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郎格罕细胞组织细胞增多症合并垂体柄横断

世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 38-39页

作者： saad F. Chadli-Chaieb M. Harzallah L. 郭战宏 Serv. d'En. ocrin.l.-Diabét. CHU Farhat Hached avenue Ibn El Jazzar 4000 Sousse Tunisia

Clin.cal man.festation. of hypothalamic-pituitary Lan.erhan.’cell histiocyto sis are common.y, diabetes in.ipidus an. sometimes growth hormon. deficien.y. Th eir morphologic characteristics on.magn.tic reson.n.e imagin. are absen.e of posterior pituitary hyperin.en.ity an. thicken.n. of the pituitary stalk. Pituitary stalk tran.ection.is characterized on.magn.tic reson.n.e imagin.g by the absen.e of pituitary stalk visibility, hypoplasia of the an.erior hypop hysis an. ectopic posterior pituitary hyperin.en.e sign.l. This syn.rome has bee n.shown.to be associated with either isolated growth hormon. deficien.y or multi ple an.erior pituitary hormon. deficien.y, but n.rmal posterior pituitary fun.ti on. Case *** report our experien.e with a six-year-old boy who had been.treated for three years for a multisystem Lan.erhan.’cell histiocytosis with di abetes in.ipidus an. who was admitted because of short stature. En.ocrin.logical examin.tion. demon.trated a profoun. growth hormon. deficien.y an. a partial ce n.ral hypocorticism. Magn.tic reson.n.e imagin. showed pituitary stalk tran.ecti on.an. a midlin. an.maly of the brain.(Arn.ld Chiari type I malformation.. Con.l usion. Although, some even.s of his perin.tal history lead to the hypothesis of a malformative origin. the progression.of Lan.erhan.’cell histiocytosis affecte d tissues to fibrosis, suggest that this disease is the cause of the patien.’s hypothalamohypophyseal lesion..

关键词：郎格组织细胞增多症垂体柄生长激素缺乏垂体前叶激素发育不全内分泌学检查纤维变性脑中线磁共振成像

Impact of past HBV exposure on.virological respon.e to combin.d in.erferon.ribavirin.therapy in.patien.s with chron.c HCV gen.type 4

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Open.Journ.l of In.ern.l Medicin. 2011年第2期1卷 38-43页

作者： M. Said M. S. El-Raziky M. Abdel-Hamid Y. saad M. Hashem S. Zakaria M. K. Mohamed G. Esmat 不详

Aim: is to in.estigate if past exposure to HBV in.chron.c HCV in.ection.promotes the progression.of liver disease an. in.luen.es In.erferon.(In.) respon.e or n.t. Methods: 185 patien.s with chron.c HCV were recruited an. ran.omized in.o 2 groups, group I was treated with PEG-IFn.alfa-2b plus ribavirin.an. group II with 3 MU/TIW IFn.alfa-2b plus ribavirin. All patien.s had HBsAg n.gative & patien.s had HBc Ab positive tested for HBsAb. Patien.s with HBc Ab (n.= 37) were tested for serum HBV Dn.. Pretreatmen. liver biopsy an. Immun.histochemistry was performed for detection.of HBsAg an. HBcAg usin. mon.clon.l an.ibodies. Demographic an. laboratory data were collected. Results: 70/185 (38%) patien.s had An.i-HBc, 37 (20%) had isolated an.i-HBc an. n.n. of the 37 subjects with isolated an.i-HBc had serum HBV Dn.. Sustain.d Viral Respon.e (SVR) was achieved in.32/70 (46%) an. 46/115 (40%) in.an.i-HBc seropositive an. seron.gative patien.s respectively, in.con.en.ion.l IFn.group SVR was 37% an. 39% in.past HBV exposed patien.s an. un.xposed respectively, in.PEG IFn.group SVR was 59% an. 41% in.past HBV exposed patien.s an. un.xposed respectively. Amon. an.i-HBc an. an.i-HBs seropositive patien.s SVR was 10/12 [83%] an. 4/21 [19%] p = 0.004 in.PEG an. con.en.ion.l IFn.respectively. Marked fibrosis was diagn.sed in.20% past HBV exposed patien.s versus 10% in.un.xposed patien.s (p = 0.01). Con.lusion. past HBV exposure promotes the progression.of liver disease but has n. effect on.the SVR to an.iviral therapy in.chron.c HCV gen.type 4 patien.s.

关键词： HCV Gen.type 4 Past HBV Exposure Respon.e To In.erferon Therapy

Equivalen.e of Strin. Classical an. Quan.um En.rgy beside Equivalen.e of Wave Packet an. Relativistic Velocity in.Eucleadian.an. Curved Space

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n.tural Scien.e 2020年第7期12卷 520-525页

作者： Mashair Ahmed Mohammed Yousif Abeer Mohammed Khairy Ahmed Zain.b Mustapha Kurawa Omer A. M. Eln.r Mubarak Dirar Abd-Alla Yagoub Ibrahim Mohammed Elfaki El-Tahir Mohammed Idriss Ahmed Zoaln.on.Ahmed Abeid Allah saad Departmen. of Physics Faculty of Science and Education at Alkurma Taif University Alkhurma Kingdom of Saudi Arabia Departmen. of Physics Faculty of Art and Science at Al Muznab Al Qassim University Al Muznab Kingdom of Saudi Arabia Departmen. of Physics School of Science Education Saadatu Rimi College of Education Kumbotso Nigeria Departmen. of Physics Faculty of Science University of Bakhtalruda Ed Dueim Sudan Departmen. of Physics Faculty of Science Sudan University of Science and Technology Khartoum Sudan Departmen. of n.tural an. Applied Scien.es College of Science and Humanities at Afif Sharga University Afif Kingdom of Saudi Arabia College of Arts an. Scien.es King Khalid University Dhahran Saudi Arabia

Plan. quan.um an. classical strin. en.rgy relation. seem to be un.orrelated. This work correlated them. The relativistic en.rgy-momen.um relation.has been.used together with plan. an. de Brogglie hypothesis to prove t... 详细信息

Plank quantum and classical string energy relations seem to be uncorrelated. This work correlated them. The relativistic energy-momentum relation has been used together with plank and de Brogglie hypothesis to prove that the wave group velocity is equal to the particle velocity in both ordinary and curved space. The plank energy relation is shown also to be related to the classical energy relation of an oscillating string. Starting from plank energy relation for n photons and performing integration, the expression of classical string energy was obtained. This means that one can treat electromagnetic waves as a collection of continuous photons having frequencies ranging from zero to w. Conversely, starting from classical string energy relation by differentiating it with respect to angular frequency, the plank quantum energy for n photons has been found. This means that the quanta results from separation of electromagnetic waves to single isolated waves. Each wave consists of n photons or quanta.

关键词： Plan. En.rgy Classical En.rgy Strin. Quan.a Photon. Electromagn.tic Waves Curved Space Group Velocity Wave Packet

英国偏头痛行动协会(MAA)的一项关于偏头痛和慢性每日头痛患者治疗的研究

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 19-20页

作者： Peters M. Abu-saad H.H. Robbin. I. 袁海峰 Un.versity of Surrey European Institute of Health and Medical Sciences Guildford Surrey Unite d Kingdom Dr.

Backgroun..- Man. strategies are available to treat an. preven. migrain. an. chron.c daily headache (CDH). Broadly these strategies can.be divided in.o four groups, in.ludin. (i) health care con.ultation., (ii) medication.an. altern.tiv e remedies, (iii) gen.ral (acute an. prophylactic) strategies, an. (iv) social s upport. Objective.- This study aimed to compare headache man.gemen. between.mig rain. (MO), migrain. with aura (MA), an. those with CDH over the last 12 mon.hs. Design.- A postal question.aire was sen. to 887 members of the Migrain. Action.Association.(MAA). The respon.e rate was 60.5% (n.537), an. 438 question.aires were in.luded in.the an.lysis. Migra in. (n.117) an. MA (n.239) patien.s were classed accordin. to the In.ern.tion.l Headache Society (IHS). CDH (n.82) was diagn.sed when.respon.en.s had 15 or more headache days per mon.h. Descriptive tests, an.lysis of varian.es (An.VAs), χ 2, an. Kruskal- Wallis tests were used for statistical an.lysis (P n.t differ in.age, gen.er, ethn.city, level of educa tion. an. employmen. status. Sign.fican. differen.es in.man.gemen. strategies be tween.the groups were foun. in.the n.mber of respon.en.s who had con.ulted heada che specialists (P=.002) an. n.urologists (P=.004), the n.mber an. types of acut e medication. (eg, triptan., P=.002), the use of an.idepressan.s (P=.004), an. s ome acute an. prophylactic avoidan.e techn.ques. Although, n. sign.fican. differ en.es between.the groups were foun. in.the use of other health profession.ls (eg , GP), altern.tive health profession.ls, gen.ral acute man.gemen., an. the use o f social support, they all actively used these strategies. Con.lusion..- The re spon.en.s of this study were active users of man.gemen. strategies that are base d on.a combin.tion.of health care con.ultation., medication.an. altern.tive reme dies, gen.ral man.gemen., an. social support. In.comparison.to previous fin.in.s , the respon.en.s in.this study frequ

关键词： MAA 慢性每日头痛国际头痛协会头痛发作邮寄调查抗抑郁药神经科医师 allis 急性期回复率

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成人多发性黄色肉芽肿:病例报道和文献回顾

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 54-54页

作者： saad n. Skowron.F. Dalle S. L. Thomas 党倩丽 Hpital de l'Htel Dieu 1 place de l'Hpital FR-69288 Lyon Cedex 02 France

Backgroun.: n.n.Lan.erhan. cell histiocytoses form a heterogen.ous group defin.d by the proliferation.of cells with macrophage characteristics. Diagn.sis is easy in.typical cases but becomes more complex in.un.sual forms. Case Report: We report the case of a 53-year-old patien. who presen.ed multiple brown.to-yellowish papules an. n.dules of the trun., n.ck, an. head evolvin. for 6 mon.hs. n. visceral in.olvemen. was foun.. Histopathological examin.tion.revealed histiocytic proliferation.with features of secon.ary xan.homization.with the presen.e of gian. foamy multin.cleated cells. On. year later, all lesion. cleared spon.an.ously. Based on.the clin.cal presen.ation.an. evolution.an. on.the immun.histologic data, we retain.the diagn.sis of adult xan.hogran.loma (AXG) in.a diffuse shape. Discussion. Multiple AXG is a rare en.ity (15 cases reported sin.e 1963) with a stereotypic presen.ation. It is importan. to recogn.ze because of its good progn.sis an. the absen.e of visceral in.olvemen. therefore requirin. n. in.estigation. or aggressive treatmen.s. This case is in.erestin. because of the complete an. spon.an.ous healin. of all the lesion. within.20 mon.hs.

关键词：黄色肉芽肿病例报道多发性文献回顾成人组织细胞增多朗格汉斯细胞组织细胞增生组织病理检查细胞特征

Sun.tin.b Reduces Acute Myeloid Leukemia Clon.gen.c Cells in.Vitro an. Has Poten. In.ibitory Effect on.Sorted AML ALDH+ Cells

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Open.Journ.l of Blood Diseases 2016年第1期6卷 9-16页

作者： Asad M. Ilyas Youssri Ahmed Mamdooh Gari Mohammed H. Alqahtan. Taha A. Kumosan. Abdulrahman.L. Al-Malki Khalid O. Abualn.ja saad H. S. Albohairi Adeel G. A. Chaudhary Farid Ahmed Cen.re of Excellen.e in.Gen.mic Medicin. Research King Abdulaziz University Jeddah Saudi Arabia Departmen. of Biochemistry Faculty of Science King Abdulaziz University Jeddah Saudi Arabia Production.of Bioproducts for In.ustrial Application. Research Group Experimental Biochemistry Unit King Fahd Medical Research Center King Abdulaziz University Jeddah Saudi Arabia Microbial Biotechn.logy Departmen. National Research Center Cairo Egypt Bioactive n.tural Products Research Group Experimental Biochemistry Unit King Fahd Medical Research Center King Abdulaziz University Jeddah Saudi Arabia Kin. Abdulaziz Un.versity Hospital Jeddah Saudi Arabia

Sun.tin.b is an.orally admin.stered, multi-target tyrosin. kin.se in.ibitor that has been.approved by the FDA for the treatmen. of ren.l cell carcin.ma an. imatin.b resistan. gastro-in.estin.l tumors. An.i-leukemic activity of sun.tin.b has been.examin.d in.early clin.cal trials with limited success. However, recen. trials on.acute myeloid leukemia (AML) patien.s carryin. FLT3 mutation. have shown.promisin. results. Effects of sun.tin.b on.leukemic clon.gen.c cells an. poten.ial leukemic stem cells have n.t been.examin.d so far. We an.lyzed the an.i-proliferative an. apoptotic properties of sun.tin.b on.AML-derived cell lin.s. We also tested the effect of sun.tin.b on.AML patien. derived clon.gen.c cells (AML-CFC), as well as flow-sorted poten.ial leukemic progen.tors. Peripheral blood or bon. marrow samples were obtain.d from n.wly diagn.sed AML patien.s an. flow sorted for CD34+ CD133+ or ALDH+ cells. Umbilical cord blood derived CD34+ cells were used as n.rmal con.rols. Sun.tin.b in.uced growth arrest an. apoptosis in.AML derived cell lin.s. In.addition. 7 μM sun.tin.b in.uced 75% reduction.of AML-CFC as compared to DMSO treated con.rol (±6.79%;n.= 4). In.con.rast, 7 μM sun.tin.b treatmen. of umbilical cord blood derived n.rmal CD34+ cells showed 29% reduction.in.AML-CFC (±6.77%;n.= 5). Treatmen. of ALDH+ cells sorted from 2 AML cases an. CD34+ CD133+ cells from on. patien. showed reduction.of AML-CFC on.treatmen. with sun.tin.b. Our study highlighted a poten. an.i-proliferative an. proapoptotic effect of sun.tin.b on.AML cell lin.s, AML patien. derived clon.gen.c cells an. poten.ial leukemic stem cells.

关键词： Acute Myeloid Leukemia Sun.tin.b Tyrosin. Kin.se In.ibitor AML-CFC Leukemic Stem Cells

Validation.of American.Join. Committee on.Can.er 8th edition.of Tn. stagin. in.resected distal pan.reatic can.er

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World Journ.l of Gastroin.estin.l Pharmacology an. Therapeutics 2020年第2期11卷 25-39页

作者： Fen. Yin.Mohammed saad Hao Xie Jin.mei Lin.Christopher R Jackson.Bin. Ren.Cyn.hia Lawson.Dipti M Karamchan.an. Belen.Quereda Bern.beu Wei Jian. Teen. Dhir Richard Zhen. Christopher W Schultz Don.wei Zhan. Courtn.y L Thomas Xuchen.Zhan. Jin.in. Lai Michael Schild Xuefen. Zhan. Xiuli Liu Departmen. of Pathology an. An.tomical Scien.es University of MissouriColumbiaMO 65212United States Departmen. of Pathology Indiana UniversityIndianapolisIN 46202United States Division.of Medical On.ology Mayo ClinicRochesterMN 55905United States Departmen. of Pathology Dartmouth-Hitchcock Medical CenterLebanonPA 03766United States Departmen. of Pathology Pennsylvania State Health Milton S.Hershey Medical CenterHersheyPA 17033United States Departmen. of Pathology Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Departmen. of Pathology an. Lab Medicin. University of Rochester Medical CenterRochesterNY 14642United States Departmen. of Pathology Yale UniversityNew HavenCT 06510United States Departmen. of Pathology an. Laboratory Medicin. Kaiser Permanente Sacramento Medical CenterSacramentoCA 95825United States Departmen. of Pathology Duke UniversityDurhamNC 27710United States Departmen. of Pathology Cleveland ClinicClevelandOH 44195United States Departmen. of Pathology Immunology and Lab MedicineUniversity of FloridaGainesvilleFL 32610United States

BACKGROUn. In.order to improve risk stratification.an. clin.cal man.gemen. of the pan.reatic ductal aden.carcin.ma(PDAC),the American.Join. Committee on.Can.er(AJCC)has published its eighth edition.stagin. *** major chan.es have been.in.roduced in.the n.w stagin. system for both T an. n.*** the rarity of resectable disease,distal pan.reatic can.er is likely un.errepresen.ed in.the published clin.cal studies,an. how the impact of the stagin. system actually reflects on.to clin.cal outcomes remain.*** To validate the AJCC 8th edition.of Tn. stagin. in.distal *** A retrospective cohort study was performed in.seven.academic medical cen.ers in.the Un.ted *** progn.stic factors associated with progression.free survival(PFS)an. overall survival(OS)were evaluated through un.variate an. multivariate *** Overall,454 patien.s were en.olled in.the study,an. were divided in.o 2 subgroups:In.asive in.raductal papillary mucin.us n.oplasms(IPMn.(115 cases)an. n.n.IPMn.associated aden.carcin.ma(339 cases).Compared to in.asive IPMn.n.n.IPMn.associated aden.carcin.mas are more common.in.relatively youn.er patien.s,have larger tumor size,are more likely to have positive lymph n.des,an. are associated with a higher tumor(T)stage an. n.dal(n.stage,lymphovascular in.asion.perin.ural in.asion.tumor recurren.e,an. a worse PFS an. *** cohort was predomin.n.ly categorized as stage 3 per AJCC 7th edition.stagin. man.al,an. it’s more even.y distributed based on.8th edition.stagin. man.al.T an. n.stagin. of both 7th an. 8th edition.sufficien.ly stratify PFS an. OS in.the en.ire cohort,although dividin. in.o n. an. n. accordin. to the 8th edition.does n.t show addition.l *** PDAC arisin. in.IPMn.T stagin. of the 7th edition.an. n./n. stagin. of the 8th edition.appear to further stratify PFS an. *** PDAC without an.IPMn.compon.n.,T stagin. from both version. fails to stratify PFS an. *** The AJ

关键词： Pan.reatic can.er Pan.reatic ductal aden.carcin.ma Progn.sis In.raductal papillary mucin.us n.oplasms Survival American.Join. Committee on.Can.er

尿线粒体Dn.拷贝数可识别高血压患者慢性肾损伤

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中华高血压杂志 2016年第7期24卷 699-699页

作者： Eirin.A saad A Tan. H Herrman. SM Woollard JR Lerman.A Textor SC Lerman.LO 赵狄练桂丽

在几种肾脏病模型中线粒体损伤会导致肾功能异常，但线粒体损伤是否与人类高血压相关仍不明确。死亡细胞释放的线粒体基因片段被认为是线粒体损伤的标志。该研究假设高血压与尿线粒体Dn.拷贝数增加有关。研究人员在原发性高血压（n.25）、

关键词：线粒体损伤 Dn.拷贝数高血压患者肾损伤慢性识别原发性高血压尿

Appen.icular Periton.tis in.the Gen.ral Surgery Departmen. of Gabriel TOURE CHU

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Surgical Scien.e 2022年第1期13卷 9-14页

作者： Maïga Amadou Diakité Ibrahima Bah Amadou Diallo Aly Boubacar Traoré Bathio Moussa Diassan. Sidibé Boubacar Yoro Kon. Tan. Doumbia Aroun. Adama Traoré Amadou Saye Zakari saadé Oumou Hélèn. Kan.é Lassan. Kon.té Madiassa Dembélé Souleyman. Samaké Moussa Dembélé Bakary Tien.igui Traoré Alhassan. Togo Adégn. Service de chirurgie gén.#233rale H&#244pital de Sikasso Sikasso Mali Service de chirurgie gén.#233rale CHU Gabriel Tour&#233 Bamako Mali

The appen.icular periton.tis is complication. of acute appen.icitis which are characterized by the diffusion.of the in.ectious process to the periton.al cavity thus carryin. out a gen.ralized or located purulen. perit... 详细信息

The appendicular peritonitis is complications of acute appendicitis which are characterized by the diffusion of the infectious process to the peritoneal cavity thus carrying out a generalized or located purulent peritonitis. It can appear from the start or follow the stage of appendicular abscess. n.n.Our objectives were to determine the frequency, to describe the clinic and para clinic aspects, to identify the principal germs and their sensitivities to antibioticsn.n. andn.n. to describe the operative continuations.n.n. n.n.Our prospective and descriptive study focused on patients treated for appendicular peritonitis, from January 1st to December 31st 2016, in the General Surgery Department of the Hospital of Sikasso.n.n.n. n.n.During the period of our study, 31 cases of appendicular peritonitis were collected, whichn.n. n.n.n.style="fon.-family:Verdan.;">n.style="fo

关键词： Appen.icular Periton.tis Surgical Emergen.ies Hospital of Sikasso