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放射性基因组分析非小细胞肺癌18F-FDG PET、预后与上皮-间叶转型间的相关性

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国际医学放射学杂志 2016年第5期 567-567页

作者： s.yamamoto D.Huang L.Du R.L.Korn N.Jamshidi B.L.Burnette 林奈尔 Department of Radiology The David Geffen School of Medicine at University of California-Los Angeles (UCLA)

摘要目的探讨非小细胞肺癌（NsCLC）标准摄取值（sUV）最大值(sUVmax)较高时是否出现更多上皮-间叶转型（EMT）表达。材料与方法本研究获得了机构伦理委员会批准。使用26例NsCLC病人的18氟-氟脱氧葡萄糖(18F FDG)正电子发射体层成像（PE... 详细信息

摘要目的探讨非小细胞肺癌（NsCLC）标准摄取值（sUV）最大值(sUVmax)较高时是否出现更多上皮-间叶转型（EMT）表达。材料与方法本研究获得了机构伦理委员会批准。使用26例NsCLC病人的18氟-氟脱氧葡萄糖(18F FDG)正电子发射体层成像（PET）和信使RNA表达谱的公开

关键词：小细胞肺癌 FDG F-FDG PET 放射性上皮 NsCLC 基因组染色体组相关性

Prevention of recurrence after surgery for Crohn's disease: Efficacy of infliximab

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World Journal of Gastroenterology 2010年第43期16卷 5405-5410页

作者： Takayuki yamamoto Inflammatory Bowel Disease Center and Department of surgery Yokkaichi Social Insurance Hospital

After surgery for Crohn's disease (CD), early endoscopic lesions are frequently observed despite no symptomatic recurrence. The severity of lesions found at postoperative endoscopy is reported to be a strong predictive factor for future clinical recurrence. If endoscopic lesions in the early postoperative period can be reduced with medications, symptomatic recurrence will likely be delayed and decreased. Before the introduction of biologic therapies, various medications were used for the maintenance of clinical remission after surgery; however, few demonstrated consistent efficacy. Infliximab is a recombinant anti-tumor necrosis factor-α antibody. Although infliximab is one of the most effective medications in the management of CD, its efficacy for early endoscopic lesions after surgery has not yet been assessed. The author and colleagues recently conducted a prospective study in order to investigate the impact of infliximab on early endoscopic lesions after resection for CD. We found that infliximab therapy showed clear suppressive effects on clinical and endoscopic disease activity in patients with early endoscopic lesions after resection.

关键词： Crohn’s disease Postoperative recurrence Endoscopic lesion Infliximab

An Inverse Problem for Maxwell's Equations in Anisotropic Media

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Chinese Annals of Mathematics,series B 2007年第1期28卷 35-54页

作者： Masahiro yamamoto Graduate school of Mathematical sciences The University of Tokyo 3-8-1 Komaba Meguro Tokyo 153Japan

The authors consider Maxwell＇s equations for an isomagnetic anisotropic and inhomogeneous medium in two dimensions, and discuss an inverse problem of determining the permittivity tensor （ε1,ε2,ε2,ε3 ） and the permeability μ in the constitutive relations from a finite number of lateral boundary measurements. Applying a Carleman estimate, the authors prove an estimate of the Lipschitz type for stability, provided that ε1,ε2,ε3,μ satisfy some a priori conditions.

关键词： Anisotropic media Inverse problem Maxwell's equations Carleman estimate Lipschitz stability

Factors affecting recurrence after surgery for Crohn's disease

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World Journal of Gastroenterology 2005年第26期11卷 3971-3979页

作者： Takayuki yamamoto Inflammatory Bowel Disease Center and Department of surgery Yokkaichi social Insurance Hospital YokkaichiMie 510-0016Japan

Although in Crohn's disease post-operative recurrence is common, the determinants of disease recurrence remain speculative. The aim of this study was to examine factors affecting post-operative recurrence of Crohn's disease. A Medline-based literature review was carried out. The following factors were investigated: age at onset of disease, sex, family history of Crohn's disease,smoking, duration of Crohn's disease before surgery,prophylactic medical treatment (corticosteroids, 5-amino salicylic acid [5-AsA] and immunosuppressants),anatomical site of involvement, indication for surgery (perforating or non-perforating disease), length of resected bowel, anast-omotic technique, presence of granuloma in the specimen, involvement of disease at the resection margin, blood transfusions and postoperative complications. smoking significantly increases the risk of recurrence (risk is approximately twice as high), especially in women and heavy smokers. Quitting smoking reduces the post-operative recurrence rate. A number of studies have shown a higher risk when the duration of the disease before surgery was short. There were, however, different definitions of 'short' among the studies. Prophylactic cortic-osteroids therapy is not effective in reducing the post-operative recurrence. A number of randomized controlled trials offered evidence of the efficacy of 5-AsA (mesalazine) in reducing post-operative recurrence. Recently, the thera-peutic efficacy of immunosuppressive drugs (azathioprine and 6-mercaptopurine) in the prevention of post-operative recurrence has been investigated and several studies have reported that these drugs might help prevent the recurrence. Further clinical trials would be necessary to evaluate the prophylactic efficacy of *** studies showed a higher recurrence rate in patients with perforating disease than in those with non-perforating disease. However, evidence for differing recurrence rates in perforating and non-perforating dis

关键词： Crohn's disease Post-operative recurrence Predictive factors Resection surgery

soft x-ray tomographic reconstruction of Heliotron J plasma for the study of magnetohydrodynamic equilibrium and stability

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Plasma science and Technology 2019年第6期21卷 72-78页

作者： s PUROHIT Y sUZUKI s OHDACHI s.yamamoto sOKENDAI The Graduate University for Advanced Studies Toki Gifu 509-5292 Japan National Institute for Fusion science Toki Gifu 509-5292 Japan Institute of Advanced Energy Kyoto University Gokasho Uji Kyoto 611-0011 Japan

The preparation for an experimental soft x-ray tomography study on the Heliotron J (H-J) machine is carried out,with the objectives of evaluating the capability of the current soft x-ray tomographic system in terms of the identification of different mode structures and their poloidal rotation,and the axis shift with different plasma and machine parameters,and fixing the physics goals for the experimental *** preparations were carried out via a simulated soft x-ray data set arising from different plasma conditions,such as magnetic islands,low beta and high *** x-ray tomography (sXT) is performed by the discrete pixel method including singular value decomposition and Phillips-Tikhonov regularization,to obtain clear and smooth *** H-J soft x-ray tomography results from simulated soft x-rays for the equilibrium H-J plasma sensed the magnetic axis shift clearly and an estimate was also *** reconstruction for mode structure m =1/n =1 was obtained along with the realization of the poloidal rotation of the *** reconstruction for the m =2/n =1 mode was not very clear for the current soft x-ray diagnostic *** mode identification was not possible due to the lack of *** sXT from the current soft x-ray diagnostic on H-J,the magnetic axis shift can be estimated and the m =1/n =1 mode can be *** of higher poloidal modes is difficult with the current design.

关键词： Heliotron J tomography soft x-ray magnetohydrodynamics

surgery for luminal Crohn's disease

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World Journal of Gastroenterology 2014年第1期20卷 78-90页

作者： Takayuki yamamoto Toshiaki Watanabe Inflammatory Bowel Disease Center and Department of surgery Yokkaichi Social Insurance HospitalMie 510-0016Japan Department of surgical Oncology The University of TokyoHongoTokyo 113-0033Japan

Many patients with Crohn’s disease (CD) require surgery. Indications for surgery include failure of medical treatment, bowel obstruction, fistula or abscess formation. The most common surgical procedure is resection. In jejunoileal CD, strictureplasty is an accepted surgical technique that relieves the obstructive symptoms, while preserving intestinal length and avoiding the development of short bowel syndrome. However, the role of strictureplasty in duodenal and colonic diseases remains controversial. In extensive colitis, after total colectomy with ileorectal anastomosis (IRA), the recurrence rates and functional outcomes are reasonable. For patients with extensive colitis and rectal involvement, total colectomy and end-ileostomy is safe and effective; however, a few patients can have subsequent IRA, and half of the patients will require proctectomy later. Proctocolectomy is associated with a high incidence of delayed perineal wound healing, but it carries a low recurrence rate. Patients undergoing proctocolectomy with ileal pouch-anal anastomosis had poor functional outcomes and high failure rates. Laparoscopic surgery has been introduced as a minimal invasive procedure. Patients who undergo laparoscopic surgery have a more rapid recovery of bowel function and a shorter hospital stay. The morbidity also is lower, and the rate of disease recurrence is similar compared with open procedures.

关键词： Crohn’ s disease, Laparoscopic surgery, Resection, strictureplasty, surgery

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Effect of tumor necrosis factor-α antagonists on oxidative stress in patients with Crohn's disease

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World Journal of Gastroenterology 2015年第35期21卷 10208-10214页

作者： Kazunari yamamoto Toshimi Chiba Takayuki Matsumoto Division of Gastroenterology Department of Internal MedicineSchool of MedicineIwate Medical University

AIM: To investigate changes in oxidative stress in Crohn's disease(CD) before and after anti-tumor necrosis factor(TNF)-α ***: A total of 42 patients with active CD, who were scheduled to be treated by anti-TNF-α antibodies, were enrolled. serum levels of diacron-reactive oxygen metabolites(d-ROM), biological antioxidant potential(BAP), and modified ratio of oxidative stress and antioxidant capacity(m-OA) were measured using the Free Radical Analytical system before and 8 wk after induction of therapy with infliximab or adalimumab. The values for oxidative stress were correlated with disease activity and clinical response as determined by the CD activity index(CDAI) at 8 and 54 wk after the ***: Prior to treatment, d-ROM showed significant correlations with CDAI(r = 0.42, P s a significant negative correlation between m-OA and CDAI before and after treatment(r =-0.48 vs r =-0.42, P sed significantly by 8 wk after treatment(CDAI; 223.3 ± 113.2 vs 158.3 ± 73.4, P s 312 ± 101, P significantly. In patients who had responded to the treatment at 8 wk, d-ROM, BAP, and m-OA levels before treatment did not differ significantly between patients with and without loss of ***: Anti-TNF-α therapy decreases oxi-dative stress in patients with CD, but does not alter the production of antioxidants. Dysregulation of antioxidants may be associated with the disease.

关键词： Crohn’s disease severity Oxidative stress Anti-tum