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FGF2和VEGF对食管鳞癌、腺癌荷瘤裸鼠肿瘤组织结构血管、灌注血管及缺氧程度的影响分析

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胃肠病学和肝病学杂志 2003年第2期12卷 124-129页

作者：郭敏 IvanDing 王立东 Department of Radiation Oncology University of Rochester Medical CenterRochesterNYU.S.A.146421 郑州大学医学院癌症研究室

目的探索FCG2及VEGF对食管癌结构血管和灌注血管的影响,阐明与食管癌快速生长、转移密切相关的血管生成调节机制。方法本实验采用人食管癌细胞系TE-1(鳞状细胞癌),sEG-1和BIC-1(腺癌)及其荷瘤动物模型。利用体外细胞培养技术观察重组... 详细信息

目的探索FCG2及VEGF对食管癌结构血管和灌注血管的影响,阐明与食管癌快速生长、转移密切相关的血管生成调节机制。方法本实验采用人食管癌细胞系TE-1(鳞状细胞癌),sEG-1和BIC-1(腺癌)及其荷瘤动物模型。利用体外细胞培养技术观察重组人FGF2、VEGF对三种细胞系生长增殖的影响,采用多探针RNA酶保护性分析方法检测FGF2和VEGFmRNA水平,采用免疫组织化学和免疫荧光方法观察食管癌组织结构血管、灌注血管密度及瘤内缺氧程度的影响。结果 ①体外细胞培养实验中,不同浓度FGF2(10ng,100ng)对人食管癌细胞系TE-1,sEG-1和BIG-1的增殖速度和生长曲线无影响。②FGF2和VEGRmRNA基础水平的定量检测显示食管鳞癌细胞系TE-1的FGF2为4.92,VEGF为57.57。食管腺癌细胞系sEG-1的FGF2、VEGF分别为49和53.62;BIC-1不表达FGF2,VEGF为17.04。③在TE-1、sEG-1、BIC-1三种食管癌荷瘤裸鼠模型中,FGF2、VFGF对食管癌结构血管(CD31)以及灌注血管(DIOC7)平均距离的影响分析显示:VEGF处理组结构血管和灌注血管密度较对照组显著增加(PsEG-1模型中显著增加(P<0.05)。④在TE-1和BIC-1模型中,FGF2处理组EF5/Cy3染色的平均强度与对照组无明显差别,VEGF处理组EF5/Cy3染色的平均强度明显降低。

关键词： FGF2 VEGF 食管鳞癌食管腺癌肿瘤组织结构血管生成调节因子细胞增殖荷瘤裸鼠模型

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barrett’s食管的研究现状与展望

胃肠病学和肝病学杂志 2003年第2期12卷 107-111页

作者：邹莉萍罗和生欧阳静萍武汉大学人民医院消化内科武汉430060

barrett食管(barrett's esophagus,BE)是由英国心胸外科医生barrett [1]在上世纪50年代首次报告提出并以他的名字命名的,2000年日本barrett黏膜定义研讨会制订了barrett食管的定义、诊断与分类[2],定义barrett食管是指食管下段复层鳞状... 详细信息

barrett食管(barrett's esophagus,BE)是由英国心胸外科医生barrett [1]在上世纪50年代首次报告提出并以他的名字命名的,2000年日本barrett黏膜定义研讨会制订了barrett食管的定义、诊断与分类[2],定义barrett食管是指食管下段复层鳞状上皮被单层柱状上皮所取代,以食管与胃黏膜交界的连接线(齿状线)为界,在齿状线2cm以上出现柱状上皮者即为barrett食管.

关键词： barrett'’s食管食管癌鳞状上皮柱状上皮胃-食管反流食管黏膜

使用乙酸的放大色素内镜检查barrett食管中肠化生和异常增生的诊断准确度

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 28-28页

作者： Réaud s. Croue A. Boyer J. 张诗峰 service d'Hépato-Gastroentérologie CHU d'Angers4 rue Larrey49033 Angers Cedex 01

Objectives-Endoscopy with systematic randomized biopsies aims to improve the detection of intestinal metaplasia(IM)and dysplasia in barrett’s esophagus(BE).Magnifying chromoendoscopy with alcoholic acetic acidmight allow directed biopsies to improve detection of IM and *** and methods-Twenty-eight patients were studied with magnifying chromoendoscopy(Optical power zoom x 115,alcoholic acetic acid).Endoscopy biopsies were performed on one or several zones of BE chosen randomly,for which the chromoendoscopic pattern was determined according to Guelrud’s ***-Among seventy-two biopsies,the agreement between magnifying chromoendoscopy and histology and the positive predictive value of the association of patterns III and IV for the diagnosis of IM were 72.4%;sensibility and specificity were respectively 95.5%and 42.9%.The diagnostic accuracy was 75%.Among the six biopsies that showed high-grade dysplasia,three were suspected because of two particular patterns:local loss of ridged cerebriform pattern due to the disorganization of the mucosal folds and hypervascularization of the ***-Magnifying chromoendoscopy with acetic acid allows targeted biopsies of the IM in BE and may help to detect high-grade dysplasia.

关键词： barrett食管色素内镜检查异常增生诊断准确度乙酸法肠化生放大色素内镜随机活检

barrett食管:肉眼检查与组织学诊断的差异

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世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 34-34页

作者： Endlicher E. Rümmele P. Beer s. 廖新华 Dept. of Internal Medicine I University of Regensburg 93042 Regensburg Germany.Dr

Background and study aims: The diagnosis of barrett’s esophagus at present requires endoscopic and histological confirmation of specialized intestinal metaplasia. This study prospectively analyzed the endoscopic and histological prevalence of barrett’s esophagus and the risk factors for the presence of barrett’s esophagus among patients being treated in an endoscopy unit. Patients and methods: A total of 474 unselected patients (58%men; mean age 52 y) were included in the study. Two biopsy specimens each were taken from below and above the squamocolumnar junction and from the antrum and gastric body. Four-quadrant biopsies were taken every 1-2 cm to confirm a macroscopic suspicion of barrett’s esophagus. Results: barrett’s esophagus was suspected at endoscopy in 109 patients (23%). Of the 109 patients with endoscopically suspected barrett’s esophagus, only 46 (42%) had the finding confirmed histologically. The sensitivity and specificity for the endoscopic diagnosis of barrett’s esophagus were 62%and 84%, respectively. A multivariate logistic regression analysis identified age (P = 0.0001; odds ratio per life-year 1.087; 95%CI, 1.046-1.139),male sex (P = 0.0020; OR 6.346; 95%CI, 2.094-22.314), and the number of biopsies (P = 0.0025; OR 1.661; 95%CI, 1.247-2.392) as factors associated with evidence of intestinal metaplasia on biopsy. Conclusion: The striking discrepancy between the endoscopic findings and the histological diagnosis may be due to the focal distribution of intestinal metaplasia. This emphasizes the importance of an adequate biopsy protocol. In addition, better methods of detecting focal islands of intestinal metaplasia that are not visible at conventional endoscopy are needed.

关键词： barrett 肉眼检查组织学诊断柱状上皮组织学检查内镜检查结果肠上皮化生活组织检查诊

论“治未病”思想在barrett食管辨治中的指导意义

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山东中医杂志 2011年第11期30卷 769-770页

作者：王昌雄宋力伟鄢连和徐磊叶洁桐浙江省丽水市人民医院消化内镜中心浙江丽水323000

探讨中医"治未病"思想的学术渊源、理论内涵以及在防治恶性肿瘤中的意义,并从未病先防、既病防变等方面研究"治未病"思想在barrett食管诊治中的作用,为临床应用"治未病"思想指导消化道癌前病变的防治提供参考。

关键词：治未病 barrett食管指导意义