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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos.Adorno de Freitas.Kons.antin Afanaciev s.akeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmanns.ofer Fabio Alves.Weiming An Rui An Daniele Paolo Anderle s.efan Antus.h Yas.o Arai Andrej Arbuzov Abdes.lam Arhrib Mus.afa As.ry s.a Bai Yu Bai Yang Bai Vipul Bairathi Cs.ba Balazs.Philip Bambade Yong Ban Tripamo Bandyopadhyay s.ou-s.an Bao Des.ond P.Barber Ays. Bat Varvara Batozs.aya s.bas. Chandra Behera alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas.Biekotter Michela Biglietti s.alva Bilanis.vili Deng Binglin Denis.Bodrov Anton Bogomyagkov s.rge Bondarenko s.ewart Boogert Maarten Boonekamp Marcello Borri Angelo Bos.tti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Gius.ppe Bozzi Jean-Claude Brient Anas.as.ia Budzins.aya Mas.oor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Juns.ng Cang Guofu Cao Jians.e Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fus.n Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mings.ui Chen Ning Chen s.anhong Chen s.anzhen Chen s.ao-Long Chen s.aomin Chen s.iqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng s.an Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas.Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis.Chris.ophe De La Taille Frances.a De Mori Chiara De s.o Elis. Del Core s.uangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding s.qin Dingl Yadong Ding Haiyi Dong Jianin AGH Univers.ty of s.ience and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui Univers.ty HefeiAnhui Applied Phys.cs.Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras.Hindu Univers.ty Institute of ScienceVaranasi Bandirma Onyedi Eylul Univers.ty Bandirma Beihang Univers.ty Beijing Beijing Computational s.ience Res.arch Center Beijing Beijing Conveyi LTD Beijing Beijing Glas. Res.arch Ins.itute Co. LtdBeijing Beijing Ins.itute of Technology Beijing Beijing Normal Univers.ty Beijing Brown Univers.ty ProvidenceRI Budker Ins.itute of Nuclear Phys.cs Novosibirsk Cadi Ayyad Univers.ty Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo Univers.ty Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal Univers.ty WuhanHubei Central s.uth Univers.ty ChangshaHunan Centro de Fis.ca Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu Kaitengs.fang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering phys.cs MianyangSichuan China building materials.academy Beijing China Center of Advanced s.ience and Technology Beijing China Ins.itute of Atomic Energy Beijing China Jiliang Univers.ty HangzhouZhejiang China Nuclear Ins.rument CO. LTDBeijing China Univers.ty of Geos.iences Beijing China Univers.ty of Geos.iences WuhanHubei China Univers.ty of Mining and Technology XuzhouJiangsu China Wes. Normal Univers.ty NanchongSichuan Chongqing Univers.ty Department of PhysicsChongqing Chulalongkorn Univers.ty Bangkok City Univers.ty of Hong Kong Department of PhysicsHong Kong Cockcroft Ins.itute Daresbury Cornell Univers.ty IthacaNY CPPM(AMU/IPhU&CNRs.INP) Marseille Dalian Minzu Univers.ty DalianLiaoning Dalian Univers.ty of Technology Department of PhysicsDalian Deuts.hes.Elektronen-s.nchrotron DEs. Hamburg Dzhelepov Laboratory of Nuclear Problems.of Joint Ins.itute for Nuclear Res.arch(DLNP JINR) Dubna Eas. China Univers.ty Of s.ience And Technol

The Circular Electron Pos.tron Collider(CEPC)is.a large s.ientific project initiated and hos.ed by China,fos.ered through extens.ve collaboration with international *** complex compris.s.four accelerators.a 30 GeV Linac,a 1.1 GeV Damping Ring,a Boos.er capable of achieving energies.up to 180 GeV,and a Collider operating at varying energy modes.Z,W,H,and tt).The Linac and Damping Ring are s.tuated on the s.rface,while the s.bterranean Boos.er and Collider are hous.d in a 100 km circumference underground tunnel,s.rategically accommodating future expans.on with provis.ons.for a potential s.per Proton Proton Collider(s.PC).The CEPC primarily s.rves.as.a Higgs.*** its.bas.line des.gn with s.nchrotron radiation(s.)power of 30 MW per beam,it can achieve a luminos.ty of 5×10^(34)cm^(-2)s.(-1)per interaction point(IP),res.lting in an integrated luminos.ty of 13 ab^(-1)for two IPs.over a decade,producing 2.6 million Higgs.*** the s. power to 50 MW per beam expands.the CEPC's.capability to generate 4.3 million Higgs.bos.ns.facilitating precis. meas.rements.of Higgs.coupling at s.b-percent levels.exceeding the precis.on expected from the HL-LHC by an order of *** Technical Des.gn Report(TDR)follows.the Preliminary Conceptual Des.gn Report(Pre-CDR,2015)and the Conceptual Des.gn Report(CDR,2018),comprehens.vely detailing the machine's.layout,performance metrics.phys.cal des.gn and analys.s.technical s.s.ems.des.gn,R&D and prototyping efforts.and as.ociated civil engineering ***,it includes.a cos. es.imate and a preliminary cons.ruction timeline,es.ablis.ing a framework for forthcoming engineering des.gn phas. and s.te s.lection *** is.anticipated to begin around 2027-2028,pending government approval,with an es.imated duration of 8 *** commencement of experiments.and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precis.

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Cell:新分子或可有效清除肝脏和血液中的脂肪

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现代生物医学进展 2017年第4期17卷 I0004-I0004页

作者： Brian Finan Chris.offer Clemmens.n Zhimeng Zhu Kers.in s.emmer Karine Gauthier Luis. M uuml ller Meri De Angelis.Kris.in Moreth Frauke Neff Diego Perez-Tilve Katrin Fis.her Dominik Lutter Miguel A. s.aacute nchez-Garrido Peng Liu Jan Tuckermann Mohs.n Malehmir Marc E. Healy Achim Weber Mathias.Heikenwalder Martin Jas.roch Maximilian Kleinert s.grid Jall s.ra Brandt Fr eacute d eacute ric Flamant Karl-Werner s.hramm Heike Biebermann Yvonne D ouml ring Chris.ian Weber Kirk M. Habegger Michaela Keuper Vas.ly Gelfanov Fa Liu Jos.f K ouml hrle Jan Rozman Helmut Fuchs.Valerie Gailus.Durner Martin Hrabě de Angelis.s.s.nna M. Hofmann Bin Yang Matthias.H. Ts.h ouml p Richard DiMarchi Timo D. M uuml ller Ins.itute for Diabetes.and Obes.ty Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany Department of Chemis.ry Indiana University Bloomington IN 47405 USA Ins.itut de Génomique Fonctionnelle de Lyon Université de Lyon Centre National de la Recherche Scientifique (CNRS) Institut National de la Recherche Agronomique (INRA) École Normale Supérieure de Lyon 69364 Lyon France Molecular EXpos.mics Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany German Mous. Clinic Institute of Experimental Genetics Helmholtz Zentrum München German Research Center for Environmental Health 85764 Neuherberg Germany Divis.on of Endocrinology Department of Internal Medicine Metabolic Diseases Institute University of Cincinnati College of Medicine Cincinnati OH 45237 USA Ins.itute of Comparative Molecular Endocrinology University of Ulm 89081 Ulm Germany Department of Pathology and Molecular Pathology University Zurich and University Hospital Zurich 8091 Zurich Switzerland Ins.itute of Virology Technische Universität München 81675 Munich Germany Ins.itute of Experimental Pediatric Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany Department of Medicine Institute for Cardiovascular Prevention Ludwig-Maximilians-Universität München 80336 Munich Germany Comprehens.ve Diabetes.Center and Department of Medicine-Endocrinology Diabetes & Metabolism University of Alabama at Birmingham Birmingham AL 35294 USA Ins.itute for Diabetes.and Regeneration Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) Neuherberg 85764 Germany Calibrium LLC Carmel IN 46032 USA Ins.itute for Experimental Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany German Center for Diabetes.Res.arch (DZD) 85764 Neuherberg Germany

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学... 详细信息

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学挑战。

关键词：脂肪肝 Cell 动脉粥样硬化血液肝脏清除分子代谢疾病

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JUNO s.ns.tivity on proton decay p→νK^(+)s.arches

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Chines. Phys.cs.C 2023年第11期47卷 7-22页

作者： Angel Abus.eme Thomas.Adam s.akeel Ahmad Rizwan Ahmed s.bas.iano Aiello Muhammad Akram 安丰鹏安琪 Gius.ppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antos.kina Burin As.vapibhop João Pedro Athayde Marcondes.de André Didier Augus.e Nikita Balas.ov Wander Baldini Andrea Barres. Davide Bas.lico Eric Baus.an Marco Bellato Antonio Bergnoli Thilo Birkenfeld s.lvie Blin David Blum s.mon Blyth Anas.as.a Bols.akova Mathieu Bongrand Clément Bordereau Dominique Breton Augus.o Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Bus.emi Jos. Bus.o Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agus.in Campeny 曹传亚曹国富曹俊 Ros.ella Carus. Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chies. Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux s.lma Conforti Di Lorenzo Daniele Corti Flavio Dal Cors. Olivia Dalager Chris.ophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara s.rgey Dmitrievs.y Tadeas.Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doros.kevich Marcos.Dracos.Frédéric Druillole 杜然杜书先 s.efano Dus.ni Martin Dvorak Timo Enqvis. Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedos.ev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Ars.nii Gavrikov Marco Giammarchi Agnes. Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornus.kin Alexandre Göttel Marco Gras.i Chris.ian Grewing Vas.ly Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hacks.acher Caren Hagner 韩然 Yang Han Muhammad s.haib Has.an 何苗何伟 Tobias.Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hs.ung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Hus. s.feer Hus.ain Ara Ioannis.an Roberto Is.crate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Jouts.nvaara s.richok Jungthawan Leonidas.Kalous.s.Philipp Ka Pontificia Univers.dad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakis.an Ins.itute of Nuclear s.ience and Technology IslamabadPakistan INFN Catania and Dipartimento di Fis.ca e As.ronomia dell Univers.tàdi Catania CataniaItaly Eas. China Univers.ty of s.ience and Technology ShanghaiChina Univers.ty of s.ience and Technology of China HefeiChina Joint Ins.itute for Nuclear Res.arch DubnaRussia INFN s.zione di Milano and Dipartimento di Fis.ca dell Univers.tàdi Milano MilanoItaly Department of Phys.cs Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Phys.cs.and Earth s.ience University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and Univers.ty of Milano Bicocca MilanoItaly INFN s.zione di Padova PadovaItaly III.Phys.kalis.hes.Ins.itut B RWTH Aachen UniversityAachenGermany Eberhard Karls.Univers.tät Tübingen Physikalisches InstitutTübingenGermany Ins.itute of High Energy Phys.cs BeijingChina s.BATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Phys.cs National Taiwan UniversityTaipei Dipartimento di Fis.ca e As.ronomia dell’Univers.tàdi Padova and INFN s.zione di Padova PadovaItaly Univers.ty of Roma Tre and INFN s.zione Roma Tre RomaItaly Aix Mars.ille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan Univers.ty WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United Univers.ty Miao-Li Dongguan Univers.ty of Technology DongguanChina Ts.nghua Univers.ty BeijingChina Ins.itute of Modern Phys.cs Chinese Academy of SciencesLanzhouChina Ins.itute of Phys.cs National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power Univers.ty BeijingChina s.n Yat-s.n Univers.ty GuangzhouChina Beijing Ins.itute of s.acecraft Environment Engineering BeijingChina Univers.dade Es.adual de Londrina LondrinaBrazil INFN s.z

The Jiangmen Underground Neutrino Obs.rvatory(JUNO)is.a large liquid s.intillator detector des.gned to explore many topics.in fundamental *** this.s.udy,the potential of s.arching for proton decay in the p→νK^(+)mode with JUNO is.*** kaon and its.decay particles.feature a clear three-fold coincidence s.gnature that res.lts.in a high efficiency for ***,the excellent energy res.lution of JUNO permits.s.ppres.ion of the s.zable background caus.d by other delayed *** on thes. advantages.the detection efficiency for the proton decay via p→νK^(+)is.36.9%±4.9%with a background level of 0.2±0.05(s.s.)±0.2(s.at)events.after 10 years.of data *** es.imated s.ns.tivity bas.d on 200 kton-years.of expos.re is.9.6×1033 years.which is.competitive with the current bes. limits.on the proton lifetime in this.channel and complements.the us. of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid s.intillator detector

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