检索结果-南通市图书馆

New insights into the therapeutic approaches for the treatment of tauopathies

Neural Regeneration Research 2024年第5期19卷 1020-1026页

作者： Himanshi singh Asmita Das mohammad Moshahid Khan Tayebeh Pourmotabbed Department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA Department of Biotechnology Delhi Technological UniversityShahbad DaulatpurDelhiIndia Department of Neurology College of MedicineUniversity of Tennessee Health Science CenterMemphisTNUSA Neuroscience Institute University of Tennessee Health Science CenterMemphisTNUSA Center for Muscle Metabolism and NeuropathologyDivision of Regenerative and Rehabilitation Sciences and Department of Physical TherapyCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA

Tauopathies are a group of neurological disorders,including Alzheimer’s disease and frontotemporal dementia,which involve progressive neurodegeneration,cognitive deficits,and aberrant tau protein *** development of tauopathies cannot currently be stopped or slowed down by treatment *** the significant contribution of tau burden in primary tauopathies and the strong association between pathogenic tau accumulation and cognitive deficits,there has been a lot of interest in creating therapies that can alleviate tau pathology and render neuroprotective ***,small molecules,immunotherapies,and gene therapy have been used to reduce the pathological tau burden and prevent neurodegeneration in animal models of ***,the major pitfall of the current therapeutic approach is the difficulty of drugs and gene-targeting modalities to cross the blood-brain barrier and their unintended side *** this review,the current therapeutic strategies used for tauopathies including the use of oligonucleotide-based gene therapy approaches that have shown a promising result for the treatment of tauopathies and Alzheimer’s disease in preclinical animal models,have been discussed.

关键词： dementia gene therapies immunotherapy neurodegeneration oligonucleotides tau tauopathies therapies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Opportunities and Challenges in Advancing Plant Research with single-cell Omics

引用

Genomics, Proteomics & Bioinformatics 2024年第2期22卷 13-26页

作者： mohammad saidur Rhaman Muhammad Ali Wenxiu Ye Bosheng Li Peking University Institute of Advanced Agricultural sciences Shandong Laboratory of Advanced Agricultural Sciences in WeifangWeifang 261325China

Plants possess diverse cell types and intricate regulatory mechanisms to adapt to the ever-changing environment of *** strategies have been employed to study cell types and their developmental progressions,including single-cell sequencing methods which provide high-dimensional catalogs to address biological *** recent years,single-cell sequencing technologies in transcriptomics,epigenomics,proteomics,metabolomics,and spatial transcriptomics have been increasingly used in plant science to reveal intricate biological relationships at the single-cell ***,the application of single-cell technologies to plants is more limited due to the challenges posed by cell *** review outlines the advancements in single-cell omics technologies,their implications in plant systems,future research applications,and the challenges of single-cell omics in plant systems.

关键词： Multi-omics single-cell transcriptomics spatial transcriptomics single-cell epigenomics single-cell proteomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Temperature-jump tensile tests to induce optimized TRIP/TWIP effect in a metastable austenitic stainless steel

引用

International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2025-2036页

作者： mohammad Javad sohrabi Hamed Mirzadeh saeed sadeghpour Abdol Reza Geranmayeh Reza Mahmudi school of Metallurgy and Materials Engineering College of EngineeringUniversity of Tehran14395-515TehranIran Centre for Advanced steels Research Materials and Mechanical EngineeringUniversity of Oulu90014 OuluFinland

In the present work,plastic deformation mechanisms were initially tailored by adjusting the deformation temperature in the range of 0 to 200℃ in AIsI 304L austenitic stainless steel,aiming to optimize the strength-ductility *** was shown that the combined twinning-induced plasticity(TWIP)/transformation-induced plasticity(TRIP)effects and a wider strain range for the TRIP effect up to higher strains by adjusting the deformation temperature are good strategies to improve the strength-ductility synergy of this metastable stainless *** this regard,by consideration of the observed temperature-dependency of plastic deformation,the controlled sequence of TWIP and TRIP effects for archiving superior strength-ductility trade-off was intended by the pre-designed temperature jump tensile ***,the optimum tensile toughness of 846 MJ/m^(3) and total elongation to 133% were obtained by this strategy via exploiting the advantages of the TWIP effect at 100℃ and the TRIP effect at 25℃ at the later stages of the ***,a deformation-temperature-transformation(DTT)diagram was developed for this metastable ***,based on work-hardening analysis,it was found that the main phenomenon constraining further improvement in the ductility and strengthening was the yielding of the deformation-induced α′-martensite.

关键词： metastable stainless steels transformation-induced plasticity twinning-induced plasticity stacking fault energy mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Big Model strategy for Bridge structural Health Monitoring Based on Data-Driven, Adaptive Method and Convolutional Neural Network (CNN) Group

引用

structural Durability & Health Monitoring 2024年第6期18卷 763-783页

作者： Yadong Xu Weixing Hong mohammad Noori Wael A.Altabey Ahmed silik Nabeel s.D.Farhan Nanjing Highway Development Center Changzhou211106China Nanjing Zhixing Information Technology Co. Ltd.Nanjing210000China Department of Mechanical Engineering California Polytechnic State UniversitySan Luis ObispoCA 93405USA Department of Mechanical Engineering Faculty of EngineeringAlexandria UniversityAlexandria21544Egypt Department of Civil Engineering Nyala UniversityP.O.Box 155NyalaSudan school of Civil Engineering University of LeedsLeedsLS29JTUK

This study introduces an innovative“Big Model”strategy to enhance Bridge structural Health Monitoring(sHM)using a Convolutional Neural Network(CNN),time-frequency analysis,and fine element *** ensemble methods,collaborative learning,and distributed computing,the approach effectively manages the complexity and scale of large-scale bridge *** CNN employs transfer learning,fine-tuning,and continuous monitoring to optimize models for adaptive and accurate structural health assessments,focusing on extracting meaningful features through time-frequency *** integrating Finite Element Analysis,time-frequency analysis,and CNNs,the strategy provides a comprehensive understanding of bridge *** diverse sensor data,sophisticated feature extraction,and advanced CNN architecture,the model is optimized through rigorous preprocessing and hyperparameter *** approach significantly enhances the ability to make accurate predictions,monitor structural health,and support proactive maintenance practices,thereby ensuring the safety and longevity of critical infrastructure.

关键词： structural Health Monitoring(sHM) bridges big model Convolutional Neural Network(CNN) Finite Element Method(FEM)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-trial Vector-based Whale Optimization Algorithm

引用

Journal of Bionic Engineering 2024年第3期21卷 1465-1495页

作者： mohammad H.Nadimi-shahraki Hajar Farhanginasab shokooh Taghian Ali safaa sadiq s.yedali Mirjalili Faculty of Computer Engineering Najafabad BranchIslamic Azad UniversityNajafabad***Iran Big Data Research Center Najafabad BranchIslamic Azad UniversityNajafabad***Iran Department of Computer science Nottingham Trent UniversityNottinghamNG118NSUK Centre for Artificial Intelligence Research and Optimisation Torrens UniversityBrisbane4006Australia

The Whale Optimization Algorithm(WOA)is a swarm intelligence metaheuristic inspired by the bubble-net hunting tactic of humpback *** spite of its popularity due to simplicity,ease of implementation,and a limited number of parameters,WOA’s search strategy can adversely affect the convergence and equilibrium between exploration and exploitation in complex *** address this limitation,we propose a new algorithm called Multi-trial Vector-based Whale Optimization Algorithm(MTV-WOA)that incorporates a Balancing strategy-based Trial-vector Producer(Bs_TVP),a Local strategy-based Trial-vector Producer(Ls_TVP),and a Global strategy-based Trial-vector Producer(Gs_TVP)to address real-world optimization problems of varied degrees of ***-WOA has the potential to enhance exploitation and exploration,reduce the probability of being stranded in local optima,and preserve the equilibrium between exploration and *** the purpose of evaluating the proposed algorithm's performance,it is compared to eight metaheuristic algorithms utilizing CEC 2018 test ***,MTV-WOA is compared with well-stablished,recent,and WOA variant *** experimental results demonstrate that MTV-WOA surpasses comparative algorithms in terms of the accuracy of the solutions and convergence ***,we conducted the Friedman test to assess the gained results statistically and observed that MTV-WOA significantly outperforms comparative ***,we solved five engineering design problems to demonstrate the practicality of *** results indicate that the proposed MTV-WOA can efficiently address the complexities of engineering challenges and provide superior solutions that are superior to those of other algorithms.

关键词： swarm intelligence algorithms Metaheuristic algorithms Optimization Engineering design problems Whale optimization algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrospun Aloe Vera Extract Loaded Polycaprolactone scaffold for Biomedical Applications:A Promising Candidate for Corneal stromal Regeneration

引用

Journal of Bionic Engineering 2024年第4期21卷 1949-1959页

作者： Amin Orash Mahmoud salehi mohammad Rafienia Narsimha Mamidi saeed Heidari Keshel Alireza Baradaran-Rafii Department of Chemistry and Nanotechnology School of Engineering and ScienceTecnologico de MonterreyMonterreyNuevo Leon64849Mexico Biosensor Research Center Isfahan University of Medical SciencesIsfahan81746-73461Iran Wisconsin Center for NanoBiosystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWisconsin53705USA Medical Nanotechnology Research Center Shahid Beheshti University of Medical SciencesTehran19857-17443Iran Department of Ophthalmology Ophthalmic Research CenterLabbafinejad Medical CenterShahid Beheshti University of Medical SciencesTehran19395-4631Iran Department of Ophthalmology Morsani College of MedicineUniversity of South FloridaTampaFL33612USA Department of Tissue Engineering and Applied Cell science School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehran19857-17443Iran

Corneal diseases,the second leading cause of global vision loss affecting over 10.5 million people,underscores the unmet demand for corneal tissue *** the scarcity of fresh donor corneas and the associated risks of immune rejection,corneal tissue engineering becomes *** nanofibrous scaffolds that mimic the natural corneal structure is crucial for creating transparent and mechanically robust corneal equivalents in tissue ***,Aloe Vera Extract(AVE)/Polycaprolactone(PCL)nanofibrous scaffolds were primed using *** electrospun AVE/PCL fibers exhibit a smooth,bead-free morphology with a mean diameter of approximately 340±95 nm and appropriate light *** measurements reveal Young’s modulus and ultimate tensile strength values of around 3.34 MPa and 4.58 MPa,respectively,within the range of stromal *** addition,cell viability of AVE/PCL fibers was measured against Human stromal Keratocyte Cells(HsKCs),and improved cell viability was *** cell-fiber interactions were investigated using scanning electron *** conclusion,the incorporation of Aloe Vera Extract enhances the mechanical,optical,hydrophilic,and biological properties of PCL fibers,positioning PCL/AVE fiber scaffolds as promising candidates for corneal stromal regeneration.

关键词： Corneal stromal regeneration Aloe vera extract Polycaprolactone Electrospinning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Levisticum officinale extract protects against CCl4-induced hepatotoxicity through anti-inflammatory,anti-fibrotic,and antioxidant properties in rats

引用

Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 331-340页

作者： Nahid Ghaedi Iran Pouraboli Mansour Mirtadzadini mohammad-mehdi Moeini-aghtaie Department of Biology Faculty of SciencesShahid Bahonar University of KermanKermanIran Department of Pathology Pathology and Stem Cell Research CenterAfzalipour Medical FacultyKerman University of Medical SciencesKermanIran

Objective:To investigate the hepatoprotective effects of Levisticum officinale extract on CCl4-induced ***:Different doses of Levisticum officinale extract were given orally to rats for 10 days,then rats received a single dose of CCl4(2.5 mL/kg,50%v/v in liquid paraffin).Biochemical and histopathological assays were performed to assess the effects of the extract on liver function and ***,antioxidant and oxidative markers as well as inflammatory and fibrotic indicators were ***:Pretreatment with Levisticum officinale extract significantly mitigated CCl4-induced damage to liver structure,improved serum levels of alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,urea,total bilirubin,and total protein,enhanced glutathione content and superoxide dismutase and catalase activities in the liver,as well as decreased plasma and hepatic malondialdehyde *** results demonstrated that the extract reduced Ki-67 andα-sMA expression and Masson’s trichrome staining revealed decreased liver collagen in rats treated with Levisticum officinale ***,Levisticum officinale extract markedly decreased the gene expressions of TNF-α,IL-6,TGF-β1,MCP-1,and ***:Levisticum officinale extract exerts hepatoprotective effects on CCl4-induced hepatotoxicity through antioxidant,anti-inflammatory,and anti-fibrotic activities.

关键词： Levisticum officinale CCl4 Inflammation Liver toxicity Antioxidant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

special Column on Recent Advances in PCMs as Thermal Energy storage in Energy systems

引用

Journal of Thermal science 2024年第2期33卷 395-395页

作者： mohammad Hossein AHMADI Tingzhen MING Marc A.ROsEN s.A.sHERIF mohammad Mehdi RAsHIDI shahrood University of Technology Iran Wuhan University of Technology China University of Ontario Institute of Technology Canada University of Florida USA University of Electronic science and Technology of China China

Thermal energy storage technology has the advantages of high energy storage density,small size,and high energy conversion *** is one of the key energy storage technologies and an important way to achieve carbon peaking and carbon neutrality *** change materials (PCMs) offer this opportunity to store high amount of energy and release it in the form of latent heat when needed,and therefore have the advantage of being capable to alleviate the intrinsic intermittency of renewable power production,especially in wind and solar farms.

关键词： efficiency store latent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interplay between temperature-dependent strengthening mechanisms and mechanical stability in high-performance austenitic stainless steels

引用

International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2182-2188页

作者： mohammad Javad sohrabi Hamed Mirzadeh saeed sadeghpour Milad Zolfipour Aghdam Abdol Reza Geranmayeh Reza Mahmudi school of Metallurgy and Materials Engineering College of EngineeringUniversity of Tehran14395-515 TehranIran Centre for Advanced steels Research Materials and Mechanical EngineeringUniversity of Oulu90014 OuluFinland Department of Mechanical Engineering College of EngineeringUniversity of Tehran14395-515 TehranIran

The effects of deformation temperature on the transformation-induced plasticity(TRIP)-aided 304L,twinning-induced plasti-city(TWIP)-assisted 316L,and highly alloyed stable 904L austenitic stainless steels were compared for the first time to tune the mechan-ical properties,strengthening mechanisms,and strength-ductility *** this purpose,the scanning electron microscopy(sEM),electron backscattered diffraction(EBsD),X-ray diffraction(XRD),tensile testing,work-hardening analysis,and thermodynamics calcu-lations were *** induced plasticity effects led to a high temperature-dependency of work-hardening behavior in the 304L and 316L stainless *** the deformation temperature increased,the metastable 304L stainless steel showed the sequence of TRIP,TWIP,and weakening of the induced plasticity mechanism;while the disappearance of the TWIP effect in the 316L stainless steel was also ***,the solid-solution strengthening in the 904L superaustenitic stainless steel maintained the tensile properties over a wide temper-ature range,surpassing the performance of 304L and 316L stainless *** this regard,the dependency of the total elongation on the de-formation temperature was less pronounced for the 904L alloy due to the absence of additional plasticity *** results re-vealed the importance of solid-solution strengthening and the associated high friction stress for superior mechanical behavior over a wide temperature range.

关键词： austenitic stainless steels mechanical behavior stacking fault energy metastability mechanical twinning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multifunctional snO_(2) QDs/MXene Heterostructures as Laminar Interlayers for Improved Polysulfide Conversion and Lithium Plating Behavior

引用

Nano-Micro Letters 2024年第11期16卷 156-169页

作者： shungui Deng Weiwei sun Jiawei Tang mohammad Jafarpour Frank Nüesch Jakob Heier Chuanfang Zhang College of Materials science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China Laboratory for Functional Polymers Swiss Federal Laboratories for Materials Science and Technology(EMPA)Überlandstrasse 1298600 DübendorfSwitzerland Institute of Materials science and Engineering Ecole Polytechnique Fédérale de Lausanne(EPFL)Station 121015 LausanneSwitzerland Key Laboratory of Quantum Materials and Devices of Ministry of Education School of PhysicsSoutheast UniversityNanjing 211189People’s Republic of China sEU‑FEI Nano‑Pico Center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 210096People’s Republic of China

Poor cycling stability in lithium–sulfur(Li–s)batteries necessitates advanced electrode/electrolyte design and innovative interlayer *** catalysis has emerged as a promising approach,leveraging the adsorption and catalytic performance on lithium polysulfides(LiPss)to inhibit LiPss shuttling and improve redox *** this study,we report an ultrathin and laminar snO_(2)@MXene heterostructure interlayer(snO_(2)@MX),where snO_(2) quantum dots(QDs)are uniformly distributed across the MXene *** combined structure of snO_(2) QDs and MXene,along with the creation of numerous active boundary sites with coordination electron environments,plays a critical role in manipulating the catalytic kinetics of sulfur *** Li–s cell with the snO_(2)@MX-modified separator not only demonstrates superior electrochemical performance compared to cells with a bare separator but also induces homogeneous Li deposition during *** a result,an areal capacity of 7.6 mAh cm^(-2) under a sulfur loading of 7.5 mg cm^(-2) and a high stability over 500 cycles are *** work demonstrates a feasible strategy of utilizing a laminar separator interlayer for advanced Li–s batteries awaiting commercialization and may shed light on the understanding of heterostructure catalysis with enhanced reaction kinetics.

关键词： Lithium-sulfur battery Heterogeneous catalysis Heterostructure Redox kinetics Lithium dendrites

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：