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Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

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Neural Regeneration Research 2025年第09期 2587-2588页

作者： Laetitia Aubry Timothy barrett sovan sarkar I-sTEM CECSCorbeil-EssonnesFrance (Aubry L) Universite Paris-SaclayUniversité d'EvryINS ERMI-STEM Institute of Cancer and Genomic sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of Birmingham Department of Endocrinology Birmingham Women's and Children's Hospital

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the "powerhouse" of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca2+) homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,and β-oxidation of fatty acids.

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Multitarget Thiol-Activated Tetrapyridyl Gold(Ⅲ)Complexes for Hypoxic Cancer Therapy

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CCs Chemistry 2024年第3期6卷 783-797页

作者： Xue-Quan Zhou selda Abyar Imma Carbo-Bague Lan Wang sebastian Türck Maxime Asiegler Uttara Basu Ingo ott Rongfang Liu Adriaan PIJzerman sylvestre Bonnet Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School(SIGS)Tsinghua UniversityShenzhen 518055 Leiden Institute of Chemistry Leiden University2333 CC Leiden Department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6 Institute of Medicinal and Pharmaceutical Chemistry Technische Universität Braunschweig38106 Braunschweig Department of Chemistry Johns Hopkins UniversityBaltimoreMaryland 21218 Division of Drug Discovery&safety Leiden Academic Centre for Drug ResearchLeiden University2333 CC Leiden

Gold complexes have emerged as promising anticancer metallodrugs due to their efficient thioredoxin reductase(TrxR)inhibition,which disturbs the redox balance of cancer ***,in this model,the role of the ligand(s)coordinated to gold is often *** this work,we present a series of tetrapyridyl Au(Ⅲ)complexes that exhibit thiol-induced release of a Au(Ⅰ)ion and a tetrapyridyl *** formation of a free Au(Ⅰ)center is responsible for the expected TrxR ***,the released ligand,which was visible in cells due to its intense blue fluorescence,showed excellent binding properties to the hERG potassium ***,these ligands ended up in the lysosomes,resulting in significant lysosome ***,the Au(Ⅲ)complexes presented in this work showed broad-spectrum anticancer properties,both in hypoxic 2D monolayers and 3D tumor *** suggest that the interaction of the released Au(Ⅰ)center and the tetrapyridyl ligand with two different protein targets may combine into prodrugs that overcome hypoxia-induced drug deactivation.

关键词： anticancer Au(Ⅲ)complexes enzyme inhibtion potassium channel affinity lysosome damage cell imaging prodrug

Rock mechanics for design of Brisbane tunnels and implications of recent thinking in relation to rock mass strength

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 676-683页

作者： L.B.McQueen A.Purwodihardjo s.V.L.barrett Golder Associates Pty Ltd. 124 Pacific HighwaySt.LeonardsNSW2065Australia Golder Associates Pty Ltd. 147 Coronation DriveMiltonQueensland4064Australia Golder Associates Pty Ltd. Building 7Botanicca Corporate Park570 e 588 Swan StreetRichmondVictoria3121Australia

This paper explores the potential implications of recent thinking in relation to rock mass strength for future tunnelling projects in Brisbane,Australia,particularly as they are constructed within deep horizons where the in situ stress magnitudes is *** mass failure mechanisms for the current tunnels in Brisbane are generally discontinuity controlled and the potential for stress-induced failure is relatively *** the road tunnels which have been constructed in Brisbane over the last 12 years,the strength of the more massive rock masses for continuum analysis has been estimated by the application of the Hoek-Brown(H-B)failure criterion using the geological strength index(GsI)to determine the H-B parameters mb,s and *** the last few years,alternative approaches to estimating rock mass strength for‘massive to moderately jointed hard rock masses’have been proposed by others,which are built on the work completed by *** and *** in this area over their joint *** paper explores one of these alternative approaches to estimating rock mass strength for one of the geological units(the Brisbane Tuff),which is often encountered in tunnelling projects in *** potential implications of these strength forecasts for future tunnelling projects are discussed along with the additional work which will need to be undertaken to confirm the applicability of such alternative strength criteria for this rock mass.

关键词： Rock mass strength Hoek-Brown(H-B)failure criterion Triaxial testing Brittle failure Brisbane Tuff

Clinical features of gastroesophageal reflux disease and erosive esophagitis:Insights from patients undergoing esophagogastroduodenoscopy in resource-limited Ethiopia

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World Journal of Gastroenterology 2024年第34期30卷 3883-3893页

作者： Firehiwot A Mengistie Abate B shewaye Abel T Tasamma Zekarias s Ayalew Department of Internal Medicine Addis Ababa UniversityAddis Ababa 1176Addis AbabaEthiopia Department of Internal Medicine Rheum Rheumatology and Internal Medicine Specialty ClinicAddis Ababa 1000Addis AbabaEthiopia Division of Gastroenterology and Hepatology Department of Internal MedicineAdera Medical and Surgical CenterAddis Ababa 1000Addis AbabaEthiopia

BACKGROUND Gastroesophageal reflux disease(GERD)is a common disease worldwide with varying clinical presentations and risk *** data for Africa is lacking,but an increasing trend is expected due to demographic and epidemiological *** endoscopic studies for general gastrointestinal disorders have shown some patients with erosive esophagitis(EE),no studies in Ethiopia have investigated the clinical characteristics,risk factors,and severity of GERD using esophagogastroduodenoscopy(EGD).AIM To assess the clinical features of GERD in Ethiopian patients who underwent EGD and determine the severity and risk factors of *** We conducted a multicenter,retrospective cross-sectional study of 221 patients diagnosed with GERD and endoscopic findings of EE at Trauma Associated severe Hemorrhage and Amniotic Membrane stem Cell between January 2019 and August *** were collected from electronic medical records and phone call *** used descriptive statistics and binary logistic regression analysis with sPss version 26 to identify the association between variables with a statistical significance set at P valuesD age of the patients was 44.8(±15.9)years,with a male-to-female ratio of 1.6:*** most commonly reported symptom was epigastric pain(80.5%),followed by heartburn(43%).Los Angeles(LA)-A EE was diagnosed in 71.1%of patients,followed by LA-B(14.9%),LA-C(7.7%),and LA-D(5.9%).Multivariate analysis showed that age 50 or above,presence of bleeding,and endoscopic findings of duodenitis/duodenopathy were significantly associated with severe EE(Pstricture and barrett’s esophagus were observed in 4.5%and 1.36%of patients with EE,*** Most of the patients had milder EE with fewer ***,severe EE was more prevalent in older patients and those with duodenitis/duodenopathy.

关键词： Gastroesophageal reflux disease Erosive esophagitis Hiatal hernia Esophagogastroduodenoscopy Heart burn

The evolution of plant reproductive ecology in China

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Journal of Plant Ecology 2015年第2期8卷 101-108页

作者： spencer C.H.barrett Department of Ecology and Evolutionary Biology University of TorontoTorontoOntario M5S 3B2Canada

scientific interest in plant reproduction has a long and venerable history going back to early European naturalists including Carl Linnaeus,Christian Konrad sprengel,Joseph Kölreuter,Fritz and Hermann Müller,George Henslow and of course,Charles *** can be considered the founder of modern plant reproductive *** three books(Darwin 1862,1876,1877)laid the conceptual foundation for the field,and many of the ideas they contain are still topics of active research(reviewed in barrett 2010).The turn of the 20th century saw the rediscovery of Mendel’s Laws and breeding experiments on flowering plants played an important role in establishing many key elements of modern *** the 1940s,Fisher had developed the population genetic principles for theoretical analysis of the evolution of plant mating systems(Fisher 1941)。

关键词： reproductive plant evolution

Mechanisms for amplified mediator release from colonic mast cells:Implications for intestinal inflammatory diseases

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World Journal of Gastroenterology 2004年第5期10卷 617-619页

作者： Kim E.barrett Division of Gastroenterology Department of MedicineUniversity of CaliforniaSan DiegoSchool of Medicine San DiegoCA 92103USA

The mast cell is an enigmatic cell type whose physiological function has preoccupied large numbers of investigators for decadest. some have concluded that the absence of mast cells is incompatible with life, at least in humans, because no human conditions have been documented where these cells are absent from the body. On the other hand, mice harboring specific mutations in certain growth factors, or their receptors, that

关键词： Colon Humans Inflammation Mediators Mast Cells Research support, Non-U.s. Gov't Research support, U.s. Gov't, P.H.s.

Modernity@Zero Hour:Three Women(Lee Miller,Hannah Hoch,Anonyma)

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Journal of Foreign Languages and Cultures 2020年第1期4卷 40-64页

作者： barrett Watten Wayne state University

This essay is a part of a longer work on literary and visual modernism at the“moment”of destruction in 1945:stunde Null or Zero ***,I focus on the t4constructedness,'of universals via the material,psychological,and political destruction in Germany at war's *** this moment,destruction and universals interconnect in three temporal modes:anticipatory,punctual,and ***“punctual”universals,I read Lee Miller’s war journalism,published in Vogue,in relation to her war and Holocaust photography,as uniting modernist aesthetic values and the“event”of *** the construction of“anticipatory”universals,I discuss the work of Hannah Hoch,dada painter and collagist,who emerged from internal exile in Berlin to participate in the first modernist exhibitions in the destroyed city after stunde ***,the anonymously authored A Woman in Berlin,documenting the survival strategies to mass sexual predation by soviet troops immediately at and after stunde Null,extends from punctual accounts of destruction to a retrospective *** each case,modernist visual and verbal forms-and an ethical imperative to keep interpretive horizons open-negotiates between the“radical particularity”of the lived experience of destruction and universal *** constructedness of universals in modernist works anticipates the construction of political,ethical,and aesthetic universals in the global order after 1945.

关键词： modernism World War II feminism art history destruction universals

A micromechanical model for efective conductivity in granular electrode structures

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Acta Mechanica sinica 2013年第5期29卷 682-698页

作者： Julia ott Benjamin Vlker Yixiang Gan Robert M.Mc Meeking Marc Kamlah Institute of Applied Materials Karlsruhe Institute of Technology76131 Karlsruhe Germany Department of Mechanical Engineering University of CaliforniaSanta BarbaraCA 93106 USA school of Civil Engineering The University of SydneyNSW 2006 Australia Materials Department University of CaliforniaSanta BarbaraCA 93106 USA school of Engineering University of AberdeenKing’s CollegeAberdeenAB24 3UE Scotland UK INM-Leibniz Institute for New Materials Campus D22 66123 Saarbrücken Germany

Optimization of composition and microstructure is important to enhance performance of solid oxide fuel cells （sOFC） and lithium-ion batteries （LIB）. For this, the porous electrode structures of both sOFC and LIB are modeled as a binary mixture of electronic and ionic conducting particles to estimate effective transport properties. Particle packings of 10000 spherical, binary sized and randomly positioned particles are created numerically and densified considering the different manufacturing processes in sOFC and LIB： the sintering of sOFC electrodes is approximated geometrically, whereas the calendering process and volume change due to intercalation in LIB are modeled physically by a discrete el- ement approach. A combination of a tracking algorithm and a resistor network approach is developed to predict the con- nectivity and effective conductivity for the various densified structures. For sOFC, a systematic study of the influence of morphology on connectivity and conductivity is performed on a large number of assemblies with different compositions and particle size ratios between 1 and 10. In comparison to percolation theory, an enlarged percolation area is found, es- pecially for large size ratios. It is shown that in contrast to former studies the percolation threshold correlates to varying coordination numbers. The effective conductivity shows not only an increase with volume fraction as expected but also with size ratio. For LIB, a general increase of conductivity during the intercalation process was observed in correlation with increasing contact forces. The positive influence of cal- endering on the percolation threshold and the effective conductivity of carbon black is shown. The anisotropy caused by the calendering process does not influence the carbon black phase.

关键词： Granular electrode structures Effective conductivity - Percolation

smoking increases the risk of extraintestinal manifestations in Crohn's disease

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World Journal of Gastroenterology 2014年第34期20卷 12269-12276页

作者： Claudia ott Angela Takses Florian Obermeier Elisabeth schnoy Martina Müller Department of Internal Medicine I University of Regensburg93042 RegensburgGermany

AIM:To demonstrate a high prevalence of extraintestinal manifestations(EIMs)in a prospective populationbased cohort of inflammatory bowel disease(IBD)patients at first diagnosis as well as during the early course of the ***:EIMs are common in patients with *** on the frequency of EIMs have mostly been assessed in patients from tertiary centers;however,data about the prevalence of EIMs at first diagnosis as well as factors influencing their incidence during the early course of disease from prospective population-based cohorts are *** present data of patients of our population-based"Oberpfalz cohort"(Bavaria,Germany)from first diagnosis(up to 3 mo after first diagnosis)as well as during the early course of the *** risk factors were assessed by calculating the relative risk(RR)as well as using logistic regression ***:In total,data of 257 newly diagnosed patients with IBD were evaluated[161 Crohn’s disease(CD),96 ulcerative colitis(UC)].Median duration of follow-up was 50 mo after first *** 63.4%of all patients(n=163),an EIM was diagnosed at any point during the observation *** first diagnosis,patients with CD had a significantly increased risk of an EIM[n=69(42.9%)]compared with UC patients[n=21(21.9%);Psmoking increased the risk of CD patients developing an EIM during the early course of the disease,but notably not of UC patients(P=0.046;RR=1.96;95%CI:1.01-3.79).In addition,using logistic regression analysis,the need for IBD-related surgery and a young age at first diagnosis were identified as risk factors for the development of an EIM in CD *** association with EIMs was found for the factors sex,localization of the disease and positive family history of *** contrast,no key factors which increased the risk of development of an EIM could be identified in UC ***:We found a high prevalence of EIM in this cohort at first diagnosis and during th

关键词： Extraintestinal manifestations Crohn's disease Ulcerative colitis smoking surgery Age at onset