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Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure

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Nano Research 2022年第5期15卷 4201-4211页

作者： Tsukasa Akasaka Miho Tamai Yoshitaka Yoshimura Natsumi Ushijima shinichiro Numamoto Atsuro Yokoyama Hirofumi Miyaji Ryo Takata s.uichi yamagata Yoshiaki sato Ko Nakanishi Yasuhiro Yoshida Department of Biomaterials and Bioengineering Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Immune signal Unit Okinawa Institute of Science and Technology Graduate UniversityOkinawa 904-0495Japan Department of Pharmacology Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan support section for Education and Research Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Oral Functional Prosthodontics Division of Oral Functional ScienceFaculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Periodontology and Endodontology Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Orthodontics Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan

The surface topography of a material can influence osteoclast ***,the surface structural factors that promote osteoclast activity have not yet been investigated in ***,we investigated osteoclastogenesis by testing various defined patterns with different dimensions and *** systematic patterns,made of a cyclo-olefin polymer,were prepared at a micron-,submicron-,and nano-scale with a groove,hole,or pillar shape with a 1:1 pitch ***264.7 cells were cultured on these patterns in the presence of the receptor activator of NF-κB ligand(RANKL).Osteoclast formation was induced in the order:pillar>groove≥*** two-dimensional factors also indicated that submicron-sized patterns strongly induced osteoclast *** optimal pillar dimension for osteoclast formation was 500 nm in diameter and 2μm in ***,we observed two types of characteristic actin structure,i.e.,belt-like structures with small hollow circles and isolated ring-like structures,which formed on or around the pillars depending on size and ***,resorption pits were observed mainly on the top of calcium phosphate-coated ***,osteoclasts prefer convex shapes,such as pillars for differentiation and *** results indicate that osteoclastogenesis can be controlled by designing surfaces with specific morphologies.

关键词： micro/nano-pattern pillar RAW264.7 osteoclast actin structure resorption pit

Microstructural evolution during reheating of A356 machining chips at semisolid state

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矿物冶金与材料学报：英文版 2017年第8期24卷 891-900页

作者： Fang Wang Wen-qiang Zhang Wen-long Xiao Hiroshi yamagata Chao-li Ma Key Laboratory of Aerospace Advanced Materials and Performance of the Ministry of Education School of Materials Science and Engineering Beihang University Center for Advanced Die Engineering and Technology Gifu University

The microstructural evolution of A356 machining chips in the semisolid state was studied at different temperatures and holding times. The results showed that the elongated α-Al grains first recrystallized in the semisolid state and then became globular with a high shape factor(sF). Both the temperature and the holding time clearly affected the grain size and sF. When the heating temperature or holding time was increased, the grain size and sF gradually increased and finally became stable. Moreover, the Vickers hardness of primary α-Al grains gradually decreased with increasing heating temperature. The optimal slurry for semisolid processing, with a good combination of grain size and sF, was obtained when the chips were held at 600℃ for 15 min. The semisolid slurry of A356 chips exhibited a lower coarsening rate of α-Al grains than those produced by most of the conventional semisolid processes. The coarsening coefficient was determined to be 436 μm^3·s^(-1) on the basis of the linear Lifshitz–slyozov–Wagner(LsW) relationship.

关键词： semisolid slurry aluminum chips microstructural evolution grain coarsening microhardness

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Paradoxical brain embolism followed by percutaneous atrial septal closure： stroke in a patient＇s thirties highlighting some issues surrounding brain stroke in an emergency setting

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World Journal of Emergency Medicine 2017年第4期8卷 308-309页

作者： Daisuke Matsubara Koichi Kataoka Teppei Matsubara Takaomi Minami Takanori yamagata Department of Pediatrics Jichi Medical University Tochigi Japan Department of Clinical Neurophysiology Neurological Institute Graduate School of Medical Sciences Kyushu UniversityFukuoka Japan

Brain stroke in patients younger than 40 deprivessociety of its work force. Paradoxical brain embolism（PBE） is sometimes responsible. PBE should never beoverlooked in emergency settings because its recurrencemay be ... 详细信息

关键词：小学英文教学辅导教材

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日本卫生政策的现状及问题(英文)

日本卫生政策的现状及问题(英文)

Prevention of Lifestyle-related Diseases and Preventive Nursing Care Policies in Japan

北京论坛（2010）文明的和谐与共同繁荣——为了我们共同的家园：责任与行动

作者： Zentaro yamagata Department of Health sciences Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi

There are a lot of issues in health systems in Japan,though the medical system in Japan is at the world’s highest level in many *** issues drive from the increased proportion of the elderly and socioeconomic *** of the elderly(those age 65 or older) is about 22%and total fertility rate is *** indicate acceleration of declining birthrate and a growing proportion of elderly *** change of the age proportion of population forces to the change of the social systems including health *** socioeconomic inequality has expanded in *** reduces performance of health *** need reform health and medical care system by giving priority to prevention and controlling inequality. I introduce present state and issues of the Japanese health policies including prevention policy of metabolic syndrome,the long-term care insurance and measures of declining birthrate.

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Prevention of Lifestyle-related Diseases and Preventive Nurs...

北京论坛（2006）文明的和谐与共同繁荣—对人类文明方式的思考

作者： Zentaro yamagata Department of Health sciences Faculty of MedicineUniversity of Yamanashi

Currently,Japan enjoys the world’s highest standard of health as shown in such indicators as low infant mortality rate and long average life *** that greatly contribute to this high standard are introducing in 1961 a...

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机匣处理在无喷嘴径流涡轮叶片抑振中的应用

风机技术 2022年第6期64卷 1-9页

作者：潘镭杨名洋 shota Murae Wataru sato Naoto shimohara Akihiro yamagata 上海交通大学 IHI Corporation

高周疲劳是无喷嘴径流涡轮叶片损坏的主要原因。大部分有关叶片抑振的研究都侧重于修改叶片与蜗壳几何,然而这些方法具有周期长、通用性差、影响涡轮气动性能等缺陷。本文采用流固耦合数值方法并结合实验验证,研究基于机匣处理的抑振流... 详细信息

高周疲劳是无喷嘴径流涡轮叶片损坏的主要原因。大部分有关叶片抑振的研究都侧重于修改叶片与蜗壳几何,然而这些方法具有周期长、通用性差、影响涡轮气动性能等缺陷。本文采用流固耦合数值方法并结合实验验证,研究基于机匣处理的抑振流动控制方法。由广义力方法的基本原理可知,通过引入额外的激振力以抵消蜗壳产生的激振力,从而降低振幅。通过在叶片尾缘附近的机匣壁面上设计轴向沟槽以实现这一目标。首先研究蜗舌与沟槽相对位置对气动激振的影响。结果表明,当沟槽与蜗舌距离最大时,叶片振幅显著降低。广义力和流场分析进一步表明,在该位置处,蜗壳与沟槽的激振效应抵消。接下来研究沟槽尺寸参数对气动激振的影响。结果表明,通过合理调节参数,振幅最多下降了94%。其中两个参数只影响广义力的长度而不改变相位,极大地方便了沟槽的优化设计。本研究可用于指导高性能、高可靠性无喷嘴涡轮的设计。

关键词：机匣处理无喷嘴径流涡轮叶片抑振高周疲劳涡轮增压动-静干涉

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Evaluation of Flight Trajectory and Unsteady Fluid Forces on Kicked Non-spinning soccer Ball by Digital Image Analysis

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Journal of Flow Control, Measurement & Visualization 2013年第3期1卷 86-93页

作者： Takayuki yamagata Takuya Nagasawa Nobuyuki Fujisawa Takeshi Asai Institute of Health and sports sciences Tsukuba University Tsukuba Ibaraki Japan Visualization Research Center Niigata University Ikarashi Nishi-ku Niigata Japan

This paper describes the experimental method for evaluating the flight trajectory and the aerodynamic performance of a kicked non-spinning soccer ball. The flight trajectory measurement is carried out using the digital image analysis. A centroid method and a template matching method are tested for the flight trajectory analysis using the artificial images generated by the data of a free-fall experiment. The drag coefficient obtained by the centroid method is better suited for the sports ball experiment than that by the template matching method, which is due to the robustness of the centroid method to the non-uniform illumination. Then, the flight trajectory analysis is introduced to a kicked experiment for a non-spinning soccer ball. The experimental result obtained from the stereo observation indicates that the s-shaped variation is found in the three-dimensional flight trajectory and in the side force coefficient during the flight of the non-spinning soccer ball.

关键词： Non-spinning soccer Ball Fluid Force Flight Trajectory Measurement stereo Image Analysis

Improved Visualization of the Anterior Thalamic Radiation in Bipolar Disorder by Diffusion Tensor Tractography

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Case Reports in Clinical Medicine 2018年第9期7卷 505-512页

作者： Richi Niida Akihiko Uechi Akira Niida Hiroshi Matsuda Bun yamagata Masaru Mimura Department of Neuropsychiatry School of Medicine Keio University Shinjuku Japan Cognitive Neuroscience Research Project Kansai Gaidai University Hirakata Japan Department of Radiology Nanbu Hospital Itoman Japan Integrative Brain Imaging Center National Center of Neurology and Psychiatry Kodaira Japan

Diffusion tensor imaging (DTI) is a method for noninvasively measuring and imaging the diffusion of water molecules using MRI. Diffusion tensor tractography (DTT) can be used to presume macroscopic nerve fascicle distribution by determining, based on information obtained by DTI, whether the diffusion anisotropy vectors of adjacent voxels are continuous or not. We prepared a DTT map of the cerebral white matter nerve fascicles and investigated its usefulness for differentiation between Alzheimer’s disease and bipolar disorder (BD), a major depressive disorder, based on the nerve fiber depiction, in addition to the fractional anisotropy and apparent diffusion coefficient values. We encountered two cases of BD in which the DTT image of the anterior thalamic radiation (ATR) improved following effective treatment with lamotrigine. Lamotrigine increases the synaptic strength due to its effect of promoting the traffic of the α-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor on the neuronal membrane. Downregulation of postsynaptic AMPA receptor expression can reportedly be observed during depressive episodes in BD. We consider that visualization of improvement of the ATR in response to treatment with lamotrigine (related to its pharmacological effect on the AMPA receptor) is valuable, as it suggests reversibility of the damage of the nerve fibers in this disease condition.

关键词： Diffusion Tensor Tractography Bipolar Disorder Diffusion Tensor Imaging Magnetic Resonance Imaging Anterior Thalamic Radiation

Proso Millet Protein Elevates Plasma Level of High-Density Lipoprotein:A New Food Function of Proso Millet

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Biomedical and Environmental sciences 1996年第2期9卷 209-212页

作者： N. NIsHIZAWA s. sHIMANUKI H. FUJIHAsHI H. WATANABE Y. FUDAMOTO AND T. NAGAsAWA (Department of Bioscience and Technology, Faculty of Agriculture, Iwate University Morioka, Iwate 020, Japan Research Laboratory,Nitto Best Co., Ltd, sagae, yamagata 991 Ka Department of Bioscience and Technology Faculty of Agriculture Iwate University Morioka Japan.

We examined the effects of dietary proso-millet protein on plasma levels of high-density lipoprotein (HDL) cholesterol in different rats from animals reported in our previous studies. The results showed also, in this animal, that the ingestion of the millet protein elevates plasma levels of HDL-cholesterol like our earlier works. Taking into account the anti-atherogenic function of HDL, therefore, the millet protein would be useful as a new food ingredient which has the function that regulates cholesterol metabolism

关键词： HDL Proso Millet Protein Elevates Plasma Level of High-Density Lipoprotein

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