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Intervention effect of Cigu Xiaozhi prescription(慈菇消脂方)on ceramide lipoapoptosis in non-alcoholic fatty liver disease

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Journal of Traditional Chinese Medicine 2024年第1期44卷 63-69页

作者： YANG Shaojun MA Yanhua BAI Zhouxia yu Ye FANG Buwu ZHANG Li WANG Li Department of Spleen and Stomach Diseases Beihai Traditional Chinese Medicine hospitalBeihai 536000China the First Clinical Medical College of Gansu University of Traditional Chinese Medicine Lanzhou 730000China Department of Clinical Laboratory Affiliated Hospital of Gansu University of Traditional Chinese MedicineLanzhou 730000China Department of Pharmacology School of Basic MedicineTianjin Medical UniversityTianjin 300070China

OBJECTIVE:To explore the mechanism of the Chinese medicine Cigu Xiaozhi prescription(慈菇消脂方,CGXZ)in the treatment of the non-alcoholic fatty liver disease(NAFLD)by detoxification and phlegm-reducing,the effect of CGXZ prescription on ceramide-mediated lipid apoptosis in Hep G2 cells with ***:The experiment was randomly divided into 6groups:normal control group,model group,CGXZ prescription medicated serum high,medium,and low dose groups,and pioglitazone positive control *** 500μmol/L free fatty acid(FFA)mixture to induce Hep G2 cells to establish NAFLD cell model,respectively,with 2%,4%,and 6%concentration of CGXZ prescription medicated serum intervention for 24 *** changes in organelles and lipid droplet accumulation were observed under the electron ***,Td T-mediated d UTP Nick-End Labeling method was used to assay hepatocyte apoptosis;Biochemical determination of glutamic-pyruvic transaminase,glutamic oxalacetic transaminase,triglycerides,and FFA levels in Hep G2cells;the content of ceramide was determined by highperformance thin-layer ***,Western Blot and quantitative real-time polymerase chain reaction(q RT-PCR)were used to determine the protein and gene expression levels,such as inducible nitric oxide synthase(i NOS),nuclear factorκB(NF-κB),B cell lymphoma 2(Bcl-2)and Bcl-2-associated X(Bax).RESULTS:Under the electron microscope,the cells in the model group showed moderate-to-severe steatosis,and apoptotic bodies could be *** model group had greater improvements in the apoptosis rate(P0.05).Compared with the model group,the levels of ceramide C2 and FFA(P<0.01),the protein expressions of NF-κB,i NOS,and Bax(P<0.05)in the CGXZ prescription treatment group and pioglitazone pos

关键词： non-alcoholic fatty liver disease ceramides Cigu Xiaozhi prescription detoxification and phlegm removal

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1D p-type molecular-based coordination polymer semiconductor with ultrahigh mobility

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Science Bulletin 2024年第17期69卷 2705-2711页

作者： Chenhui yu Xinxu Zhu Kefeng Li Guan-E Wang Gang Xu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China

One-dimensional(1D)semiconductor nanostructures exhibit exceptional performance in mitigating short-channel effects and ensuring low power ***,the scarcity of high-mobility ptype 1D materials impedes further ***-based materials offer high designability in structure and properties,making them a promising candidate for 1D p-type semiconductor materials.A molecular-based 1D p-type material was developed under the guidance of coordination ***-HT(HT is the abbreviation of p-hydroxy thiophenol)combines the merits of highly orbital overlap between Cu and S,fully covered surface modification with phenol functional groups,and unique cuprophilic(Cu-Cu)*** such,Cu-HT has a remarkable hole mobility of 27.2 cm2V-1s-1,which is one of the highest reported values for 1D molecular-based materials to date and even surpass those of commonly used amorphous silicon as well as the majority of 1D inorganic *** achievement underscores the significant potential of coordination polymers in optimizing carrier transport and represents a major advancement in the synthesis of high-performance,1D p-type semiconductor materials.?2024 Science China *** by Elsevier *** Science China *** rights are reserved.

关键词： Molecular-basedmaterials Hole mobility Coordinationpolymer Field-effecttransistors

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江西德安彭山矿田遥感找矿预测研究

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岩石矿物学杂志 2024年第4期43卷 973-981页

作者：谭荣徐裕敏徐先宇王天晨余振东江西省地质局第三地质大队江西九江332100

矿田找矿预测过程中受基础地质大数据的影响较大,导致其应用于地质复杂区域时筛选结果的准确性较差,为此研究了江西省德安县彭山矿田遥感找矿预测方法。以下鞭山锡矿区作为彭山地区的典型矿田,分析了其地质特征与成矿规律,依据分析结果... 详细信息

矿田找矿预测过程中受基础地质大数据的影响较大,导致其应用于地质复杂区域时筛选结果的准确性较差,为此研究了江西省德安县彭山矿田遥感找矿预测方法。以下鞭山锡矿区作为彭山地区的典型矿田,分析了其地质特征与成矿规律,依据分析结果再结合遥感技术,获得遥感找矿要素与遥感蚀变信息,建立遥感综合信息找矿靶区预测模型,得到彭山地区找矿靶区定量预测结果输出。预测结果显示,研究区共定量预测出3个典型找矿靶区,分别位于该区的西北侧、西侧及东侧区域,主要具环形与条带状构造,构造发育方向主要为东北向、西北向及近南北向,所提取到的遥感蚀变信息主要有碳酸盐化、绿帘石化、绿泥石化、绢云母化、高岭土化及铁染,3个靶区均具有较好的成矿条件;野外实际查证证实3个靶区中存在高岭土化、铁染及碳酸盐化等蚀变发育,且蚀变岩块中Cu与Au的含量较高,预测结果得到证实,可为该区域的找矿勘探提供可靠的参考依据。

关键词：德安县彭山矿田地质成矿规律找矿靶区遥感技术蚀变信息

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De novo design of highly efficient type-Ⅰphotosensitizer based onπ-conjugated oligomer for photodynamic eradication of multidrug-resistant bacterial infections

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Chinese Chemical Letters 2024年第3期35卷 389-393页

作者： Qi Zhao Guangchao Qing Jie yu Ying Liu Jianliang Shen Yang Luo Xingjie Zan Shengliang Li State Key Laboratory of Ophthalmology Optometry and Vision ScienceSchool of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou InstituteUniversity of Chinese Academy of SciencesOujiang Laboratory(Zhejiang Lab for Regenerative MedicineVision and Brain Health)Wenzhou 325001China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Center of Smart Laboratory and Molecular Medicine School of MedicineChongqing UniversityChongqing 400044China College of Life Science and Laboratory Medicine Kunming Medical UniversityKunming 650050China

Traditional photosensitizers show limited singlet oxygen generation in hypoxic infection lesions,which greatly suppress their performance in antibacterial ***,there still is lack of feasible design strategy for developing hypoxia-overcoming photosensitizers ***,radical generation ofπ-conjugated small molecules is efficiently manipulated by an individual selenium(Se)*** this strategy,the first proof-of-concept study of a Se-anchored oligo(thienyl ethynylene)(OT-Se)with high-performance superoxide radical(O_(2)^(·-))and hydroxyl radical(·OH)generation capability is present,and achieves efficient antibacterial activities towards the clinically extracted multidrug-resistant bacteria methicillin-resistant ***(MRSA)and carbapenem-resistant ***(CREC)at sub-micromolar concentration under a low white light irradiation(30 mW/cm^(2)).The water-dispersible OT-Se shows a good bacteria-anchoring capability,biocompatibility,and complete elimination of multidrug-resistant bacteria wound infection in *** work offers a strategy to boost type-I photodynamic therapy(PDT)performance for efficient antibacterial treatments,advancing the development of antibacterial agents.

关键词： Photodynamic therapy Antibacterial Type-Ⅰphotosensitizers Multidrug-resistant bacteria Conjugated oligomers

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薏苡仁活性成分研究进展

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中国中药杂志 2024年第6期49卷 1474-1484页

作者：吴静雨陈晓凡徐万爱陈雨迅于欢江西中医药大学药学院江西南昌330004

薏苡仁作为我国常用的一种药食同源资源,种植与药用历史悠久。中医认为,薏苡仁具有健脾补肺、清热利湿、排脓除痹、止泻等功效,用来治疗水肿、脚气、脾虚泄泻等症,上述功效与其含有多种活性成分密切相关,如酯类及脂肪酸类、多糖类、蛋... 详细信息

薏苡仁作为我国常用的一种药食同源资源,种植与药用历史悠久。中医认为,薏苡仁具有健脾补肺、清热利湿、排脓除痹、止泻等功效,用来治疗水肿、脚气、脾虚泄泻等症,上述功效与其含有多种活性成分密切相关,如酯类及脂肪酸类、多糖类、蛋白质类,以及酚酸、甾醇、黄酮、内酰胺、三萜、生物碱、腺苷等。现代研究发现,薏苡仁还具有抗癌、抗炎、抗氧化、降血糖、降血压、提高免疫力、调节血脂代谢等多种药理活性。薏苡仁在我国分布广泛,主产于贵州、云南、福建、四川等地,各产地薏苡仁质量参差不齐。从古至今,薏苡仁炮制方法经历了由简到繁的过程,辅料的种类也越来越广泛,如土、麸、河砂等,这些炮制方法历代传承,如今常用的为麸炒、清炒、砂炒法等。该文通过查阅近几年国内外相关文献,对薏苡仁主要活性成分及相关药理作用进行梳理概括,总结不同产地与炮制方法对薏苡仁化学成分差异的影响,以期为薏苡仁的综合开发利用和进一步作用机制研究提供参考。

关键词：薏苡仁活性成分不同产地炮制药理作用

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Anion-induced differential assembly and structural transformation of supramolecular coordination cages

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Chinese Chemical Letters 2024年第3期35卷 268-272页

作者： Shao-Ping Zheng Yao-Wei Xu Pei-Yang Su Chen-Hui Liu Yin-Hui Huang yu-Lin Lu Zhang-Wen Wei Zhiwei Jiao Hai-Sen Xu Cheng-Yong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510006China Institute of Environmental Research at Greater Bay Area Guangzhou UniversityGuangzhou 510006China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The intimate host-anion interactions will regulate thermodynamics and kinetics in the self-assembly of cationic cages mimicking biological ***,we report construction and transformation of three Pd(Ⅱ)-based metal-organic cages(MOCs)depending on different *** conversions of the lantern-shaped MOC-34 into either octahedral MOC-35 or tricapped trigonal prism MOC-36 are induced by BF_(4)^(–)or NO_(3)^(–),***-36 is kinetically favored and can undergo quantitative conversion to the thermodynamically preferred MOC-35 upon heating,accelerated by excess BF_(4)^(–)to motivate dissociative dynamics of Pd-vertices and lower activation barrier of cage *** guest encapsulation behaviors of MOC-35 and MOC-36 have also been *** results manifest a significance of host-anion dynamics beyond complementary anion template,shedding light on the understanding of intricate anion recognition in nature.

关键词： Supramolecular coordination cage Dynamic host-anion interactions Structural transformation Anion receptor Guest inclusion

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SiRAP2-12,a Positive Regulatory Factor,Effectively Improves the Waterlogging Tolerance of Foxtail Millet(Setaria italica)

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 445-465页

作者： Xueyan Xia Xiaohong Fu yu Zhao Jihan Cui Nuoya Xiao Jingxin Wang Yiwei Lu Meihong Huang Cheng Chu Jia Zhang Mengxin Yang Shunguo Li Jianfeng Liu Institute of Millet Crops Hebei Academy of Agriculture and Forestry Sciences/Key Laboratory of Genetic Improvement and Utilization for Featured Coarse Cereals(Co-Construction byMinistry and Province)Ministry of Agriculture and Rural Affairs/The Key Research Laboratory of Minor Cereal Crops of Hebei ProvinceShijiazhuang050035China School of Life Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaoding071002China

Foxtail millet(Setaria italica)growth was inhibited because of waterlogging stress,which has caused yield *** family plays an important role to plant adversity *** our study,we obtained 19,819 differential expressed genes(DEGs)between the two treatments based on the RNA-seq sequencing of foxtail millet of water-logging ***,a total of 28 ERF family members were obtained,which have a complete open read-ing *** studied the evolution and function of SiERF family and how they affected the waterlogging *** was found that SiERF1A/B/C(GenBank ID:OR775217,OR775219,OR775218)and SiRAP2-12(GenBank ID:OR775216)have similar functions to the known waterlogging tolerance genes of other *** them,the SiRAP2-12 expression was obviously signiﬁcantly up-regulated in foxtail millet after 5d water-logging *** SiRAP2-12 was silenced,the activity of defense enzymes in millet decreased signiﬁ*** details,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD),the osmotic regulator proline(Pro),and the activity of the anaerobic respiratory enzyme alcohol dehydrogenase(ADH)content were decreased by 78.61%,29.52%,79.95%,19.41%and 54.77%,*** contrast,the relative electrical conductivity contents(REC),malondialdehyde(MDA),and hydrogen peroxide(H_(2)O_(2))of the foxtail millet subjected to virus-induced gene silencing clearly increased by 1.03-fold,36.09%,and 15.21%,*** content of sodium(Na^(+))in the SiRAP2-12-silenced foxtail millet also increased,but that of potassium(K^(+))***,we found that ethylene content was signiﬁcantly ***,the SiAOC1 expression,an essential gene for ethylene synthesis,was inhibited in SiRAP2-12-silenced foxtail millet after waterlogging *** together,we hypothesized that SiRAP2-12 might be a positive regulator of millet tolerance to waterlogging stress.

关键词： Foxtail millet waterlogging SiRAP2-12 VIGS ethylene

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Emerging trends in early-onset gastric cancer

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中华医学杂志(英文版) 2024年第18期137卷 2024 Aug 15页

作者： Wang Xinlin Gao Xianchun yu Jun Zhang Xiaotian Nie Yongzhan State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Xi’an Shaanxi China National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi’an Shaanxi China Beijing Key Laboratory of Carcinogenesis and Translational Research Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp Institute Beijing China

The incidence of early-onset gastric cancer (EOGC) is consistently increasing, and its etiology is notably complex. This increase may be attributed to distinctive factors that differ from those associated with late-onset gastric cancer (LOGC), including genetic predispositions, dietary factors, gastric microbiota dysbiosis, and screening of high-risk cases. These factors collectively contribute to the onset of cancer. EOGC significantly differs from LOGC in terms of clinicopathological and molecular characteristics. Moreover, multiple differences in prognosis and clinical management also exist. This study aimed to systematically review the latest research advancements in the epidemiological characteristics, etiological factors, clinicopathological and molecular features, prognosis, and treatment modalities of EOGC.

关键词： Early-onset gastric cancer Epidemiology Etiology Clinicopathological features Molecular signaling Prognosis Clinical management

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基于透视变换和SNc-YOLOv5的大块煤识别方法应用

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西安科技大学学报 2024年第1期44卷 54-63页

作者：于涛国家能源集团新疆能源有限责任公司新疆乌鲁木齐830011

为了提高带式输送机大块煤识别的准确率,避免大块煤堆积对皮带造成的磨损,延长输送机的使用寿命,提出了基于透视变换和SNc-YOLOv5的大块煤识别方法,该方法首先利用透视变换技术对原始图像进行处理,有效地将图像中的非输送机区域滤除,并... 详细信息

为了提高带式输送机大块煤识别的准确率,避免大块煤堆积对皮带造成的磨损,延长输送机的使用寿命,提出了基于透视变换和SNc-YOLOv5的大块煤识别方法,该方法首先利用透视变换技术对原始图像进行处理,有效地将图像中的非输送机区域滤除,并对输送机区域进行坐标矫正;然后,采用SNc-YOLOv5模型对经过标准化处理的图像进行深度学习建模,得到大块煤识别模型;最后,通过试验分析和现场应用对该方法进行有效性验证。结果表明:该方法在1号煤矿数据集的试验分析精确率为94.8%,召回率为83.2%,在2号煤矿数据集的试验分析精确率为92.8%,召回率为85.3%,现场应用置信度达到0.9,与其他方法进行比较,精确率和召回率指标均优于其他方法;该方法在图像预处理阶段提取带式输送机区域对图像进行标准化,仅对感兴趣区域进行处理,提高了大块煤识别的准确率。该算法部署到某煤矿现场,能够实现实时监测,为带式输送机的安全运行和延长使用寿命提供了有力保障。

关键词：大块煤识别带式输送机透视变换图像标准化

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基于树状多分支残差注意力网络的真实场景图像超分辨率重构

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控制与决策 2024年第10期39卷 3442-3450页

作者：韩玉兰顾琴崔玉杰兰朝凤哈尔滨理工大学测控技术与通信工程学院哈尔滨150000

真实场景图像超分辨率重构方法的研究进一步推动了超分辨率重构的应用,成为研究的热点.针对现有方法多采用单一输出代表高分辨率图像的高频特征细节,难以保障稳定、准确高频细节的问题,提出一种基于树状多分支残差注意力网络的真实场景... 详细信息

真实场景图像超分辨率重构方法的研究进一步推动了超分辨率重构的应用,成为研究的热点.针对现有方法多采用单一输出代表高分辨率图像的高频特征细节,难以保障稳定、准确高频细节的问题,提出一种基于树状多分支残差注意力网络的真实场景图像超分辨率重构方法.该方法通过树状结构形成多分支超分辨率重构网络,增强特征表现能力,进而丰富重构图像高频细节.每条分支采用双通道残差策略对基础块进行连接,允许更多低频特征通过.进一步设计了基础块,融入密集残差结构和注意力机制,可以在加深网络的同时使网络在通道和空间上进行全局信息自适应调整.面对树状分支的多个重构结果,采用空间频率方法进行融合.实验结果表明,同当前先进的同类方法相比,所提出方法具有更佳的重构效果.

关键词：超分辨率真实场景注意力树状多分支结构双通道残差结构

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