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Network Pharmacology Based Elucidation of Molecular Mechanisms of Laoke Formula for Treatment of Advanced Non-small Cell Lung Cancer

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Chinese Journal of Integrative Medicine 2024年第11期30卷 984-992页

作者： feng Yu-yu LIU Jin-feng XUE Yang LIU Dan WU Xiong-zhi Department of Nursing Tangshan Vocational and Technical College school of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Department of Oncology Tianjin Medical University General Hospital Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for China Tianjin Nankai Hospital Tianjin Medical University

Objective: To explore the specific pharmacological molecular mechanisms of Laoke Formula(LK)on treating advanced non-small cell lung cancer(NsCLC) based on clinical application, network pharmacology and experimental validation. Methods: Kaplan-Meier method and Cox regression analysis were used to evaluate the survival benefit of Chinese medicine(CM) treatment in 296 patients with NsCLC in Tianjin Medical University Cancer Institute and Hospital from January 2011 to December 2015. The compounds of LK were screened using the Traditional Chinese Medicine systems Pharmacology Database and Analysis Platform, and the corresponding targets were performed from swiss Target Prediction. NsCLC-related targets were obtained from Therapeutic Target Database and Comparative Toxicogenomics Database. Key compounds and targets were identified from the compound-target-disease network and protein-protein interaction(PPI) network analysis, respectively. Kyoto Encyclopedia of Genes and Genomes(KEGG) and Gene Ontology(GO) enrichment analysis were used to predict the potential signaling pathways involved in the treatment of advanced NsCLC with LK. The binding affinities between key ingredients and targets were further verified using molecular docking. Finally, A549 cell proliferation and migration assay were used to evaluate the antitumor activity of LK. Western blot was used to further verify the expression of key target proteins related to the predicted pathways. Results: Kaplan-Meier survival analysis showed that the overall survival of the CM group was longer than that of the non-CM group(36 months vs.26 months), and COX regression analysis showed that LK treatment was an independent favorable prognostic factor(P=0.027). Next, 97 components and 86 potential targets were included in the network pharmacology, KEGG and GO analyses, and the results indicated that LK was associated with proliferation and apoptosis. Moreover,molecular docking revealed a good binding affinity between the key

关键词： Chinese medicine LaoKe Formula anti-tumor network pharmacology non-small cell lung cancer

Galectin 2 regulates JAK/sTAT3 signaling activity to modulate oral squamous cell carcinoma proliferation and migration in vitro

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BIOCELL 2024年第5期48卷 793-801页

作者： XINRU feng LI XIAO Medical school University of Electronic Science and Technology of ChinaChengdu610072China Department of stomatology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China

Background:Galectin 2(LGALs2)is a protein previously reported to serve as a mediator of disease progression in a range of *** function of LGALs2 in oral squamous cell carcinoma(OsCC),however,has yet to be explored,prompting the present study to address this literature ***:Overall,144 paired malignant tumor tissues and paracancerous OsCC patient samples were harvested and the LGALs2 expression levels were examined through qPCR and western *** LGALs2 coding sequence was introduced into the pcDNA3.0 vector,to enable the overexpression of this gene,while an LGALs2-specific shRNA and corresponding controls were also *** functionality of LGALs2 as a regulator of the ability of OsCC cells to grow and undergo apoptotic death in vitro was assessed through EdU uptake and CCK-8 assays,and flow cytometer,whereas a Transwell system was used to assess migratory activity and *** agonist of the Janus Kinase 2(JAK2)/signal Transducer and Activator of Transcription 3(sTAT3)pathway was also used to assess the role of this pathway in the context of LGALs2 ***:Here,we found that lower LGALs2 protein and mRNA expression were evident in OsCC tumor tissue samples,and these expression levels were associated with clinicopathological characteristics and patient survival *** LGALs2 enhanced proliferation in OsCC cells while rendering these cells better able to resist *** opposite was instead observed after LGALs2 was ***,the ability of LGALs2 to suppress the progression of OsCC was related to its ability to activate the JAK/sTAT3 signaling ***:Those results suggest a role for LGALs2 as a suppressor of OsCC progression through its ability to modulate JAK/sTAT3 signaling,supporting the potential utility of LGALs2 as a target for efforts aimed at treating OsCC patients.

关键词： LGALs2 Oral squamous cell carcinoma(OsCC) Janus Kinase 2/signal Transducer and Activator of Transcription 3(JAK2-sTAT3) Progression

Monocyte to High-density Lipoprotein Cholesterol Ratio as a Predictor of Nonalcoholic Fatty Liver Disease in Childhood Obesity

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Current Medical science 2024年第4期44卷 692-697页

作者： Jun-feng ZHANG feng-qing CAI Xiu-cai ZHANG Qing YE Department of Laboratory Medicine Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou310052China

Objective Inflammation is involved in the development and progression of nonalcoholic fatty liver disease(NAFLD).The monocyte to high-density lipoprotein cholesterol ratio(MHR)has emerged as a marker for various inflammation-related *** aim of the present study was to investigate the association between the MHR and NAFLD in a population with childhood *** Based on hepatic ultrasound,a total of 504 children with obesity(357 with NAFLD and 147 without NAFLD)were included in the *** correlation between the MHR and NAFLD risk factors was assessed by Pearson’s and spearman’s *** stepwise logistic regression analyses were conducted to explore the association between the MHR and the risk of *** The MHR in patients with NAFLD was significantly greater than that in patients without NAFLD[0.52(0.44-0.67)versus 0.44(0.34-0.57),Pstepwise logistic regression analysis demonstrated that the MHR[odds ratio(OR):1.033,95%confidence interval(CI):1.015-1.051;Ps an independent predictor of NAFLD in childhood obesity patients,as were age(OR:1.205,95%CI:1.059-1.371;P=0.005],waist circumference[OR:1.037,95%CI:1.008-1.067;P=0.012],and alanine transaminase[OR:1.067,95%CI:1.045-1.089;Ps showed a significant positive association with the incidence of NAFLD after adjusting for potential confounding *** The present study showed that the MHR may serve as an available and useful indicator of NAFLD in individuals with childhood obesity.

关键词： nonalcoholic fatty liver disease obesity monocyte-to-high-density lipoprotein ratio marker

High-performance si/VO_(2)-nanorod heterojunction photodetector based on photothermoelectric effect for detecting human radiation

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Rare Metals 2024年第3期43卷 1177-1185页

作者： Fu-Hai Guo Lan-Zhong Hao Wei-zhuo Yu si-Qi Li Guan-Chu Liu Jing-Yi Hao Yun-Jie Liu College of science China University of PetroleumQingdao266580China school of Materials science and Engineering China University of PetroleumQingdao266580China

As a typical candidate of optoelectronic materials,vanadium dioxide(VO_(2))has wide applications in photodetectors(PDs),but is still challenging in largely enhancing the photodetecting performance for low-power human ***,high-performance si/VO_(2)nanorods(NRs)heterojunction PDs based on the photothermoelectric(PTE)effect are *** uniform VO_(2)-NRs array films were deposited on si by using magnetron sputtering technique,and a si/VO_(2)heterojunctions were *** device exhibits a four-stage photoresponse and broadband photoresponse from ultraviolet to long-wavelength *** from the unique nanorods structure and the strong PTE effect,the fabricated device exhibits a large enhancement of the photodetecting performance,showing an ultrahigh photodetectivity of 1.6×10^(13)Jones and ultrafast response rates with a risingedge time of~65.0μs,three orders of magnitude higher than other VO_(2)-based ***,the device exhibits unique abilities to detect human radiation even when the human fingers are far away from the device surface up to 10.0 ***,the fabricated si/VO_(2)devices can also be applied as breath sensors to distinguish different breathing *** results supply an effective route to design high-performance photodetectors toward detecting human thermal radiation and respiration.

关键词： Vanadium dioxide Heterojunction Photodetector Photothermoelectric Human radiation and respiration sensing

Extrusion 3D printing of carbon nanotube-assembled carbon aerogel nanocomposites with high electrical conductivity

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Nano Materials science 2024年第3期6卷 312-319页

作者： Lukai Wang Jing Men Junzong feng Yonggang Jiang Liangjun Li Yijie Hu Jian feng science and Technology on Advanced Ceramic Fibers and Composites Laboratory College of Aerospace Science and EngineeringNational University of Defense Technology109 De Ya RdChangshaHunan410073PR China

Carbon nanotubes(CNTs)with high aspect ratio and excellent electrical conduction offer huge functional improvements for current carbon ***,there remains a major challenge for achieving the on-demand shaping of carbon aerogels with tailored micro-nano structural textures and geometric ***,a facile extrusion 3D printing strategy has been proposed for fabricating CNT-assembled carbon(CNT/C)aerogel nanocomposites through the extrusion printing of pseudoplastic carbomer-based inks,in which the stable dispersion of CNT nanofibers has been achieved relying on the high viscosity of carbomer *** extrusion printing,the chemical solidification through polymerizing RF sols enables 3D-printed aerogel nanocomposites to display high shape fidelity in macroscopic *** from the micro-nano scale assembly of CNT nanofiber networks and carbon nanoparticle networks in composite phases,3D-printed CNT/C aerogels exhibit enhanced mechanical strength(fracture strength,0.79 MPa)and typical porous structure characteristics,including low density(0.220 g cm^(-3)),high surface area(298.4 m^(2)g^(-1)),and concentrated pore diameter distribution(~32.8nm).More importantly,CNT nanofibers provide an efficient electron transport pathway,imparting 3D-printed CNT/C aerogel composites with a high electrical conductivity of 1.49 s cm^(-1).Our work would offer feasible guidelines for the design and fabrication of shape-dominated functional materials by additive manufacturing.

关键词： Carbon aerogel Extrusion 3D printing Carbon nanotube Electrical conductivity Rheology

微生物菌剂对连作芹菜根际土壤真菌群落多样性与结构的影响

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干旱地区农业研究 2024年第2期42卷 53-61,70页

作者：冯海萍陈卓杨虎宁夏农林科学院园艺研究所宁夏银川750002

以宁南旱区连作4年芹菜根际土壤为研究对象,采用田间定位试验结合高通量测序技术,以常规施肥(CK)为对照,研究常规施肥+枯草·哈茨复合菌剂(MF),常规施肥+枯草芽孢杆菌(Bs),常规施肥+哈茨木霉菌(TH)3个处理对芹菜连作根际土壤真菌多样性... 详细信息

以宁南旱区连作4年芹菜根际土壤为研究对象,采用田间定位试验结合高通量测序技术,以常规施肥(CK)为对照,研究常规施肥+枯草·哈茨复合菌剂(MF),常规施肥+枯草芽孢杆菌(Bs),常规施肥+哈茨木霉菌(TH)3个处理对芹菜连作根际土壤真菌多样性及群落组成的影响。结果表明:施用枯草·哈茨复合菌显著提高了土壤有效磷、速效钾含量,增幅分别为34.29%和9.98%。施用微生物菌剂增加了土壤脲酶、蔗糖酶活性,平均增幅分别为43.16%和12.98%,并显著改变了土壤真菌的β-多样性。被孢霉属(Mortierella)、织球壳属(Plectosphaerella)、赤霉菌属(Gibberella)、链格孢属(Alternaria)、镰刀菌属(Fusarium)是各处理优势菌属,施用枯草·哈茨复合菌显著降低了赤霉菌属、链格孢属、镰刀霉属等真菌性病原菌的相对丰度,降幅分别为59.88%、51.63%、36.13%。冗余分析表明土壤蔗糖酶、脲酶、碱性磷酸酶活性、pH值和全磷是影响真菌群落结构组成的主要驱动因子。综合而言,枯草·哈茨复合菌剂的施用不仅降低了连作芹菜根际土壤镰刀菌属、链格孢属、赤霉菌属等病原菌的富集,还通过改变有效磷、速效钾等土壤理化性质,进一步重塑土壤真菌群落结构。

关键词：芹菜连作微生物菌剂土壤理化性质真菌群落结构宁南山区

Constructal design of a rectangular parallel phase change microchannel in a three-dimensional electronic device

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science China(Technological sciences) 2024年第5期67卷 1381-1390页

作者： ZHANG JiWen feng HuiJun CHEN LinGen GE YanLin Institute of Thermal science and Power Engineering Wuhan Institute of TechnologyWuhan430205China College of Power Engineering Naval University of EngineeringWuhan430033China Hubei Provincial Engineering Technology Research Center of Green Chemical Equipment Wuhan430205China school of Mechanical&Electrical Engineering Wuhan Institute of TechnologyWuhan430205China

Based on constructal theory,a rectangular parallel phase change microchannel model in a three-dimensional electronic device(TDED)is established with R134a as the cooling *** on the minimization of a complex function(CF)composed of linear weighting sum of maximum temperature difference and pumping power consumption,constructal design of the TDED is conducted first;and then,maximum temperature difference and pumping power consumption are minimized by non-dominated sorting genetic algorithm-II *** results reveal that there exist an optimal mass flow rate(0.0012 kg/s)and a quadratic optimal aspect ratio(AR)(0.39)of the microchannel which lead to quadratic minimum CF(0.817).Compared with the original value,the CF after optimization is reduced by 18.34%.Reducing the inlet temperature of cooling fluid and microchannel number appropriately can help to enhance the overall performance of *** using the artificial neural network and genetic algorithms in the toolboxes of Matlab software,the optimal AR gained in the Pareto solution set is located between 0.2–*** smallest deviation index among three discussed strategies is 0.346,and the corresponding optimal AR is 0.413,which is selected as the optimal design strategy of the microchannel in the TDED under multiple *** findings in this study can serve as theoretical guides for thermal designs of electronic devices.

关键词： constructal theory parallel microchannel evaporation phase change three-dimensional electronic device multi-objective optimization artificial neural network

Resilient sliding mode control for 2D CPss under denial-of-service attacks

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science China(Information sciences) 2024年第6期67卷 262-278页

作者： Lingling LI Rongni YANG Zhiguang feng Ligang WU College of Intelligent systems science and Engineering Harbin Engineering University school of Control science and Engineering Shandong University school of Astronautics Harbin Institute of Technology

This study addresses the resilient sliding mode control(sMC) problem for two-dimensional cyber-physical systems(2D CPss) characterized by the Roesser model under denial-of-service attack(DosA), which can interfere with signal transmission over the communication network. First, the Dos-A model is established by introducing constraints on the Do s frequency and duration. Then, based on active or silent attack situations, the considered system is described as a switched mode. Furthermore, together with Lyapunov theory, the average dwell time technique is employed to deduce sufficient criteria that assure the existence of the desired sliding mode controller. Finally, verification examples are provided to show the validity of the established sMC scheme.

关键词： two-dimensional systems cyber-physical systems denial-of-service attack resilient sliding mode control

Effect of oxide inclusions on Mns precipitates and tensile mechanical property of high-strength low-alloy steel

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Journal of Iron and steel Research International 2024年第5期31卷 1210-1220页

作者： Xiao-yong Gao Hong Wei Li-feng Zhang school of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiChina school of Materials science and Engineering Yanshan UniversityQinhuangdao066004HebeiChina school of Mechanical and Materials Engineering North China University of TechnologyBeijing100144China

The key role of oxide inclusions on the microstructure and mechanical property of a high-strength low-alloy steel was *** field emission scanning electron microscope equipped with energy-dispersive spectrometry was used to characterize Mns *** inclusions play an important role in the shape control of Mns *** oxides fovored to decrease the size and the aspect ratio of Mns *** less oxide inclusions in the steel,approximately over 16.7%Mns precipitates were with aspect ratio a>5 and pure Mns precipitates accounted for 75.9%in ***,with more oxide inclusions in the steel,only 7.4%Mns precipitates were with a>5 and pure Mns precipitates accounted for 60.1%in *** of Mns by oxide inclusions improved the strength and inhibited the *** oxide inclusions in the steel increased the yield strength and tensile strength of the steel in both longitudinal and transverse directions,and lowered the anisotropy of the mechanical property.

关键词： High-strength low-alloy steel Mns Oxide inclusion Mechanical property Anisotropy