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Z-score in Fetal Echocardiography–Is there still Room for New studies?

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Congenital Heart Disease 2024年第3期19卷 305-314页

作者： Marcio Fragoso Vieira Nathalie jeanne Bravo-Valenzuela Edward Araujo júnior Department of Obstetrics Paulista School of MedicineFederal University of São Paulo(EPM-UNIFESP)São Paulo-SP04023-062Brazil Department of Obstetrics Federal University of Ceará(UFC)Sobral-CE60020-181Brazil Department of Pediatrics Pediatric CardiologySchool of MedicineFederal University of Rio de Janeiro(UFRJ)Rio de Janeiro-RJ21941-853Brazil

Congenital heart disease(CHD)is the most common type of birth defect,representing a significant cause of peri-natal morbidity and *** diagnosis of such anomalies is crucial for improving *** pro-tocols recommend a qualitative assessment of cardiac structures using two-dimensional ultrasound(2DUs)and color Doppler *** cases of suspected abnormalities,quantitative assessments through cardiac structure measurements and reference curves can aid in accurate *** to centiles widely employed in obste-trics,Z-scores provide more precise quantification of various cardiac structures,particularly at the extremes of the *** the development of reference curves and Z-scores has progressed over the past two decades,a lack of standardization in measurements and statistical methodology for their determination is *** reference curves requires adherence to specific recommendations to improve their *** purpose of this study is to provide a narrative review of the major studies that have generated reference values for cardiac struc-tures using 2DUs and Z-scores,to evaluate their methodology,and to provide a summary of the results.

关键词： Z-scores reference ranges fetal echocardiography

A review on the scale-up of high-shear wet granulation processes and the impact of process parameters

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Particuology 2024年第9期92卷 180-195页

作者： Ana Rita alves Marta Filipe simões sérgio simões joão Gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty of Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HsG)one of the most employed technologies in the pharmaceutical *** most critical process parameters of HsG are discussed in this *** main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all *** scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based *** engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule *** work presents the effect of different HsG process parameters on the scale-up,as well as the use of process analytical tools(PAT)and modelling *** aim is to review applied scale-up approaches in HsG and discuss benefits and *** is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.

关键词： High-shear wetgranulation Parametric-based Attribute-based Physics-based modelling Impeller design scale-up

supercritical fluid technology as a sustainable alternative method for textile dyeing:An approach on waste,energy,and CO_(2)emission reduction

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journal of Environmental sciences 2024年第6期140卷 123-145页

作者： Carlos Rafael silva de Oliveira Patrícia Viera de Oliveira Leandro Pellenz Catia Rosana Lange de Aguiar Afonso Henrique da silva júnior Federal University of santa Catarina Textile Engineering Department2514 João Pessoa St.BlumenauSC89036-004Brazil Federal University of santa Catarina Chemical Engineering DepartmentS/n Biotério Central St.FlorianópolisSC88040-900Brazil

The clothing industry is considered one of the most polluting industries on the planet due to the high consumption of water,energy,chemicals/dyes,and high generation of solid waste and *** with environmental concerns,the textile ennoblement sector is the most critical of the textile production chain,especially the traditional dyeing *** an alternative to current problems,dyeing with supercritical CO_(2)(scCO_(2))has been presented as a clean and efficient process for a sustainable textile *** fluid dyeing(sFD)has shown a growing interest due to its significant impact on environmental preservation and social,economic,and financial *** main sFD benefits include economy and reuse of non-adsorbed dyes;reduction of process time and energy expenditure;capture of atmospheric CO_(2)(greenhouse gas);use and recycling of CO_(2)in sFD;generation of carbon credits;water-free process;effluent-free process;reduction of CO_(2)emission and auxiliary *** being still a non-scalable and evolving technology,sFD is the future of *** review presented a comprehensive overview of the environmental impacts caused by traditional processes and confronted the advantages of *** sFD technique was introduced,along with its latest advances and future *** and environmental gains were also discussed.

关键词： Textile industry supercritical dyeing sustainable processes Water free dyeing Energy saving Cleaner production

Unveiling DNA methylation in Alzheimer’s disease:a review of array-based human brain studies

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Neural Regeneration Research 2024年第11期19卷 2365-2376页

作者： Victoria Cunha alves Eva Carro joana Figueiro-silva Neurodegenerative Diseases Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Network Center for Biomedical Research Neurodegenerative Diseases(CIBERNED)MadridSpain PhD Program in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurotraumatology and subarachnoid Hemorrhage Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Neurobiology of Alzheimer’s Disease Unit Functional Unit for Research Into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpain Institute of Medical Genetics University of ZurichZurichSwitzerland Department of Molecular Life science University of ZurichZurichSwitzerland

The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA *** review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer’s disease *** examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer’s disease *** entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the ***,ANK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal ***,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory *** complex role of BIN1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation *** the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease *** research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.

关键词： Alzheimer’s disease ANK1 BIN1 DNA methylation epigenome-wide association studies HOXA3 MCF2L RHBDF2

ENsO impacts on litter stocks and water holding capacity in secondary forests in eastern Amazonia

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journal of Forestry Research 2024年第1期35卷 83-89页

作者： julia Isabella de Matos Rodrigues Walmer Bruno Rocha Martins Victor Pereira de Oliveira Myriam suelen da silva Wanzerley Hélio Brito dos santos júnior Francisco de Assis Oliveira Graduate Program in Forestry sciences Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil National Institute of Amazonia Research Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Among the impacts of climate change,there is the intensification of phenomena such as the El Niño south-ern Oscillation(ENsO)responsible for El Niño and La Niñ***,understanding their effects on the functional pro-cesses of forests is ***,this study evaluated the effects of ENsO on litter stock and water holding capac-ity(WHC)in a successional forest in eastern *** occurred in periods with the most rainfall in El Niño(2019)and least in La Niña(2021)*** permanent plots were used to sample *** effects were evident for WHC,higher during El Niñ***,this influence was not clear for litter,as only in the rainy season effects were *** was a positive correlation of WHC with precipitation and humidity,while litter stocks were negatively correlated with temperature and wind *** the subject of this study requires long-term assessments,preliminary results suggests that,depending on the intensity of ENsO,forest functional processes can be strongly impacted and *** conclusion reinforces warnings by the scientific community about the impacts of climate change on the maintenance of litter stocks,decomposition and,consequently,the biogeochemical cycle and essential ecosystem services for the maintenance of Amazonia *** need to develop long-term research to understand the effects of climatic change on litter stocks and water holding capacity is highlighted,especially in Amazonia.

关键词： seasonality Climate change succession ecosystem Biogeochemical cycle Amazonia biodiversity

Colorectal cancer screening:A review of current knowledge and progress in research

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World journal of Gastrointestinal Oncology 2024年第4期16卷 1119-1133页

作者： sara Ramos Lopes Claudio Martins Inês Costa santos Madalena Teixeira Élia Gamito Ana Luisa alves Department of Gastroenterology Centro Hospitalar de SetúbalSetúbal 2910-446Portugal

Colorectal cancer(CRC)is one of the most prevalent malignancies worldwide,being the third most commonly diagnosed malignancy and the second leading cause of cancer-related deaths *** the progress in screening,early diagnosis,and treatment,approximately 20%-25%of CRC patients still present with metastatic disease at the time of their initial ***,the burden of disease is still expected to increase,especially in individuals younger than 50 years old,among whom early-onset CRC incidence has been *** and early detection are pivotal to improve CRC-related *** is well established that CRC screening not only reduces incidence,but also decreases deaths from *** screening strategies have proven effective in decreasing both CRC incidence and mortality,though variations in efficacy have been reported across the ***,uncertainties persist regarding the optimal screening method,age intervals and ***,adherence to CRC screening remains globally *** recent years,emerging technologies,notably artificial intelligence,and non-invasive biomarkers,have been developed to overcome these ***,controversy exists over the actual impact of some of the new discoveries on CRC-related outcomes and how to effectively integrate them into daily *** this review,we aim to cover the current evidence surrounding CRC *** will further critically assess novel approaches under investigation,in an effort to differentiate promising inno-vations from mere novelties.

关键词： Colorectal cancer screening Review Oncology Artificial intelligence

Plant community on a volcano mountaintop reveals unique high-altitude vegetation in southeastern Brazil

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journal of Mountain science 2024年第9期21卷 3018-3030页

作者： Igor Musauer KEssOUs Ruy joséValka alves Nílber Gonçalves da sILVA Amilcar Walter sAPORETTI jUnior Biodiversity Laboratory Federal Institute of EducationScience and Technology of Southern Minas Gerais(IFSULDEMINAS)Av.Dirce Pereira Rosa300-Jardim Esperança37713-100Poços de CaldasMGBrazil Department of Botany National MuseumFederal University of Rio de JaneiroQuinta da Boa Vista s.n.São Cristóvão20949-040Rio de JaneiroRJBrazil Gothenburg Global Biodiversity Centre Carl Skottsbergs Gata 22BSE 41319GothenburgSweden

Mountains exhibit a high degree of endemism and diversity,however,quantifying their biodiversity can be *** to islands,species isolation in mountainous regions results in comparable patterns of evolution and extinction,rendering their biodiversity unique and highly susceptible to anthropogenic *** topographic relief in mountains plays a crucial role in creating habitat complexity,which in turn contribute to high plant ***,we investigated plant diversity in the volcano mountaintop vegetation on the Poços de Caldas Plateau,a region situated in the ecotone between the Atlantic Forest and Cerrado,characterized by natural radiation and significant anthropogenic *** employed an automated approach through the filtering of georeferenced and non-georeferenced data to obtain a list of plant species in the ***,we statistically investigated the similarity among different high-altitude vegetations belonging to the campos de altitude from the Atlantic Forest and campos rupestres from the *** plateau exhibits high plant diversity,including 1,659 specific and infraspecific taxa,especially belonging to Asteraceae and *** analyses suggest that geographical distance is a strong predictor of dissimilarity and that the Poços de Caldas Plateau is more floristically related to the campos rupestres,despite being associated with campos de *** region possesses a unique set of biodiversity,indicating that it may be a distinct ***,we hypothesize that Pleistocene events likely influenced the conformation of the current floristic composition in the region through species interchange between the Cerrado and Atlantic *** study also highlights the few taxa assessed for conservation status and anthropogenic threats that this habitat is facing.

关键词： Atlantic Forest Biogeography Cerrado Community ecology Grassland

Influence of biological maturation on cardiac autonomic recovery in female volleyball players during&after repeated sprints training:An experimental trial

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sports Medicine and Health science 2024年第3期6卷 279-286页

作者： Paulo Francisco de Almeida-Neto Fernanda Cristina silva de Oliveira jose Marcondes de Oliveira-júnior júlio Cesar Medeiros alves Matheus de Lima Rocha Iago Medeiros da silva Roberto Felipe C^amara Rocha Paulo Moreira silva Dantas Breno Guilherme de Araújo Tin^oco Cabral Health sciences Center Federal University of Rio Grande do NorteCCS-UFRNNatal59012-570RNBrazil Department of Physical Education Federal University of Rio Grande do NorteDEF-UFRNNatal59078-970RNBrazil

Previously,it was suggested that biological maturation(BM)could be linked to cardiac autonomic recovery(CAR)in the pediatric ***,this influence hasn’t been confirmed *** aim was to investigate the impact of BM on CAR in female volleyball *** study with a sample of 38 volleyball players,comprising 20 girls(age:[11.62.1]years)and 18 women(age:[24.55.5]years),we analyzed BM,comparing maturing subjects(girls)with mature subjects(women).Additionally,we assessed peak height velocity(PHV)in *** conducted a training session involving repeated sprints(3 rounds of 6 sprints interspersed by 5 min[min]of passive rest).Using short-range radio telemetry,we analyzed CAR during(at the end of the 1st and 2nd rounds)and after(following the 3rd round)the training session of repeated sprints by applying the 60-s to 300-s heart rate recovery index(HRR-Index).Girls exhibited superior CAR compared to women(round 2:60-s,120-s,240-s,and 300-s,psubgroup analyses of BM indicated that individuals in the Late-PHV stage demonstrated superior CAR compared to those in the Early-PHV and During-PHV groups.(60-s to 300-s,η2p>0.4,psubjects in the During-PHV stage were superior to those in the Early-PHV stage(240-sa 300-s,η2 p>0.4,ps a significant impact on cardiac autonomic recovery.

关键词： Exercise sport Volleyball Heart rate Pediatric

Generalized polynomial chaos expansion by reanalysis using static condensation based on substructuring

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 819-836页

作者： D.LEE s.CHANG j.LEE Department of Automotive Engineering Hanyang UniversitySeoul 04763Republic of Korea school of Mechanical Engineering Chungnam National UniversityDaejeon 34134Republic of Korea Department of Mechanical Robotics and Energy EngineeringDongguk UniversitySeoul 04620Republic of Korea

This paper presents a new computational method for forward uncertainty quantification(UQ)analyses on large-scale structural systems in the presence of arbitrary and dependent random *** method consists of a generalized polynomial chaos expansion(GPCE)for statistical moment and reliability analyses associated with the stochastic output and a static reanalysis method to generate the input-output data *** the reanalysis,we employ substructuring for a structure to isolate its local regions that vary due to random *** allows for avoiding repeated computations of invariant substructures while generating the input-output data *** substructuring with static condensation further improves the computational efficiency of the reanalysis without losing ***,the GPCE with the static reanalysis method can achieve significant computational saving,thus mitigating the curse of dimensionality to some degree for UQ under high-dimensional *** numerical results obtained from a simple structure indicate that the proposed method for UQ produces accurate solutions more efficiently than the GPCE using full finite element analyses(FEAs).We also demonstrate the efficiency and scalability of the proposed method by executing UQ for a large-scale wing-box structure under ten-dimensional(all-dependent)random inputs.

关键词： forward uncertainty quantification(UQ) generalized polynomial chaos expansion(GPCE) static reanalysis method static condensation substructuring