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Bietti crystalline dystrophy and choroidal neovascularization in childhood

International Journal of Ophthalmology(English edition) 2019年第9期12卷 1514-1516页

作者： sabiha gungor kobat Fatih Cem Gul Elif Yusufoglu Department of Ophthalmology Elazig Health Sciences UniversityElazig 23000Turkey

Dear Editor,I am *** gungor kobat,from the Department of Ophthalmology,Elazig Health Sciences University,Elazig,Turkey.I am writing to present an exceedingly rare case of two siblings,one of whom developed Bietti crystalline dystrophy(BCD)with choroidal neovascularization at the age of 13 years,and the other has asymptomatic BCD at 8 years old.

关键词： RPE BCD Bietti crystalline dystrophy and choroidal neovascularization in childhood

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The effect on wound healing of pazopanib and bevacizumab compared with corticosteroid in experimental glaucoma filtration surgery

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1909-1915页

作者： sabiha gungor kobat Fatma Ulku Celiker Adile Ferda Dagli Kader Kasar Department of Ophthalmology Elazig Health Sciences University Department of Ophthalmology School of Medicine Firat University Department of Pathology School of Medicine Firat University Department of Ophthalmology Ordu State Hospital

AIM: To compare the effects of bevacizumab and pazopanib with corticosteroids on wound healing after trabeculectomy. METHODS: In the study, 35 New Zealand white rabbits were randomly divided into five groups. Apart from the first group, limbus-based trabeculectomy was performed for the eyes of rabbits. No postoperative treatment was administered for group Ⅰ. Topically administered saline, prednisolone acetate(1%), bevacizumab 5 mg/mL, pazopanib 5 mg/mL for group Ⅱ, Ⅲ, Ⅳ and Ⅴ respectively were applied for groups 6 h daily for 28 d. On day 28 of the experiment, eyes were enucleated and histologically and immunohistochemically ***: The fibroblast counts of groups Ⅳ and Ⅴ were determined to be lower than those of groups Ⅱ and Ⅲ(P0.05). The immunohistochemical staining intensity of fibroblast growth factor β(FGF-β) and vascular endothelial growth factor(VEGF) was determined to be lower in groups Ⅳ and Ⅴ than in groups Ⅱ and Ⅲ(P0.05). The platelet derived growth factor β(PDGF-β) intensity was lower in group Ⅴ than in groups Ⅱ, Ⅲ and Ⅳ(P0.05). CONCLUSION: Bevacizumab and pazopanib might be good alternatives of corticosteroid treatment on delaying wound healing in glaucoma surgery.

关键词： trabeculectomy wound healing corticosteroid bevacizumab pazopanib

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QT interval dispersion in the patients with central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 61-65页

作者： Necati Dagli Burak Turgut Rumeysa Tanyildizi sabiha kobat Mehmet Ali kobat Orhan Dogdu Department of Cardiology School of MedicineFirat University Department of Ophthalmology School of MedicineFirat University Elazig Education and Research Hospital

AIM: To evaluate QT dispersion(QTD) in patients with central serous chorioretinopathy(CSC).METHODS: This clinical, comperative, case-control study included 30 patients with CSC at acute phase(Group 1) and 30 age- and sex-matched healthy subjects(Group 2, the control group). From all subjects, a 12-lead surface electrocardiography was obtained. The heart rate(HR), QT maximum(QT max), QT minimum(QT min), QT corrected(QT c), QTD and T mean were manually measured and analyzed. Student’s t-test and Pearson’s method of correlation were used for statistical analysis.· RESULTS: The patient and control groups were matched for age, smoking status(rate and duration) and gender. There were no significant differences with regard to these among the groups(P >0.05). The participants included 19 men(63.3%) and 11 women(36.7%) in Group1, 20 men(66.7%) and 10 women(33.3%) in Group *** max, QTD and QT c were significantly higher than those of healthy controls(P 0.05 for HR). No significant correlation was found between duration of the disorder and QTD values(r =0.13, P >0.05).CONCLUSION: These findings suggest that CSC may be associated with an increase in QTD and that the patients might be at risk for ventricular arrhythmia.

关键词： central serous chorioretinopathy electrocardiography QT dispersion ventricular arrhythmia

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Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 453-460页

作者： Fatih Cem Gül sabiha Güngör kobat FatihÇelik Süleyman Aydin Ramazan Fazil Akkoç Ophthalmology Clinic Elazığ City HospitalElazig 23200Turkey Department of Biochemistry Firat UniversityElazig 23119Turkey Department of Anatomy Firat UniversityElazig 23119Turkey

AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic ***: The study included three age and gendermatched groups of 20 cataract patients with no diabetes or additional disease(Group C), 20 cataract patients with diabetes and no retinopathy(Group DM+C), and 20 cataract patients with diabetic retinopathy(Group DR+C).All the patients were examined with respect to body mass index(BMI), fasting plasma glucose, hemoglobin A1c(HbA1c), and lipid *** and intraocular lens(Phaco+IOL) implantation were performed to all patients in all the groups, and aqueous samples were taken during the *** plasma and aqueous adiponutrin and pannexin 1 levels were analyzed using enzyme-linked immunosorbent ***: A statistically significant difference was determined between the groups with respect to BMI, fasting plasma glucose, and HbA1c levels(P<0.05 for all parameters tested).The plasma adiponutrin levels of Group DR+C were statistically significantly lower than those of Group C and Group DM+C(P<0.001, P=0.004).No statistically significant difference was determined in the aqueous adiponutrin levels in three *** plasma pannexin 1 levels of Groups DM+C and DR+C were statistically significantly lower than those of Group C(both P=0.001).The aqueous pannexin 1 levels of Group DR+C were statistically significantly higher than those of Group C and Group DM+C(P=0.001, P<0.001).CONCLUSION: Adiponutrin and pannexin 1, which play an important role in the pathophysiology of diabetes and obesity, and have a regulatory role in hyperglycemia and insulin *** measurement of adiponutrin and pannexin 1 levels may support clinicians in determining the risk of DR development.

关键词： diabetes mellitus retinopathy adiponutrin pannexin 1

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