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Two Cases of Hallopeau Type of Pemphigus Vegetans in Two Women in Burkina Faso

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Journal of Cosmetics, Dermatological sciences and Applications 2017年第3期7卷 199-203页

作者： Jean-Baptiste Andonaba Issouf Konaté Konségré Valentin Boukary Diallo Muriel s Ouédraogo Nina Néssiné Korsaga-somé Université Nazi Boni de Bobo-Dioulasso Bobo-Dioulasso Burkina Faso Université Ki-Zerbo de Ouagadougou Ouagadougou Burkina Faso

Pemphigus of Hallopeau (PH) is a mild and pustular form of pemphigus vegetans, termed initially as “pyodermite végétante” described by Hallopeau. We report cases in two black women. Two women aged 32 and 36 respectively (case 1 and case 2) were seen for a pustulosis associated with blisters and erosions. Their history and their review have found the mouth ulcerations. The clinical examination showed pustules on the cephalic end, the trunk, the limbs and the large folds. Lesions had a polycyclic aspect and spread in a centrifugal way, developing towards budding, squamous and scabby erosions quickly surrounded by new pustules. Regression left a pigmented macula. Histological examination of the skin lesion showed images similar to vulgaris pemphigus (PV), together with hyperacanthosis and papillomatosis. Aspects observed in immunofluorescence were identical to those of PV (case1). General corticoid therapy led to a rapid disappearance of lesions in Case 1 but in Case 2 the Lever protocol combining corticoid and methotrexate have been used. PH is rarely described in our regions. Clinical diagnosis is not obvious for the uninitiated. Beyond the clinical presentation, PH has the same paraclinical diagnosis and the same treatment as PV.

关键词： Pemphigus Vegetans Hallopeau Black Women Burkina Faso

Chronic Carriage of Hepatitis B Virus at the University Teaching Hospital Yalgado Ouedraogo: Therapeutic Aspects and Outcome in a Cohort of HBeAg+ Outpatients

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Open Journal of Epidemiology 2021年第3期11卷 245-255页

作者： Eric Nagaonlé somé Félicité W. Nana Bertrand I. Méda Moussa son Drabo Maxime séni Kouanda Roger sombié Biomedical and Public Health Department Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Gastro-Enterology Department UFR des Sciences de la Santé Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

Introduction: The HbsAg prevalence in Burkina Faso was 9.1%. We aimed at describing the therapeutic features and the clinical outcome for the patients taking antiretroviral treatment. Materials and Methods: We impleme... 详细信息

strong>Introduction: strong>The HbsAg prevalence in Burkina Faso was 9.1%. We aimed at describing the therapeutic features and the clinical outcome for the patients taking antiretroviral treatment. strong>Materials and Methods:strong> We implemented a cross-sectional study from January 1st, 2004 to December 31st, 2015. Patients aged more than 15 years with positive hepatitis B surface antigen for over six months and positive hepatitis B e-antigen were included. strong>Results:strong> We analyzed the data of 148 participants for a sex ratio of 3;sixty-three patients including 49 men (77.8%) were on treatment. and 81.5% had inflammatory activity greater than one. Under tenofovir, the normalization of ALT was observed in 42 (84%) patients while HBV-DNA became undetectable in 24/33 patients. HBeAg negativation was observed in 16/25 (64%) patients after seven years of treatment. With lamivudine, 2/9 patients had a complete virologic response and six had a normalization of their ALT. Two and 9 patients lost HBeAg after 7 and 9 years of treatment, respectively. Overall 63% and 27% of the patients were in the high or low-adherence group, respectively. In the low-adherence group, all patients had normal or abnormal ALT, but detectable HBV DNA. Ten patients taking lamivudine developed resistance including primary resistance in three patients. No resistance has been observed with tenofovir. strong>Conclusion: strong>The management of the viral hepatitis B includes often a long follow up period without any medication. When antiviral is indicated, the adherence to the treatment is crucial to a long-term control of the virus. In our setting, the low purchase power of the patients may jeopardize their therapeutic future and there is a need to support this group of patients with free-of-charge medicines as it is provided for the HIV infected people.

关键词： Viral Hepatitis B HBe Antigen Antiretroviral Therapy Adherence Resistance

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared s.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

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Cellular & Molecular Immunology 2022年第1期19卷 79-91页

作者： seon-Yeong Lee su-Jin Moon Young-Mee Moon Hyeon-Beom seo Jun-Geol Ryu A Ram Lee Chae Rim Lee Da-som Kim Yang-Mi Her Jeong Won Choi seung-Ki Kwok sung-Hwan Park Mi-La Cho The Rheumatism Research Center The Catholic University of KoreaSeoulSouth Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health sciences College of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Medical Lifescience College of MedicineThe Catholic University of KoreaSeoulSouth Korea These author contributed equally:seon-Yeong Lee Su-Jin MoonYoung-Mee Moon

OBJECTIVE:The interleukin(IL)-12 cytokine family is closely related to the development of T helper cells,which are responsible for autoimmune disease enhancement or ***-12 family members are generally heterodimers and share threeα-subunits(p35,p19,and p28)and twoβ-subunits(p40 and EBI3).However,aβ-sheet p40 homodimer has been shown to exist and antagonize IL-12 and IL-23 signaling ***,we assumed the existence of a p40-EBI3 heterodimer in nature and sought to investigate its role in immune ***:The presence of the p40-EBI3 heterodimer was confirmed by ELIsA,immunoprecipitation,and western blotting.A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collageninduced arthritis(CIA).The anti-inflammatory effects of p40-EBI3 were analyzed with regard to clinical,histological,and immune cell-regulating features in mice with ***:Clinical arthritis scores and the expression levels of proinflammatory cytokines(e.g.,IL-17,IL-1β,IL-6,and TNF-α)were significantly attenuated in p40-EBI3-overexpressing and p40-EBI3-Fc-treated mice with CIA compared to vehicle-treated mice with *** joint damage and vessel formation-related gene expression were also reduced by p40-EBI3 heterodimer *** vitro,the p40-EBI3-Fc protein significantly suppressed the differentiation of Th17 cells and reciprocally induced CD4+CD25+Foxp3+(regulatory T)cells.p40-EBI3 also inhibited osteoclast formation in a concentrationdependent ***:In this study,p40-EBI3 ameliorated proinflammatory conditions both in vivo and in *** propose that p40-EBI3 is a novel anti-inflammatory cytokine involved in suppressing the immune response through the expansion of Treg cells and suppression of Th17 cells and osteoclastogenesis.

关键词： cytokine p40-EBI3 Rheumatoid arthritis Autoimmune disease regulatory T cell

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论柬埔寨的穆斯林文化(英文)

论柬埔寨的穆斯林文化(英文)

Triggering star formation:Experimental compression of a foam ball induced by Taylor–sedov blast waves

北京论坛（2005）文明的和谐与共同繁荣——全球化视野中亚洲的机遇与发展

作者： som somuny 柬埔寨皇家学院

Around 90%of Cambodia’s populations of twelve millions people are ethnic *** the remaining 10%there is a significant diversity of ethnic *** minorities have been referred to as highlanders,uplanders or hill tribes,and ironically as the minorities of Cambodia. But Cambodia’s ethnic minorities are far more diverse,containing large groups,which are not hill tribe *** ethnic Vietnamese is the second largest community in Cambodia;the ethnic Chinese is the third.

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Matter and Radiation at Extremes 2022年第3期7卷 31-39页

作者： B.Albertazzi P.Mabey Th.Michel G.Rigon, J.R.Marques s.Pikuz s.Ryazantsev E.Falize L.Van Box som J.Meinecke N.Ozaki G.Gregori M.Koenig LULI-CNRs CEASorbonne UniversitesEcole PolytechniqueInstitut Polytechnique de ParisF-91120 Palaiseau cedexFrance Department of Physics Freie Universitat Berlin14195 BerlinGermany JIHT-RAs 13-2 Izhorskaya st.Moscow 125412Russia National Research Nuclear University“MEPhI ”Moscow 115409Russia CEA-DAM-DIF F-91297 ArpajonFrance Clarendon Laboratory University of OxfordParks RoadOxford OX13PUUnited Kingdom Graduate school of Engineering Osaka UniversitySuitaOsaka 565-0871Japan Institute of Laser Engineering Osaka UniversitySuitaOsaka 565-0871Japan

The interaction between a molecular cloud and an external agent(e.g.,a supernova remnant,plasma jet,radiation,or another cloud)is a common phenomenon throughout the Universe and can significantly change the star formation rate within a *** process leads to fragmentation of the cloud and to its subsequent compression and can,eventually,initiate the gravitational collapse of a stable molecular *** is,however,difficult to study such systems in detail using conventional techniques(numerical simulations and astronomical observations),since complex interactions of flows *** this paper,we experimentally investigate the compression of a foam ball by Taylor–sedov blast waves,as an analog of supernova remnants interacting with a molecular *** formation of a compression wave is observed in the foam ball,indicating the importance of such experiments for understanding how star formation is triggered by external agents.

关键词： cloud galaxy supernova

septic Chronic Multifocal Osteomyelitis in Children: A Challenging Presentation of Osteomylitis in a Low Income Country

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Open Journal of Orthopedics 2018年第6期8卷 213-220页

作者： s. A. Kissou P. W. H. Dakouré J. M. somé M. soulama M. Diallo Department of Pediatrics Nazi BONI University Bobo-Dioulasso Burkina Faso Department of Orthopaedics and Trauma Nazi BONI University Bobo-Dioulasso Burkina Faso Department of Medical Imaging University Teaching Hospital Ouahigouya Burkina Faso

Background: The aim of this study was to describe the clinical, biological and x-ray presentation of septic Chronic Multifocal Osteomyelitis (sCMO) and discuss the therapeutic difficulties of this pathology in an African sub-saharan teaching hospital. Patients and Methods: A retrospective study was conducted in the Orthopedics and Trauma department of the university teaching hospital of Bobo-Dioulasso (Burkina Faso). Over a period of two years, we selected all cases of chronic osteomyelitis. We studied the epidemiological, diagnostic and therapeutic aspects of sCMO cases. Results: Eleven cases of sCMO were identified. The mean age of the patients was 11.8 years and the sex ratio was 1.75. There were 7 rural patients. The mean time to visit the hospital was 158 days. The most common reasons for consultation were pain (10 cases), swelling (9 cases), and fever (7 cases). Two were sickle cell patients. The most affected bones were the femur (10 cases), the tibia (9 cases) and the fibula (6 cases). The most frequent specific radiological lesions were sequestra (6 cases) followed by pandiaphysitis. staphylococcus aureus was the most common aetiology. Treatment combined antibiotherapy and surgery (sequestrectomy and/or bone curettage and/or fistulectomy). Hip dislocations, pathological fractures and bone defect complicated the course of this disease. The therapeutic results was good in 3 patients and bad in 5 patients;the other 3 patients were lost to follow-up. Conclusion: septic chronic multifocal osteomyelitis is a rare but formidable form of osteomyelitis in children. Therapeutic outcomes are often poor in hospitals with limited resources. The best strategy is prevention through early diagnosis and aggressive treatment of acute osteomyelitis.

关键词： Bacterial Children Hematogen Multifocal Osteomyelitis

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som描绘天津未来蓝图智能可持续地区规划

时代建筑 2010年第5期53卷 30-35页

作者： som Chicago and shanghai Team som建筑设计事务所芝加哥公司及上海办公室

近年来,中国政府和业界领导已对智能性和可持续性兼备的未来城市发展作出意义深远的承诺。而承诺的核心是以科学为基础的城市功能布局所造就的"近距离(尺度)"城市,它们既能互为补充,又能同时推动经济、社会和生态发展。中国在天津滨海... 详细信息

近年来,中国政府和业界领导已对智能性和可持续性兼备的未来城市发展作出意义深远的承诺。而承诺的核心是以科学为基础的城市功能布局所造就的"近距离(尺度)"城市,它们既能互为补充,又能同时推动经济、社会和生态发展。中国在天津滨海新区的努力,已朝这一承诺大步迈进。2007年春,som建筑事务所芝加哥办公室接受委托,为一片27km^2的区域编制总体规划,旨在将这一昔日的工业用地转型为繁荣新城。通过活跃的中心商务区、完善的公共交通网络、综合功能的社区邻里以及壮丽的滨河公园,som的规划将滨海新区中心商务区定位为全球精英城市网络中的一员——将其发展为经济成功的象征、绿色开发的模范以及容纳健康和可持续生活的载体。

关键词： som 天津总体规划城市设计中心商务区可持续性

The Haemorrhoids’ Pathology: Epidemiological, Diagnostic, Therapeutic and Evolutionary Aspects

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Open Journal of Gastroenterology 2016年第11期6卷 343-352页

作者： A. Coulibaly R. Kafando K. s. somda C. Doamba M. Koura C. C. somé T. Ouédraogo s. Traoré Gastroenterology service of the University Hospital Centre Yalgado Ouédraogo (CHUYO) Ouagadougou Burkina Faso surgery of CHUYO Ouagadougou Burkina Faso Gastroenterology service of the University Hospital Centre sanou sourou (CHUss) Bobo-Dioulasso Burkina Faso Medicine Department of the Regional Hospital of Kaya Kaya Burkina Faso surgery of the Polyclinic Notre Dame de la Paix (PNDP) Ouagadougou Burkina Faso

Background: Hemorrhoidal disease is most frequently encountered in proctology affection;it is defined by signs or symptoms attributed to hemorrhoids. Its pathogenesis is based on old theories and vascular mechanical which are nevertheless based on the current therapeutic approach. General Aim of the study: To study haemorrhoids’ pathology in order to improve its management. Methodology: A retrospective cross-sectional study was conducted over a period of two (2) years from 1 January 2012 to 31 December 2013. Data were collected from outpatients records in hepato-gastroenterology and digestive surgery services at “Polyclinique Notre Dame de la Paix” in Ouagadougou (2294 files). Results: 140 cases of haemorrhoids were recorded during our study period. The frequency was 6.1% of consultations. Males predominated with 75.71% of patients (sex ratio = 3.12). The average age was 39.58 years. Civil servants were most affected by this disease (60%). Rectal bleeding was the most common reason of consultation (52.14%). The crown shape was predominated (59%). The frequency of external haemorrhoids was the highest (65.71%) and stage 4 (40.79%) was the most represented. Anal fissure was the proctologic pathology, the most associated to haemorrhoids (17.14%). Medical treatment concerned 89.28% of patients with 69.6% of favorable short-term evolution. No instrumental treatment was performed. surgical treatment consisted of 10.71% of patients and the technique used was the Milligan-Morgan performed under spinal anesthesia. The postoperative complications were mainly represented by anal intense pain and acute urinary retention. The healing period of wounds was on average 6 weeks. Conclusion: The hemorrhoid has often underestimated in our regions. The instrumental treatment is nonexistent and should take an important place;it must be an indication before surgery.

关键词： Haemorrhoids Epidemiology Diagnosis Treatment Evolution Burkina Faso