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surgical cystogastrostomy: Is it still worthwhile?

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World Journal of Gastroenterology 2024年第17期30卷 2298-2301页

作者： kin Pan Au Kenneth siu Ho Chok Department of surgery Queen Mary HospitalThe University of Hong KongHong Kong 999077China Department of surgery The Chinese University of Hong KongHong Kong 999077China

The article by Ker et al explores the treatment of peripancreatic fluid collection(PFC).The use of percutaneous drainage,endoscopy,and surgery for managing PFC are *** drainage is noted for its low risk profile,while endoscopic cystogastrostomy is more effective due to the wider orifice of the metallic *** cystogastrostomy is a definitive treatment with a reduced need for reintervention,especially for cases with extensive collections and significant *** choice of treatment modality should be tailored to individual patient characteristics and disease factors,considering the expertise available.

关键词： Endoscopic cystgastrostomy surgical cystgastrostomy Pancreatitis Pancreatic necrosis Peripancreatic collection

Characterization of a smog chamber for studying formation of gas-phase products and secondary organic aerosol

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Journal of Environmental sciences 2024年第2期136卷 570-582页

作者： Qi Yuan Zhuozhi Zhang Meng Wang kin Fai Ho Tao Wang shuncheng Lee Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina school of Public Health and Primary Care The Chinese University of Hong KongShatinHong KongChina

smog chambers provide a potent approach to explore the secondary organic aerosol formation under varied *** study describes the construction and characterization of a new smog chamber facility for studying the formation mechanisms of gas-phase products and secondary organic aerosol from the photooxidation of volatile organic *** chamber is a 5.4 m^(3) Fluorinated Ethylene Propylene(FEP)Teflon reactor with the potential to perform photooxidation experiments at controlled temperature and relative *** characterizations were conducted for evaluation of stability of environmental parameters,mixing time,background contamination,light intensity,and wall losses of gases and *** photolysis rate of NO_(2)(J_(NO2))ranged from(1.02-3.32)×10^(-3)sec^(-1),comparable to the average J_(NO2)in ambient *** wall loss rates for NO,NO_(2),and O_(3)were 0.47×10^(-4),0.37×10^(-4),and 1.17×10^(-4)min^(-1),while wall loss of toluene was obsoletely found in a 6 hr *** particle number wall loss rates are(0.01-2.46)×10^(-3)min^(-1)for 40-350 nm with an average lifetime of more than one day.A series of toluene photooxidation experiments were carried out in absence of NO_xunder dry *** results of the simulation experiments demonstrated that the chamber is well designed to simulate photolysis progress in the atmosphere.

关键词： smog chamber Gas-phase oxidation Chamber characterization Chemical mechanism

Effect of Eu3+,Bi3+,and Li+ doping on luminescent property of GdNbO4

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Journal of Rare Earths 2024年第1期42卷 66-75页

作者： s.W.Wi Y.s.Lee Department of Physics and Integrative Institute of Basic sciences Soongsil University

We investigated the emission properties of Eu3+-doped GdNbO4-based oxide phosphors,aiming at improving the Eu3+emission by codoping of Bi3+and Li+.Eu3+singly doped,Eu3+and Bi3+doubly doped,and Eu3+,Bi3+,and Li+triply doped GdNbO4were prepared using a high-temperature solid-state reaction *** red-orange emissions from Eu3+in the singly doped samples are significantly improved by the codoping of Bi3+,mainly due to the energy transfer from Bi3+to Eu3+.The additional codoping of Li+is found to increase the Eu3+emission *** improvement might be attributed to the increase in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu3+in GdNbO4does not change significantly with the codoping of Bi3+and Li+.Our results indicate that Li+doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO4phosphors.

关键词： Eu 3+ GdNbO 4 Codoping of Li + Photoluminescence sensitizer Rare earths

First evidence for chiral wobbling of triaxial nuclei

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Nuclear science and Techniques 2024年第7期35卷 4-7页

作者： s.Frauendorf Department of Physics and Astronomy University of Notre DameNotre DameIN 46556USA

Chirality(Greek“handiness”)is a property of many com-plex *** molecules exist in two forms,one being the mirror image of the *** for our hands,it is impossible to make the images identical by a suitable *** two forms are called left-handed and *** have the same binding energy,because the electro-magnetic interaction,which holds the molecule together,does not change under a *** properties that are insensitive to the geometry are also the *** different geometry is the reason why the left-handed form turns the polarization plane of transmitted light in one direction by some angle while the right-handed form turns it in the oppo-site direction by the same ***,the geometrical differences between the two species may have other *** two species of the carvon molecule shown in Fig.1 taste quite differently.

关键词： turns Chiral mirror

Tribological behavior of lubricant-impregnated porous polyimide

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Friction 2024年第4期12卷 711-725页

作者： Jinbang LI Ningning ZHOU Janet s.s.WONG school of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China Beijing Key Laboratory of Long-life Technology of Precise Rotation and Transmission Mechanisms Beijing Institute of Control EngineeringBeijing 100029China Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Porous materials impregnated with lubricants can be used in conditions where limited lubricant is *** this work,three porous polyimides(PPI)with different densities were ***(PAO)impregnated PPI(iPPI)discs were rubbed against steel and sapphire *** operando observations of the iPPI-sapphire contacts show that oil is released under an applied load,forming a meniscus around *** at the outlet is created at high sliding *** amount of released oil increases with increasing PPI *** moduli,E*,estimated based on the actual contact size show that trapped oil in iPPIs contributes to load *** higher speeds,tribological rehydration of the contact occurs in low density iPPI,with that E*rises with *** high density PPIs,high speeds give a constantly high E*which is limited by the viscoelastic properties of the PPI network and possibly the rate of oil *** of iPPI-steel contacts is governed by the mechanical properties of the PPI,the flow of the lubricant,and the roughness of the PPI *** low-and medium-density(highly porous,high roughness)PPIs,large amount of oil is released,and lubrication is mainly via lubricant restricted in the contact in the pores and possibly tribological *** high density(low porosity)PPI,with lower roughness,hydrodynamic lubrication is achieved which gives the lowest *** results show that polymeric porous materials for effective lubrication require the optimization of its surface roughness,stiffness,oil flow,and oil retentions.

关键词： polyimide porous material friction mechanism polymer limited lubrication

Regulation of PM_(2.5)on mitochondrial damage in H9c2 cells through miR-421/sIRT3 pathway and protective effect of miR-421 inhibitor and resveratrol

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Journal of Environmental sciences 2024年第4期138卷 288-300页

作者： shanshan Chen Wenqi Chen Zhiping Li Jianwei Yue Ken kin Lam Yung Ruijin Li Institute of Environmental science Shanxi UniversityTaiyuan 030006China Institute of Judicial Identification Techniques for Environmental Damage Shanxi University and Shanxi Unisdom Testing Technology Co.Ltd.Taiyuan 030006China Department of Biology Hong Kong Baptist UniversityHong KongChina shanxi Yellow River Laboratory Taiyuan 030006China

Fine particulate matter(PM_(2.5))exposure is associated with cardiovascular disease(CVD)morbidity and *** are sensitive targets of PM_(2.5),and mitochondrial dysfunction is closely related to the occurrence of *** epigenetic mechanism of PM_(2.5)-triggered mitochondrial injury of cardiomyocytes is *** study focused on the mi R-421/sIRT3 signaling pathway to investigate the regulatory mechanism in cardiac mitochondrial dynamics imbalance in rat H9c2 cells induced by PM_(2.5).Results illustrated that PM_(2.5)impaired mitochondrial function and caused dynamics homeostasis ***,PM_(2.5)up-regulated mi R-421 and down-regulated sIRT3 gene expression,along with decreasing p-FOXO3a(sIRT3 downstream target gene)and p-Parkin expression and triggering abnormal expression of fusion gene OPA1 and fission gene ***,mi R-421 inhibitor(mi R-421i)and resveratrol significantly elevated the sIRT3 levels in H9c2 cells after PM_(2.5)exposure and mediated the expression of sOD2,OPA1 and Drp1,restoring the mitochondrial morphology and *** suggests that mi R-421/sIRT3 pathway plays an epigenetic regulatory role in mitochondrial damage induced by PM_(2.5)and that mi R-421i and resveratrol exert protective effects against PM_(2.5)-incurred cardiotoxicity.

关键词： Fine particulate matter Rat H9c2 cells Mitochondrial damage MiR-421 sIRT3 Resveratrol

Enhancing fatigue performance of AZ31 magnesium alloy components fabricated by cold metal transfer-based wire arc directed energy deposition through LPB

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Journal of Magnesium and Alloys 2024年第4期12卷 1638-1662页

作者： shambhu Kumar Manjhi srikanth Bontha A.s.s.Balan Department of Mechanical Engineering National Institute of Technology KarnatakaSurathkalSrinivasanagarMangaloreKarnataka 575025India

Cold Metal Transfer-Based Wire Arc Directed Energy Deposition(CMT-WA-DED)presents a promising avenue for the rapid fabrication of components crucial to automotive,shipbuilding,and aerospace ***,the susceptibility to fatigue of CMT-WA-DED-produced AZ31 Mg alloy components has impeded their widespread adoption for critical load-bearing *** this study,a comprehensive investigation into the fatigue behaviour of WA-DED-fabricated AZ31 Mg alloy has been carried out and compared to commercially available wrought AZ31 *** findings indicate that the as-deposited parts exhibit a lower fatigue life than wrought Mg alloy,primarily due to poor surface finish,tensile residual stress,porosity,and coarse grain microstructure inherent in the WA-DED *** Plasticity Burnishing(LPB)treatment is applied to mitigate these issues,which induce significant plastic deformation on the *** treatment resulted in a remarkable improvement of fatigue life by 42%,accompanied by a reduction in surface roughness,grain refinement and enhancement of compressive residual stress ***,during cyclic deformation,WA-DED specimens exhibited higher plasticity and dislocation density compared to both wrought and WA-DED+LPB specimens.A higher fraction of Low Angle Grain Boundaries(LAGBs)in WA-DED specimens contributed to multiple crack initiation sites and convoluted crack paths,ultimately leading to premature *** contrast,wrought and WA-DED+LPB specimens displayed a higher percentage of High Angle Grain Boundaries(HAGBs),which hindered dislocation movement and resulted in fewer crack initiation sites and less complex crack paths,thereby extending fatigue *** findings underscore the effectiveness of LPB as a post-processing technique to enhance the fatigue performance of WA-DED-fabricated AZ31 Mg alloy *** study highlights the importance of LPB surface treatment on AZ31 Mg components produced by CMT-WA-DED to remove surface d

关键词： Wire arc additive manufacturing AZ31 Mg alloy Low plasticity burnishing Low cycle fatigue test strain amplitude

Ren-integrable and ren-symmetric integrable systems

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Communications in Theoretical Physics 2024年第3期76卷 62-69页

作者： s Y Lou school of Physical science and Technology Ningbo UniversityNingbo315211China

A new type of symmetry,ren-symmetry,describing anyon physics and corresponding topological physics,is ***-symmetry is a generalization of super-symmetry which is widely applied in super-symmetric physics such as super-symmetric quantum mechanics,super-symmetric gravity,super-symmetric string theory,super-symmetric integrable systems and so *** and Grassmann numbers are,in some sense,dual conceptions,and it turns out that these conceptions coincide for the ren situation,that is,a similar conception of ren-number(R-number)is devised for *** particular,some basic results of the R-number and ren-symmetry are exposed which allow one to derive,in principle,some new types of integrable systems including ren-integrable models and ren-symmetric integrable *** examples of ren-integrable KdV-type systems and ren-symmetric KdV equations are explicitly given.

关键词： symmetries integrable systems anyon physics extended supersymmetry ren-symmetry

Exploring treatment options in cancer: Tumor treatment strategies

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signal Transduction and Targeted Therapy 2024年第8期9卷 3337-3380页

作者： Beilei Liu Hongyu Zhou Licheng Tan kin To Hugo siu Xin-Yuan Guan Department of Clinical Oncology The University of Hong Kong-Shenzhen HospitalShenzhenChina Department of Clinical Oncology The University of Hong KongHong KongChina state Key Laboratory for Liver Research The University of Hong KongHong KongChina Advanced Energy science and Technology Guangdong Laboratory HuizhouChina MOE Key Laboratory of Tumor Molecular Biology Jinan UniversityGuangzhouChina

Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical and psychological ***,the landscape of tumor treatment has undergone a comprehensive and remarkable *** as fervently pursued modalities are small molecule targeted agents,antibody-drug conjugates(ADCs),cell-based therapies,and gene *** cutting-edge treatment modalities not only afford personalized and precise tumor targeting,but also provide patients with enhanced therapeutic comfort and the potential to impede disease ***,it is acknowledged that these therapeutic strategies still harbour untapped potential for further *** a comprehensive understanding of the merits and limitations of these treatment modalities holds the promise of offering novel perspectives for clinical practice and foundational research *** this review,we discussed the different treatment modalities,including small molecule targeted drugs,peptide drugs,antibody drugs,cell therapy,and gene *** will provide a detailed explanation of each method,addressing their status of development,clinical challenges,and potential *** aim is to assist clinicians and researchers in gaining a deeper understanding of these diverse treatment options,enabling them to carry out effective treatment and advance their research more effciently.

关键词： drugs treatment holds