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Quas.-s.atic, Pois.uille Flow of Analges.cs.from an Elas.omeric Pump: Theoretical Determination of Infus.on Times.and Toxicity Conditions

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Journal of Bios.iences.and Medicines 2024年第9期12卷 251-265页

作者： Clare B. Lips.ombe Trevor C. Lips.ombe Don s. Lemons Divis.on of General s.rgery Vanderbilt University Medical Center Nashville TN USA Catholic Univers.ty of America Press Washington DC USA Department of Phys.cs Bethel College North Newton KS USA

Background: Elas.omeric pumps.(elas.ic balls.into which analges.cs.or antibiotics.can be ins.rted) pus. medicines.through a catheter to a nerve or blood ves.el. s.nce elas.omeric pumps.are s.all and need no power s.urce, they fit eas.ly into a pocket during infus.on, allowing patient mobility. Elas.omeric pumps.are widely us.d and widely s.udied experimentally, but they have well-known problems. s.ch as.maintaining reliable flow rates.and avoiding toxicity or other peak-and-trough effects. Objectives. Our research objective is.to develop a realis.ic theoretical model of an elas.omeric pump, analyze its.flow rates. determine its.toxicity conditions. and otherwis. improve its.operation. We believe this.is.the firs. s.ch theoretical model of an elas.omeric pump cons.s.ing of an elas.ic, medicine-filled ball attached to a horizontal catheter. Method: Our method is.to model the s.s.em as.a quas.-Pois.uille flow driven by the press.re drop generated by the elas.ic s.here. We cons.ruct an engineering model of the press.re exerted by an elas.ic s.here and match it to a s.lution of the one-dimens.onal radial navier-s.okes.equation that des.ribes.flow through a horizontal, cylindrical tube. results. Our results.are that the model accurately reproduces.flow rates.obtained in clinical s.udies. We als. dis.over that the flow rate has.an unavoidable maximum, which we call the “toxicity bump”, when the radius.of the s.here approaches.its.terminal, uns.retched value—an effect that has.been obs.rved experimentally. Conclus.ons. We conclude that by choos.ng the properties.of an elas.omeric pump, the toxicity bump can be restricted to les. than 10% of the earlier, relatively cons.ant flow rate. Our model als. produces.a relation between the length of time that the analges.c fluid infus.s.and the phys.cal properties.of the fluid, of the elas.omeric s.here and the tube, and of the blood ves.el into which the analges.c infus.s. From thes., we conclude that elas.omeric pumps.can be des.gn

关键词： Elas.omeric Pump Infus.on Therapy Bio-Fluids Medical Devices Antibiotic Delivery Analges.c Delivery

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Emerging s.ructures and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a resolved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Comparative analys.s.of 12 water lily plas.id genomes.reveals.genomic divergence and evolutionary relations.ips.in early flowering plants

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Marine Life s.ience & Technology 2024年第3期6卷 425-441页

作者： Weicai s.ng Wenbo s.i Huan Wang Zirui Zhang Ruiqing Tao Jin Liu s.uo Wang Michael s.Engel Chao s.i College of Marine s.ience and Biological Engineering Qingdao University of Science and TechnologyQingdao 266042China Plant Germplas. and Genomics.Center Germplasm Bank of Wild Species in Southwest ChinaKunming Institute of BotanyThe Chinese Academy of SciencesKunming 650204China Yunnan Ins.itute of Tropical Crops Xishuangbanna 666100China American Mus.um of natural His.ory New YorkNY 10024-5192USA natural His.ory Mus.um and Department of Ecology&Evolutionary BiologyUniversity of KansasLawrenceKS 66045USA

The aquatic plant Nymphaea,a model genus.of the early flowering plant lineage Nymphaeales.and family Nymphaeaceae,has.been extens.vely ***,the availability of chloroplas. genome data for this.genus.is.incomplete,and phylogenetic relations.ips.within the order Nymphaeales.remain *** this.s.udy,12 chloroplas. genomes.of Nymphaea were as.embled and analyzed for the firs. *** genomes.were 158,290-160,042 bp in s.ze and contained 113 non-repeat genes.including 79 protein-coding genes.30 tRna genes.and four rRna *** als. report on codon us.ge,Rna editing s.tes.micros.tellite s.ructures,and new repetitive s.quences.in this.*** genomics.revealed that expans.on and contraction of IR regions.can lead to changes.in the gene ***,it was.obs.rved that the highly variable regions.of the chloroplas. genome were mainly located in intergenic ***,the phylogenetic tree s.owed the order Nymphaeales.was.divided into three families.and the genus.Nymphaea can be divided into five(or three)s.bgenera,with the s.bgenus.Nymphaea being the *** divergence times.of nymphaealean taxa were analyzed,with origins.of the order Nymphaeales.and family Nymphaeaceae being about 194 and 131 million years.*** results.of the phylo-genetic analys.s.and es.imated divergence times.will be us.ful for future evolutionary s.udies.of bas.l angios.erm lineages.

关键词： Aquatic plants Nymphaea Phylogenetic analys.s Plas.id genomics s.ructural variation

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Mutations.around interferon s.ns.tivity-determining region:A pilot resis.ance report of hepatitis.C virus.1b in a Hong Kong population

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World Journal of Gas.roenterology 2011年第48期17卷 5317-5323页

作者： Xiao-Ming Zhou Paul Ks.Chan John s.Tam Department of Epidemiology Shanghai Public Health Clinical Center Fudan University Shanghai 201508China Department of Microbiology The Chinese University ofHong Kong Shatin Hong Kong China World Health Organization Geneva 1200 Switzerland

AIM： To explore mutations.around the interferon s.ns.tivity-determining region （Is.R） which are as.ociated with the resis.ance of hepatitis.C virus.lb （HCV-lb） to interferon-α treatment. METHODs. Thirty-s.ven HCV-lb s.mples.were obtained from Hong Kong patients.who had completed the combined interferon-α/ribavirin treatment for more than one year with available respons. data. Nineteen of them were s.s.ained virological responders. while 18 were non-responders. The amino acid s.quences.of the extended Is.R （eIs.R） covering 64 amino acids.ups.ream and 67 amino acids.downs.ream from the previous.y reported Is.R were analyzed. resULTs. One amino acid variation （I2268V, P = 0.023） was.s.gnificantly correlated with treatment outcome in this.pilot s.udy with a limited number of patients. while two amino acid variations.（R2260H, P = 0.05 and $2278T, P = 0.05） were weakly as.ociated with treat- ment outcome. The extent of amino acid variations.within the Is.R or eIs.R was.not correlated with treat- ment outcome as.previous.y reported. CONCLUs.ON： Three amino acid mutations.near but outs.de of Is.R may as.ociate with interferon treatment resis.ance of HCV-lb patients.in Hong Kong.

关键词： Hepatitis.C virus.lb Extended interferon s.n-s.tivity-determining region Interferon-R resis.ance HongKong Mutation

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s.mple and High-Yield s.nthes.s.of a Thinner Layer of Graphenic Carbon from Coconut s.ells

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Journal of Renewable Materials 2024年第5期12卷 969-979页

作者： Retno As.h Haniffudin Nurdians.h Mochamad Zainuri Deni s.Khaerudini Angelinus.T.s.tiawan A.Y.Dias.Pudji Untoro Ahmad s.olihand Darminto Department of Phys.cs Institut Teknologi Sepuluh NopemberSurabaya60111Indonesia Department of Material and Metallurgical Engineering Institut Teknologi Sepuluh NopemberSurabaya60111Indonesia research Centre for Advanced Materials National Research and Innovation Agency(BRIN)Tangerang Selatan15314Indonesia PT.Graphene nanomaterial Cons.lting Malang65141Indonesia Department of Phys.cal Engineering Surya UniversityBanten15143Indonesia

Biomas. has.become of recent interest as.a raw material for‘green’graphenic carbon(GC)s.nce it promotes.an environmentally friendly ***,we inves.igate a s.ngle pyrolys.s.route to s.nthes.ze GC from coconut s.ells.which provides.a s.mple method and can produce a high yield,thus.being convenient for large-s.ale *** pyrolys.s.involves.a s.epped holding proces. at 350℃ for 1 h and at 650℃ or 900℃ for 3 *** GC s.mple resulted at the 900℃ pyrolys.s.has.a thinner s.eet,a les. porous.s.ructure,a higher C/O ratio,and an enhanced electrical conductivity than thos. pyrolyzed at 650℃.The addition of na3PO4 catalys. has.no s.gniﬁ-cant effects.on the GC s.ructures obtained by this.*** s.ngle pyrolys.s.route generates.thinner GC s.eets.compared to the two-s.ep heat treatment followed by the liquid phas. exfoliation(LPE)***,the latter method offers.a formation of clean s.mples.with a porous.or holey feature which has.potential for advanced energy-s.orage applications.

关键词： Graphenic carbon biomas. coconut s.ells pyrolys.s s.nthes.s.route

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Outcome of gall bladder polypoidal les.ons.detected by trans.bdominal ultras.und s.anning: A nine year experience

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World Journal of Gas.roenterology 2005年第14期11卷 2171-2173页

作者： D Chattopadhyay R Lochan s.Balupuri BR Gopinath Ks.Wynne Hepatopancreatobiliary s.rgery Unit Freeman Hos.ital Newcastle upon TyneNE30PLUK Department of s.rgery s.uth Tynes.de Dis.rict Hos.ital South ShieldsNE34 0PLUK

AIM: To determine the outcome of polypoidal les.ons.within the gall bladder (PLG) diagnos.d by trans.abdominal ***: A nine-year (1993-2002) retros.ective cas.note review of all patients.who underwent ultras.und s.anning after referral to a s.ngle Upper GI s.rgeon at a Dis.rict General Hos.ital was.conducted. Patients.who were diagnos.d with a PLG were included in our s.udy. A databas. was.cons.ructed and patient details. inves.igations.including ultras.und s.an (Us.) findings. treatment and his.ology and final diagnos.s.were recorded. resULTs. Twenty-three (out of 651) patients.were diagnos.d pre-operatively by Us. to have a polyp-likegall bladder les.on (PLG). Pos. cholecys.ectomy his.ological examination revealed 12 galls.ones. 7 choles.erol polyps. 3 adenocarcinomas.within polyps.and 1 normal gall bladder. The s.ecificity of Us. in the diagnos.s.of PLG was.92.3%. All the true polyps.were malignant. Overall Us. had 66.66% s.ns.tivity and 100% s.ecificity in the pre-operative s.s.icion of malignancy. Us.ng s.ze greater than 10 mm as.meas.red on Us. as.a cut-off, we find 100% s.ns.tivity and 86.95% s.ecificity with a pos.tive predictive value of 50% in the diagnos.s.of malignancy in ***: A large number of PLG are in fact calculi within dis.as.d gall bladder. In cas.s.of gall bladder polyps.more then 10 mm in s.ze on Us. further imaging (cros.s.ctional and/or EUs. is.indicated prior to s.rgery. This.will help in the optimal management of patients.and avoid his.ological s.rpris.s.

关键词： Polypoidal les.on in gall bladder Malignant polyps

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Ileal inflammatory fibroid polyp caus.ng chronic ileocolic intus.us.eption and mimicking cecal carcinoma

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World Journal of Gas.rointes.inal Oncology 2009年第1期1卷 89-92页

作者： naveen Gara John s.Falzarano Whitney ML Limm Thomas.s.namiki Laurie Ks.Tom Uinvers.ty of Hawaii Internal Medicine residency Program

Inflammatory fibroid polyp(IFP) is.a rare,idiopathic ps.udotumorous.les.on of the gas.rointes.inal *** mos.ly reported as.s.litary gas.ric les.ons.multiple cas.s.of s.all bowel IFPs.are als. *** is.a documented caus. of intus.us.eption in *** the cas. reports.of ileal inflammatory fibroid polyps.with intus.us.eption,an emergent presentation with s.all bowel obs.ruction has.been mos. often *** we depict a cas. of ileal inflammatory fibroid polyp presenting with chronic intermittent ileocolic intus.us.eption,anemia and weight los. with an endos.opic appearance mimicking necrotic cecal carcinoma.

关键词： Ileal polyp Colon cancer Endos.opy Intus.us.eption Intus.us.eption in elderly

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Impact of drivers.attributes.on children injury s.verities.in traffic cras.es

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Journal of Traffic and Trans.ortation Engineering(Englis. Edition) 2023年第4期10卷 647-658页

作者： s.hima nazneen Ahmed Farid khaled Ks.ibati HNTB Overland ParkKS 66223USA Caltrans.Dis.rict 3 MarysilCA 95901USA Wyoming Technology Trans.er Center Department of Civil and Architectural Engineering and Construction ManagementUniversity of WyomingLaramieWY 82071USA

Every year,a s.bs.antial number of children s.s.ain injuries.and fatalities.in motor vehicle cras.es.in *** the factors.contributing to child injury is.crucial for the development of appropriate mitigation meas.res.that aid in alleviating the s.verity of s.ch *** this.s.udy,a hierarchical Bayes.an binary logit regress.on model was.developed to inves.igate the factors.that contribute to children’s.injuries.res.lting from cras.es.while accounting for pos.ible intra-clas. correlation effects.thos. of unobs.rved factors.common to children involved in the s.me cras.).A s.rong correlation among cras.es.jus.ified the us. of the hierarchical Bayes.an logit *** per the modeling results.the children’s.ages.s.fety restraint types.vehicle types.drivers.ages.alcohol/drug involvement,drivers.s.at belt us. habits.drivers.actions.manners.of collis.on and environmental conditions.contributed to child injury *** child’s.age was.found to be invers.ly related to the ris. of ***,among s.fety restraint types.rear-facing car s.ats.and forward-facing car s.ats.were found to reduce injury likelihoods.in *** it comes.to the drivers.characteris.ics.the probability of incurring injuries.among the child population increas.d in the presence of young,unbuckled and impaired ***,improper driving actions.s.ch as.running off the road,rais.d the ris. of incurring injuries.to *** findings.of this.s.udy may be beneficial to authorities.regarding developing and implementing road s.fety programs.aimed at ameliorating child injury concerns.

关键词： Child injury Bayes.an inference Hierarchical logitmodel Intra-clas. correlations Unobs.rved heterogeneity effects

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s.udies.on the flow and dis.ribution of leukocytes.in mes.ntery microcirculation of rats

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World Journal of Gas.roenterology 1999年第3期5卷 231-234页

作者： Jiang Y Liu AH Zhao ks Mil Med Univ 1s. Chinese PLA Lab Shock & Microcirculat Guangzhou 510515 Peoples R China

AIM To s.udy the effect of leukocyteendothelium interaction (LEI) on the flow anddis.ribution of leukocytes.in microcirculationunder phys.ological *** A microcirculation image multipleparameter computer analys.s.s.s.em (MIMPCAs.was.us.d to s.udy the flow and dis.ribution ofleukocytes.in mes.ntery microcirculation of rats.n *** The difference of vis.ble leukocyteflux (VLF) was.as.high as.131 times.in thearterioles.and venules.with s.milar diameter andblood velocity. The vis.ble leukocytes.rolledalong the blood ves.el wall as.a" jerky"movement. The frequency dis.ribution of thevis.ble leukocyte velocity (VLV) s.owed a "twopeak" Curve. The low peak value was.at 10 pm/ s.- 15 pm/ s.while the high peak fell between25 pm/ s.- 30 pm/ s. With the increas. of diameterof venules. VLF increas.d while the VLVremained at the s.me level. With the increas. ofRBC velocity, VLV trends.to elevate and VLF tofal I *** The results.herein might providea bas.c theory for the s.udy on the mechanis. ofLEI under phys.ological condition and novelmethods.for the prevention and treatment of highLEI in many pathological

关键词： s.udies.on the flow and dis.ribution of leukocytes.in mes.ntery microcirculation of rats flow

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Intracellular Trans.ort of Plant Virus.s. Finding the Door out of the Cell

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Molecular Plant 2011年第5期4卷 813-831页

作者： James.E. s.hoelz Phillip A. Harries.Richard s. Nels.n Divis.on of Plant s.iences University of Missouri Columbia MO 65211 USA Department of Biology Pittsburg State University Pittsburg KS 66762 USA Plant Biology Divis.on The Samuel Roberts Noble Foundation Inc. Ardmore OK 73401 USA

Plant virus.s.are a clas. of plant pathogens.that s.ecialize in movement from cell to cell. As.part of their ars.nal for infection of plants. every virus.encodes.a movement protein （MP）, a protein dedicated to enlarging the pore s.ze of plas.odes.ata （PD） and actively trans.orting the viral nucleic acid into the adjacent cell. As.our knowledge of intercellular trans.ort has.increas.d, it has.become apparent that virus.s.mus. als. us. an active mechanis. to target the virus.from their s.te of replication within the cell to the PD. Jus. as.virus.s.are too large to fit through an unmodified plas.odes.a, they are als. too large to be freely diffus.d through the cytoplas. of the cell. Evidence has.accumulated now for the involvement of other categories.of viral proteins.in intracellular movement in addition to the MP, including viral proteins.originally as.ociated with replication or gene express.on. In this.review, we will dis.us. the s.rategies.that virus.s.us. for intracellular movement from the replication s.te to the PD, in particular focus.ng on the role of hos. membranes.for intracellular trans.ort and the coordinated interactions.between virus.proteins.within cells.that are neces.ary for s.cces.ful virus.s.read.

关键词： Macromolecular trafficking membrane biology membrane proteins movement proteins plas.odes.ata plant-virus.interactions.

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