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Comparison of two different treatment regimens’ efficacy in neovascular age-related macular degeneration in Turkish population—based on real life data-Bosphorus rWE study Group

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 104-111页

作者： Burak Erden selim Bolükbasi Abdullah Ozkaya Levent karabas Cengiz Alagoz Zeynep Alkin Ozgür Artunay sadik Etka Bayramoglu Gokhan Demir Mehmet Demir Ali Demircan Gürkan Erdogan Mehmet Erdogan Erdem Eris Havva kaldirim Ismail Umut Onur Ozen Ayranci Osmanbasoglu sezin Ozdogan Erkul Mine Oztürk Irfan Perente kübra sarici Nihat sayin Dilek Yasa Ihsan Yilmaz Zeynep Yilmazabdurrahmanoglu 无 Ophthalmology Clinic Okmeydani Training and Research Hospital Ophthalmology Clinic Memorial Sisli Hospital Department of Ophthalmology Kocaeli University Faculty of Medicine Ophthalmology Clinic Beyoglu Eye Training and Research Hospital Ophthalmology Clinic Kanuni Sultan Süleyman Training and Research Hospital Ophthalmology Clinic Sisli Etfal Training and Research Hospital Ophthalmology Clinic Bagcilar Training and Research Hospital Ophthalmology Clinic Bakirkoy Dr.Sadi Konuk Training and Research Hospital Ophthalmology Clinic Istanbul Training and Research Hospital1 Ophthalmology Clinic Haseki Training and Research Hospital Bosphorus retina study Group

AIM: To compare two different anti-vascular endothelial growth factor(anti-VEGF) treatment regimens'-a priori pro re nata(PrN) and PrN regimen following^(th)e loading phaseanatomical and functional results in neovascular agerelated macular degeneration(n AMD) patients. METHODs: Totally 544 n AMD patients followed and treated with aflibercept(n=135) and ranibizumab(n=409)at 9 different centers between 2013 and 2015 were enrolled into^(th)is retrospective multicenter study. Patients with initial best corrected visual acuity(BCVA) interval of 1.3-0.3(log mar) and a minimum follow-up of 12 mo were included. Patients under two different regimens-a priori pro re nata(1+PrN) or 3 consecutive intravitreal injections followed by a PrN regimen(3+PrN)-were compared in BCVA at 3^(th), 6^(th) and 12^(th) months, and in central macular^(th)ickness(CMT) at 6^(th) and 12^(th) months. The total study group, intravitreal ranibizumab(IVr) and intravitreal aflibercept(IVA) groups were evaluated separately. rEsULTs: The mean CMT decreased in^(th)e 1+PrN(n=101) regimen from 407 to 358 and 340 μm and in^(th)e 3+PrN(n=443) group from 398 to 318 and finally to 310 μm at months 6 and 12, respectively. Anatomically,^(th)e CMT reduction at 6^(th) month(48.5 vs 76.4;Ps statistically significant in favor of 3+PrN group. BCVA changed in 1+PrN group from 0.77 to 0.78, 0.75 and 0.75;in 3+PrN group from 0.81 to 0.69, 0.72, and 0.76 at months 3, 6, and 12, respectively. Visual gain was statistically better in 3+PrN group at 3^(th) month(-0.01 vs 0.12;Pr group, CMT reduction was in greater in 3+PrN at 6^(th)(44 vs 72) and 12^(th) month(61 vs 84), but statistically insignificant. The 3+PrN group revealed statistically better visual results at 3^(th) month(-0.02 vs 0.11, Proup, although statistically insignificant, CMT reduction(61 vs 89, 6^(th) month;85 vs 97, 12^(th) month) and visual gain(0.02 vs 0.16;0.02 vs 0.14;0.05 vs 0.11) was found in favor of 3+PrN group

关键词： aflibercept neovascular age-related macular degeneration ranibizumab loading dose treatment regimen

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关于马氏积分逼近法

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数学学报 1953年第2期 148-153页

作者：徐利治东北人民大学数学系

1.在光学上为了研究光像内光的分布,maréchal 曾设计了一种机械的积分仪,此种积分仪系根据亚几米德螺缐γ=αφ(0≤γ≤r)上的曲线积分2πα(?)_cf(γ,φ)ds 来逼近于圆形域上的重积分(?)f(γ,φ)γdrdφ.Wilkins曾在一个短文中,利用... 详细信息

1.在光学上为了研究光像内光的分布,maréchal 曾设计了一种机械的积分仪,此种积分仪系根据亚几米德螺缐γ=αφ(0≤γ≤r)上的曲线积分2πα(?)_cf(γ,φ)ds 来逼近于圆形域上的重积分(?)f(γ,φ)γdrdφ.Wilkins曾在一个短文中,利用富氏级数(C,1)求和理论证示此种逼近方法的合理,其结果即:若f(γ,φ)是一个在0≤γ≤r,0≤φ<2π上连续的函数,且是φ的周期函数,周期为2π.则有(?)很明显地,从(1)式两端积分号下取消因子γ亦无不可,这只需作代换ρ=γ~2,dρ=2γdγ即得.又如取

关键词：逼近法徐利治计算方法单位圆

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