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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju OKECHUKWU Innocent Onyezue safayet jamil OLALEKAN John Okesanya DON Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

Analysis of b→cτν¯_(τ)anomalies using weak effective Hamiltonian with complex couplings and their impact on various physical observables

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Chinese Physics C 2024年第8期48卷 56-75页

作者： Muhammad Arslan Tahira Yasmeen Saba Shafaq Ishtiaq Ahmed Muhammad jamil Aslam Department of Physics Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Physics International Islamic UniversityIslamabad 44000Pakistan National Center for Physics Islamabad 44000Pakistan

Recently,the experimental measurements of the branching ratios and different polarization asymmetries for processes occurring through flavor-changing-charged current(b→cτν¯_(τ))transitions by BABAR,Belle,and LHCb have revealed some significant differences from the corresponding Standard Model(SM)*** has triggered an interest to search for physics beyond the SM in the context of various new physics(NP)models and using the model-independent weak effective Hamiltonian(WEH).Assuming left-handed neutrinos,we add the dimension-six vector,(pseudo-)scalar,and tensor operators with complex Wilson coefficients(WCs)to the SM *** 60%,30%,and 10%constraints resulting from the branching ratio of B_(c)→τν¯_(τ),we reassess the parametric space of these new physics WCs accommodating the current anomalies based on the most recent HFLAV data of R_(τ/μ,e)(D)and R_(τ/μ,e)(D^(*))and Belle data of F_(L)(D^(*))and P_(τ)(D^(*)).We find that the allowed parametric region of left-handed scalar couplings strongly depends on the constraints of the B_(c)→τν¯_(τ)branching ratio,and the maximum pull from the SM predictions results from the<60%branching ratio ***,the parametric region changes significantly if we extend the analysis by adding LHCb data of R_(τ/μ)(J/ψ)and R_(τ/ℓ)(Λ_(c)).Furthermore,due to the large uncertainties in the measurements of R_(τ/μ)(J/ψ)and R_(τ/ℓ)(X_(c)),we derive the sum rules which complement them with R_(τ/μ,e)(D)and R_(τ/μ,e)(D^(*)).Using the best-fit points of the new complex WCs along with the latest measurements of R_(τ/μ,e)(D(^(*))),we predict the numerical values of the observable R_(τ/ℓ)(Λ_(c)),R_(τ/μ)(J/ψ),and R_(τ/ℓ)(X_(c))from the sum *** simultaneous dependence of abovementioned physical observables on the NP WCs is established by plotting their correlation with R_(D) and R_(D^(*)),which are useful to discriminate between various NP *** find that the most significant impact of NP results from the WC C^(S)_(L)=4C^(T).Fi

关键词： B meson anomalies new physics complex coupling HFLAV

Analysis of b→cτ■ anomalies using weak effective Hamiltonian with complex couplings and their impact on various physical observables

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Chinese Physics C 2024年第8期 59-78页

作者： Muhammad Arslan Tahira Yasmeen Saba Shafaq Ishtiaq Ahmed Muhammad jamil Aslam Department of Physics Quaid-i-Azam University Department of Physics International Islamic University National Center for Physics

Recently,the experimental measurements of the branching ratios and different polarization asymmetries for processes occurring through flavor-changing-charged current（b→cτvτ）transitions by BABAR,Belle,and LHCb have revealed some significant differences from the corresponding Standard Model（SM） *** has triggered an interest to search for physics beyond the SM in the context of various new physics（NP） models and using the model-independent weak effective Hamiltonian（WEH）.Assuming left-handed neutrinos,we add the dimension-six vector,（pseudo-）scalar,and tensor operators with complex Wilson coefficients（WCs） to the SM *** 60%,3 0%,and 10% constraints resulting from the branching ratio of Bc→τvτ,we reassess the parametric space of these new physics WCs accommodating the current anomalies based on the most recent HFLAV data of Rτ/μ,e（D） and Rτ/μ,e（D*） and Belle data of FL（D*） and Pτ（D*）.We find that the allowed parametric region of lefthanded scalar couplings strongly depends on the constraints of the Bc→τvτbranching ratio,and the maximum pull from the SM predictions results from the <60% branching ratio ***,the parametric region changes significantly if we extend the analysis by adding LHCb data of Rτ/μ（J/ψ） and Rτ/l（Λc）.Furthermore,due to the large uncertainties in the measurements of Rτ/μ（J/ψ） and Rτ/l（Xc）,we derive the sum rules which complement them with Rτ/μ,e（D） and Rτ/μ,e（D*）.Using the best-fit points of the new complex WCs along with the latest measurements of Rτ/μ,e(D（*）),we predict the numerical values of the observable Rτ/l（Λc）,Rτ/μ（J/ψ）,and Rτ/l（Xc） from the sum *** simultaneous dependence of abovementioned physical observables on the NP WCs is established by plotting their correlation with RDand RD*,which are useful to discriminate between various NP *** find that the most significant impact of NP results from the WC CLS=***,we study the impact of these NP couplings on various angular and CP triple product asym

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Simulated rainfall in Brazil:An alternative for assesment of soil surface processes and an opportunity for technological development

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International Soil and Water Conservation Research 2024年第1期12卷 29-42页

作者： Camila Calazans da Silva Luz Wilk Sampaio de Almeida Adilson Pacheco de Souza Nivaldo Schultz jamil Alexandre Ayach Anache Daniel Fonseca de Carvalho Postgraduate Program in Agronomy-Soil Sciences Federal Rural University of Rio de JaneiroSeropédicaRJBrazil Agronomy Department Federal Institute of EducationScience and Technology of RondôniaAriquemesROBrazil Federal University of Mato Grosso SinopMTBrazil Federal Rural University of Rio de Janeiro SeropédicaRJBrazil Federal University of Mato Grosso do Sul Campo GrandeMSBrazil

Rainfall simulators(RS)have been used,above all,to evaluate hydrological processes related to soil water infiltration,surface runoff and soil *** allow repeatability of rain application with different precipitation intensities in field and/or laboratory conditions and should produce events with physical characteristics similar to natural *** this manuscript,we carried out a bibliometric and scientometric analysis of studies with simulated rainfall in Brazil to assess the temporal evolution of publications,the main topics addressed and the degree of technological development of the *** searched for the terms“rainfall simulator”OR“simulated rainfall”AND“Brazil”in the Scopus,Web of Science,SciELO and Google Scholar *** found 143 articles published in the last 37 years(1985-2022).Our findings indicate that the main research areas covered in papers are soil erosion(57.34%),soil water infiltration(24.47%),nutrient losses(9.8%)and RS development and calibration/assessment(8.39%).In recent years,the number of published papers in international high-impact factor journals has *** of the papers(49.65%)refer to studies carried out by institutions located in the south and southeast regions of ***,there is a large gap of studies on simulated rainfall in other regions of Brazil,where important biomes such as the Cerrado,Amazon,Caatinga,and their transitions are *** study informs research priorities on soil erosion under simulated rainfall and provides a bibliographic database that can assist in more detailed future analyses.

关键词： Rainfall simulator Soil and water losses Soil water infiltration Bibliometrics Scientific review

早期结直肠癌内镜治疗后追加外科手术必要性的临床分析

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中国普通外科杂志 2024年第4期33卷 656-662页

作者：赵志红刘蕊王青霞 jamil Mehwish 李乾中南大学湘雅医院消化内科湖南长沙410008 中南大学湘雅医院消化内科内镜中心湖南长沙410008

背景与目的:以内镜下黏膜切除术(EMR)和内镜下黏膜下层剥离术(ESD)为主的内镜下切除手术已成为目前治疗早期结直肠癌的主要方式。然而,在临床实践中,大多数早期结直肠癌患者,无论内镜治疗后标本病理提示是否为治愈性切除,后续仍追加了... 详细信息

背景与目的:以内镜下黏膜切除术(EMR)和内镜下黏膜下层剥离术(ESD)为主的内镜下切除手术已成为目前治疗早期结直肠癌的主要方式。然而,在临床实践中,大多数早期结直肠癌患者,无论内镜治疗后标本病理提示是否为治愈性切除,后续仍追加了外科手术。本研究通过比较早期结直肠癌患者行内镜下治愈性或非治愈性切除治疗后的肿瘤残留情况,分析内镜治疗后追加外科手术的必要性,以期为医生临床决策提供参考。方法:回顾性收集2016年5月—2023年7月中南大学湘雅医院收治的行内镜下治疗手术后追加外科根治性切除术的早期结直肠癌患者病例资料。根据内镜切除后标本送检的病理结果将患者分为治愈性切除组(无肿瘤残留且无脉管神经侵犯)和非治愈性切除组[有肿瘤残留和(或)有脉管神经侵犯],分析两组患者的临床基本资料、病理特征和肿瘤残留情况的差异。结果:在接受内镜下切除治疗后追加外科手术的82例早期结直肠癌患者中,治愈性切除组53例,非治愈性切除组29例。两组患者在性别、年龄、症状、息肉部位、息肉形状、息肉大小、病理类型、浸润深度、追加外科手术间隔时间等基线数据方面均无统计学差异(均P>0.05)。外科手术标本病理结果显示,4例患者有肿瘤残留,其中治愈性切除组2例(3.77%,2/53)、非治愈性切除组2例(6.90%,2/29)。内镜下治愈性或非治愈性切除与有无肿瘤残留差异无统计学意义(χ^(2)=0.008,P=0.927)。结论:EMR、ESD可为早期结直肠癌患者带来良好的切除效果。无论内镜下是否为治愈性切除,均需综合患者自身特点、内镜标本病理资料以及内镜医生的处理方式,个体化分析追加外科手术的必要性。其次,无论是否追加外科手术,均需建议患者保持定期规律的内镜随访。

关键词：结直肠肿瘤胃肠道内窥镜外科手术肿瘤,残余

Observability of parameter space for charged Higgs boson in its bosonic decays in two Higgs doublet model Type-1

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Chinese Physics C 2024年第2期48卷 57-65页

作者： Ijaz Ahmed Waqas Ahmad M.S.Amjad jamil Muhammad Federal Urdu University of Arts Science and TechnologyIslamabad Pakistan Riphah International University Sector I-14Hajj ComplexIslamabad Pakistan National University of Technology Islamabad Pakistan Sang-Ho College and Department of PhysicsKonkuk UniversitySeoul 05029South Korea

This study explores the possibility of discovering H±through its bosonic decays,i.e.,H±→W±φ(whereφ=h or A),within the Type-I two Higgs doublet model(2HDM).The main objective is to demonstrate the available parameter space after applying recent experimental and theoretical exclusion *** suggest that mH±=150 GeV is the most probable mass for the H±→W±φdecay channel in pp collisions at s1/2=8,13,and 14 *** also report on the application of a modern machine learning approach to a multivariate technique for heavy charged Higgs production in association with a single top quark through weak interaction to demonstrate its observability in comparison with the most relevant Standard Model backgrounds using the neural networks of boosted decision Tree(BDT),likelihood(LH),and multilayer perceptron(MLP).

关键词： charged Higgs MSSM LHC

Excess non-COVID-19-related mortality among inflammatory bowel disease decedents during the COVID-19 pandemic

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World Journal of Gastroenterology 2024年第20期30卷 2677-2688页

作者： Sarah Rotondo-Trivette Xin-Yuan He jamil S Samaan Fan Lv Emily Truong Michaela Juels Anthony Nguyen Xu Gao Jian Zu Yee Hui Yeo Fan-Pu Ji Gil Y Melmed Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Infectious Disease The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Karsh Division of Gastroenterology and Hepatology Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049Shaanxi ProvinceChina David Geffen School of Medicine University of CaliforniaLos AngelesLos AngelesCA 90095United States Division of Gastroenterology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Key Laboratory of Surgical Critical Care and Life Support(Xi’an Jiaotong University) Ministry of EducationXi’an 710004Shaanxi ProvinceChina

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic disrupted healthcare in the United *** To investigate COVID-19-related and non-COVID-19-related death and characteristics associated with excess death among inflammatory bowel disease(IBD)*** We performed a register-based study using data from the National Vital Statistics System,which reports death data from over 99%of the United States population,from January 1,2006 through December 31,***-related deaths among adults 25 years and older were stratified by age,sex,race/ethnicity,place of death,and primary cause of *** and actual age-standardized mortality rates(ASMRs)per 100000 persons were *** 49782 IBD-related deaths occurred during the study ***-COVID-19-related deaths increased by 13.14%in 2020 and 18.12%in 2021[2020 ASMR:1.55 actual vs 1.37 predicted,95%confidence interval(CI):1.26-1.49;2021 ASMR:1.63 actual vs 1.38 predicted,95%CI:1.26-1.49].In 2020,non-COVID-19-related mortality increased by 17.65%in ulcerative colitis(UC)patients between the ages of 25 and 65 and 36.36%in non-Hispanic black(NHB)Crohn’s disease(CD)*** the pandemic,deaths at home or on arrival and at medical facilities as well as deaths due to neoplasms also *** IBD patients suffered excess non-COVID-19-related death during the *** death was associated with younger age among UC patients,and with NHB race among CD *** death at home or on arrival and due to neoplasms suggests that delayed presentation and difficulty accessing healthcare may have led to increased IBD mortality.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease COVID-19 Excess death Race Sex Disparities

Identifying and validating MMP family members(MMP2,MMP9,MMP12,and MMP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KIRC)

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Oncology Research 2024年第4期32卷 737-752页

作者： KUNLUN LI DANDAN LI BARBOD HAFEZ MOUNIR M.SALEM BEKHIT YOUSEF A.BIN JARDAN FARS KAED ALANAZI EHAB I.TAHA SAYED H.AUDA FAIQAH RAMZAN MUHAMMAD jamil The Second Affiliated Hospital of Harbin Medical University Harbin Medical UniversityHarbinChina Department of Pharmaceutical Engineering Jiangsu Ocean UniversityLianyungangChina Department of Biological Engineering University of SalfordSalfordUK Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Animal and Poultry Production Faculty of Veterinary and Animal SciencesGomal UniversityDera Ismail KhanPakistan Department of Arid Zone Research PARC instituteDera Ismail KhanPakistan

Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and *** MMP family assumes a crucial role in tumor invasion and *** study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KIRC)through a comprehensive approach encompassing both computational and molecular ***,Cytoscape,UALCAN,GEPIA,OncoDB,HPA,cBioPortal,GSEA,TIMER,ENCORI,DrugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for *** performing STRING and Cytohubba analyses of the 24 MMP gene family members,MMP2(matrix metallopeptidase 2),MMP9(matrix metallopeptidase 9),MMP12(matrix metallopeptidase 12),and MMP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree *** analyzing MMP2,MMP9,MMP12,and MMP16 via various TCGA databases and RT-qPCR technique across clinical samples and KIRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KIRC samples relative to *** notable effect of the up-regulated MMP2,MMP9,MMP12,and MMP16 was also documented on the overall survival(OS)of the KIRC ***,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(MMP2,MMP9,MMP12,and MMP16).In addition to this,hub genes were involved in various diverse oncogenic *** MMP gene family members(MMP2,MMP9,MMP12,and MMP16)may serve as therapeutic targets and prognostic biomarkers in KIRC.

关键词： KIRC MMP gene family Chemotherapy Overall survival

In-depth analysis of Bt cotton adoption:farmers'opinions,genetic landscape,and varied perspectives——a case study from Pakistan

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Journal of Cotton Research 2024年第3期7卷 277-288页

作者： SHAHZAD Rahil jamil Shakra CHAUDHRY Urooj Fatima RAHMAN Sajid Ur IQBAL Muhammad Zaffar Genetically Modified Organisms Development and Testing Laboratory Agricultural Biotechnology Research InstituteAyub Agricultural Research InstituteFaisalabadPunjab 38000Pakistan Centre of Excellence for Olive Research and Trainings(CEFORT) BaraniAgricultural Research InstituteChakwalPunjabPakistan

Background Bt technology has played significant role in controlling bollworms and increasing cotton yield in earlier days of its introduction,a subsequent decline in yield became apparent over *** decline may be attributed to various environmental factors,pest dynamics,or combination of ***,the present biophysical survey and questionnaire were designed to evaluate the impact of Bt cotton on bollworms management and its effect on reducing spray costs,targeting farmers with varied landholdings and educational ***,data on farmers'cultivated varieties and the prevalence of bollworms and sucking insects in their fields were ***,about eleven thousand cotton samples from farmer fields were tested for Cry1Ac,Cry2Ab and Vip3A genes by strip *** In this analysis,83% of the farmers planting approved varieties believe that Bt technology control bollworms,while 17% hold contradictory ***,among farmers cultivating unapproved varieties,77% agree on effectiveness of Bt technology against bollworms,while 23% *** the other hand,67% of farmers planting approved varieties believe that Bt technology does not reduce spray costs,while 33% agree with the ***,78% of farmers cultivating unapproved varieties express doubt regarding its role to reduce spray costs,while 22% are in favour of this *** in opinions on the effectiveness of Bt cotton in controlling bollworms and reducing spray cost between farmers planting unapproved and approved varieties may stem from several *** major cause is the heavy infestation of sucking insects,which is probably due to the narrow genetic variation of the cultivated ***,the widespread cultivation of unapproved varieties(21.67%)is also an important factor to cause different opinions on the effectiveness of Bt *** Based on our findings,we propose that the ineffective control of pests on cotton crop may

关键词： Bollworms Cry1Ac Cry2Ab Cotton Farmer's perception Purposive sampling Sucking insects Unapproved varieties Vip3A

Effect of Light Emitting Diodes (LEDs) on Growth, Mineral Composition, and Nutritional Value of Wheat & Lentil Sprouts

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1117-1128页

作者： Abdul Momin Amana Khatoon Wajahat Khan Dilsat Bozdoğan Konuşkan Muhammad Mudasar Aslam Muhammad jamil Shafiq Ur Rehman Baber Ali Alevcan Kaplan Sana Wahab Muhammad Nauman Khan Sezai Ercisli Mohammad Khalid Al-Sadoon Department of Botany Kohat University of Science&TechnologyKohat26000Pakistan Department of Food Engineering Faculty of AgricultureHatay Mustafa Kemal UniversityHatay31000Türkiye Department of Botany University of Science&TechnologyBannu28100Pakistan Department of Biotechnology and Genetic Engineering Kohat University of Science&TechnologyKohat26000Pakistan Department of Biology University of HaripurKhyber Pakhtunkhwa22620Pakistan School of Science Western Sydney UniversityPenrithNew South Wales2151Australia Department of Crop and Animal Production Sason Vocational SchoolBatman UniversityBatman72060Türkiye Department of Plant Sciences Quaid-i-Azam UniversityIslamabad45320Pakistan Department of Botany Islamia College PeshawarPeshawar25120Pakistan Department of Horticulture Agricultural FacultyAtaturk UniversityErzurum25240Türkiye HGF Agro Ata TeknokentErzurumTR-25240Türkiye Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Sprouts are ready-to-eat and are recognized worldwide as functional components of the human *** advances in innovative agricultural techniques could enable an increase in the production of healthy *** use of light-emitting diode(LED)in indoor agricultural production could alter the biological feedback loop,increasing the functional beneﬁts of plant foods such as wheat and lentil sprouts and promoting the bioavailability of *** effects of white(W),red(R),and blue(B)light were investigated on the growth parameters and nutritional value of wheat and lentil *** the laboratory,seeds were sown under three different LED treat-ments:white,red,and blue light,while normal incandescent light served as a *** seed germina-tion improved by 18.34%and 12.67%for wheat and 18.34%and 12.67%for lentil sprouts under LED treatments R and B,*** increase in total soluble protein and sugar by 33.4%and 9.23%in wheat and by 31.5%and 5.87%in lentils was observed under the R LED *** C concentrations in wheat and lentils were signiﬁcantly increased by R LED compared to all other *** parameters,including potassium and sodium concentrations,were signiﬁcantly increased under red and blue light compared to the control;white light,on the other hand,signiﬁcantly decreased all these *** to the experimental data,red and blue LED light could be beneﬁcial in the production of functional wheat and lentil sprouts with high nutrient concentrations.

关键词： Growth parameters LED nutritional value sprouts total soluble proteins