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A Novel Dynamic Quadrature scheme for solving Boltzmann Equation with Discrete Ordinate and Lattice Boltzmann Methods

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Communications in Computational Physics 2012年第4期11卷 1397-1414页

作者： C.T.Hsu s.w.chiang K.F.sin Department of Mechanical Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong

The Boltzmann equation(BE)for gas flows is a time-dependent nonlinear differential-integral equation in 6 *** current simplified practice is to linearize the collision integral in BE by the BGK model using Maxwellian equilibrium distribution and to approximate the moment integrals by the discrete ordinatemethod(DOM)using a finite set of velocity quadrature *** simplification reduces the dimensions from 6 to 3,and leads to a set of linearized discrete *** main difficulty of the currently used(conventional)numerical procedures occurs when the mean velocity and the variation of temperature are large that requires an extremely large number of quadrature *** this paper,a novel dynamic scheme that requires only a small number of quadrature points is *** is achieved by a velocity-coordinate transformation consisting of Galilean translation and thermal normalization so that the transformed velocity space is independent of mean velocity and *** enables the efficient implementation of Gaussian-Hermite *** velocity quadrature points in the new velocity space are fixed while the correspondent quadrature points in the physical space change from time to time and from position to *** this dynamic nature in the physical space,this new quadrature scheme is termed as the dynamic quadrature scheme(DQs).The DQs was implemented to the DOM and the lattice Boltzmann method(LBM).These new methods with DQs are therefore termed as the dynamic discrete ordinate method(DDOM)and the dynamic lattice Boltzmann method(DLBM),*** new DDOM and DLBMhave been tested and validated with several testing *** the same accuracy in numerical results,the proposed schemes are much faster than the conventional ***,the new DLBM have effectively removed the incompressible and isothermal restrictions encountered by the conventional LBM.

关键词： Dynamics quadrature dynamic discrete ordinatemethod dynamic lattice Boltzmann method thermal lattice Boltzmann method

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MDMA对基底节-丘脑-皮质环路的潜在长期效应:1H-MRs及扩散张量成像的研究

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国际医学放射学杂志 2011年第5期 489-490页

作者： H.w.Chung N.Y.Cho s.w.chiang 张竞文 Department of Radiology Tri-Service General Hospital and National Defense Medical Center325 ChengKung RdNeiHuTaipeiTaiwan 114Repubilc of China

目的利用1H-MRs和扩散张量成像(DTI)观察3,4-亚甲二氧基甲基苯丙胺(MDMA,也称"摇头丸")对脑内代谢物和基底节-丘脑-皮质环路功能相关的解剖结构的

关键词：扩散张量基底节区 MDMA 丘脑间脑 MRs 皮质

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福安花猪调查研究

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福建农学院学报 1959年第Z1期 1-17页

作者：蒋树威陈焕新

一前言福安县位于本省东北部,是本省优良福安花猪的原产地。这次我们下放在福安花猪的中心产区——赛岐,参加生产劳动锻炼,因此有进一步了解福安花猪的机会,为了对花猪有一全面的了解,我们又到离赛岐61公里的霞浦县进行一次调查访问,兹... 详细信息

一前言福安县位于本省东北部,是本省优良福安花猪的原产地。这次我们下放在福安花猪的中心产区——赛岐,参加生产劳动锻炼,因此有进一步了解福安花猪的机会,为了对花猪有一全面的了解,我们又到离赛岐61公里的霞浦县进行一次调查访问,兹就我们在调查访问以及生产劳动中所搜集的资料,综合整理如下:

关键词：母猪仔猪福安县种猪种公猪初配年龄初配适龄肥育性能肥育特性生产性能体尺胸深山猪乳头数

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Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed wMatthijs Blankesteijn sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-school for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-school for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(csVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term csVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CsVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

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stellar X-ray sources in the Rosette Nebula

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Chinese Journal of Astronomy and Astrophysics 2004年第2期4卷 153-165页

作者： w.P.Chen P.s.chiang J.Z.Li Institute of Astronomy National Central UniversityChung-Li 32054Taiwan National Astronomical Observatories Chinese Academy of SciencesBeijing 100012

we present optical photometric and spectroscopic studies of ROsAT X-ray stellar sources in the Rosette Nebula star-forming region. The brightest X-ray sources are either massive stars or active T Tauri stars associated with the open cluster NGC 2244, or are foreground stars. some of the spectra of the young stars newly identified in the region are presented.

关键词： stars: early-type stars: pre-main sequence stars: formation HII regions

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