNorway Department of Ophthalmology Drammen HospitalVestre Viken Hospital TrustDrammenNorway Department of Histology and Embryology School of MedicineMarmara UniversityIstanbulTurkiye

Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors,leading to progressive photoreceptor *** research supports the beneficial effect of electrical stimulation on photoreceptor *** study aims to identify the most effective electrical stimulation parameters and functional advantages of transcorneal electrical stimulation(tcES)in mice affected by inherited retinal ***,the study seeked to analyze the electric field that reaches the retina in both eyes in mice and post-mortem *** this study,we recorded waveforms and voltages directed to the retina during transcorneal electrical stimulation in C57BL/6J mice using an intraocular needle probe with rectangular,sine,and ramp *** investigate the functional effects of electrical stimulation on photoreceptors,we used human retinal explant cultures and rhodopsin knockout(Rho^(-/-))mice,demonstrating progressive photoreceptor degeneration with *** retinal explants isolated from the donors’eyes were then subjected to electrical stimulation and cultured for 48 hours to simulate the neurodegenerative environment in *** density was evaluated by rhodopsin *** vivo Rho^(-/-)mice were subjected to two 5-day series of daily transcorneal electrical stimulation using rectangular and ramp *** function and visual perception of mice were evaluated by electroretinography and optomotor response(OMR),*** was used to assess the morphological and biochemical changes of the photoreceptor and bipolar cells in mouse *** recordings indicated effective delivery of rectangular,sine,and ramp waveforms to the retina by transcorneal electrical stimulation,of which the ramp waveform required the lowest *** of the total conductive resistance of the post-mortem human compared to the mouse eyes indicated higher cornea-to-retina resistance in human *** tem

关键词： bipolar cells electrical stimulation neuroprotection photoreceptor degeneration retina retinal explants retinitis pigmentosa transcorneal electrical stimulation waveform

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

隐藏世界——上海滴水湖洲际酒店

引用

中国建筑装饰装修 2024年第5期 17-23+16页

作者： sabine Beck Hirsch Bedner Associates (HBA)

这座位于上海临港新城的豪华型湖滨度假酒店是独岛酒店,有着“一岛一酒店”的美称。酒店前身为滴水湖皇冠假日酒店,其建筑造型别致,宛若一朵在湖水上盛开的桃花临湖亲水,景致迷人。本次翻新设计以“隐藏世界”为概念,打造宛如一扇连接...

这座位于上海临港新城的豪华型湖滨度假酒店是独岛酒店,有着“一岛一酒店”的美称。酒店前身为滴水湖皇冠假日酒店,其建筑造型别致,宛若一朵在湖水上盛开的桃花临湖亲水,景致迷人。本次翻新设计以“隐藏世界”为概念,打造宛如一扇连接陆地和水域并通往海洋世界的门户,带给入住客人沉浸于想象和探索之境的体验。

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Domain patterning in nonpolar cut PMN–PT by focused ion beam

引用

Journal of Advanced Dielectrics 2024年第2期14卷 83-89页

作者： Elena Pashnina Dmitry Chezganov Alla Slautina anton Turygin Andrei Ushakov Qingyuan Hu Xin Liu Zhuo Xu Xiaoyong Wei Vladimir Shur School of Natural Sciences and Mathematics Ural Federal University Yekaterinburg 620002 Russia Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric Research School of Electronic Science and Engineering Xi’an Jiaotong University Xi’an 710049 P.R.China

The formation of the ferroelectric domain structure as a result of irradiation by focused ion beam of[100]-cut 0.61Pb(Mg_(1/3)Nb_(2/3)TO_(3)–0.39PbTiO_(3)(PMN–PT)single crystals covered by surface artificial dielectric layer and with free surface was *** dot irradiation resulted in formation of the wedge-like domains grown along[001]*** irradiation of the free surface,the domains are mainly located under the surface,while at the irradiated surface with an artificial dielectric layer the domains are located at the *** was shown that the subsurface wedge-shaped part of the domain is unstable and completely disappears after a month due to spontaneous backswitching under the action of the residual depolarization *** revealed nonlinear dose dependence of the domain sizes was attributed to the distribution of the electric field using the point charge *** domain interaction for the distance between irradiated dots below 30m has been revealed in all *** was shown that the decrease of the distance between irradiated dots in the created domain row leads to an increase in the length of the central domains,which is explained by the contribution of all injected charges to the switching field.

关键词： Ion beam domain patterning dielectric layer domain interaction spontaneous backswitching domain engineering relaxor ferroelectric

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

引用

Signal Transduction and Targeted Therapy 2024年第4期9卷 1730-1744页

作者： Zhenzhen Fang Gang Shen Yina Wang Fuyan Hong Xiumei Tang Yongcheng Zeng Ting Zhang Huanyi Liu Yanmei Li Jinhong Wang Jing Zhang anton Gao Weiwei Qi Xia Yang Ti Zhou Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Department of VIP Medical Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Physical Examination Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Clinical Laboratory Guangzhou First People's HospitalGuangzhou 510080China Guangdong Key Laboratory of Liver Disease Research the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 51008China Department of Health Sciences College of Health SolutionsArizona State UniversityTempeUSA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-Sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Diabetology Guangzhou 510o80China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,and the development of nonalcoholic steatohepatitis(NASH)might cause irreversible hepatic ***(HLP)is the leading risk factor for *** study aims to illuminate the causative contributor and potential mechanism of Kallistatin(KAL)mediating HLP to NAFLD.221 healthy control and 253 HLP subjects,62 healthy control and 44 NAFLD subjects were *** plasma KAL was significantly elevated in HLP subjects,especially in hypertriglyceridemia(HTG)subjects,and positively correlated with liver ***,KAL levels of NAFLD patients were significantly *** transgenic mice induced hepatic steatosis,inflammation,and fibrosis with time and accelerated inflammation development in high-fat diet(HFD)*** contrast,KAL knockout ameliorated steatosis and inflammation in high-fructose diet(HFruD)and methionine and choline-deficient(MCD)diet-induced NAFLD ***,KAL induced hepatic steatosis and NASH by down-regulating adipose triglyceride lipase(ATGL)and comparative gene identification 58(CGl-58)by LRP6/Gas/PKA/GSK3βpathway through down-regulating peroxisome proliferator-activated receptor(PPARy)and up-regulating kruppel-like factor four(KLF4),***-58 is bound to NF-kB p65 in the cytoplasm,and diminishing CGl-58 facilitated p65 nuclear translocation and TNFa ***,hepatic CGl-58-overexpress reverses NASH in KAL transgenic ***,free fatty acids up-regulated KAL against thyroid hormone in ***,Fenofibrate,one triglyceride-lowering drug,could reverse hepatic steatosis by down-regulating *** results demonstrate that elevated KAL plays a crucial role in the development of HLP to NAFLD and may be served as a potential preventive and therapeutic target.

关键词： GSK3β inflammation elevated

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

数字化赋能流程工业可持续发展

引用

流程工业 2024年第3期 16-17页

作者： sabine Mühlenkamp 《PROCESS》编辑部

在保持流程工业竞争力的同时,如何不忽视可持续发展?整个流程行业都在寻找答案,尤其是目前正处于经济危机和能源转型双重压力下,自动化在其中正发挥着关键作用。

关键词：经济危机工业可持续发展能源转型流程工业流程行业数字化竞争力双重压力

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Demonstrating grating-based phase-contrast imaging of laser-driven shock waves

引用

Matter and Radiation at Extremes 2024年第4期9卷 90-97页

作者： Leonard Wegert Stephan Schreiner Constantin Rauch Bruno Albertazzi Paulina Bleuel Eric Frojdh Michel Koenig Veronika Ludwig Artem SMartynenko Pascal Meyer Aldo Mozzanica Michael Müller Paul Neumayer Markus Schneider Angelos Triantafyllidis Bernhard Zielbauer Gisela anton Thilo Michel Stefan Funk Plasma Physics Department GSI Helmholtzzentrum fur SchwerionenforschungPlanckstraBe 164291 DarmstadtGermany Erlangen Centre for Astroparticle Physics(ECAP) Friedrich-Alexander-Universität Erlangen-NurnbergNikolaus-Fiebiger-StraBe 291058 ErlangenGermany LULI-CNRS CEASorbonne UniversitésEcole PolytechniqueInstitut Polytechnique de ParisF-91120 Palaiseau CedexFrance Paul Scherrer Institut(Psi) Forschungsstrasse 1115232VilligenSwitzerland Karlsruhe Institute of Technology Institute of Microstructure TechnologyHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Single-shot X-ray phase-contrast imaging is used to take high-resolution images of laser-driven strong shock *** a two-grating Talbot interferometer,we successfully acquire standard absorption,differential phase-contrast,and dark-field images of the shocked *** agreement is demonstrated between experimental data and the results of two-dimensional radiation hydrodynamics simulations of the laser-plasma *** main sources of image noise are identified through a thorough assessment of the interferometer’s *** acquired images demonstrate that grating-based phase-contrast imaging is a powerful diagnostic tool for high-energy-density *** addition,we make a novel attempt at using the dark-field image as a signal modality of Talbot interferometry to identify the microstructure of a foam target.

关键词： interaction shock phase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Managing reservoir sedimentation by venting turbidity currents:A review

引用

International Journal of Sediment Research 2016年第3期31卷 195-204页

作者： sabine Chamoun Giovanni De Cesare anton J.Schleiss Laboratory of Hydraulic Constructions(LCH) Swiss Federal Institute of Technology Lausanne(EPFL)

Reservoir sedimentation is an issue that dam operators are increasingly facing as dams are *** only does it reduce a reservoir's capacity but it also affects its outlet structures such as bottom outlets and powerhouse *** may also impoverish downstream *** these reasons,several strategies for sediment management are being investigated and applied *** these methods,venting of turbidity currents reaching the dam can be very beneficial and *** measure helps in preserving a certain continuity of sediment transport in rivers obstructed by ***,several practical but also theoretical challenges hamper this technique,rendering its use less common and its aspects relatively *** present paper aims to gather the actual state-of-the-art concerning turbidity currents venting and to present an outlook for future development and research in this field.

关键词： Reservoir management Sedimentation Turbidity current Venting efficiency Bottom outlet

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Vanadium mineralization at Los Chihuidos sediment-hosted Cu-V deposit,Neuquén Basin,Argentina:An approach to vanadium ore forming processes

引用

Geoscience Frontiers 2024年第1期15卷 225-246页

作者： Ana L.Rainoldi Daniel Beaufort Marta B.Franchini Adolfo Giusiano sabine Petit Patricia Patrier M.Josefina Pons Dpto.de Geología Universidad Nacional del Sur(UNS)8000 Bahía BlancaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Centro Patagónico de Estudios MetalogenéticosArgentina Universitéde Poitiers IC2MPCNRS-UMR 7285HydrasaF-86022 Poitiers CedexFrance Universidad Nacional del Comahue Facultad de IngenieríaDepartamento de Geología y Petróleo8300 NeuquénArgentina Consultant Geologist 8300 NeuquénArgentina Universidad Nacional de Río Negro Instituto de Investigación en Paleobiología y GeologíaRío NegroArgentina

Vanadium mineralization at Los Chihuidos deposit of the Neuquén Basin is linked to the development of a redox front system related to the inflow of hydrocarbons into the red sandstone of the Huincul *** of hydrocarbons with oxidized red beds and connate water generated redox reactions where hematite was dissolved due to iron reduction resulting in the discoloration of the red *** the contact between oxidized red sandstone and reduced white sandstone,precipitation of specific mineral phases resulted in the V ore with minor amounts of *** the implementation of the redox interface,abundant V-montmorillonite and V-hematite precipitated at the more oxidizing conditions and Cu-V-corrensite-type at the more reducing conditions of the redox *** the redox front advanced with fluids constantly migrating into the reservoir,more reducing conditions were stablished,promoting chloritization and minor illitization with V-Cu incorporation and continuous upgrading of the *** ore mineralogy consists of clay minerals including V-bearing montmorillonite,Cu-V-corrensite-type,V-di-trioctahedral chlorite and Cu-tri-trioctahedral chlorite with minor V-illite-smectite mixed-layer minerals and associated secondary *** over illitization was favored due to high amounts of Fe and Mg in detrital clasts and in connate fluids and by low K availability related to low amounts of detrital *** spatial transition of V and/or Cu bearing clay minerals observed through the mineralized redox front at Los Chihuidos deposit(kaolinite→smectite→illite/smectite→corrensite-type→di-trioctahedral-chlorite→tri-trioctahedral-chlorite)and the related variation of V-Cu concentrations in bulk rock are indicative of increasing pH and decreasing Eh of resident solutions from red to white sandstones during the hypogene mineralization *** influx of Cu-rich oxidized basinal brines precipitated main copper ore with Cu-sulfides in the white sandst

关键词： Clay minerals V-chlorite Redox front Bleaching Hydrocarbons

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：