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Comparison of semilunar coronally repositioned flap with gingival massaging using an Ayurvedic product(irimedadi taila) in the treatment of class-Ⅰ gingival recession: A clinical study

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World Journal of Clinical Cases 2014年第10期2卷 534-540页

作者： Amit Kumar Mishra Kanteshwari Kumathalli Raja sridhar Rahul Maru Brijesh Mangal sameer Kedia Ravi shrihatti EsIC Hospital Nanda Nagar Indore (M.P) 125-A Sai Bagh Colony Indore Madhya Pradesh 452001 India sri Aurobindo College of Dentistry Village Bhawrasala Indore Madhya Pradesh 453112 India Modern Dental College and Research Centre Gandhinagar Indore Madhya Pradesh 453112 India Index Dental College Indore (M.P) 452001 India Dr. D Y Patil Dental College and Hospital Pune Maharashtra 411018 India

AIM: To study the comparison in terms of root coverage the effect of gingival massaging using an ayurvedic product and semilunar coronally repositioned flap(sCRF) to assess the treatment outcomes in the management of Miller's class Ⅰ gingival recessions over a-6mo period. METHODs: The present study comprised of total of 90 sites of Miller's class-Ⅰ gingival recessions in the maxillary anteriors, the sites were divided into three groups each comprising 30 sites, Group Ⅰ-were treated by massaging using a Placebo(Ghee) Group Ⅱ-were treated by massaging using an ayurvedic product(irimedadi taila). Group Ⅲ-were treated by sCRF. Clinical parameters assessed included recession height, recession width, probing pocket depth, width of attached gingiva, clinical attachment level and thickness of keratinized tissue. Clinical recordings were performed at baseline and 6 mo later. The results were analyzed to determine improvements in the clinical parameters. The comparison was done using Wilcoxon signed rank test. The overall differences in the clinical improvements between the three groups was done using Kruskal-Wallis test. The probability value(P-value) of less than 0.01 was considered as statistically ***: Non-surgical periodontal therapy and gingival massaging improves facial gingival recessions and prevents further progression of mucogingival defects. Root coverage was achieved in both the experimental groups. The sCRF group proved to be superior in terms of all the clinical ***: Root coverage is significantly better with semilunar coronally repositioned flap compared with the gingival massaging technique in the treatment of shallow maxillary Miller class Ⅰ gingival recession defects.

关键词： Gingival recession semilunar flaps Gingival massaging Non-surgical

systems pharmacology modeling in neuroscience: Prediction and outcome of PF-04995274, a 5-HT4 partial agonist, in a clinical scopolamine impairment trial

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Advances in Alzheimer's Disease 2013年第3期2卷 83-98页

作者： Timothy Nicholas.sridhar Duvvuri Claire Leurent David Raunig Tracey Rapp Phil Iredale Carolyn Rowinski Robert Carr Patrick Roberts Athan spiros Hugo Geerts ICON North Wales USA In silico Biosciences Lexington USA Pfizer Global Research and Development Groton USA

Background: 5-HT4receptors in cortex and hippocampus area are considered as a possible target for modulation of cognitive functions in Alzheimer’s disease (AD). A systems pharmacology approach was adopted to evaluate the potential of the 5-HT4 modulation in providing beneficialeffects on cognition in AD. Methods: A serotonergic synaptic cleft model was developed by integrating serotonin firing, release, synaptic half-life, drug/tracer properties (affinity and agonism) as inputs and5-HT4 activity as output. The serotonergic model was calibrated using bothinvivo data on free 5-HT levels in preclinical models and human imaging data. The model was further expanded to other neurontransmitter systems and incorporated into a computer-based cortical network model which implemented the physiology of 12 different membrane CNs targets. A biophysically realistic, multi-compartment model of 80 pyramidal cells and 40 interneurons was further calibrated usingdata reported for working memory tasks in healthyhumans and schizophrenia patients. Model output was the duration of the network firing activity in response to an external stimulus. Alzheimer’s disease (AD) pathology, in particular synapse and neuronal cell loss in addition to cholinergic deficits, was calibrated to align with the natural clinical disease progression. The model was used to provide insights into the effect of 5-HT4 activation on working memory and to prospectively simulate the response of PF- 04995274, a 5-HT4partial agonist, in a scopolamine-reversal trial in healthy human subjects. Results: The model output suggested a beneficial effect of 5-HT4 agonism on working memory. The model also projected no effect or an exacerbation of scopolamine impairment for low in- trinsic activity 5-HT4agonists, which was supported by the subsequent human trial outcome. The clinical prediction of the disease model strongly suggests that 5-HT4 agonists with high intrinsic activity may have a beneficial effect on cognition in AD

关键词： systems Pharmacology 5-HT4 Receptor Partial Agonist scopolamine-Reversal

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中印度洋初始热液事件的证据

地质学报 2005年第1期79卷 143-143页

作者： sridhar D.IYER National Institute of Oceanography Dona PaulaGoa 403004India

中印度洋发育有海山、深海山丘、断裂、线形构造等地貌构造单元及来源不同的基性和硅铝质火山岩.有证据表明这一带出现了初始热液事件:①由低温热液作用于早期玄武岩而形成的细碧岩;②玄武质玻璃产生的沸石岩片;③铁锰壳的化学变化;④... 详细信息

中印度洋发育有海山、深海山丘、断裂、线形构造等地貌构造单元及来源不同的基性和硅铝质火山岩.有证据表明这一带出现了初始热液事件:①由低温热液作用于早期玄武岩而形成的细碧岩;②玄武质玻璃产生的沸石岩片;③铁锰壳的化学变化;④大量的含有赭石沉积物和磁铁矿球粒的火山-热液物质.火山-热液物质表明它们是富铁热液与周围沉积物相互作用的产物.中印度洋的球粒出现于约10 ka和425～650 ka的沉积物中,比盆地的50～60Ma的年龄要年轻几个数量级.在盆地北部ODP钻井717～719(1°s/81°E)地点,由于现行的板内变形,出现了无机方解石和硫化物矿物(7.5～9 Ma和0.5 Ma)的热液沉淀.综合以上证据,表明在中印度洋有多期局部的热液事件.

关键词：低温热液海山印度洋火山岩构造单元玄武岩沉积物沸石岩物相产物

Eosinophilic ascites,an unusual presentation of eosinophilic gastroenteritis:A case report and review

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World Journal of Gastrointestinal Pathophysiology 2010年第5期1卷 166-170页

作者： Iryna s Hepburn subbaramiah sridhar Robert R schade section of Gastroenterology and Hepatology Department of Me-dicineMedical College of Georgia

Eosinophilic ascites(EA)is a rare disorder of unknown etiology that has been reported in both adult and pediatric *** is a part of the syndrome of eosinophilic gastroenteritis,which is characterized by eosinophilic infiltration of any or all layers of the gut wall and may involve any segment of the gastrointestinal *** eosinophilia may or may not be *** report a case of EA that developed post partum.

关键词： Ascites Eosinophilia Pregnancy

Identification of CYP 2A6 inhibitors in an effort to mitigate the harmful effects of the phytochemical nicotine

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 272-283页

作者： Navneet Goyal Jayalakshmi sridhar Camilla Do Melyssa Bratton shahensha shaik Quan Jiang Maryam Foroozesh Department of Chemistry Xavier University of LouisianaNew OrleansLA 70125USA Cell and Molecular Biology and Bioinformatic Core College of PharmacyXavier University of LouisianaNew OrleansLA70125USA.

Aim:In this study,our goal was to study the inhibition of nicotine metabolism by P4502A6,as a means for reduction in tobacco use and consequently the prevention of smoking-related ***,a phytochemical,is an addictive stimulant,responsible for the tobacco-dependence in *** of the other phytochemicals in tobacco,including polycyclic aromatic hydrocarbons,N-nitrosamines,and aromatic amines,are potent systemic *** smoking causes about one of every five deaths in the United states *** plasma concentration is maintained by the smokers’smoking behavior within a small *** is metabolized by cytochrome P450s 2A6 and 2A13 to *** metabolism causes a decrease in nicotine plasma levels,which in turn leads to increased tobacco smoking,and increased exposure to the tobacco ***:Using the phytochemical nicotine as a lead structure,and taking its interactions with the P4502A6 binding pocket into consideration,new pyridine derivatives were designed and synthesized as potential selective mechanism-based inhibitors for this ***:The design and synthesis of two series of novel pyridine-based compounds,with varying substituents and substitution locations on the pyridine ring,as well as their inhibitory activities on cytochrome P4502A6 and their interactions with its active site are discussed *** at position 3 of the pyridine ring with an imidazole or propargyl ether containing group showed the most optimal interactions with the P4502A6 active ***:The pyridine compounds with an imidazole or propargyl ether containing substituent on position 3 were found to be promising lead compounds for further ***-bonding interactions were determined to be crucial for effective binding of these molecules within the P4502A6 active site.

关键词： Phytochemicals cytochrome P450 enzymes tobacco smoking nicotine

Emerging links between type 2 diabetes and Alzheimer's disease

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World Journal of Diabetes 2015年第5期6卷 744-751页

作者： Gumpeny R sridhar Gumpeny Lakshmi Gumpeny Nagamani Endocrine and Diabetes Centre Department of Obstetrics and GynecologyAndhra Medical College

Type 2 diabetes mellitus and Alzheimer's disease are both associated with increasing age,and each increases the risk of development of the ***,clinical,biochemical and imaging studies have shown that elevated glucose levels and diabetes are associated with cognitive dysfunction,the most prevalent cause of which is Alzheimer's *** sectional studies have clearly shown such an association,whereas longitudinal studies are equivocal,reflecting the many complex ways in which the two *** the dichotomy,common risk and etiological factors(obesity,dyslipidemia,insulin resistance,and sedentary habits) are recognized;correction of these by lifestyle changes and pharmacological agents can be expected to prevent or retard the progression of both *** pathogenic factors in both conditions span a broad sweep including chronic hyperglycemia per se,hyperinsulinemia,insulin resistance,acute hypoglycemic episodes,especially in the elderly,microvascular disease,fibrillar deposits(in brain in Alzheimer's disease and in pancreas in type 2 diabetes),altered insulin processing,inflammation,obesity,dyslipidemia,altered levels of insulin like growth factor and occurrence of variant forms of the protein *** interest not only do lifestyle measures have a protective effect against the development of cognitive impairment due to Alzheimer's disease,but so do some of the pharmacological agents used in the treatment of diabetes such as insulin(especially when delivered intranasally),metformin,peroxisome proliferator-activated receptors γ agonists,glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 *** must be recognized as a risk for development of Alzheimer's disease;clinicians must ensure preventive care be given to control and postpone both conditions,and to identify cognitive impairment early to manage it appropriately.

关键词： Cognition Insulin resistance Insulin Butyrylcholinesterase Dementia

MicroRNA-328 is associated with （non-small） cell lung cancer （NsCLC） brain metastasis and mediates NsCLC migration

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中国神经肿瘤杂志 2011年第1期9卷 38-38页

作者： Arora s Ranade AR Tran NL Nasser s.sridhar s Korn RL Ross JT Dhruv H Foss KM sibenaller Z Ryken T Gotway MB Kim s Weiss GJ Cancer and Cell Biology Division Translational Genomics Research Institute Phoenix AZ.

Brain metastasis (BM) can affect?25% of nonsmall cell lung cancer (NsCLC) patients during their lifetime. Efforts to characterize patients that will develop BM have been disappointing, microRNAs (miRNAs) regulate the expression of target mRNAs, miRNAs play a role in regulating a variety of targets and, consequently, multiple pathways, which make them a powerful tool for early detection of disease, risk assessment, and prognosis.

关键词：非小细胞肺癌 microRNA miRNA 迁移介导关联脑 mRNA

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致命性肺栓塞的6岁儿童

世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 22-22页

作者： sridhar A.V. Chakraborty s. 郭战宏 Department of Child Health Robert Kilpatrick Clinical Sciences Building University Hospitals of Leicester NHS Trust Leicester LE2 7LX United Kingdom

Pulmonary thromboembolism is rarely recognized in young children, even in hospital settings. All current management decisions for children with deep vein thrombosis (DVT) are directly extrapolated from treatment recommendations for adults with no further validation. We report the case of a 6-y-old child presenting with deep vein thrombosis of the leg veins and fatal pulmonary embolism. The fatal outcome in our case highlights the need for more epidemiological studies in children, not only to predict the recurrence of pulmonary emboli but also to prepare standard treatment guidelines for the management of DVT and pulmonary emboli in children. We speculate that there may be a role for temporary inferior vena cava filters in young children with extensive DVT of the legs. Conclusions: This case highlights the need for more epidemiological studies to predict the recurrence of pulmonary emboli and effective guidelines for the management of paediatric DVT and pulmonary emboli in children.

关键词：肺栓塞深静脉血栓形成下肢静脉处理决策流行病学研究治疗建议下腔静脉

烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点

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中华高血压杂志 2017年第2期25卷 199-199页

作者： Chen J sysol JR singla s Zhao s Yamamura A Valdez-Jasso D Abbasi T shioura KM sahni s Reddy V sridhar A Gao H Torres J Camp sM Tang H Ye sQ Comhair s Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉叶鹏

肺动脉高压（pulmonary arterial hypertension,PAH）是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶（nicotinamide phosphoribosyl transferase,NAMPT）是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还... 详细信息

肺动脉高压（pulmonary arterial hypertension,PAH）是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶（nicotinamide phosphoribosyl transferase,NAMPT）是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑,

关键词：烟酰胺腺嘌呤二核苷酸核糖基转移酶肺血管重塑肺动脉高压治疗靶点 hypertension 磷酸 arterial