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孟鲁司特与布地奈德治疗咳嗽变异性哮喘患儿的效果及肺功能改善情况分析

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中外医疗 2024年第19期43卷 118-121页

作者：李巧特杨燕青李巧尔安溪县医院儿科福建泉州362400

目的分析咳嗽变异性哮喘(Cough Variant Asthma, CVA)患儿予孟鲁司特与布地奈德用药的效果及肺功能改善作用。方法随机选取2021年6月—2023年6月安溪县医院收治的80例CVA患儿为研究对象,结合随机数字表分为两组,各40例。对照组予布地... 详细信息

目的分析咳嗽变异性哮喘(Cough Variant Asthma, CVA)患儿予孟鲁司特与布地奈德用药的效果及肺功能改善作用。方法随机选取2021年6月—2023年6月安溪县医院收治的80例CVA患儿为研究对象,结合随机数字表分为两组,各40例。对照组予布地奈德单药治疗,观察组予布地奈德、孟鲁司特联合治疗。对比两组的咳嗽症状、肺功能、血清炎症指标以及用药安全性。结果治疗后,观察组日间及夜间咳嗽症状得分均低于对照组,各项肺功能指标值均高于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组血清白细胞介素-6、嗜酸性粒细胞水平均低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率为10.00%,高于对照组的5.00%,但差异无统计学意义(χ^(2)=0.180,P=0.671)。结论对CVA患儿予孟鲁司特与布地奈德联合治疗,可更有效缓解其咳嗽症状,改善肺功能,减轻机体炎症反应,且用药安全性较高。

关键词：咳嗽变异性哮喘孟鲁司特布地奈德肺功能

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超声弹性指数与美国甲状腺学会超声风险系统对甲状腺结节诊断效能的比较研究

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全科医学临床与教育 2024年第1期22卷 24-27页

作者：谢端儿周木雅陶浩然浙江中医药大学、杭州市萧山区第三人民医院超声科浙江杭州310053 海宁市人民医院医院超声科安吉县人民医院超声科

目的比较分析超声弹性指数与美国甲状腺学会(ATA)超声风险系统对甲状腺结节诊断效能。方法回顾性分析118例经术后病理检查确诊的甲状腺结节患者临床资料,所有患者均行超声弹性指数、ATA超声风险系统评估,以术后病理结果为“金标准”,... 详细信息

目的比较分析超声弹性指数与美国甲状腺学会(ATA)超声风险系统对甲状腺结节诊断效能。方法回顾性分析118例经术后病理检查确诊的甲状腺结节患者临床资料,所有患者均行超声弹性指数、ATA超声风险系统评估,以术后病理结果为“金标准”,分析超声弹性指数联合ATA超声风险系统对甲状腺结节诊断效能。结果经术后病理结果检查显示,118例患者中,共146个结节,良性结节98个,占比67.12%,恶性结节48个,占比32.88%。以术后病理结果作为“金标准”,经超声弹性指数诊断显示,误诊16个,漏诊10个,Kappa=0.54;经ATA超声风险系统诊断显示,误诊8个,漏诊4个,Kappa=0.83;经超声弹性指数与ATA超声风险系统联合诊断显示,误诊4个,漏诊2个,Kappa=0.94;两种方法联合诊断甲状腺结节良恶性的灵敏度、准确度高于单独采用超声弹性指数检查(χ~2分别=6.61、5.42,P均<0.05)。结论超声弹性指数与ATA超声风险系统均对甲状腺结节具有一定的诊断效能,但两者联合诊断可弥补单一诊断中的缺点与不足,诊断效能较高,可为甲状腺结节诊断病变性质的判定提供有效判定依据。

关键词：甲状腺结节超声弹性指数美国甲状腺学会超声风险系统诊断效能

护理风险管理对呼吸内科护理人员工作能力的影响探究与讨论

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中国卫生产业 2024年第4期21卷 96-98,102页

作者：张冬梅李楚儿莫明珊广州市第十二人民医院呼吸科广东广州510620 中山大学孙逸仙纪念医院ICU 广东广州510120

目的分析护理风险管理对呼吸内科护理人员工作能力的影响。方法选取2023年1—12月广州市第十二人民医院和中山大学孙逸仙纪念医院呼吸内科工作的15名护理人员为研究对象,于2023年1—6月实施传统管理模式(对照组),于2023年7—12月实施护... 详细信息

目的分析护理风险管理对呼吸内科护理人员工作能力的影响。方法选取2023年1—12月广州市第十二人民医院和中山大学孙逸仙纪念医院呼吸内科工作的15名护理人员为研究对象,于2023年1—6月实施传统管理模式(对照组),于2023年7—12月实施护理风险管理(观察组),对比两组应用效果。结果观察组的理论知识、技能操作、工作积极性、工作态度、风险防护能力、随机应变能力、对话沟通能力和护理管理能力评分均高于对照组,不良事件发生率明显低于对照组,差异有统计学意义(P均<0.05)。结论在呼吸内科护理人员中实施护理风险管理,可丰富护理人员医疗知识储备,提高其工作能力。

关键词：护理管理风险管理工作能力风险事件呼吸内科

Influence of systemic immune and cytokine responses during the acute phase of zoster on the development of postherpetic neuralgia

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2009年第8期10卷 625-630页

作者： sheng-mei ZHU Yong-min LIU er-dan AN Qing-lian CHEN Department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Anesthesiology the Second People's Hospital Jiaxing 314000 China

Postherpetic neuralgia(PHN) is a severe sequela of herpes zoster(HZ).Until now,only age and pain severity were considered predisposing factors for the development of *** evaluated 49 patients with acute phase HZ,10 of whom developed PHN(Group A) and 39 of whom did not develop PHN(Group B).Twenty-five healthy volunteers similar in age and gender distribution to the study group were recruited as controls(Group C).Numbers of serum CD3+(pan-T lymphocytes),CD4+(helper/inducer),and CD8+(suppressor/cytotoxic) lymphocytes were decreased significantly in Groups A and B relative to the control group,but there were no statistical differences between Groups A and ***(IL)-1β,IL-6,tumor necrosis factor(TNF)-α,IL-8,and IL-10 were significantly elevated in Groups A and B relative to Group ***-6 was significantly higher in Group A than in Group B,and was significantly positively correlated with pain severity scored on a visual analog ***,we suggest that the inflammatory response,especially that of IL-6,in the acute phase of HZ may be associated with hyperalgesia and the development of PHN.

关键词： T lymphocyte Cytokines Postherpetic neuralgia (PHN) Herpes zoster (HZ)

Optimization of hot-air microwave combined drying control system based on air outlet temperature and humidity monitoring

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International Journal of Agricultural and Biological Engineering 2021年第4期14卷 255-261页

作者： Fujie Zhang Anqi’er Hu Ruikai song Lixia Li Faculty of Agriculture and Food Kunming University of Science and TechnologyKunming 650500China Mechanization Engineering Research Center of Yunnan Province Colleges and Universities Kunming 650500China

Microwave drying is one of the most important drying methods in *** online measurement and control of material dried,as a challenging research issue,is helping to improve the drying quality of the final product and the energy utilization efficiency of microwave *** order to realize the online measurement of temperature in microwave drying,a detection strategy was based on the temperature and humidity monitoring at the air outlet of coupling hot air and microwave drying *** programming software was employed to collect the temperature and humidity signal value at the outlet of the dryer to estimate the drying degree of the *** to the amount of moisture removal in real-time,the microwave input power was adjusted gradually in the microwave drying *** potato as material dried,the microwave power of microwave and hot air coupling drying is monitored to realize the real-time *** results showed that the total color difference value of the product of 3.09,the rehydration ratio of 2.92,the unit energy consumption of 17419.35 kJ/kg,and the drying rate of 0.442 g/s were *** minimum comprehensive weighted score of the product was *** with the orthogonal experiment,the optimal drying process was obtained as the total color difference value of the product of 2.84,the rehydration ratio of 3.01,the unit energy consumption of 17419.35 kJ/kg,and the drying rate of 0.397 g/*** minimum comprehensive weighted score of the product was 20.67,and the difference was not *** control strategy not only solves the non-uniform phenomenon of drying,and makes the microwave drying real-time and continuous,but also improves the drying efficiency and quality.

关键词： microwave drying temperature humidity control power potato

Numerical Analysis of Emergency River Restoration scheme for Qingping Mega Debris Flow

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Journal of Mountain science 2013年第1期10卷 130-136页

作者： CHEN Ri-dong LIU Xing-nian HUANG er GUO Zhi-xue state Key Laboratory of Hydroscience and Engineering Tsinghua University state Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

The mega debris flow occurred on August 13 th 2010 in Qingping town,China(hereafter called '8.13' Debris Flow) have done great damage to the local habitants as well as to the re-construction projects in the quake-hit areas,and the channel-fill deposit problem caused by the debris flow was the most ***,it is of high possibility that an even severe deposit problem would reappear and result in worse *** order to maximize risk reduction of this problem,relevant departments of the government established a series of emergency river restoration schemes,for which the numerical analysis is an important procedure to evaluate and determine the optimized *** study presents a numerical analysis by applying a twodimensional debris flow model combined with a relevant water-sediment model to simulate the deposit during the progress of the debris flow,and to calculate and analyze the river flow field under both the present condition and different restoration *** results show that the debris flow model,which takes the confluence of the Wenjia Gully to the main river into account,could simulate the deposit process quite *** the reproduced debris flow from the simulation of the '8.13' Debris Flow,the original river flow path has switched to a relatively lower place just along the right bank with a high speed of near 7m.s-1 after being blocked by the deposit,which is highly *** prevent this hazard,a recommended scheme is derived through inter-comparison of different restoration *** shows that the recommended scheme is able to reduce the water level and as well to regulate the flow *** on the given conditions of the mainstream and the tributary confluence for the simulated '8.13' Debris Flow,when encountering a debris flow with deposit volume less than 0.5 million m3,the river channel can endure a 20-year return flood;however,when the deposit volume increases to 2 million m3,the flood capacity of the river will be

关键词： Flash flood Debris flow River restoration Numerical analysis Finite element method

The efficacy and safety of pramipexole er versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study

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Translational Neurodegeneration 2014年第1期3卷 80-88页

作者： Ying Wang shenggang sun suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel shengdi Chen for the Pramipexole er study Team Ruijin Hospital affiliated to shanghai Jiao Tong University school of Medicine ShanghaiChina Union Hospital affiliated to Tongji Medical College of Huazhong University of science and Technology WuhanChina Tongji Hospital affiliated to Tongji Medical College of Huazhong University of science and Technology WuhanChina The second Affiliated Hospital of soochow University SuzhouChina Qilu Hospital affiliated to shandong University JinanChina Nanjing Brain Hospital NanjingChina West China Hospital affiliated to sichuan University ChengduChina First Affiliated Hospital of China Medical University ShenyangChina Boehringer Ingelheim International Trading(shanghai)Co LtdShanghaiChina Boehringer Ingelheim Pharmaceuticals IncRidgefieldCTUSA Boehringer Ingelheim France s.A.s ReimsFrance Department of Neurology Ruijin Hospital affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina 不详

Objective:To evaluate the non-inferiority of pramipexole extended-release(er)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group ***:subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-*** received treatment with pramipexole er(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRs(Parts II+III)total ***:For the primary endpoint,the adjusted mean changes(standard error)of UPDRs Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for er and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole er and IR was *** incidence of adverse events(AEs)was 68.8%in the er arm and 73.6%in the IR arm with few severe AEs(er:2.1%;IR:3.8%).Conclusion:Based on the UPDRs II+III score,pramipexole er was non-inferior to pramipexole *** safety profiles of pramipexole er and IR were *** results were based on comparable mean daily doses and durations of treatment for both formulations.

关键词： Parkinson’s disease Pramipexole er Pramipexole IR Non-inferiority Unified Parkinson’s Disease Rating scale(UPDRs) safety

Numerical analysis of supersonic jet flow and dust transport induced by air ingress in a fusion reactor

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Nuclear science and Techniques 2021年第7期32卷 72-82页

作者： Bu-er Wang shi-Chao Zhang Zhen Wang Jiang-Tao Jia Zhi-Bin Chen Institute of Nuclear Energy safety Technology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of science and Technology of China Hefei 230026China

During a loss of vacuum accident(LOVA),the air ingress into a vacuum vessel(VV)may lead to radioactive dust resuspension,migration,and even explosion,thereby posing a great threat to the safe operation of future fusion reactors;thus,it is crucial to understand the flow characteristics and radioactive dust transport behavior induced by ***,only a few studies have identified the characteristics of the highly under-expanded jet flow at a scale of milliseconds during ***,the occurrence and behavior of a Mach disk is yet to be captured in existing *** this study,we used a more advanced model with a finer mesh and adaptive mesh strategies to capture the Mach disk in a VV during *** detail,a computational fluid dynamics–discrete phase model one-way coupled multiphase approach was established using the computational fluid dynamics code ANsYs FLUENT and applied to the analysis during the first seconds of *** results showed that air ingress into the VV behaved like a highly free under-expanded jet at the initial stage and Mach disk was formed at~6 ***,the flow field dramatically changed at the position of the Mach *** jet core before the Mach disk had a maximum velocity of~8 Mach with the corresponding lowest static pressure(~100 Pa)and temperature(few tens of K).The friction velocities in the lower part of the VV,which is an area of concern due to dust deposition,were generally larger than 15 m/s near the inlet ***,the crude prediction of the particle trajectories demonstrated the spiral trajectories of the dust following the air ***,this study provided a basis for further safety analysis and accident prevention related to dust transport and explosion in future fusion reactors.

关键词： supersonic jet Radioactive dust Loss of vacuum accident Mach disk Friction velocity

Impacts of formal credit on rural household income:Evidence from deprived areas in western China

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Journal of Integrative Agriculture 2021年第4期20卷 927-942页

作者： CHEN si LUO er-ga Lita ALITA HAN Xiao NIE Feng-ying College of Mathematics and Informatics South China Agricultural UniversityGuangzhou 510642P.R.China Department of Agricultural Economics and Management School of Public AffairsChina Academy for Rural Development(CARD)Zhejiang UniversityHangzhou 310000P.R.China Environmental Policy Group Wageningen UniversityHollandseweg 16706KN Wageningen China Agricultural science and Technology Press Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Agricultural Information Institute Chinese Academy of Agricultural SciencesBeijing 100081P.R.China

Financial support is a crucial part of China's poverty alleviation ***,it is vital to understand how formal credit impacts income growth in rural *** 2012,2015,and 2018,a survey was conducted to obtain a panel dataset of 592 rural households from 6 poverty-stricken counties in western China,including counties in Guizhou,Yunnan,and shaanxi *** use the data to examine the effect of formal credit on rural household income and the mechanism that underlies this *** find that formal credit can significantly increase rural households'income in deprived areas in western ***,formal credit promotes the reallocation of household labor from the agricultural sector to the non-agricultural sector and changes rural households'decisions about investment-consumption *** are the drivers of changes in the amount and structure of household *** analyses show that formal credit may widen income inequality among rural households in western China's deprived *** individual characteristics of rural households,such as different levels of material capital,human capital,and social capital,bring about differences in the effects of formal credit on income *** study emphasizes that the implementation of formal credit is an essential strategy for poverty alleviation in underdeveloped areas,but policymakers should not excessively interfere with the financial market.

关键词： formal credit rural household income rural finance poverty-stricken areas in western China