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早产儿语言发展的影响因素及其干预对策

生物化学与生物物理进展 2024年第6期51卷 1292-1304页

作者：洪恬张琴芬范娇娇上海交通大学人文学院上海200030 南通大学附属常州儿童医院儿童健康研究中心常州213003

早产儿的语言发展受到多种因素的影响,可能导致他们在词汇、语法、语音等方面出现发展滞后或障碍。本文首先简述了影响早产儿语言发展的生物学和环境因素的研究进展,其中生物学因素包括早产程度、体重和性别、新生儿发病率和疾病严重程... 详细信息

早产儿的语言发展受到多种因素的影响,可能导致他们在词汇、语法、语音等方面出现发展滞后或障碍。本文首先简述了影响早产儿语言发展的生物学和环境因素的研究进展,其中生物学因素包括早产程度、体重和性别、新生儿发病率和疾病严重程度等,环境因素则包括新生儿重症监护室的环境、家庭中的语言环境和社会因素等。在明确这些影响因素的基础上,本文强调了早期评估和早期干预是优化早产儿语言发育效果的关键步骤,并分析了具体的干预对策,例如生理和神经干预、优化新生儿重症监护室(NICU)环境、增强家庭语言互动、多学科合作和社会支持等。此综述旨在探讨影响早产儿语言发展的各种因素,并总结出有效的早期干预措施,为其提供更为全面的语言发展支持。

关键词：早产儿语言发展生物和环境因素早期干预

Relationship between Kawasaki disease and abdominal pain

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World Journal of Clinical Cases 2024年第17期12卷 2932-2934页

作者： Yan Pan Fu-Yong jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina shaanxi Kawasaki Disease Diagnosis and Treatment Center Children's HospitalShaanxi Provincial People's Hospital of Xi'an Jiaotong UniversityXi'an 710000Shaanxi ProvinceChina

This editorial presents an analysis of an article recently published in the World Journal of Clinical *** disease(KD)is a well-known pediatric vasculitis characterized by fever,rash,conjunctivitis,oral mucosal changes,and swelling of the *** editorial aims to delve into the intricate relationship between KD and abdominal pain,drawing insights from recent research findings to provide a comprehensive understanding and potential avenues for future investigation.

关键词： Kawasaki disease Abdominal pain Relationship Research Investigation

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平台“二选一”与反垄断

系统工程理论与实践 2024年第1期44卷 29-51页

作者：沈波焦倩孙祥武汉大学经济与管理学院武汉430072 中山大学岭南学院广州510275 武汉大学经济发展研究中心、高级研究中心、经济与管理学院武汉430072

本文通过考虑平台企业之间和卖家之间的不完全竞争,研究非对称平台企业实施“二选一”行为的动机,并系统分析其对市场竞争、消费者和福利的影响.研究发现,只有当平台之间差异化足够小以及卖家之间同质性较强时,具有市场优势地位的平台... 详细信息

本文通过考虑平台企业之间和卖家之间的不完全竞争,研究非对称平台企业实施“二选一”行为的动机,并系统分析其对市场竞争、消费者和福利的影响.研究发现,只有当平台之间差异化足够小以及卖家之间同质性较强时,具有市场优势地位的平台企业才能通过与卖家签订“二选一”形式的排他性合约从而排除其竞争对手.此时,“二选一”行为将通过提高平台制订的佣金水平,进而提高卖家商品的价格,并最终降低消费者剩余以及社会总福利.因此,禁止平台实施“二选一”可以提高消费者剩余以及总福利水平,尽管未必增加卖家与竞争平台的利润.这说明禁止平台使用“二选一”等排他性交易的初衷不应是保护卖家或者小型竞争性平台,而是维护消费者权益以及保障平台市场的效率.本文的结论为平台“二选一”的反竞争效应的判定提供了理论支持,同时为平台经济领域中此类行为的规制提供了实践指导.反垄断实践中是否应当将优势平台“二选一”行为判定为其滥用市场支配地位,除了重点关注平台的差异化程度以及卖家之间的竞争程度外,还需要综合考虑平台内卖家的数量、平台“二选一”合约的形式以及平台披露的合约信息等因素.

关键词：平台经济 “二选一”行为排他性交易反垄断

Rethinking Kawasaki disease diagnosis:Continuing the search for new biomarkers

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World Journal of Clinical Cases 2024年第30期12卷 6346-6348页

作者： Yan Pan Fu-Yong jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina shaanxi Kawasaki Disease Diagnosis and Treatment Center Children's HospitalShaanxi Provincial People's Hospital of Xi'anJiaotong UniversityXi'an 710000Shaanxi ProvinceChina

Recent findings by Yamashita et al report a Kawasaki disease(KD)case with normal biomarker levels,challenging traditional diagnostic *** editorial explores the implications of such atypical KD presentations,emphasizing the need for novel biomarkers and revised diagnostic *** case underscores the limitations of current biomarkers,the importance of clinical judgment,and the necessity for comprehensive research to identify new diagnostic *** technologies in proteomics and genomics offer potential avenues for discovering reliable *** clinical guidelines to incorporate flexibility for atypical presentations is *** timely and accurate KD diagnosis,even without elevated traditional biomarkers,prevents severe *** advancements should focus on novel biomarkers to improve patient outcomes.

关键词： Kawasaki disease Diagnostic criteria Guide line Biomarker Technologies

基于效果定价模式的网络直播广告定价决策研究

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管理工程学报 2024年第1期38卷 193-204页

作者：李莉胡娇南京理工大学经济管理学院江苏南京210094

网络直播广告作为一种新型营销方式快速发展,优化直播广告运营主体努力水平及定价策略是一项值得深入研究的课题。本文基于广告投放效果的两种定价模式,构建了包含两个广告商和一个主播的网络直播广告定价决策模型,探索广告商与主播的... 详细信息

网络直播广告作为一种新型营销方式快速发展,优化直播广告运营主体努力水平及定价策略是一项值得深入研究的课题。本文基于广告投放效果的两种定价模式,构建了包含两个广告商和一个主播的网络直播广告定价决策模型,探索广告商与主播的最优努力水平选择及广告定价策略。研究发现:CPW(cost per watch)定价模式下,广告商承担了消费者是否购买的不确定性风险,当消费者敏感性系数偏低时,广告商会提交较低的出价,且B/D两类广告商赢得竞拍的概率相等;对比CPW模式,在CPA(cost per action)定价模式下广告商的努力水平更低,且CPA定价模式中B型(品牌型)广告商赢得竞拍的概率更大,但赢得竞拍的广告商边际利润往往较低;与广告商相反,主播在CPA定价模式下的收益大于CPW,且随消费者敏感性系数的增加,两种定价模式下的收益差逐渐增大;CPW定价模式下预期观看直播的用户量和购买率均高于CPA,网络直播市场倾向于从CPW广告定价合同中获得较大收益。

关键词：直播广告定价模式努力水平广告决策

Regulated reaction pathway of CO_(2)photoreduction into CH_(4)by metal atom pair sites

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Rare Metals 2024年第9期43卷 4620-4627页

作者： Dong-Po He Guang-Bing Huang Jun Hu Yang Wu Xiao-Dong Li Qing-Xia Chen shan Zhu Wen-sheng Yan Jun-Fa Zhu Yang Pan Xing-Chen jiao Key Laboratory of synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Hefei National Research Center for Physical sciences at Microscale National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230026China Max Planck Institute of Microstructure Physics Weinberg 206120 HalleGermany state Grid Anhui Electric Power Research Institute Hefei 230601China

The carbon dioxide(CO_(2))reduction process involves complex protonation,making the resulting product often *** achieve the desired product,it is crucial to manipulate the reaction ***,we build the metal atom pair sites for selective CO_(2)photoreduction into *** a prototype,Ni atom pair sites loaded on the Mo s_(2)nanosheets were synthesized and verified by highresolution transmission electron microscopy(HRTEM),X-ray photoelectron spectroscopy(XPs)and X-rayabsorption near edge structure spectra(XANEs).In-situ Fourier transform infrared spectroscopy(FTIR)monitors the*CHO group,a crucial intermediate in CH_(4)production,during CO_(2)photoreduction on the Ni-Mo s_(2)nanosheets,whereas this monitoring is not observed for the Mo s_(2)***,theoretical calculations disclose that over the Ni-Mo s_(2)nanosheet slab,the formation energy of*CHO intermediates is determined to be lower(0.585 e V)than the desorption energy of*CO intermediates for CO production(0.64 e V),implying the higher selectivity of CH_(4)production.

关键词： steps dioxide desired

Correction of a CADAsIL point mutation using adenine base editors in hiPsCsandbloodvessel organoids

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Journal of Genetics and Genomics 2024年第2期51卷 197-207页

作者： Jingwen Wang Lei Zhang Guanglan Wu Jinni Wu Xinyao Zhou Xiaolin Chen Yongxia Niu Yiren jiao Qianyi Liu Puping Liang Guang shi Xueqing Wu Junjiu Huang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Key Laboratory of Reproductive Medicine of Guangdong Province The First Affiliated Hospital and School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Center of Reproductive Medicine Children's Hospital of Shanxi and Women Health Center of ShanxiTaiyuanShanxi 030013China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADAsIL) is a monogenic small vessel disease caused by mutations in the NOTCH3 gene. However, the pathogenesis of CADAsIL remains unclear, and patients have limited treatment options. Here, we use human induced pluripotent stem cells (hiPsCs) generated from the peripheral blood mononuclear cells of a patient with CADAsIL carrying a heterozygous NOTCH3 mutation (c.1261C>T, p.R421C) to develop a disease model. The correction efficiency of different adenine base editors (ABEs) is tested using the HEK293T-NOTCH3 reporter cell line. ABEmax is selected based on its higher efficiency and minimization of predicted off-target effects. Vascular smooth muscle cells (VsMCs) differentiated from CADAsIL hiPsCs show NOTCH3 deposition and abnormal actin cytoskeleton structure, and the abnormalities are recovered in corrected hiPsC-derived VsMCs. Furthermore, CADAsIL blood vessel organoids generated for in vivo modeling show altered expression of genes related to disease phenotypes, including the downregulation of cell adhesion, extracellular matrix organization, and vessel development. The dual adeno-associated virus (AAV) split-ABEmax system is applied to the genome editing of vascular organoids with an average editing efficiency of 8.82%. Collectively, we present potential genetic therapeutic strategies for patients with CADAsIL using blood vessel organoids and the dual AAV split-ABEmax system.

关键词： CADAsIL Induced pluripotent stem cells Adenine base editors AAV Blood vessel Organoid

Trametinib boosts palbociclib’s efficacy in breast cancer via autophagy inhibition

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Oncology Research 2024年第7期32卷 1197-1207页

作者： ANGUO WU jiao YAN TING sU CHI FENG XIN LONG YIRU PAN RUPEI YE TIAN XIA HANAN LONG JIANMING WU XIULI XIAO sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaKey Laboratory of Medical Electrophysiology of Ministry of EducationSchool of PharmacySouthwest Medical UniversityLuzhou646000China The Department of Pathology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China The Department of Pathology Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang621000China The Department of Pathology Yongchuan Hospital of Chongqing Medical UniversityChongqing402160China school of Basic Medical sciences Southwest Medical UniversityLuzhou646000China school of Clinical Medical sciences Southwest Medical UniversityLuzhou646000China

Breast cancer,a predominant global health issue,requires ongoing exploration of new therapeutic ***(PAL),a well-known cyclin-dependent kinase(CDK)inhibitor,plays a critical role in breast cancer *** its efﬁcacy is recognized,the interplay between PAL and cellular autophagy,particularly in the context of the RAF/MEK/ERK signaling pathway,remains insufﬁciently *** study investigates PAL’s inhibitory effects on breast cancer using both in vitro(MCF7 and MDA-MB-468 cells)and in vivo(tumor-bearing nude mice)*** at elucidating the impact of PAL on autophagic processes and exploring the potential of combining it with trametinib(TRA),an MEK inhibitor,our research seeks to address the challenge of PAL-induced drug ***ﬁndings reveal that PAL signiﬁcantly decreases the viability of MCF7 and MDA-MB-468 cells and reduces tumor size in mice while showing minimal cytotoxicity in MCF10A ***,PAL also induces protective autophagy,potentially leading to drug resistance via the RAF/MEK/ERK pathway *** TRA effectively neutralized this autophagy,enhancing PAL’s anti-tumor efﬁcacy.A combination of PAL and TRA synergistically reduced cell viability and proliferation,and in vivo studies showed notable tumor size *** conclusion,the PAL and TRA combination emerges as a promising strategy for overcoming PAL-induced resistance,offering a new horizon in breast cancer treatment.

关键词： Palbociclib Trametinib Protective autophagy RAF/MEK/ERK MCF7 MDA-MB-468

Interfacial molecular screening of polyimide dielectric towards high-performance organic field-effect transistors

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Chinese Chemical Letters 2024年第2期35卷 268-271页

作者： Yingshuang Zheng Huchao Li Ting Jiang Fei jiao Jie Li Yong Lei Guofeng Tian Jinshun Bi Yundong Xuan Liqiang Li Deyang Ji Wenping Hu Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesInstitute of Molecular Aggregation ScienceTianjin UniversityTianjin 300072China GPL Photonics Laboratory State Key Laboratory of Applied OpticsChangchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Haihe Laboratory of sustainable Chemical Transformations Tianjin 300192China Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesSchool of ScienceCollaborative Innovation Center of Chemical Science and EngineeringTianjin UniversityTianjin 300072China Joint school of National University of singapore and Tianjin University Fuzhou 350207China Fachgebiet Angewandte Nanophysik Institut für Physik & IMN MacroNanoTechnische Universität IlmenauIlmenau 98693Germany state Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of sciences Beijing 100101China

The compatibility of the gate dielectrics with semiconductors is vital for constructing efficient conducting channel for high charge ***,it is still a highly challenging mission to clearly clarify the relationship between the dielectric layers and the chemical structure of semiconductors,especially vacuum-deposited small ***,interfacial molecular screening of polyimide(Kapton)dielectric in organic field-effect transistors(OFETs)is comprehensively *** is found that the semiconducting small molecules with alkyl side chains prefer to form a high-quality charge transport layer on polyimide(PI)dielectrics compared with the molecules without alkyl side *** this basis,the fabricated transistors could reach the mobility of 1.2 cm^(2) V^(−1)s^(−1) the molecule with alkyl side chains on bare PI *** is more,the compatible semiconductor and dielectric would further produce a low activation energy(E_(A))of 3.01 meV towards efficient charge transport even at low temperature(e.g.,100 K,0.9 cm^(2) V^(−1)s^(−1)).Our research provides a guiding scheme for the construction of high-performance thin-film field-effect transistors based on PI dielectric layer at room and low temperatures.

关键词： Interfacial molecular screening Polyimide dielectrics Organic semiconductors Interface engineering Thin-film transistors