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Applied Mathematics and Mechanics(English Edition) 2025年第01期 81-100页

作者： s.saurabh R.KIRAN D.sINGH R.VAIsH V.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Impacts of Bioinoculants Pseudomonas jesenii MP1 and Rhodococcus qingshengii s10107 on Chickpea (Cicer arietinum L.) Yield and soil Nitrogen status

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Pedosphere 2019年第3期29卷 388-399页

作者： Divya JOsHI Ramesh CHANDRA Deep Chandra sUYAL saurabh KUMAR Reeta GOEL Department of Microbiology College of Basic Sciences and Humanities Govind Ballabh Pant University of Agriculture and Technology Pantnag ar-263145 Uttarakhand (India) Department of soil science College of Agriculture Govind Ballabh Pant University of Agriculture and Technology Pantnagar- 263145 Uttarakhand (India)

Cold-adapted bioinoculants are considered as harbingers of sustainable hill agriculture. Therefore, two previously characterized psychrotolerant diazotrophs, Pseudomonas jesenii MP1 and Rhodococcus qingshengii s10107, were evaluated for their plant growthpromoting potential for chickpea (Cicer arietinum L.) grown under natural field conditions. Comparative analysis of agronomical and biochemical crop parameters revealed the irrelevance of chemical fertilizers for chickpea production;the diazotrophs alone were sufficient to fulfil the crop's nutritional requirement. However, the integrated use of bacterial strains in combination with urea at 20 kg N ha^-1 as urea was being recommended for higher crop yield and better soil nitrogen status. Quantitative polymerase chain reaction (qPCR) and denaturing gradient gel electrophoresis (DGGE)-based soil bacterial dynamics unveiled the persistence of both diazotrophs until the end of the crop maturation period without affecting the native micro-flora. Therefore, these bioinoculants can be explored as natural nitrogen resource, and an additional incentive in their bio-formulation will be a step towards agricultural sustainability.

关键词： agricultural sustainability denaturing gradient gel electrophoresis (DGGE) hill agriculture psychrotolerance N fertilizer N fixation N uptake quantitative polymerase chain reaction (qPCR)

Revisiting novel symmetries in coupled N=2 supersymmetric quantum systems:examples and supervariable approach

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Communications in Theoretical Physics 2020年第10期72卷 103-112页

作者： Aditi Pradeep Anjali s Binu M Nair saurabh Gupta Department of Physics and Astronomy University of British ColumbiaVancouver Campus325-6224 Agricultural RoadVancouverBC V6T 1Z1Canada Department of Physics National Institute of Technology Calicut

We revisit the novel symmetries in N=2 supersymmetric quantum mechanical models by considering specific examples of coupled ***,we extend our analysis to a general case and list out all the novel *** each case,we show the existence of two sets of discrete symmetries that correspond to the Hodge duality operator of differential ***,we are able to provide a proof of the conjecture which points out the existence of more than one set of discrete symmetry transformations corresponding to the Hodge duality ***,we derive on-shell nilpotent symmetries for a generalized superpotential within the framework of supervariable approach.

关键词： N=2 sUsY quantum mechanical system continuous and discrete symmetries de Rham cohomological operators (anti-)chiral supervariable approach sUsY invariant restrictions

Effect of deep cryogenic treatment on the microstructural,mechanical and ballistic properties of AA7075-T6 aluminum alloy

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Defence Technology（防务技术） 2023年第12期30卷 101-110页

作者： s.Dharani kumar U.Magarajan saurabh s Kumar Rodríguez-Millan M Centre for Machining and Material Testing KPR Institute of Engineering and TechnologyCoimbatoreIndia Department of Mechanical Engineering Sri Venkateswara College of EngineeringChennaiIndia scientific Officer Ballistic Research Centre&Testing RangeNational Forensic Sciences UniversityGandhi NagarIndia Department of Mechanical Engineering University Carlos Ⅲ of MadridLeganesMadridSpain

The study focused on investigating the effect of Deep Cryogenic Treatment(DCT)on the mechanical and ballistic properties of AA7075-T6 aluminum *** microstructure,microhardness,tensile strength,and impact strength of the Base Material(BM)and DCT-treated 7075 samples were analyzed through metallographic analysis and mechanical *** microstructure of the DCT-treated 7075 samples revealed fine grains and a distribution of secondary phase *** tensile strength,impact strength,and microhardness of DCT-treated samples increased by 7.41%,4%,and 9.68%,respectively,compared to the BM *** fractography analysis of the tensile samples showed cleavage facets,microvoids,and dimples in both the *** ballistic behavior of the BM and DCT target plates were studied by impacting hard steel core projectiles at a velocity of 750±10 m/*** target plates failed due to petaling and ductile hole enlargement,and the depth of penetration(DOP)of the DCT target was less than that of the BM target,indicating a higher ballistic *** post-ballistic microstructure examination of the target plates showed the formation of an Adiabatic shear Band(AsB)without any *** was concluded that the DCT treatment improved the mechanical and ballistic properties of the aluminum alloy due to grain refinement and high dislocation density.

关键词： Deep cryogenic treatment AA7075-T6 Mechanical properties Ballistic Adiabatic shear band

Non-linear state recovery in power system under bad data and cyber attacks

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Journal of Modern Power systems and Clean Energy 2019年第5期7卷 1071-1080页

作者： Ali TAJER saurabh sIHAG Khawla ALNAJJAR Rensselaer Polytechnic Institute 1108th StreetTroyNY 12180USA University of sharjah United Arab EmiratesP.O.Box 27272SharjahUAE

The problems of recovering the state of power systems and detecting the instances of bad data have been widely studied in ***,these two operations have been designed and optimized for the most part in ***,state estimators are optimized based on the minimum mean-square error criteria,which is only optimal when the source of distortions in the data is Gaussian random ***,the state estimators fail to perform optimality when the data is further contaminated by bad data,which cannot necessarily be modeled by additive Gaussian *** problem of power state estimation has been studied *** the fundamental performance limits and the attendant decision rules are unknown when the data is potentially compromised by random bad data(due to sensor failures)or structured bad data(due to cyber attacks,which are also referred to false data injection attacks).This paper provides a general framework that formalizes the underlying connection between state estimation and bad data detection *** aim to carry out the combined tasks of detecting the presence of random and structured bad data,and form accurate estimations for the state of power *** paper characterizes the optimal detectors and ***,the gains with respect to the existing state estimators and bad data detectors are established through numerical evaluations.

关键词： state estimation Power system security Bad data detection Data injection attack

Capture the variation of the pore pressure with different geological age from seismic inversion study in the Jaisalmer sub-basin,India

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Petroleum science 2020年第6期17卷 1556-1578页

作者： Raman Chahal saurabh Datta Gupta Department of Applied Geophysics Indian Institute of Technology(Indian School of Mines)DhanbadDhanbadJharkhand 826004India

Geoscientific evidence shows that various parameters such as compaction,buoyancy effect,hydrocarbon maturation,gas effect and tectonic activities control the pore pressure of sub-surface *** controlled geoscientific data in the tectonically active areas is significantly useful for robust estimation of pre-drill pore *** reservoir which is tectonically complex and pore pressure is changing frequently that circumference motivated us to conduct this *** changes in pore pressure have been captured from the fine-scale to the broad scale in the Jaisalmer *** pressure variation has been distinctly observed in pre-and post-Jurassic age based on the current ***-stack seismic inversion study was conducted to capturing the variation of pore *** of low-frequency spectrum and integrated interval velocity model provided a detailed feature of pore pressure in each compartment of the study *** pressure estimated from well log data was correlated with seismic inversion based *** on the current study one well has been proposed where pore pressure was estimated and two distinguished trends are identified in the study *** approaches of the current study were analysed thoroughly and it will be highly useful in complex reservoir condition where pore pressure varies frequently.

关键词： Pore pressure seismic inversion Clastic and carbonate reservoir

Performance analysis and design of MIMO-OFDM system using concatenated forward error correction codes

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Journal of Central south University 2017年第6期24卷 1322-1343页

作者： Arun Agarwal saurabh N.Mehta PhD scholar School of Electrical EngineeringDepartment of Information TechnologyAMET UniversityTamil NaduChennai 603112India Department of Electronics and Telecommunication Engineering Vidyalankar Institute of TechnologyMumbai-400037MaharashtraIndia

This work investigates the performance of various forward error correction codes, by which the MIMO-OFDM system is deployed. To ensure fair investigation, the performance of four modulations, namely, binary phase shift keying(BPsK), quadrature phase shift keying(QPsK), quadrature amplitude modulation(QAM)-16 and QAM-64 with four error correction codes(convolutional code(CC), Reed-solomon code(RsC)+CC, low density parity check(LDPC)+CC, Turbo+CC) is studied under three channel models(additive white Guassian noise(AWGN), Rayleigh, Rician) and three different antenna configurations(2×2, 2×4, 4×4). The bit error rate(BER) and the peak signal to noise ratio(PsNR) are taken as the measures of performance. The binary data and the color image data are transmitted and the graphs are plotted for various modulations with different channels and error correction codes. Analysis on the performance measures confirm that the Turbo + CC code in 4×4 configurations exhibits better performance.

关键词： bit error rate (BER) convolutional code (CC) forward error correction peak signal to noise ratio (PsNR) Turbo code