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Mathematical modeling and simulations of stress mitigation by coating polycrystalline particles in lithium-ion batteries

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 947-962页

作者： N.IQBAL J.CHOI s.F.sHAH C.LEE s.LEE Department of Mechanical Roboticsand Energy EngineeringDongguk University-SeoulSeoul 04620Republic of Korea

A chemo-mechanical model is developed to investigate the effects on the stress development of the coating of polycrystalline Ni-rich LiNixMnyCo_(z)O_(2)(x≥0.8)(NMC)particles with poly(3,4-ethylenedioxythiophene)(PEDOT).The simulation results show that the coating of primary NMC particles significantly reduces the stress generation by efficiently accommodating the volume change associated with the lithium diffusion,and the coating layer plays roles both as a cushion against the volume change and a channel for the lithium transport,promoting the lithium distribution across the secondary particles more ***,the lower stiffness,higher ionic conductivity,and larger thickness of the coating layer improve the stress *** paper provides a mathematical framework for calculating the chemo-mechanical responses of anisotropic electrode materials and fundamental insights into how the coating of NMC active particles mitigates stress levels.

关键词： lithium-ion battery(LIB) polycrystalline particle coating finite element simulation Ni-rich LiNixMnyCo_(z)O_(2)(x>0.8)(NMC)

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老年患者强化血压控制和心血管预后:基于60岁切点的收缩压干预试验的二次分析

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中华高血压杂志(中英文) 2024年第5期 500-500页

作者： Manal FC Butt z Gilani s shafiq s Cheema s Manash KD 刘青练桂丽

在最初的收缩压干预试验(the systolic blood pressure intervention trial,sPRINT)中,对年龄分组的切点为75岁,与之前许多临床试验的60岁不同。方法:sPRINT将9 361例高血压患者随机分配到目标收缩压<120 mm Hg(1 mm Hg=0.133 k Pa)和<1...

在最初的收缩压干预试验(the systolic blood pressure intervention trial,sPRINT)中,对年龄分组的切点为75岁,与之前许多临床试验的60岁不同。方法:sPRINT将9 361例高血压患者随机分配到目标收缩压<120 mm Hg(1 mm Hg=0.133 k Pa)和<140 mm Hg的治疗组(即分别为强化治疗组与标准治疗组)。年龄按照为<60岁和≥60岁重新分组,并计算结局和不良事件的HR和95%CI。结果:强化治疗降低年龄<60岁和≥60岁组患者的主要结局,

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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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Journal of sport and Health science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda z.Arthuso Myriam Filion spencer J.Allen stephanie M.Ntoukas Gordon J.Bell Jessica McNeil Qinggang Wang Margaret L.McNeely Jeff K.Vallance Lin Yang s.Nicole Culos-Reed Leanne Dickau John R.Mackey Christine M.Friedenreich Kerry s.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(psleep quality(p=0.009),significant fatigue(p=0.008),any symptom(psymptoms(pstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression sleep quality Cardiorespiratory fitness

Nonstationary laser-supported ionization wave in layer of porous substance with subcritical density

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Matter and Radiation at Extremes 2024年第1期9卷 58-70页

作者： s.Yu Gus’kov R.A.Yakhin P.N.Lebedev Physical Institute of Russian Academy of sciences Leninskii Prospect 53Moscow 119991Russia

A time-dependent analytical solution is found for the velocity of a plane ionization wave generated under nanosecond laser pulse action on the surface of a flat layer of low-z porous substance with density less than the critical density of the produced *** corrections for the two-dimensional nature of the problem when a laser beam of finite radius interacts with a flat target,this solution is in quantitative agreement with measurements of ionization wave velocity in various *** solution compared with experimental data covering wide ranges of performance conditions,namely,(3-8)×10^(14)W cm^(−2)for laser pulse intensity,0.3-3 ns for pulse duration,0.35-0.53μm for laser wavelength,100-1000μm for laser beam radius,380-950μm for layer thickness,4.5-12 mg cm^(−3)for average density of porous substance,and 1-25μm for average pore *** parameters of the laser beam that ensure the generation of a plane ionization wave in a layer of subcritical porous matter are determined for the problem statements and are found to meet the requirements of practical applications.

关键词： laser pulse porous

Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı serdar Kabatas ErdinçCivelek Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MsCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MsCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MsCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MsCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MsCs(UC-MsC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),Gross Motor Function Classification system(GMFCs),and Manual Ability Classification scale(MACs)*** utilized the Modified Ashworth scale(MAs)to measure *** We found significant improvements in MAs scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFIM results(P>0.05).GMFCs and MACs scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUsION In light of our findings,we believe that UC-MsC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

Reply to “Beyond microbial carbon use efficiency”

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National science Review 2024年第4期11卷 35-37页

作者： Feng Tao Johannes Lehmann Ying-Ping Wang Lifen Jiang Bernhard Ahrens Kostiantyn Viatkin stefano Manzoni Benjamin z.Houlton Yuanyuan Huang Xiaomeng Huang Yiqi Luo Department of Ecology and Evolutionary Biology Cornell University soil and Crop sciences section School of Integrative Plant ScienceCornell University CsIRO Environment Max Planck Institute for Biogeochemistry Department of Physical Geography and Bolin Centre for Climate Research Stockholm University Department of Global Development Cornell University Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Department of Earth system science Ministry of Education Key Laboratory for Earth System Modelling Institute for Global Change Studies Tsinghua University

In their commentary, Xiao et al.[1]cautioned that the conclusions on the critical role of microbial carbon use efficiency (CUE) in global soil organic carbon (sOC) storage in the paper by Tao et al.[2] might be too *** claimed that Tao et al.’s study lacked mechanistic consideration of sOC formation and excluded important data *** et al. brought up important points,which can be largely reconciled with our findings by understanding the differences in expressing processes in empirical studies and in models.

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An integrated microfluidic platform for nucleic acid testing

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Microsystems & Nanoengineering 2024年第3期10卷 181-194页

作者： Antao sun Petra Vopařilová Xiaocheng Liu Bingqian Kou TomášŘezníček TomášLednický sheng Ni JiříKudr Ondřej zítka zdenka Fohlerová Petr Pajer Haoqing zhang Pavel Neužil Ministry of Education Key Laboratory of Micro and Nano systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’anShaanxi 710072P.R.China Department of Chemistry and Biochemistry Mendel University in BrnoZemědělská161300 BrnoCzech Republic ITD Tech s.r.o Osvoboditelů100573581 BohumínCzech Republic Central European Institute of Technology Brno University of TechnologyPurkyňova 123Brno 61200Czech Republic Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Department of Microelectronics Faculty of Electrical Engineering and CommunicationBrno University of TechnologyTechnická3058/10Brno 61600Czech Republic Military Health Institute U Vojenskénemocnice 120016200 Praha 6Czech Republic The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049P.R.China Bioinspired Engineering and Biomechanics Center(BEBC) Xi’an Jiaotong UniversityXi’an 710049P.R.China

This study presents a rapid and versatile low-cost sample-to-answer system for sARs-CoV-2 *** system integrates the extraction and purification of nucleic acids,followed by amplification via either reverse transcriptionquantitative polymerase chain reaction(RT–qPCR)or reverse transcription loop-mediated isothermal amplification(RT–LAMP).By meeting diverse diagnostic and reagent needs,the platform yields testing results that closely align with those of commercial RT-LAMP and RT‒qPCR *** advantages of our system include its speed and *** assay is completed within 28 min,including sample loading(5 min),ribonucleic acid(RNA)extraction(3 min),and RT-LAMP(20 min).The cost of each assay is≈$9.5,and this pricing is competitive against that of Food and Drug Administration(FDA)-approved commercial *** some RNA loss during on-chip extraction is observed,the platform maintains a potential limit of detection lower than 297 *** makes the system particularly useful in environments where centralized laboratories are either unavailable or inconveniently *** key feature is the platform’s versatility,allowing users to choose between RT‒qPCR or RT‒LAMP tests based on specific requirements.

关键词： testing maintain versatile

Cr-induced fusion reactions to synthesize superheavy elements

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Nuclear science and Techniques 2024年第5期35卷 122-130页

作者： s.Madhu H.C.Manjunatha N.sowmya B.M.Rajesh L.seenappa R.s.susheela Department of Physics R V College of EngineeringBangalore 560074India Visvesvaraya Technological University BelagaviKarnataka 590018India Department of Physics Government First Grade CollegeSrinivasapurKarnataka 563135India Department of Physics Government First Grade CollegeDevanahallyKarnataka 562110India Department of Physics Government First Grade CollegeMulbagalKarnataka 563131India Department of Physics Government First Grade collegeNanjangudOoty RoadMysore 571301India

We investigated ^(50,52-54)Cr-induced fusion reactions for the synthesis of the superheavy element in the 104≤z≤122 *** cross sections produced in this investigation using ^(54)Cr projectiles were compared with those obtained in prior *** estimated cross sections from this analysis are consistent with the findings of prior *** the current study,the predicted cross section was found to be 42fb at 236 MeV for ^(53)Cr+^(243)Am,23.2 fb at 236 MeV for ^(54)Cr+^(247)Cm,95.6 fb at 240 MeV for ^(53)Cr+248Bk,and 1.33 fb at 242 MeV for ^(53)Cr+***,these projected cross sections with excitation energy and beam energy will be useful in future Cr-induced fusion reaction investigations.

关键词： Fusion cross sections Compound nucleus formation probability survival probability Evaporation residue cross sections

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safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of stem Cells 2024年第6期16卷 641-655页

作者： serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan sezen Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MsCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MsC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MsCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAs),motor function according to the Medical Research Council Muscle strength scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(Pscale includes both motor scores(Pscores(Pshowed a significant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly stem cell therapy Transplantation Mesenchymal stem cell