检索结果-南通市图书馆

strategies for PET imaging of the receptor for advanced glycation endproducts(RAGE)

Journal of Pharmaceutical Analysis 2020年第5期10卷 452-465页

作者： Lindsey R.Drake Allen F.Brooks Jenelle stauff Phillip s.sherman Janna Arteaga Robert A.Koeppe Aimee Reed Timothy J.Montavon Marc B.skaddan Peter J.H.scott Department of Radiology University of MichiganAnn ArborMI48109USA Department of Medicinal Chemistry University of MichiganAnn ArborMI48109USA AbbVie Process Chemistry North ChicagoIL60064USA AbbVie Centralized Medicinal Chemistry North ChicagoIL60064USA AbbVie Translational Imaging North ChicagoIL60064USA

The implication of the receptor for advanced glycation end-products(RAGE)in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory *** the context of investigating RAGE as a biomarker,there is interest in developing radiotracers that will enable quantification of RAGE using positron emission tomography(PET)*** have synthesized potential small molecule radiotracers for both the intracellular([18F]InRAGER)and extracellular([18F]RAGER)domains of *** we report preclinical evaluation of both using in vitro(lead panel screens)and in vivo(rodent and nonhuman primate PET imaging)*** radiotracers have high affinity for RAGE and show good brain uptake,but suffer from off-target *** source of the off-target PET signal is not attributable to binding to melatonin receptors,but remains *** have also investigated use of lipopolysaccharide(LPs)-treated mice as a possible animal model with upregulated RAGE for evaluation of new imaging *** of the mouse brain sections revealed increases in RAGE in the male cohorts,but no difference in the female ***,it proves challenging to quantify the changes in RAGE due to off-target binding of the ***,they are appropriate lead scaffolds for future development of 2nd generation RAGE PET radiotracers because of their high affinity for the receptor and good CNs penetration.

关键词： RAGE Neuroimaging Positron emission tomography Radiochemistry Neuroinflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

胰泌素刺激后3.0TMR表观扩散系数的测量

引用

国际医学放射学杂志 2009年第5期32卷 496-496页

作者： M.F.Akisik K.sandrasegaran s.G.Jennings A.M.Aisen s.sherman 唐光健 Department of Radiology Indiana University School of Medicine550 N University Blvd

目的对有与没有慢性胰腺炎（CP）的病人进行3．0TMR胆胰管成像扩散加权（DW）扫描，前瞻性测量胰腺的表观扩散系数（ADC）。材料与方法研究由学术委员会批准并符合HIPAA法案。对预约行MR胆胰管成像的健康志愿者与怀疑和（或）已知有CP... 详细信息

目的对有与没有慢性胰腺炎（CP）的病人进行3．0TMR胆胰管成像扩散加权（DW）扫描，前瞻性测量胰腺的表观扩散系数（ADC）。材料与方法研究由学术委员会批准并符合HIPAA法案。对预约行MR胆胰管成像的健康志愿者与怀疑和（或）已知有CP的病人均给予知情同意通知。所有受试者均行3．0TMR胆胰管成像，包括系列DWI序列（b=0、200、400s／mm2），给予胰泌素后15min采集数据。

关键词：表观扩散系数胰泌素刺激测量 MR胆胰管成像慢性胰腺炎学术委员会健康志愿者扩散加权

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of meta-instable stress state based on experimental study of evolution of the temperature field during stick-slip instability on a 5° bending fault

引用

science China Earth sciences 2012年第6期55卷 869-881页

作者： MA Jin s I sherman GUO Yanshuang state Key Laboratory of Earthquake Dynamics Institute of Geology China Earthquake Administration Beijing 100029 China Institute of the Earth＇s Crust siberian Branch of Russian Academy of sciences lrkutsk 664033 Russia

Identification of the meta-instable stress state and study of its mechanism and evolution of relevant physical fields would be of great significance for determination of potential seismic risks and estimation of critical times. In laboratory experiments, that the specimen enters the meta-instable is marked by accelerated stress release. Could we use the experimental result to identify the earthquake in natural conditions? Because the observational data from one station can only reflect the stress state beneath this station, the key problem for identification of the meta-instability is how to recognize regional stress state through observational data from many stations. In this work, we choose the evolution of the temperature field over varied deformation stages during a stick-slip event on a 5 bending fault as an example, and attempt to find the response features of the physical quantity when the fault enters the meta-instable state. We discuss the characteristics of stages for the stress build-up, stress-time process deviating from linearity before instability, meta-instability, instability, and post-instability, respectively. The result shows that the fault instability slide is a conversion process from independent activities of each fault segment to synergism activity. The instability implies completion of the synergism. The stage deviating from linearity is the onset of stress release, and it is also the onset of the synergism. At the meta-instability stages, stress release becomes dominant, while the synergism tends to finish. Therefore, the analysis of the regional overall stress state should not start from individual stations, and instead it should begin with the evolution of the whole deformation field.

关键词： earthquake risk stress state meta-instable state evolution of the temperature field synergism bending fault

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DEsIGN OF RECONFIGURABLE MANUFACTURING sYsTEMs WITH sTRONGLY COUPLED NATURE

引用

Chinese Journal of Mechanical Engineering 2007年第1期20卷 91-95页

作者： LANG sherman Y T Integrated Manufacturing Technologies Institute National Research Council Canada N6G 4X8 ON Canada

Today＇s manufacturing cnvironmem forces manufacturing companies to make as many product variations as possible at affordable costs within a short time. Mass customisation is one of most important technologies for companies to achieve their objectives. Efforts to mass customisation should be made on two aspects：（1） To modularize products and make them as less differences as possible; （2） To design manufacturing resources and make them provide as many processes variations as possible. This paper reports our recent work on aspect （2）, i.e. how to design a reconfignrable manufacturing system （RMs） so that it can be competent to accomplish various processes optimally; Reconfignrable robot system （RRs） is taken as an example. RMs design involves architecture design and configuration design, and configuration design is further divided in design analysis and design synthesis. Axiomatic design theory （ADT） is applied to architecture design, the features and issues of RRs configuration design are discussed, automatic modelling method is developed for design analysis, and concurrent design methodology is presented for design synthesis.

关键词： Mass customisation Reconfignrable manufacturing systems Reconfignrable robotic system Analysis synthesis Architecture Adaptability Reconfignrability Configuration design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Controversial conclusions from two randomized controlled trials for acupuncture’s effects on polycystic ovary syndrome or in vitro fertilization support

引用

Journal of Integrative Medicine 2020年第2期18卷 89-91页

作者： sherman Gu Arthur Yin Fan Federation of Chinese Medicine&Acupuncture societies of Australia Ltd(FCMA) MelbourneVictoria 3150Australia Knox Chinese Healing&Myotherapy Wantirna SouthVictoria 3152Australia American TCM Association ViennaVA 22182USA McLean Center for Complementary and Alternative Medicine PLCViennaVA 22182USA

Two reports of trials investigating the potential effect of acupuncture in increasing live birth rate(LBR) in women with polycystic ovary syndrome(PCOs) or those undergoing in vitro fertilization(IVF) were published by Journal of American Medical Association in 2017 and 2018 respectively. The trial investigators did not recommend acupuncture for the women with PCOs or IVF based on their findings. This paper raises the concern that the findings that acupuncture did not increase LBR for women with PCOs or undergoing IVF may be the result of methodological flaws in the studies and unintended bias such as use of an invalid control intervention and underestimation of the true acupuncture effect. Therefore, their findings may not be a valid reflection of acupuncture’s effect in improving LBR in women with these clinical conditions.

关键词： Acupuncture Randomized controlled trial Polycystic ovary syndrome Fertilization in vitro Traditional Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Alpine Ecosystems of Northwest Yunnan,China:an Initial Assessment for Conservation

引用

Journal of Mountain science 2007年第3期4卷 181-192页

作者： Ruth sherman Renee Mullen LI Haomin FANG Zhendong WANG Yi Department o/Natural Resources Cornell University Ithaca NY14853 USACorresponding author The Nature Conservancy Boise ID 83702 USA The Nature Conservancy China Program Kunming Yunnan PRC shangri-la Alpine Botanical Institute Zhongdian Yunnan PRC state Key Laboratory of systematic and Evolutionary Botany Institute of BotanyThe Chinese Academy of Sciences Beijing PRC

Implementing conservation actions on-the-ground is not a straightforward process,especially when faced with high scientific uncertainty due to limited available information. This is especially acute in regions of the world that harbor many unique species that have not been well studied,such as the alpine zone of the Hengduan Mountains of Northwest Yunnan (NWY),a global biodiversity hotspot and site of The Nature Conservancy’s Yunnan Great Rivers Project. We conducted a quantitative,but rapid regional-level assessment of the alpine flora across NWY to provide a broad-based understanding of local and regional patterns of the alpine flora,the first large-scale analysis of alpine biodiversity patterns in this region. Multivariate analyses were used to classify the major plant community types and link community patterns to habitat variables. Our analysis indicated that most species had small distributions and/or small population sizes. strong patterns emerged with higher diversity in the more northern mountains,but beta diversity was high,averaging only 10% among sites. The ordinations indicated that elevation and geographic location were the dominant environ-mental gradients underlying the differences in the species composition among communities. The high beta diversity across the alpine of these mountains implies that conservation strategies ultimately will require the protection of large numbers of species over a large geographical area. However,prioritiza-tion should be given to areas where potential payoffs are greatest. sites with high species richness also have a greater number of endemic species,and,by focusing efforts on these sites,conservation investments would be maximized by protecting the greatest number of unique species.

关键词： Biodiversity hotspot cluster analysis plant community ecology conservation action grazing Hengduan Mountains non-metric multidimensional scaling plant species richness World Heritage site Yunnan Great Rivers Project(YGRP) alpine ecosystems China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

sports Data Visualization and Data Analysis

Sports Data Visualization and Data Analysis

引用

作者： sherman Hung 上海交通大学

学位级别：硕士

Big data analysis is revolutionizing professional sports,influencing everything from game strategy and player conditioning to how fans interact with the *** help understand the underlying information,data visualization techniques are widely used to display data in a straightforward manner,while data analysis is used to extract hidden patterns in *** the advent of sensor technology,basketball is now a sport with diversed data,at the same time possessing many qualities shared by other ***,this paper uses basketball as an example to demonstrate the use of data visualization and data analysis in *** present a multifaceted web-based NBA data visualization system,BasketView,that enables basketball professionals to analyze the game from four perspectives: season level,game level,event level,and region *** level view uses a novel visualization design called BandView,where a combination of bar graph and flow graph is used to visualize win-loss statistics and game statistics *** game level view,two visualizations,namely,Playerstream and GameClock,are coupled together to reveal the changing contributions of all players during a basketball game,as well as all events that take *** complement the game level view,event level view uses a dynamic visualization called CourtChart that animates the movement of on-court players and ***,region level view uses PlayerMap to allow basketball professionals to quickly identify talents within a *** connects all four components with interactive features,providing users an easy-to-use and comprehensive toolbox to analyze basketball games.

关键词：

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

乙酰胆碱减小猫外膝体中继细胞低阈值T—型钙电导

引用

生理学报 1997年第3期49卷 307-313页

作者：罗荪 s.M.sherman 中国科学院上海脑研究所上海200031

在离体猫丘脑脑片上观察了乙酰胆碱对外膝体中继神经元膜的低阈值T-型钙电导的影响。电流箝位和电压箝位实验结果都显示：将膜电位箝制到给药前的对照水平，排除了乙酰胆碱的去极化作用后，大多数（82％）外膝体神经元的低阈值钙电导仍... 详细信息

在离体猫丘脑脑片上观察了乙酰胆碱对外膝体中继神经元膜的低阈值T-型钙电导的影响。电流箝位和电压箝位实验结果都显示：将膜电位箝制到给药前的对照水平，排除了乙酰胆碱的去极化作用后，大多数（82％）外膝体神经元的低阈值钙电导仍然被乙酰胆碱所抑制。说明这种抑制作用独立于乙酰胆碱引起的膜电位变化，而是对低阈值T-型钙通道的直接作用。

关键词：外膝体乙酰胆碱 T型钙通道钙电导

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

黏土实验模拟分段剪切拉张下的偏斜角差异对汾渭裂谷带形成演化的影响

引用

地震地质 2016年第2期38卷 259-277页

作者：卓燕群 s.A.Bornyakov 郭彦双马瑾 s.I.sherman 中国地震局地质研究所地震动力学国家重点实验室北京100029 Institute of the Earth's Crust Siberian BranchRussian Academy of SciencesSt.128 LermontovaIrkutsk 664033Russia Department of Civil Engineering University of TorontoToronto MSS1A4Canada

汾渭裂谷带由2组走向不同的盆地组成:以拉张为主的NEE向盆地(或盆地系)和以右旋走滑为主的NNE向盆地。相邻NEE向盆地(或盆地系)间的连接区由NNE向盆地和地垒组成。汾渭裂谷带南、北段总体走向NEE并以拉张为主,中段总体走向NNE且具走滑... 详细信息

汾渭裂谷带由2组走向不同的盆地组成:以拉张为主的NEE向盆地(或盆地系)和以右旋走滑为主的NNE向盆地。相邻NEE向盆地(或盆地系)间的连接区由NNE向盆地和地垒组成。汾渭裂谷带南、北段总体走向NEE并以拉张为主,中段总体走向NNE且具走滑兼拉张的性质。汾渭裂谷带各段具有以下特征:各裂谷段新生代盆地按照先南、再北、后中段的时间顺序形成;盆地连接区规模依中、北、南段递减;忻定盆地东端平行于裂谷带北段走向延伸成NEE向,西端沿逆时针方向旋转成NNE向,而临汾盆地与忻定盆地呈近似反对称的展布。但是已有模拟实验或数值实验均无法解释这些特征,原因在于它们忽略了裂谷分段性对NEE向盆地及其连接区演化的控制作用。文中结合已有地质调查资料,基于黏土实验和数字图像相关方法,观测了在基底的分段右旋剪切拉张作用下上覆黏土盖层的裂陷过程,并对黏土盖层表面的变形场时空演化进行了定量分析。实验再现了汾渭裂谷带的主要构造特征,结果表明:1)裂谷带南、北、中段偏斜角(裂谷带两侧块体的相对运动方向与裂谷带走向之间的夹角)的依次递减是造成NEE向盆地的形成时间和连接区规模在各裂谷段呈现上述特征的原因。2)相邻NEE向盆地的相互作用是形成具有右旋剪切拉张的NNE向连接区的原因。3)相邻裂谷段之间的相互作用可能是造成忻定盆地和临汾盆地特殊构造特征的原因。因此,汾渭裂谷带各段的构造差异主要源于各段偏斜角的差异。但模型还存在不足之处,其中值得进一步完善的是模型未考虑汾渭裂谷带先存构造的影响,因而未能详细模拟汾渭裂谷带南、北段内盆地的构造特征。

关键词：偏斜角盆地相互作用裂谷段相互作用变形场时空演化汾渭裂谷带

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Digital Twin-Empowered Network Planning for Multi-Tier Computing

引用

Journal of Communications and Information Networks 2022年第3期7卷 221-238页

作者： Conghao Zhou Jie Gao Mushu Li Xuemin(sherman)shen Weihua Zhuang Department of Electrical and Computer Engineering University of WaterlooWaterlooONN2L 3G1Canada school of Information Technology Carleton UniversityOttawaONK1S 5B6Canada Department of Electrical Computerand Biomedical EngineeringToronto Metropolitan UniversityTorontoONM5B 2K3Canada

In this paper,we design a resource management scheme to support stateful applications,which will be prevalent in sixth generation(6G)*** from stateless applications,stateful applications require context data while executing computing tasks from user terminals(UTs).Using a multi-tier computing paradigm with servers deployed at the core network,gateways,and base stations to support stateful applications,we aim to optimize long-term resource reservation by jointly minimizing the usage of computing,storage,and communication resources and the cost of reconfiguring resource *** coupling among different resources and the impact of UT mobility create challenges in resource *** address the challenges,we develop digital twin(DT)empowered network planning with two elements,i.e.,multi-resource reservation and resource reservation ***,DTs are designed for collecting UT status data,based on which UTs are grouped according to their mobility ***,an algorithm is proposed to customize resource reservation for different groups to satisfy their different resource ***,a Meta-learning-based approach is developed to reconfigure resource reservation for balancing the network resource usage and the reconfiguration *** results demonstrate that the proposed DTempowered network planning outperforms benchmark frameworks by using less resources and incurring lower reconfiguration costs.

关键词： 6G digital twin network planning multitier computing Meta-learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：