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IGRT技术在肺癌sBRT治疗靶区位置误差测定中的应用

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中国临床医学 2016年第6期23卷 841-845页

作者：王昌民胡伟刚彭佳元蔡旭伟傅小龙许青复旦大学附属肿瘤医院放疗科复旦大学上海医学院肿瘤学系上海200032 上海交通大学附属胸科医院放疗科上海200030

目的:探讨图像引导放射治疗(image guided radiation therapy,IGRT)技术在测定并校正肺部恶性肿瘤体部立体定向放射治疗(stereotactic body radiation therapy,sBRT)过程中靶区位置误差的意义。方法:选择复旦大学附属肿瘤医院收治的14... 详细信息

目的:探讨图像引导放射治疗(image guided radiation therapy,IGRT)技术在测定并校正肺部恶性肿瘤体部立体定向放射治疗(stereotactic body radiation therapy,sBRT)过程中靶区位置误差的意义。方法:选择复旦大学附属肿瘤医院收治的14例肺部恶性肿瘤并接受sBRT的患者。每次治疗前后均进行千伏级锥形束CT(kv-CBCT)扫描,与计划CT图像进行在线配准,校正误差后进行治疗。治疗后再次进行CBCT扫描并配准。分别记录治疗前后靶区位置误差。根据临床靶区(CTv)-计划靶区(PTv)外放公式mPTv(外放)=2.5Σ+0.7σ计算PTv外扩大小。结果:治疗前靶区位置左右、头脚、腹背方向误差最大值分别为10.0mm、16.9mm、8.7mm,误差平均值分别为(2.4±2.8)mm、(3.4±4.6)mm、(2.9±3.4)mm。在线校正并治疗后,靶区位置左右、头脚、腹背方向的误差最大值分别为7.6mm、4.6mm、7.0mm,误差平均值分别为(2.1±2.0)mm、(1.5±1.6)mm、(1.7±2.0)mm。无图像引导PTv外扩大小为左右7.96mm、头脚11.72mm、腹背9.63mm,有图像引导并在线校正PTv外扩大小为左右6.65mm、头脚4.87mm、腹背5.65mm。结论:IGRT技术可即时校正sBRT治疗前由摆位引起的靶区位置误差,并测定治疗过程中的靶区位置移动,能提高治疗精度,并有助于PTv外扩的制定。

关键词：图像引导放射治疗体部立体定向放射治疗误差计划靶区

DA加v_m26方案治疗难治性急性髓细胞性白血病15例临床观察

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实用医技杂志 1998年第12期5卷 908-908页

作者：刘小线刘凤娟山西铝厂职工医院河津043300

DA(柔红霉素、阿糖胞苷)加v_(m26)(鬼臼噻吩甙)治疗难治性急性髓细胞性白血病(AmL)15例,完全缓解(CR)12例(80.0％),CR12例中有8例仅用1个疗程即达CR。远期疗效仍在观察中。DA加v_(m26)方案骨髓抑制严重,持续时间长,支持治疗重要。v_m26... 详细信息

DA(柔红霉素、阿糖胞苷)加v_(m26)(鬼臼噻吩甙)治疗难治性急性髓细胞性白血病(AmL)15例,完全缓解(CR)12例(80.0％),CR12例中有8例仅用1个疗程即达CR。远期疗效仍在观察中。DA加v_(m26)方案骨髓抑制严重,持续时间长,支持治疗重要。v_m26通过阻断DNA拓扑酶Ⅱ,使细胞群不进入有丝分裂期,阻断在G_2期起到抗癌作用。高CR率原因可能同v_(m26)与A_(rac)的协同作用有关。

关键词：白血病阿糖胞苷鬼臼噻吩甙髓细胞性急性

Biotransformation and degradation of 2,4,6-trinitrotoluene by microbial metabolism and their interaction

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高效液相色谱-串联质谱法测定人血浆中多尼培南的浓度

Defence technology 2018年第2期 151-164页

作者： mónica Y. serrano-González Rashmi Chandra Carlos Castillo-Zacarias Felipe Robledo-Padilla magdalena de J. Rostro-Alanis Roberto Parra-saldivar Tecnologico de monterrey，school of Engineering and science，Campus monterrey

2,4,6-trinitrotoluene(TNT) and its derivatives are nitrogen-containing aromatic compounds having chemical and thermal stability at ambient temperature and pressure. TNT has high toxicity and mutagenic activity to humans, plants and animals, thus decontamination processes are necessary. many microorganisms are capable to bioremediate TNT such as bacteria from the genera Pseudomonas,Enterobacter, Rhodococcus, mycobacterium, Clostridium and Desulfovibrio: fungus such as Phanerochate and stropharia species are able to perform TNT biotransformation under aerobic and anaerobic conditions. In this work we review the state of TNT biodegradation by various routes: aerobic, anaerobic,combined, fungal, enzymatic, and bio-electrochemical.

关键词： LACCAsEs AEROBIC DEGRADATION Anaerobic DEGRADATION FUNGAL TNT DEGRADATION

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中国新药与临床杂志 2009年第5期28卷 380-384页

作者：唐红英刘江慧邹建军季宏建吴定伟娄晟湖南省邵阳市第一人民医院药剂科湖南邵阳422001 南京医科大学附属南京第一医院国家药物临床试验机构江苏南京210006 南京医科大学药学院江苏南京210029 浙江仙琚制药股份有限公司浙江台州317300

目的建立高效液相色谱-质谱联用(LC-ms-ms)法测定人血浆内多尼培南浓度的方法。方法采用Agilent Zorbax C18(2.1mm×150mm,5μm)色谱柱;柱温25℃;流动相为甲醇-水(含10mmol·L-1乙酸铵)(32∶68,v/v);流速为0.2mL·min-1;通过LC-ms-ms,电喷雾离子源(EsI),以多反应监测(mRm)方式进行检测;离子极性监测负离子(-);检测离子为多尼培南m/z419.8[m-H]-→331.4[m-H-C4H7O2]-,法罗培南(内标)m/z284.2[m-H]-→196.1[m-H-C4H7O2]-。结果多尼培南的最低定量限为3.003μg·L-1,线性范围为3.003～10010μg·L-1(r=0.9982)。结论该方法简便、灵敏度高,可以用来进行多尼培南的人体药动学和生物等效性研究。

关键词：多尼培南血浆色谱法高压液相光谱法质量电喷雾电离

芸苔族6种油料作物与油菜萝卜胞质不育系杂交的亲和性研究

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西南农业学报 2001年第1期14卷 38-42页

作者：魏琴潘裕峰周黎军陈东林周锦霞李旭峰陈放宜宾师范高等专科学校四川宜宾644007 长宁县农业局四川宜宾644000 宜宾农业学校四川宜宾644003 四川大学生命科学学院四川成都610064

对芸苔族 6种油料作物与油菜萝卜胞质不育系 (OguCms)杂交时花粉行为及柱头胼胝质反应情况进行了研究。结果表明 ,花粉行为及柱头胼胝质反应情况与杂交亲和性有关。各父本与OguCms杂交时亲和性各异 ,花粉萌发时受阻部位不同。 (1)OguCm... 详细信息

对芸苔族 6种油料作物与油菜萝卜胞质不育系 (OguCms)杂交时花粉行为及柱头胼胝质反应情况进行了研究。结果表明 ,花粉行为及柱头胼胝质反应情况与杂交亲和性有关。各父本与OguCms杂交时亲和性各异 ,花粉萌发时受阻部位不同。 (1)OguCms×“浠水白” ,OguCms×蓝花子有较大的亲和性 ,受阻部位在胚囊 ;(2 )OguCms×芝麻菜其亲和性次之 ,受阻部位在柱头 ;(3)OguCms×毛果诸葛菜 ,OguCms×海甘蓝亲和性更弱 ,受阻部位在乳突细胞 ;(4)OguCms×黑芥亲和性最弱。

关键词：芸苔族油菜萝卜胞质不育系杂交亲和性花粉行为柱头胼胝质反应油料作物

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KLN晶体生长与蓝光sHG特性

人工晶体学报 2000年第S1期29卷 9-页

作者： CHONG Tow chong 1 , XU Xue wu 1, ZHANG Guang yu 1, H.Kumagai 2, m.Hirano 2 (1.Data storage Institute,DsI Building,5 Engineering Drive 1(off Kent Ridge Crescent,NUs),singapore 117608,singapore 2.Research Center,Asahi Glass Co.Ltd.,1150 Haza

In this paper,ferroelectric tetragonal tungsten bronze type potassium lithium niobate(KLN)crystal with a size of 20mm×8mm×43mm was grown from a melt with a composition of 32mol% K 2CO 3,24mol% Li 2CO 3 and 44mol% Nb 2O 5 by the top seeded solution growth (TssG)*** KLN crystal as grown along [110]axis has a perfect crystal melt interface dominated by {110} and {210} *** constants were measured by X ray diffraction (XRD) analysis performed on {001}and {110}natural faces of single crystal *** anisotropic thermal expansion behavior of the crystal was also studied along [001] and [110] axes,respectively by using a shimadzu TmA 50 thermomechnical *** the purpose of crystal poling,the dependence of crystal capacitance *** in both heating and cooling cycles was measured and the ferroelectric Curie temperature was determined to be 514℃.The crystal was poled at 506℃ with a dc field of about 250 v/cm along the c axis of the sample,for a time corresponding to about 1.5 h/*** blue second harmonic generation (sHG)characteristics of the KLN crystal were investigated by using a 3900s Ti∶sapphire CW tunable *** laser light at wavelength 432nm was obtained by the non critical phase matching (NCPm)sHG at room *** on the wavelength and temperature tuning curves for the NCPm sHG,the wavelength acceptance and temperature acceptance of this KLN crystal were *** crystal property homogeneity along the growth axis was also studied by measuring the room temperature NCPm wavelength at different growth positions.

关键词： nonlinear optical crystal potassium lithium niobate crystal top seed solution growth method

sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam shakeel Ahmad Rizwan Ahmed sebastiano Aiello muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan marco Bellato Antonio Bergnoli Thilo Birkenfeld sylvie Blin David Blum simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich marcos Dracos Frédéric Druillole Ran Du shuxian Du stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Nunzio Giudice maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel marco Grassi vasily Gromov minghao Gu Xiaofei Gu Yu Gu mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico santa maria ValparaisoChile Beijing Institute of spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina school of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of sciences BeijingChina Jilin University ChangchunChina College of Electronic science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of south China HengyangChina Wuyi University JiangmenChina shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of science and Technology ShanghaiChina school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina school of Physics and microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

CEPC Technical Design Report

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Radiation Detection Technology and methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib mustafa Ashry sha Bai Yu Bai Yang Bai vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay shou-shan Bao Desmond P.Barber Ayse Bat varvara Batozskaya subash Chandra Behera Alexander Belyaev michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter michela Biglietti shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov serge Bondarenko stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti vincent Boudry mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen mali Chen mingjun Chen mingshui Chen Ning Chen shanhong Chen shanzhen Chen shao-Long Chen shaomin Chen shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De mori Chiara De sio Elisa Del Core shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di micco Ran Ding siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central south University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu Kaitengsifang Digital Radio&Tv Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPm(AmU/IPhU&CNRs/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-synchrotron DEsY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 Gev Linac,a 1.1 Gev Damping Ring,a Booster capable of achieving energies up to 180 Gev,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential super Proton Proton Collider(sPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(sR)power of 30 mW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the sR power to 50 mW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam shakeel Ahmad Rizwan Ahmed sebastiano Aiello muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan marco Bellato Antonio Bergnoli Thilo Birkenfeld sylvie Blin David Blum simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich marcos Dracos Frédéric Druillole 杜然杜书先 stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Agnese Giaz Nunzio Giudice maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel marco Grassi Christian Grewing vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han muhammad sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of science and Technology ShanghaiChina University of science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN sezione di milano and Dipartimento di Fisica dell Universitàdi milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN milano Bicocca and University of milano Bicocca MilanoItaly INFN sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina sUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN sezione di Padova PadovaItaly University of Roma Tre and INFN sezione Roma Tre RomaItaly Aix marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN milano Bicocca and Politecnico of milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina sun Yat-sen University GuangzhouChina Beijing Institute of spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector