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Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology

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World Journal of Gastroenterology 2011年第7期17卷 922-925页

作者： Mikkel Malham sΦren peter JΦrgensen peter ott JΦrgen Agnholt Hendrik Vilstrup Mette Borre Jens F Dahlerup Department of Medicine V (Hepatology and Gastroenterology) Aarhus University Hospital

AIM: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHoDs: our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. REsULTs: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (p oth groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-pugh score. CoNCLUsIoN: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis.

关键词： Alcoholic liver cirrhosis Child-pugh score primary biliary cirrhosis Vitamin D deficiency

A micromechanical model for efective conductivity in granular electrode structures

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Acta Mechanica sinica 2013年第5期29卷 682-698页

作者： Julia ott Benjamin Vlker Yixiang Gan Robert M.Mc Meeking Marc Kamlah Institute of Applied Materials Karlsruhe Institute of Technology76131 Karlsruhe Germany Department of Mechanical Engineering University of CaliforniaSanta BarbaraCA 93106 USA school of Civil Engineering The University of SydneyNSW 2006 Australia Materials Department University of CaliforniaSanta BarbaraCA 93106 USA school of Engineering University of AberdeenKing’s CollegeAberdeenAB24 3UE Scotland UK INM-Leibniz Institute for New Materials Campus D22 66123 Saarbrücken Germany

optimization of composition and microstructure is important to enhance performance of solid oxide fuel cells （soFC） and lithium-ion batteries （LIB）. For this, the porous electrode structures of both soFC and LIB are modeled as a binary mixture of electronic and ionic conducting particles to estimate effective transport p.operties. particle packings of 10000 spherical, binary sized and randomly positioned particles are created numerically and densified considering the different manufacturing p.ocesses in soFC and LIB： the sintering of soFC electrodes is app.oximated geometrically, whereas the calendering p.ocess and volume change due to intercalation in LIB are modeled physically by a discrete el- ement app.oach. A combination of a tracking algorithm and a resistor network app.oach is developed to predict the con- nectivity and effective conductivity for the various densified structures. For soFC, a systematic study of the influence of morp.ology on connectivity and conductivity is performed on a large number of assemblies with different compositions and particle size ratios between 1 and 10. In comparison to percolation theory, an enlarged percolation area is found, es- pecially for large size ratios. It is shown that in contrast to former studies the percolation threshold correlates to varying coordination numbers. The effective conductivity shows not only an increase with volume fraction as expected but also with size ratio. For LIB, a general increase of conductivity during the intercalation p.ocess was observed in correlation with increasing contact forces. The positive influence of cal- endering on the percolation threshold and the effective conductivity of carbon black is shown. The anisotropy caused by the calendering p.ocess does not influence the carbon black phase.

关键词： Granular electrode structures Effective conductivity - percolation

smoking increases the risk of extraintestinal manifestations in Crohn's disease

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World Journal of Gastroenterology 2014年第34期20卷 12269-12276页

作者： Claudia ott Angela Takses Florian obermeier Elisabeth schnoy Martina Müller Department of Internal Medicine I University of Regensburg93042 RegensburgGermany

AIM:To demonstrate a high prevalence of extraintestinal manifestations(EIMs)in a p.ospective populationbased cohort of inflammatory bowel disease(IBD)patients at first diagnosis as well as during the early course of the ***:EIMs are common in patients with *** on the frequency of EIMs have mostly been assessed in patients from tertiary centers;however,data about the prevalence of EIMs at first diagnosis as well as factors influencing their incidence during the early course of disease from p.ospective population-based cohorts are *** present data of patients of our population-based"oberpfalz cohort"(Bavaria,Germany)from first diagnosis(up to 3 mo after first diagnosis)as well as during the early course of the *** risk factors were assessed by calculating the relative risk(RR)as well as using logistic regression ***:In total,data of 257 newly diagnosed patients with IBD were evaluated[161 Crohn’s disease(CD),96 ulcerative colitis(UC)].Median duration of follow-up was 50 mo after first *** 63.4%of all patients(n=163),an EIM was diagnosed at any point during the observation *** first diagnosis,patients with CD had a significantly increased risk of an EIM[n=69(42.9%)]compared with UC patients[n=21(21.9%);psmoking increased the risk of CD patients developing an EIM during the early course of the disease,but notably not of UC patients(p=0.046;RR=1.96;95%CI:1.01-3.79).In addition,using logistic regression analysis,the need for IBD-related surgery and a young age at first diagnosis were identified as risk factors for the development of an EIM in CD *** association with EIMs was found for the factors sex,localization of the disease and positive family history of *** contrast,no key factors which increased the risk of development of an EIM could be identified in UC ***:We found a high prevalence of EIM in this cohort at first diagnosis and during th

关键词： Extraintestinal manifestations Crohn's disease Ulcerative colitis smoking surgery Age at onset

performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAs detector

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Chinese physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht s.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.s. Acharya C. Adam Bourdarios L. Adamczyk s.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.s. Ahmed s. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.p.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert p. Albicocco G.L. Albouy s. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali s. Ali s.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores p.p. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei s.p. Amor Dos santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders s.Y. Andrean A. Andreazza s. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal s.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin s. Argyropoulos J.-H. Arling o. Arnaez H. Arnold G. Artoni H. Asada K. Asai s. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos s. Atashi R.J. Atkin M. Atkinson H. Atmani p.A. Atmasiddha K. Augsten s. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea p. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines o.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin p. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay s. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-s. Barisits T. Barklow p. Baron D.A. Baron Mo The ATLAs Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAs Collaboration,using √s=13 TeV p.oton–p.oton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAs *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are p.ovided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAs JET QUARK GLUoN TAGGING

A GmNINa-miR172c-NNC1 Regulatory Network Coordinates the Nodulation and Autoregulation of Nodulation pathways in soybean

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Molecular plant 2019年第9期12卷 1211-1226页

作者： Lixiang Wang Zhengxi sun Chao su Yongliang Wang Qiqi Yan Jiahuan Chen Thomas.ott Xia Li state Key Laboratory of Agricultural Microbiology College of Plant Science and TechnologyHuazhong Agricultural UniversityNo.1 Shizishan RoadHongshan DistrictWuhanHubei 430070P.R.China College of Biological science and Engineering Panzhihua UniversityNo.10 Airport RoadEastern DistrictPanzhihuaSichuanChina University of Freiburg.Faculty of Biology.University of Freiburg Schdnz丨estrasse 179104 Freiburg.Germany CIBss-Centre for Integrative Biological signalling studies University of Freiburg79104 FreiburgGermany

symbiotic root nodules are root lateral organs of plants in which nitrogen-fixing bacteria(rhizobia)convert atmospheric nitrogen to *** formation and number of nodules in legumes are precisely controlled by a rhizobia-induced signal cascade and host-controlled autoregulation of nodulation(AoN).However,how these pathways are integrated and their underlying mechanisms are ***,we report that microRNA172c(miR172c)activates soybean(Glycine max)R hizobia-induced CLE1(GmRICI)and GmRIC2 by removing the transcriptional repression of these genes by Nodule Number Control 1(NNC1),leading to the activation of the AoN ***1 interacts with GmNINa,the soybean ortholog of Lotus NoDULE INCEpTIoN(NIN),and hampers its transcriptional activation o i G m RICI and ***,GmNINa acts as a transcriptional activator of ***,NNC1 can transcriptionally repress miR172c expression,adding a negative feedback loop into the NNC1 regulatory ***,GmNINa interacts with NNC1 and can relieve the NNC1-mediated repression of miR172c ***,the GmNINa-miR172c-NNC1 network is a master switch that coordinately regulates and optimizes NF and AoN signaling,sup.orting the balance between nodulation and AoN in soybean.

关键词： nodule number autoregulation of nodulation miR172c-NNC1 negative feedback loop nodule inception

sildenafil does not influence hepatic venous pressure gradient in patients with cirrhosis

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World Journal of Gastroenterology 2008年第40期14卷 6208-6212页

作者： Jens.otto Clemmesen Annamaria Giraldi peter ott Kim Dalhoff Bent Adel Hansen Fin stolze Larsen Department of Hepatology RigshospitaletUniversity Hospital of Copenhagen Clinical pharmacology RigshospitaletUniversity Hospital of Copenhagen

AIM： To investigate if sildenafil increases splanchnic blood flow and changes the hepatic venous pressure gradient （HVpG） in patients with cirrhosis. p.osp.odiesterase type-5 inhibitors are valuable in the treatment of erectile dysfunction and pulmonary hypertension in patients with end-stage liver disease. However, the effect of p.osp.odiesterase type-5 inhibitors on splanchnic blood flow and portal hypertension remains essentially unknown. METHoDs： Ten patients with biopsy p.oven cirrhosis （five females/five males, mean age 54：1：8 years） and an HVpG above 12 mmHg were studied after informed consent. Measurement of splanchnic blood flow and the HVpG during liver vein catheterization were done before and 80 min after oral administration of 50 mg sildenafil. Blood flow was estimated by use of indocyanine green clearance technique and Fick＇s principle, with correction for non-steady state. REsULTs： The plasma concentration of sildenafil was 222 ± 136 ng/mL 80 min after administration. Mean arterial blood pressure decreased from 77 ±7 mmHg to 66 ± 12 mmHg, p = 0.003, while the splanchnicblood flow and oxygen consumption remained unchanged at 1.14 ± 0.71 L/min and 2.3 ± 0.6 mmol/ min, respectively. Also the HVpG remained unchanged （18 ± 2 mmHg vs 16 ± 2 mmHg） with individual changes ranging from -8 mmHg to ±2 mmHg. In seven patients, HVpG decreased and in three it increased. CoNCLUsIoN： In spite of arterial blood pressure decreases 80 min after administration of the p.osp.odiesterase type-5 inhibitor sildenafil, the present study could not demonstrate any clinical relevant influence on splanichnic blood flow, oxygen consumption or the HVpG.

关键词： Cirrhosis sildenafil portal hypertension portal hemodynamics Hepatic blood flow Erectile dysfunction Hepatic venous pressure gradient

Reduced Vector Helmholtz Wave Equation Analysis on the Wave-Number side

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Journal of Electromagnetic Analysis and Applications 2019年第9期11卷 161-172页

作者： Randy ott Retired Researcher Albuquerque NM USA

The resolvent helps solve a pDE defined on all of wave-number space, . Almost all electromagnetic scattering p.oblems have been solved on the spatial side and use the spatial Green’s function app.oach. This work is motivated by solving an EM p.oblem on the Fourier side in order to relate the resolvent and the Green’s function. Methods used include Matrix Theory, Fourier Transforms, and Green’s function. A closed form of the resolvent is derived for the electromagnetic Helmholtz reduced vector wave equation, with Dirichlet boundary conditions. The resolvent is then used to derive expressions for the solution of the EM wave equation and p.ovide sobolev estimates for the solution.

关键词： Helmholtz em Vector Wave Equation Closed form of Resolvent sobolev Estimates for solution

obeticholic acid for severe bile acid diarrhea with intestinal failure:A case report and review of the literature

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World Journal of Gastroenterology 2018年第21期24卷 2320-2326页

作者： Christian Lodberg Hvas peter ott peter paine simon Lal soren peter Jorgensen Jens Frederik Dahlerup Department of Hepatology and Gastroenterology Aarhus University HospitalAarhus C 8000Denmark Department of Gastroenterology Salford Royal NHS Foundation TrustSalfordManchester M6 8HDUnited Kingdom

Bile acid diarrhea results from excessive amounts of bile acids entering the colon due to hepatic overexcretion of bile acids or bile acid malabsorption in the terminal ileum. The main therapies include bile acid sequestrants, such as colestyramine and colesevelam, which may be given in combination with the op.oid recep.or agonist loperamide. some patients are refractory to conventional treatments. We report the use of the farnesoid X recep.or agonist obeticholic acid in a patient with refractory bile acid diarrhea and subsequent intestinal failure. A 32-year-old woman with quiescent colonic Crohn's disease and a normal terminal ileum had been diagnosed with severe bile acid malabsorption and complained of watery diarrhea and fatigue. The diarrhea resulted in hypokalemia and sodium depletion that made her dependent on twice weekly intravenous fluid and electrolyte infusions. Conventional therapies with colestyramine, colesevelam, and loperamide had no effect. second-line antisecretory therapies with pantoprazole, liraglutide, and octreotide also failed. Third-line treatment with obeticholic acid reduced the number of stools from an average of 13 to an average of 7 per 24h and imp.oved the patient's quality of life. The fluid and electrolyte balances normalized. The effect was sustained during follow-up for 6 mo with treatment at a daily dosage of 25 mg. The diarrhea worsened shortly after cessation of obeticholic acid. This case report sup.orts the initial report that obeticholic acid may reduce bile acid p.oduction and imp.ove symp.oms in patients with bile acid diarrhea.

关键词： Bile acid malabsorption Diarrhea Farnesoid X-activated recep.or Crohn’s disease

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扩张型心肌病心肌中脂肪酸含量的研究

中华心血管病杂志 1998年第1期26卷 12-14页

作者：朱宁 WilliamE.Connor GaryY.ott 大连医科大学附属第二医院心内科美国俄勒冈健康科学大学内科

目的为了解扩张型心肌病心肌的生化改变，分析了心肌组织中脂肪酸的成分与含量。方法从心脏移植或意外死亡时取下的新鲜心脏左室前壁中取心肌组织。标本共分三组：扩张型心肌病１０例，冠心病１０例，正常对照１０例。用薄层色谱法分离... 详细信息

目的为了解扩张型心肌病心肌的生化改变，分析了心肌组织中脂肪酸的成分与含量。方法从心脏移植或意外死亡时取下的新鲜心脏左室前壁中取心肌组织。标本共分三组：扩张型心肌病１０例，冠心病１０例，正常对照１０例。用薄层色谱法分离出心肌脂质提取液中磷脂及甘油三酯部分，经毛细管柱气相色谱分析得到各种脂肪酸的相对含量。结果扩张型心肌病组的心肌磷脂中亚油酸与正常对照组比较明显缺乏，为１８．３±０．９％比２５．３±３．０％（Ｐ＜０．０５）；冠心病组的亚油酸含量高于心肌病组但低于正常组。甘油三酯中各脂肪酸含量三组间差异无显著性。结论心肌收缩功能中起重要作用的前列腺素是由亚油酸为前体的花生四烯酸合成的，因此心肌病人亚油酸缺乏，可能影响前列腺素的合成，从而造成收缩功能降低。增加心肌病病人饮食中的亚油酸含量，则有可能对扩张型心肌病的预后产生一定的影响。

关键词：扩张型心肌病心肌脂肪酸