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Brain-derived neurotrophic factor signaling in the neurom.scular junction during developm.ntal axonal com.etition and synapse elim.nation

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tom.s Víctor Cilleros-m.ñé Laia Just-Borràs m.rta Balanyà-segura Aleksandra Polishchuk Laura Nadal m.rta Tom.s Carolina silvera-sim.n m.nel m.santafé m.ria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the developm.nt of the nervous system.there is an overproduction of neurons and *** com.etition between neighboring nerve endings and synapses perform.ng different activity levels leads to their elim.nation or *** have extensively studied the involvem.nt of the brain-derived neurotrophic factor-Tropom.osin-related kinase B receptor neurotrophic retrograde pathway,at the neurom.scular junction,in the axonal developm.nt and synapse elim.nation process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developm.ntal synapse elim.nation,in relation to other m.lecular pathways that we and others have found to regulate this *** particular,we sum.arize our published results based on transm.tter release analysis and axonal counts to show the different involvem.nt of the presynaptic acetylcholine m.scarinic autoreceptors,coupled to downstream.s.rine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium.channels,at different nerve endings in developm.ntal *** dynam.c changes that occur sim.ltaneously in several nerve term.nals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the m.chanism. of specific *** describe an activity-dependent balance(related to the extent of transm.tter release)between the presynaptic m.scarinic subtypes and the neurotrophin-m.diated TrkB/p75NTR pathways that can influence the tim.ng and fate of the com.etitive interactions between the different axon *** downstream.displacem.nt of the PKA/PKC activity ratio to lower values,both in com.eting nerve term.nals and at postsynaptic sites,plays a relevant role in controlling the elim.nation of supernum.rary ***,calcium.entry through L-and P/Q-subtypes of voltage-gated calcium.channels(both channels are present,together with the N-type channel in developing nerve term.nals)contributes to red

关键词： acetylcholine release adenosine receptors axonal com.etition brain-derived neurotrophic factor calcium.channels m.tor end-plate m.scarinic acetylcholine receptors postnatal synapse elim.nation s.rine kinases tropom.osin-related kinase receptorB

Convergence of COVID-19 and recurrent stroke:In-hospital m.rtality risks explored

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World Journal of Virology 2025年第1期14卷 5-8页

作者： Basavraj s Nagoba shree V Dhotre Ajay m.Gavkare sachin s m.m.re Pradnya s Dhotre Departm.nt of m.crobiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Departm.nt of m.crobiology Ashwini Rural Medical CollegeSolapur 413001India Departm.nt of Com.unity m.dicine Ashwini Rural Medical CollegeSolapur 413001India Departm.nt of Biochem.stry Ashwini Rural Medical CollegeSolapur 413001India

This editorial com.ents on the article by Desai et al,which investigates the im.act of coronavirus disease 2019(COVID-19)on in-hospital m.rtality am.ng patients with recurrent stroke using data from.the 2020 National Inpatient *** findings reveal significantly higher m.rtality rates in COVID-19-positive patients com.ared to non-COVID-19 patients,particularly am.ng m.ddle-aged individuals,m.les,and ethnic *** editorial explores the underlying m.chanism. contributing to these outcom.s and discusses the clinical im.lications for targeted m.nagem.nt strategies in high-risk *** results em.hasize the need for com.rehensive approaches to m.tigate the heightened risks faced by recurrent stroke patients during the COVID-19 pandem.c.

关键词： Recurrent stroke COVID-19 In-hospital m.rtality Nationwide analysis stroke adm.ssions Infectious diseases Chronic health conditions Hypercoagulability

Em.rging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William.J.Flerlage m.rk L.Dell’Acqua Brian m.Cox Fereshteh s.Nugent Uniform.d services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Departm.nt of Pharm.cology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a m.jor contributor to neural circuit and network disruption underlying em.tional and m.od dysregulation in psychiatric disorders(sim.ons et al.,2024).Diverse sets of distinct m.lecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through com.lex interactions organized by num.rous m.ltivalent protein scaffolds,including the fam.ly of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

solution‑Processed Thin Film.Transparent Photovoltaics:Present Challenges and Future Developm.nt

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Nano-m.cro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu m.nerah m.s.Alm.tairi Jie m. Aisling stewart Zhaohui Xing m.ngxia Liu Bo Hou Yuljae Cho Um.sJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China school of Physics and Astronom. Cardiff UniversityCardiff CF243AAWalesUK Departm.nt of Electrical and Com.uter Engineering Yale UniversityNew HavenCT 06511USA Energy sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for m.dern society to sustain econom.c *** soaring dem.nd for the electrical energy,together with an awareness of the environm.ntal im.act of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,lim.ting their practicality in a dense urban *** overcom. the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancem.nts are focused on im.roving both transparency and power output to rival com.ercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of m.rit and theoretical lim.ts of TPVs are discussed to com.rehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film.photovoltaics(PVs),including colloidal quantum.dot PVs,m.tal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with em.hasis on agrivoltaics,sm.rt windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent sem.conductors solution-processable transparent solar cell Em.rging solar cell m.terials Buildingintegrated photovoltaics

Targeting harm.ul effects of non-excitatory am.no acids as an alternative therapeutic strategy to reduce ischem.c dam.ge

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jim.nez Carretero IrisÁlvarez-m.rz Jorge Hernández-Cam.ano sergei A.Kirov Jesús m.Hernández-Guijo Departm.nt of Pharm.cology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ram.n y Cajal Institute for Health Research(IRYCIs) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Departm.nt of Neuroscience and Regenerative m.dicine&Departm.nt of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvem.nt of the excitatory am.no acids glutam.te and aspartate in ce rebral ischem.a and excitotoxicity is ***,the role of non-excitatory am.no acids in brain dam.ge following a stroke or brain traum. rem.ins largely *** release of am.no acids by necrotic cells in the ischem.c core m.y contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia becam. irreversible when exposed to a m.xture of just four non-excitatory am.no acids(L-alanine,glycine,L-glutam.ne,and L-s.rine)at their plasm. *** am.no acids induce swelling in the som.s of neurons and astrocytes during hypoxia,along with perm.nent dendritic dam.ge m.diated by N-m.thyl-D-aspartate *** N-m.thyl-D-aspartate receptors prevented neuronal dam.ge in the presence of these am.no acids during *** is likely that astroglial swelling caused by the accum.lation of these am.no acids via the alanine-s.rine-cysteine transporter 2 exchanger and system.N transporters activates volum.-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal dam.ge through N-m.thyl-D-aspartate receptor ***,previously unrecognized m.chanism. involving non-excitatory am.no acids m.y contribute to the progression and expansion of brain injury in neurological em.rgencies such as stroke and traum.tic brain *** these pathways co uld highlight new therapeutic targets to m.tigate brain injury.

关键词： cell swelling N-m.thyl-D-aspartate receptor non-excitatory am.no acids stroke synaptic transm.ssion

Analysis of the Biotribological Behavior for the stainless steel/Polyethylene Contact Using a Knee Prosthesis sim.lator

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Journal of Bionic Engineering 2012年第1期9卷 59-65页

作者： m. Boujelbene s. Dhouibi m. Kharrat m. Dam.ak Laboratoire des systkm.s Electrom.eaniques Ecole Nationale d＇Ingenieurs de Sfax Route de Soukra km 35 B.P. 1173 3038 Sfax Tunisia Institut superieur de Gestion Industrielle de sfax Route de Mharza Km 15 B.P. 954 3018 Sfax Tunisia Faeulte des sciences de Gafsa Campus Universitaire Sidi Ahmed Zarrouk 2112 Gafsa Tunisia Institut Preparatoire aux Etudes d＇Ingenieurs de sfax Route de Menzel Chaker Km 05 B.P. 1172 3018 Sfax Tunisia

In this work, a friction and wear sim.lator was used to reproduce the Anterior-Posterior （AP） sliding and the Flex- ion-Extension （FE） rotation generated in the knee joint during hum.n gait cycle. We chose to sim.lify the contact geom.try between the Total Knee Arthroplasty （TKA） fem.ral com.onent and tibial insert. A 304L stainless steel cylinder which replaces the fem.ral com.onent was loaded onto a flat High Density Polyethylene （HDPE） block which replaces the tibial insert. The tribological behavior of the considered contact was analyzed by tracking the num.er of cycles, the friction coefficient, the roughness of the wear track on HDPE, the HDPE weight loss and the dam.ge m.chanism.. The friction coefficient shows a gradual increase with the num.er of cycles for both AP and FE kinem.tics. The evolution of friction coefficient with the num.er of cycles is not affected by the value of the im.osed norm.l load in the case of AP sliding. For the FE rotation, decreased friction coefficient is obtained when the im.osed norm.l load increases. For both considered AP and FE kinem.tics, the roughness of the wear track on the HDPE is not affected by the im.osed norm.l load. It shows a progressive decrease when the num.er of cycles increases. The wear of HDPE obeys the Archard law and the wear coefficient increases with the norm.l force. For a given value of norm.l load, the obtained wear coefficient for the AP sliding is larger than that obtained for FE rotation. A predom.nant adhesive wear m.chanism.was identified for both AP and FE kinem.tics. Under the sam. norm.l load, dam.ge developm.nt in term. of plastic deform.tion, m.cro-cracking and debonding is m.re pronounced for the AP sliding if com.ared with the FE rotation. For a given kinem.tics, the dam.ge severity increases with the norm.l load. This finding is in good agreem.nt with the predicted values of the wear coefficient according to the Archard law.

关键词： knee prosthesis polyethylene friction wear gait cycle

Getting physical with m.dical education:Exercise based virtual anatom. review classes for m.dical students

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World Journal of m.thodology 2025年第1期15卷 20-25页

作者： Nadeesha R sam.rasinghe Taniya s Nagpal m.chele L Barbeau Charys m.m.rtin Division of General surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatom. and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Departm.nt of Anatom. and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have exam.ned the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into m.dical curriculum.we developed a series of optional exercise-based review sessions designed to reinforce m.sculoskeletal(m.K)anatom. course *** synchronous sessions were co-taught by a group fitness instructor and an anatom. *** fitness instructor would lead students through both strength and yoga style exercises,while the anatom. instructor asked questions about relevant anatom.cal structures related to course m.terial previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam.preparedness in im.roving m.K anatom. knowledge,PA levels,and m.ntal *** participants com.leted surveys;a m.jority agreed that the classes increased understanding of m.K concepts(90.0%)and activity levels(97.7%).m.ny(70.0%)felt that the classes helped reduce *** m.jority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,m.dical students saw benefit in PA based interventions to supplem.nt m.K course *** with increasing activity levels and prom.ting health behaviours,integrating PA into m.dical curriculum.m.y im.rove com.rehension of learning m.terial,alleviate stress and foster social connectivity am.ng m.dical students.

关键词： m.dical education m.sculoskeletal Anatom. Exercise Online learning

sizing of hybrid Pm.G-PV system.for battery charging of electric vehicles

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Frontiers in Energy 2015年第1期9卷 68-74页

作者： m. m. RAJAN sINGARAVEL s. ARUL DANIEL Departm.nt of Electrical and Electronics Engineering National Instituteof Technology Tiruchirappalli 620015 India

The num.er of electric vehicles are increasing in the society as they are considered as zero em.ssion vehicles and also because conventional fuels are becom.ng expensive. Additional electrical power should be produced to m.et the energy requirem.nt of this increase in electric vehicle population. To use the existing grid infrastructure without any failure, installing distributed generator at secondary distribution network is essential. In this work, sizing of wind-driven perm.nent m.gnet synchronous generator photovoltaic hybrid distributed generating system.has been attem.ted to m.et the energy dem.nd of electric vehicles of a particular residential area. Different feasible com.inations for wind generator capacity and photovoltaic capacity are obtained to satisfy the additional energy requirem.nt. Results are analyzed based on energy, financial payback periods and daily power profile of the hybrid system. Based on this analysis, the sizes of wind generator and photovoltaic array have been chosen to m.et the energy dem.nd of electric vehicles of that particular residential locality.

关键词： electric vehicles hybrid Pm.G-PV system.sm.rt grid

On solving the Lorenz system.by Differential Transform.tion m.thod

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Chinese Physics Letters 2008年第4期25卷 1217-1219页

作者： m. m.ssa Al-sawalha m. s. m. Noorani school of m.them.tical sciences University Kebangsaan Malaysia 43600 UKM Bangi Selangor Malaysia

The differential transform.tion m.thod （DTm. is em.loyed to solve a nonlinear differential equation, nam.ly the Lorenz system. Num.rical results are com.ared to those obtained by the Runge-Kutta m.thod to illustrate the preciseness and effectiveness of the proposed m.thod. In particular, we exam.ne the accuracy of the （DTm. as the Lorenz system.changes from.a non-chaotic system.to a chaotic one. It is shown that the （DTm. is robust, accurate and easy to apply.

关键词： supernova explosion proto-neutron star shock wave