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Lubiprostone used with polyethylene glycol in diabetic patients enhances colonoscopy preparation quality

World Journal of Gastrointestinal Endoscopy 2010年第7期2卷 263-267页

作者： Erika Grigg Moonkyung C schubert Joshua Hall Fadi Rahhal Dimple Raina subbaramiah sridhar sherman M Chamberlain section of Gastroenterology and Hepatology Medical College of GeorgiaAugustaGA 30912United States

AIM: To assess the additive effect of lubiprostone on the quality of colon preparation in diabetics given single-dosed polyethylene glycol electrolyte(PEG)for ***:This was an investigator-initiated,singlecenter,single-blinded prospective trial comparing the efficacy of L+PEG to PEG alone on colon preparation quality in diabetics undergoing screening *** study was approved by our institution’s *** PEG was given as a single-dose to address patientcompliance concerns voiced by our IRB with *** patients received only clear liquids the day prior to *** group(Grp L)received PEG+1 dose L 2 h prior to and 2 h after PEG *** group(Grp C)received only PEG the evening prior to the *** were randomly assigned to one of the 2 *** endoscopist was blinded to which colon prep was given and all colonoscopies were *** colonoscopy completion,the endoscopist rated the colon prep-quality by a validated 5-point Likert scale(1-excellent to 5-inadequate).REsULTs:sixty patients were enrolled in the study;30 Grp L and 30 Grp ***,patients were excluded due to study non-completion in 12(41%)Grp L and 5(17%) Grp C,P=*** colon preparation score Grp L =2.47 and Grp C=3.00,P=*** this was not statistically significant,there was a trend towards improved colon prep in Grp *** significance may have been achieved if completion rates had been similar between both study ***:Use of 2-L capsules with PEG resulted in a trend towards improved colon prep over PEG alone in diabetic patients when given as a single-dose regimen.

关键词： Lubiprostone Polyethylene glycol Diabetes Colonoscopy colon preparation

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