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Effects of the Indo-china Peninsula Heat Fluxes on the 1998 South china Sea Summer Monsoon

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Acta meteorologica Sinica 2005年第4期19卷 457-468页

作者：史学丽 Johnny c. L. cHAN K. c. cHOW 丁一汇 National climate center Beijing 100081 Laboratory for Atmospheric Research Department of Physics and Materials Science City University of HongkongHongkong

Sensitivity experiments to investigate the role and importance of theIndo-china Peninsula (IcP) heat fluxes (sensible and latent heat fluxes) on the South china Seasummer monsoon (ScSSM) onset and its subsequent evolution have been carried out using a regionalclimate model. Two sensitivity experiments have been conducted: cutting off the sensible heat flux(noted as Ichfx) and latent heat flux (noted as Icqfx). Results show that by cutting off theunderlying heat flux of the IcP, the precipitation decreases and low-level geopotential heightincreases over the local regions as well as the remote regions of the East china Sea, southernJapan, and western North Pacific. The westerly (easterly) zonal winds at 850 hPa (200 hPa) aregenerally weakened in May and June, especially before and during the onset of the ScSSM towards theend of May. It is worth noting that although the observed sensible heat flux is only about 1/3 ofthe latent heat flux, the differences between the control run and each of the two sensitivityexperiments are comparable.

关键词： east asian summer monsoon south china sea heat flux regional climate model

Predictive factors associated with carcinoid syndrome in patients with gastrointestinal neuroendocrine tumors

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World Journal of Gastroenterology 2017年第40期23卷 7283-7291页

作者： Beilei cai Michael S Broder Eunice chang Tingjian Yan David c Metz Novartis Pharmaceuticals corporation One Health Plaza Partnership for Health Analytic Research LLC 280 S. Beverly Dr. Division of Gastroenterology University of Pennsylvania Health System 3400 Civic Center Boulevard Perelman Center for Advanced Medicine

AIM To discover unknown factors associated with carcinoid syndrome(cS) with the goal of earlier diagnosis of *** In this retrospective case-control study using United States administrative claims, patients(≥ 18 years) newly-diagnosed with gastrointestinal neuroendocrine tumors(GI NETs) without cS(controls) were exactly matched to patients with cS(cases) based on NET diagnosis date at a 3-to-1 ratio. Study index date was first cS diagnosis(controls: same distance from NET diagnosis as cases). The most observed conditions, excluding cS-associated symptoms/diagnoses, during the year before index date were assessed. Forwardstepwise logistic regression models were used to derive predictors, and were validation within another claims database. RESULTS In the development database, 1004 patients with GI NETs were identified; 251(25%) had cS and 753(75%) were controls. In the validation database, 724 patients with GI NETs were identified; 181(25%) had cS and 543(75%) were controls. A total of 33 common diagnoses(excluding conditions already known to be associated with cS) in the development database were entered in forward step-wise logistic regression models. In the final, validated logistic regression model, three factors prior to cS diagnosis were found consistently associated with higher risks for cS, including liver disorder [odds ratio(95%cI): 3.38(2.07-5.51)], enlargement of lymph nodes [2.13(1.10-4.11)], and abdominal mass [3.79(1.87-7.69)].cONcLUSION GI NET patients with cS were 2-4 times as likely to have preexisting diagnoses(i.e., liver disorder, enlarged lymph nodes, abdominal mass) than non-cS patients.

关键词： carcinoid syndrome Gastrointestinal neuroendocrine tumors Predictive factors Data mining

Effect of O-4-ethoxyl-butyl-berbamine in combination with pegylated liposomal doxorubicin on advanced hepatoma in mice

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World Journal of Gastroenterology 2004年第7期10卷 950-953页

作者： Bai-JunFang Mei-LiYu Shao-GuangYang Lian-MingLiao Jie-WenLiu Robert-c-HZhao Sino-AmericancollaborativeLaboratory StatKeyLaboratoryofExperimentalHaematologyInstituteofHaematologyandBloodDiseaseHospitalandTissueEngineeringCenterChineseAcademyofMedicalSciencesTianjin300020China

AIM: To study the synergistic effects of calmodulin (cAM) antagonist O-4-ethoxyl-butyl-berbamine (EBB) and pegylated liposomal doxorubicin (PLD) on hepatoma-22 (H22) in vivo. METHODS: Hepatoma model was established in 50 Balb/c mice by inoculating H22 cells (2.5×10^6) subcutaneously into the right backs of the mice. These mice were divided into 5 groups, and treated with saline only, PLD only, doxorubicin (Dox) only, PLD plus EBB and Dox plus EBB, respectively. In the treatment groups, mice were given 5 intravenous of PLD or Dox on days 0, 3, 6, 9 and 12. The first dosage of PLD or Dox was 4.5 mg/kg, the other 4 injections was 1 mg/kg. EBB (5 mg/kg) was coadministered with PLD or Dox in the corresponding groups. The effect of drugs on the life spans of hepatoma-bearing mice and tumor response to the drugs were recorded. Dox levels in the hepatoma cells were measured by a fluorescence assay. Light microscopy was performed to determine the histopathological changes in the major organs of these tumor-bearing mice. The MTT method was used to analyze the effect of Dox or PLD alone, Dox in combination with EBB, or PLD in combination with EBB on the growth of H22 cells in an in vitro experiment. RESULTS: EBB (5 mg/kg) significantly augmented the antitumor activity of Dox or PLD, remarkably prolonged the median survival time. The median survival time was 18.2 d for control group, but 89.2 d for PLD+EBB group and 70.1 d for Dox+EBB group, respectively. However, Dox alone did not show any remarkable antitumor activity, and the median survival time was just 29.7 d. Addition of EBB to Dox or PLD significantly increased the level of Dox in H22 cells in vivo. Moreover, EBB diminished liver toxicity of Dox and PLD. In vitro, EBB reduced the Ic50 value of Dox or PLD on H22cells from 0.050±0.006 mg/L and 0.054±0.004 mg/L to 0.012±0.002 mg/L and 0.013±0.002 mg/L, respectively (PcONcLUSION: EBB and liposomization could improve the therapeutic efficacy of Dox in liver cancer, w

关键词： O-4-乙氧基-丁基-小檗胺阿霉素进展期肝细胞瘤动物实验联合化疗药物毒性

A call for international research on cOVID-19-induced brain dysfunctions

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National Science Review 2021年第12期8卷 13-14页

作者： Pedro A.Valdes-Sosa Alan c.Evans Mitchell J.Valdes-Sosa Mu-ming Poo Global Brain consortium University of Electronic Sciences and Technology of China (UESTC) cuban Neuroscience center (cNEURO) Cuban Academy of Sciences Global Brain consortium Royal Society of CanadaMc Gill Center for Integrative Neuroscience Mc Gill University center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceChinese Academy of Sciences

The cOVID-19 pandemic, still raging worldwide, imposes staggering human and economic costs. These will only increase as many convalescent patients suffer consequences for many *** the virus can target multiple organ s...

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Diagnostic and Therapeutic Strategies for Peritoneal Tuberculosis: A Review

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Journal of clinical and Translational Hepatology 2019年第2期7卷 140-148页

作者： David c.Wu Leon D.Averbukh George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Peritoneal tuberculosis(PTB),although rarer than its pulmonary counterpart,is a serious health concern in regions of the world with high tuberculosis *** with baseline immunocompromise condition,whether acquired or medically induced,are at greatest risk for experiencing *** medical treatment of the condition is similar to that of the pulmonary disease,the generally immunocompromised state of those infected with PTB,along with a lack of highly sensitive and specific testing methods make early diagnosis *** review discusses the risks factors,clinical features,diagnostic methods,and treatment options for PTB.

关键词： Peritoneal tuberculosis Tuberculosis Liver disease Human immunodeficiency virus

Optimum calibration of a parallel kinematic manipulator using digital indicators

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Advances in Manufacturing 2014年第3期2卷 222-230页

作者： V.B.Saputra S.K.Ong A.Y.c.Nee Department of Mechanical Engineering Faculty of EngineeringNational University of SingaporeSingapore 117576Singapore

This paper presents a calibration method for parallel manipulators using a measurement system specially installed on an external fixed frame. The external fixed frame is important as an error reference for calibration in certain operations, such as in the configuration of a parallel manip- ulator functioning as a machine tool where the workpiece is fixed to a worktable. The pose of the end-effector is mea- sured using three digital indicators installed on the external fixed frame. To enable measurement, the end-effector is assumed to be a plane large enough that all digital indicators could touch. The error is defined as the difference between the theoretical and actual readings of the digital indicators. The geometric parameters of the parallel manipulator are optimized to minimize this error. This calibration method is low cost and feasible for compensating geometric parameter errors for a parallel manipulator. Optimal pose selection for the calibration is achieved using a swarm intelligence search algorithm. The method is implemented on a prototype of a six degrees-of-freedom （DOFs） Gough-Stewart platform constructed to function as a machine tool.

关键词： calibration Parallel kinematic manipulator(PKM) Digital indicator

Grey box modeling of supermarket refrigeration cabinets

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Energy and AI 2023年第1期11卷 63-70页

作者： K.Leerbeck P.Bacher c.Heerup H.Madsen DTU compute Bygning 3242800 Kongens LyngbyDenmark Gregersensvej 2 2630 TaastrupDenmark

Aiming to enable robust large-scale fault diagnostics and optimized control for supermarket refrigerationsystems, a data-driven grey box model for an evaporator and its surrounding cooling cabinet (or room) ispresented. It is a non-linear model with two states: the cabinet temperature and the refrigerant mass in theevaporator. To demonstrate its applicability, data with one-minute sampling resolution from ten evaporators ina supermarket in Otterup (Denmark) was used. The model parameters were estimated using a Kalman filter andthe maximum likelihood method. Since the dynamical properties of the cabinets constantly change as goodsare added and removed, the parameters were re-estimated for each night, over a period of approximately 2.5years. The model is validated through a statistical analysis of the residuals and the importance of the ongoingre-estimation of parameters is highlighted. Furthermore, the physical meaning of the estimated parameters isdiscussed and potential applications for characterization and classification of cabinets are demonstrated, byshowing how they can be differentiated as either open- or closed cabinets or rooms, using only the estimatedheat transfer coefficients and heat capacities. For a selected case it is shown that the estimated parametervalues are close to physics derived values, and that the accuracy measured by the standard errors of theestimates is approximately ±10% relative to the estimated values. The analysis demonstrates that the modelis robust, accurate and reliable in terms of estimating physically meaningful parameters and it is thereforeappropriate for large-scale implementation.

关键词： Grey box modeling cO_(2) refrigeration systems Refrigeration cabinets and evaporators System identification classification

Exocytosis,endocytosis and recycling of secretory vesicles in neuroendocrine cells,and its regulation by cortical actin

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BIOcELL 2022年第8期46卷 1867-1873页

作者： ANA M.cÁRDENAS I.GALLO FERNANDO D.MARENGO centro Interdisciplinario de Neurociencia de Valparaíso Facultad de CienciasUniversidad de ValparaísoValparaíso2360102Chile Instituto de Fisiología Biología Molecular y NeurocienciasCONICET.Departamento de Fisiología y Biología Molecular y CelularFacultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires1428Argentina

The cortical actin network is a mesh of filaments distributed beneath the plasmalemma that dynamically reacts in response to *** dynamic network of cortical filaments,together with motor myosin partners,adjusts the plasmalemma tension,organizes membrane protein microdomains,remodels the cell surface and drives vesicle motion in order to fine-tune exocytosis,endocytosis and recycling of secretory *** this review,we discuss how these mechanisms work in secretory cells.

关键词： cortical actin Neuroendocrine cell chromaffin cell Exocytosis Endocytosis

Use of environmental magnetic measurements to characterize and correlate tephra-A case study in Iceland

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chinese Science Bulletin 2004年第3期49卷 286-294页

作者： XIADunsheng J.Bloemendal R.c.chiverrell J.A.Dearing JINMing KeyLaboratoryofDesertandDesertification ColdandAridRegionsEnvironmentalandEngineeringResearchInstituteChineseAcademyofSciencesLanzhou730000China EnvironmentalMagnetismLaboratory DepartmentofGeographyTheUniversityofLiverpoolLiverpoolL693BXUK

A set of environmental magnetic parameters(i.e. magnetic susceptibility, xARM, IRMs, hysteresis loops and thermomagnetic curves) has been applied to two soil sections from SE Iceland. Results demonstrate that the main magnetic minerals in the tephras are ferrimagnetic minerals (***) and canted antiferromagnetic minerals (***), with abundant paramagnetic material also present. cross plots of Mrs/Ms vs. (B0)cr/(B0)c and xfd% ***/SIRM indicate that the main magnetic grain sizes in tephras are pseudo single domain (PSD) and multidomain(MD). Initial correlation of tephra layers was achieved, usingall the measured magnetic parameters, by use of the multi-variate statistical measures of Similarity coefficient (Sc) andEuclidean Distance (ED). This demonstrates that magnetictechniques can potentially assist in the identification andcorrelation of distal tephra.

关键词：火山灰冰岛磁性参数相似系数欧几里德距离