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单室Gasar工艺中抽拉速率对藕状多孔Cu气孔形貌的影响

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金属学报 2014年第8期50卷 921-929页

作者：卓伟佳刘源李言祥清华大学材料学院北京100084 清华大学机械工程系先进成形制造教育部重点实验室北京100084

采用单室Gasar工艺,通过实验研究和Procast凝固模拟相结合,研究了坩埚抽拉速率对凝固界面形貌、铸锭平均凝固速率、藕状多孔Cu气孔形貌、气孔生长方向以及相应多孔结构参数的影响规律.研究表明,随着抽拉速率的升高,凝固界面从凸界面向... 详细信息

采用单室Gasar工艺,通过实验研究和Procast凝固模拟相结合,研究了坩埚抽拉速率对凝固界面形貌、铸锭平均凝固速率、藕状多孔Cu气孔形貌、气孔生长方向以及相应多孔结构参数的影响规律.研究表明,随着抽拉速率的升高,凝固界面从凸界面向平界面再向凹界面演化.当凝固界面为凸界面和凹界面时,气孔生长方向都会偏离铸锭抽拉方向.而只有在合适的抽拉速率条件下使凝固界面以平界面方式推进,才能获得气孔完全平直生长的优质藕状多孔Cu.实验和模拟结果显示,在本实验条件下,当抽拉速率为1 mm/s时,铸锭凝固界面基本以平界面方式推进;藕状多孔Cu铸锭的气孔率不受抽拉速率的影响,但随着抽拉速率的增大,平均孔径和通孔率会逐渐降低.

关键词：藕状多孔Cu 单室Gasar工艺抽拉速率气孔形貌

B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin

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signal Trans.uction and Targeted Therapy 2023年第3期8卷 1251-1268页

作者： Cefan Zhou Xiaoting Zhu Nanxi liu Xueying Dong Xuewen Zhang Huili Huang Yu Tang shicheng liu Mengyu Hu Ming Wang Xiaoling Deng shi Li Rui Zhang yuan Huang Hao Lyu s.uai Xiao sang Luo Declan William Ali Marek Michalak Xing-Zhen Chen Zhentian Wang Jingfeng Tang National“111”Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei University of TechnologyWuhan 430068China Membrane Protein Disease Research Group Department of PhysiologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAB T6G2R3Canada Cooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province) Hubei Key Laboratory of Industrial MicrobiologyHubei University of TechnologyWuhanChina Department of systems Biology for Medicine School of Basic Medical SciencesFudan Universityand Shanghai Fifth People’s HospitalFudan UniversityShanghai 200433China Department of Clinical Laboratory Renmin Hospital of Wuhan UniversityWuhan 430060China Ningxia Key Laboratory of stem Cell and Regenerative Medicine General Hospital of Ningxia Medical UniversityNingxia 750001China Department of Biological sciences University of AlbertaEdmontonAB T6G2R3Canada Department of Biochemistry University of AlbertaEdmontonAB T6G2R3Canada

Abnormal activation of Wnt/β-catenin-mediated transcription is closely associated with the malignancy of pancreatic *** with sequence similarity 83 member A(FAM83A)was shown recently to have oncogenic effects in a variety of cancer types,but the biological roles and molecular mechanisms of FAM83A in pancreatic cancer need further ***,we newly discovered that FAM83A binds directly toβ-catenin and inhibits the assembly of the cytoplasmic destruction complex thus inhibiting the subsequent phosphorylation and ***83A is mainly phosphorylated by the sRC non-receptor kinase family member BLK(B-lymphoid tyrosine kinase)at tyrosine 138 residue within the DuF1669 domain that mediates the FAM83A-β-catenin ***,FAM83A tyrosine 138 phosphorylation enhances oncogenic Wnt/β-catenin-mediated transcription through promotingβ-catenin-TCF4 interaction and showed an elevated nucleus translocation,which inhibits the recruitment of histone deacetylases by *** also showed that FAM83A is a direct downstream target of Wnt/β-catenin signaling and correlates with the levels of Wnt target genes in human clinical pancreatic cancer ***,the inhibitory peptides that target the FAM83A-β-catenin interaction significantly suppressed pancreatic cancer growth and metastasis in vitro and in *** results revealed that blocking the FAM83A cascade signaling defines a therapeutic target in human pancreatic cancer.

关键词： FAM83A elevated phosphorylation

Qiming granule in treating type 2 diabetic kidney disease patients:s.udy protocol for a randomized controlled trial

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Traditional Medicine Research 2021年第1期6卷 7-15页

作者： Jian Huo Jun-Guo Duan Xue-Jing Lu Fu-Wen Zhang Wen-yuan Jian Jia-Qing sui Jia-Ling Ai Li-sha liu College of Ophthalmology Chengdu University of Traditional Chinese MedicineChengdu 610075China Chengdu Women’s and Children’s Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China Ineye Hospital Chengdu 610084China

Background:Diabetic kidney disease(DKD)is a chronic renal microvas.ular complication associated with abnormal glucose *** to traditional Chinese medicine(TCM)theory,Qi and Yin deficiency with blood stasis(the name of TCM symptoms,its main clinical features are fatigue,dry mouth,red or pale tongue,weak pulse,etc.)is the primary TCM syndrome of DKD,and Qiming granule(QMG)is suitable for the treatment of Qi and Yin deficiency with blood stasis *** view of this,we designed a randomized controlled trial to assess whether QMG is efficacious and safe in treating DKD ***:This protocol is for a randomized,double-blind,placebo-controlled,parallel group,six-centre clinical trial.A total of 180 participants will be randomized into the QMG group or placebo group,with a 1:1 *** s.udy will last for 50 weeks,including a 2-week run-in period,24 weeks of intervention,and 24 weeks of *** experimental intervention will be QMG,and the control intervention will be a *** primary outcome will be the 24h urinary albumin excretion ratio and the change in the albumin-to-creatinine *** secondary outcome will be evaluation of renal function,fundus changes,management of blood lipids,TCM symptom improvement and safety *** events will be recorded during the ***:This s.udy is a randomized controlled trial to test the effectiveness and safety of QMG for DKD *** findings of this s.udy will help to provide evidence-based recommendations in treating DKD *** registration:Chinese Clinical Trial Registry,*** 23 December 2012.

关键词： Diabetic kidney disease Qiming granule Traditional Chinese medicine Randomized controlled trial

Construction of a novel brittleness index equation and analysis of anisotropic brittleness characteristics for unconventional shale formations

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Petroleum science 2020年第1期17卷 70-85页

作者： Ke-Ran Qian Tao liu Jun-Zhou liu Xi-Wu liu Zhi-Liang He Da-Jian Jiang state Key Laboratory of shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing 100083China sinopec Key Laboratory of seismic Elastic Wave Technology Beijing 100083China Key Laboratory of shale Oil and Gas Exploration and Production SINOPECBeijing 100083China Ministry of science and Technology SINOPECBeijing 100728China sinopec Petroleum Exploration and Production Research Institute Beijing 100083China

The brittleness prediction of shale formations is of interest to researchers *** methods of brittleness prediction are usually based on isotropic models while shale is *** order to obtain a better prediction of shale brittleness,our s.udy firstly proposed a novel brittleness index equation based on the Voigt–Reuss–Hill average,which combines two classical isotropic *** proposed method introduces.upper and lower brittleness bounds,which take the uncertainty of brittleness prediction into *** addition,this method can give us acceptable predictions by using limited input ***,an anisotropic rock physics model was *** parameters were introduced into our model,which can be used to simulate the lamination of clay minerals and the dip angle of *** addition,rock physics templates have been built to analyze the sensitivity of brittleness ***,the effects of kerogen,pore structure,clay lamination and shale formation dip have been investigated in terms of *** prediction shows that the vertical/horizontal Young’s modulus is always below one while the vertical/horizontal Poisson’s ratio(PR)can be either greater or less than *** s.udy finds different degrees of shale lamination may be the explanation for the random distribution of Vani(the ratio of vertical PR to horizontal PR).

关键词： Brittleness shale Rock Physics Anisotropy Voigt–Reuss–Hill average

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随身的乐园:晚明文人冯梦祯的园林世界

中国园林 2015年第11期31卷 90-93页

作者：刘源源英国爱丁堡大学艺术学院建筑与景观系

以晚明文人冯梦祯为个案,根据冯氏文集、日记及地方史志记载,考据梳理冯梦祯于嘉兴拙园、南京大司成公署、杭州孤山草堂的园林营造与栖居,绘制杭州孤山草堂平面布局想象图,深入分析孤山草堂园林空间与风水文化的关系,并阐述冯氏注重天... 详细信息

以晚明文人冯梦祯为个案,根据冯氏文集、日记及地方史志记载,考据梳理冯梦祯于嘉兴拙园、南京大司成公署、杭州孤山草堂的园林营造与栖居,绘制杭州孤山草堂平面布局想象图,深入分析孤山草堂园林空间与风水文化的关系,并阐述冯氏注重天趣与借景的园林营构观念,赏石、探梅的意旨趣味及其在丰富多样的园居生活中所体现的雅致追求。旨在从冯梦祯的个人视角揭示园林在晚明文人生活中的重要地位,探索晚明文人园林审美趣味的冲突和变化。

关键词：风景园林晚明文人冯梦祯

基于平台的在线大规模协作配送联盟拆分策略研究

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系统工程理论与实践 2023年第5期43卷 1425-1445页

作者：饶卫振袁露霞刘露山东科技大学经济管理学院青岛266590

基于平台的在线协作配送模式,容易形成大规模联盟,成本分摊时所需2n-1个子联盟成本值的数量呈指数增长,难以在合理时间内计算出成本分摊方案.基于此,文章构建成本最小化协作配送模型来分析联盟拆分的必要性,通过动态规划思想求解拆分方... 详细信息

基于平台的在线协作配送模式,容易形成大规模联盟,成本分摊时所需2n-1个子联盟成本值的数量呈指数增长,难以在合理时间内计算出成本分摊方案.基于此,文章构建成本最小化协作配送模型来分析联盟拆分的必要性,通过动态规划思想求解拆分方案种类,分析拆分的复杂性,借助网络图提出了先依据顾客地理位置分布、再根据配送区域重叠度,快速将大规模联盟拆分成数个小规模联盟的两阶段拆分策略,从而减少子联盟数量.最后,通过数值实验和实例分析,对两阶段拆分策略的有效性进行验证.结果表明:1)传统方法求解子联盟成本C(s)耗时28.15 h,而采用两阶段拆分策略后,在实验电脑上基于三阶段算法仅需64.57 s;2)文章提出的第二阶段拆分策略所得方案与精确拆分方案的偏差不超过8%,求解质量较优;3)采用第二阶段拆分策略将规模为30的大联盟拆分后,成本分摊输入数据计算耗时不到1 h.文章提出的大规模协作配送联盟两阶段拆分策略能够极大缩短耗时,在合理时间内计算出成本分摊方案.更重要的是,文章研究思路可以为其他大规模合作博弈问题提供启发.

关键词：大规模协作配送成本分摊两阶段拆分策略重叠联盟平台

China’s corridors-in-the-sky design and space-time congestion identification and the influence of air routes’ traffic flow

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Journal of Geographical sciences 2019年第12期29卷 1999-2014页

作者： DONG Yaqing Lu Zi liu yuan ZHANG Qiuluan Wu Dians.uang school of Res.urce and Environment sciences Hebei Normal UniversityShijiazhuang 050024China Decision systems&e-service Intelligence Lab Centre for Artificial IntelligeneeFaculty of Engineering and In formation TechnologyUn iversity of Technology SydneyAustralia

With rapid development of air transportation,the airspace structure of the future will need to be flexible and dynamic to accommodate the increase in traffic *** corridors-in-the-sky has become a new technology to support the full exploitation and utilization of airspace *** paper proposes a method of designing corridor,identifying congestion state,and analyzing the influence of air routes’traffic *** this,we have reached a number of conclusions.(1)The congestion periods present the multi-peak"wavy"scattered distributions and the peaks back-end agglomeration characteristics in the whole day.(2)The congestion segments present the structural characteristics of unbalanced coverage and concentrated distribution to the crossing *** corridors with high congestion level present as an italic"N-shaped"frame,which presents incomplete penetration of short segments.(3)For the temporal and spatial interaction,there are two types of congestion segments,and there are some common congestion periods in different congestion segments of multiple *** high-density air route plays a relatively decisive role in corridor congestion,and the influence of two directions is *** research can provide a basis for the dynamic evaluation of China’s airspace res.urces and corridors construction in the future.

关键词： corridors-in-the-sky congestion identification air routes,traffic flow space-time map China

A modified constitutive model for FRP confined concrete in circular sections and its implementation with Opensees programming

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Journal of Zhejiang university-science A(Applied Physics & Engineering) 2013年第12期14卷 856-866页

作者： Hui liu Ming-hua HE Yu-qi LuAN Jia GuO Lu-lu liu Department of Civil Engineering Tsinghua University Research Institute of Highway of China Ministry of Transport Institute of Chemical Machinery Zhejiang University

Opensees is a well-recognized open s.urce platform with high compatibility,and it has a well-developed fiber element method to cope with nonlinear structural *** reinforced polymer(FRP)confined concrete can effectively improve the seismic performance of concrete ***,sophisticated constitutive models for FRP confined concrete are not available in the current version of *** this paper,after reviewing several typical FRP confined concrete constitutive models,a modified constitutive model for FRP confined concrete in circular sections was proposed based on Lam and Teng(2003)’s model with four main modifications including the determination of FRP rupture strain,ultimate condition,envelope shape,and hysteretic *** embed the proposed constitutive model into Opensees is a practical solution for engineering ***,the secondary development of Opensees New userMat was briefly demonstrated and a set of critical steps were depicted in a flow ***,with the numerical implementations of a series of FRP confined concrete members covering a wide range of load cases,FRP confinement types and geometric properties,the utility and accuracy of the proposed model compared with Lam and Teng(2003)’s model and new material secondary development in Opensees were well validated.

关键词： FRP confined concrete Constitutive model Opensees user material secondary development

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基于DCF的资源可控流抽样

计算机工程与应用 2008年第19期44卷 127-128,135页

作者：刘元珍刘渊李小航江南大学信息工程学院江苏无锡214122

Cisco的NetFlow是流测量中广泛应用的方案,但因其采用静态抽样率,当网络流量突然上升时,消耗过多的路由器资源,甚至影响路由器的正常转发功能。提出了基于DCF的资源可控流抽样,对测量间隔内到达的报文采取固定数量的抽样,并采用DCF哈希... 详细信息

Cisco的NetFlow是流测量中广泛应用的方案,但因其采用静态抽样率,当网络流量突然上升时,消耗过多的路由器资源,甚至影响路由器的正常转发功能。提出了基于DCF的资源可控流抽样,对测量间隔内到达的报文采取固定数量的抽样,并采用DCF哈希算法维护流记录,有效控制了资源的消耗。理论和实验分析结果表明,该方法具有抽样率自适应性、简单性、资源可控性,同时不失准确性。

关键词：流量测量流抽样资源消耗 DCF