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Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth factor

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World Journal of stem Cells 2024年第8期16卷 811-823页

作者： Qi-Hong Chen Ying Zhang Xue Gu Peng-Lei Yang Jun Yuan Li-na Yu Jian-Mei Chen Department of Critical Care Medicine Jiangdu People’s Hospital of YangzhouJiangdu People’s Hospital Affiliated to Yangzhou UniversityYangzhou 225200Jiangsu ProvinceChina Department of Critical Care Medicine Jiangdu People’s Hospital of YangzhouYangzhou 225200Jiangsu ProvinceChina Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACKGROUND Pulmonary fibrosis is one of the main reasons for the high mortality rate among acute respiratory distress syndrome(ARDs)*** stromal cell-derived microvesicles(MsC-MVs)have been shown to exert antifibrotic effects in lung *** To investigate the effects and mechanisms of MsC-MVs on pulmonary fibrosis in ARDs mouse *** MsC-MVs with low hepatocyte growth factor(HGF)expression(siHGF-MsC-MVs)were obtained via lentivirus transfection and used to establish the ARDs pulmonary fibrosis mouse *** intubation,respiratory mechanics-related indicators were measured via an experimental small animal lung function *** of MsC-MVs in lung tissues was investigated by near-infrared live ***,western blotting,ELIsA and other methods were used to detect expression of pulmonary fibrosis-related proteins and to compare effects on pulmonary fibrosis and fibrosis-related *** The MsC-MVs gradually migrated and homed to damaged lung tissues in the ARDs model *** with MsC-MVs significantly reduced lung injury and pulmonary fibrosis ***,low expression of HGF(siHGF-MsC-MVs)significantly inhibited the effects of MsC-MVs(Ps pulmonary fibrosis group,the MsC-MVs group exhibited suppressed expression of type I collagen antigen,type III collagen antigen,and the proteins transforming growth factor-βandα-smooth muscle actin,whereas the siHGF-MVs group exhibited significantly increased expression of these *** addition,pulmonary compliance and the pressure of oxygen/oxygen inhalation ratio were significantly lower in the MsC-MVs group,and the effects of the MsC-MVs were significantly inhibited by low HGF expression(all PsION MsC-MVs improved lung ventilation functions and inhibited pulmonary fibrosis in ARDs mice partly via HGF mRna transfer.

关键词： Microvesicles derived from mesenchymal stem cells Acute respiratory distress syndrome Pulmonary fibrosis Hepatocyte growth factor Mesenchymal stromal cells

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Highly robust zinc metal anode directed by organic–inorganic synergistic interfaces for wearable aqueous zinc battery

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smartMat 2024年第1期5卷 135-146页

作者： Xixi Zhang Chuanlin Li Guangmeng Qu Chenggang Wang shunshun Zhao Tongkai Wang na Li Xiaojuan Li Xijin Xu school of Physics and Technology University of JinanJinanChina school of Chemistry and Chemical Engineering Shandong UniversityJinanChina state Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology of MaterialsBeijing University of Chemical TechnologyBeijingChina

Flexible aqueous zinc batteries(FAZBs)with high safety and environmental friendliness are promising smart power sources for smart wearable ***,the bare zinc anode usually suffers from damnable dendrite growth and rampant side reaction on the surface,greatly impeding practical applications in ***,a composite polymer interface layer is artificially self‐assembled on the surface of the zinc anode by graft‐modified fluorinated monomer(polyacrylic acid‐2‐(Trifluoromethyl)propenoic acid,PAA‐TFPA),on which an organic–inorganic hybrid(PAA‐Zn/ZnF2)solid electrolyte interface(sEI)with excellent ionic conductivity is formed by interacting with Zn2+.Both the pouch cell and fiber zinc anode exhibit excellent plating/stripping reversibility after protecting by this organic–inorganic sEI,which can be stably cycled more than 3000 h in symmetric Zn||Zn cells or 550 h in fiber Zn||Zn ***,this interface layer preserves zinc anode with excellent mechanical durability under various mechanical deformation(stably working for another 1200 h after bending 100 h).The corresponding PAA‐Zn/ZnF2@Zn||MnO2 full cell displays an ultra‐long life span(79%capacity retention after 3000 cycles)and mechanical robustness(85%of the initial capacity for another 3000 cycles after bending 100 times).More importantly,the as‐assembled cells can easily power smart wearable devices to monitor the user's health condition.

关键词： hybrid sEI mechanical durability wearable zinc battery zinc anode

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Hydrogen sulfide Promotes Platelet Autophagy via􀀳􀀧􀀪􀀩􀀵􀀐􀄮􀀒􀀳􀀬􀀖􀀮􀀒􀀤􀁎􀁗􀀃􀀶􀁌􀁊􀁑􀁄􀁏􀁌􀁑􀁊􀀃􀁌􀁑􀀃􀀦􀁌􀁕􀁕􀁋􀁒􀁗􀁌􀁆􀀃􀀷􀁋􀁕􀁒􀁐􀁅􀁒􀁆􀁜􀁗􀁒􀁓􀁈􀁑􀁌􀁄

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 625-633页

作者： Hua-Xiang Yang Yang-Jie Li Yang-Lan He Ke-Ke Jin Ling-na Lyu Hui-Guo Ding Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated to Capital Medical UniversityBeijingChina

Background and Aims:The role of platelet autophagy in cirrhotic thrombocytopenia(CTP)remains *** study aimed to investigate the impact of platelet autophagy in CTP and elucidate the regulatory mechanism of hydrogen sulfide(H_(2)s)on platelet ***:Platelets from 56 cirrhotic patients and 56 healthy individuals were isolated for in vitro *** markers(ATG7,BECN1,LC3,and sQsTM1)were quantified using enzyme-linked immunosorbent assay,while autophagosomes were visualized through electron *** blotting was used to assess the autophagy-related proteins and the PDGFR/PI3K/Akt/mTOR pathway following treatment with naHs(an H_(2)s donor),hydroxocobalamin(an H_(2)s scavenger),or AG 1295(a selective PDGFR-α/inhibitor).A carbon terachloride-induced cirrhotic BALB/c mouse model was *** mice with thrombocytopenia were randomly treated with normal saline,naHs,or hydroxocobalamin for 15 *** in platelet count and aggregation rate were observed every three ***:Cirrhotic patients with thrombocytopenia exhibited significantly decreased platelet autophagy markers and endogenous H_(2)s levels,alongside increased platelet aggregation,compared to healthy *** vitro,naHs treatment of platelets from severe CTP patients elevated LC3-II levels,reduced sQsTM1 levels,and decreased platelet aggregation in a dose-dependent manner.H_(2)s treatment inhibited PDGFR,PI3K,Akt,and mTOR *** vivo,naHs significantly increased LC3-II and decreased sQsTM1 expressions in platelets of cirrhotic mice,reducing platelet aggregation without affecting the platelet ***:Diminished platelet autophagy potentially contributes to thrombocytopenia in cirrhotic patients.H_(2)s modulates platelet autophagy and functions possibly via the PDGFR-α/PI3K/Akt/mTOR signaling pathway.

关键词： Liver cirrhosis Thrombocytopenia Platelet Autophagy Hydrogen sulfide naHs PDGFR-α PI3K/Akt/mTOR signaling

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Exploring mechanism of hidden,steep obliquely inclined bedding landslides using a 3DEC model:A case study of the shanyang landslide in shaanxi Province,China

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China Geology 2024年第2期7卷 303-314,I0001-I0003页

作者： Jia-yun Wang Zi-long Wu Xiao-ya shi Long-wei Yang Rui-ping Liu na Lu Xi’an Center of China Geological survey/Northwest China Center for Geoscience Innovation Xi’an 710119China Xi’an University of science and Technology Xi’an 710054China Wuhan Design&Research Institute Co. Ltd.of China Coal Technology&Engineering GroupWuhan 430064China

Catastrophic geological disasters frequently occur on slopes with obliquely inclined bedding structures(also referred to as obliquely inclined bedding slopes),where the apparent dip sliding is not readily *** phenomenon has become a focal point in landslide ***,there is a lack of studies on the failure modes and mechanisms of hidden,steep obliquely inclined bedding *** study investigated the shanyang landslide in shaanxi Province,*** field investigations,laboratory tests of geotechnical parameters,and the 3DEC software,this study developed a numerical model of the landslide to analyze the failure process of such *** findings indicate that the shanyang landslide primarily crept along a weak interlayer under the action of *** landslide,initially following a dip angle with the support of a stable inclined rock mass,shifted direction under the influence of argillization in the weak interlayer,moving towards the apparent dip *** slide resistance effect of the karstic dissolution zone was increasingly significant during this process,with lateral friction being the primary resistance force.A reduction in the lateral friction due to karstic dissolution made the apparent dip sliding characteristics of the shanyang landslide more ***,deformations such as bending and uplift at the slope’s foot suggest that the main slide resistance shifts from lateral friction within the karstic dissolution zone to the slope foot’s resistance force,leading to the eventual buckling failure of the *** study unveils a novel failure mode of apparent dip creep-buckling in the shanyang landslide,highlighting the critical role of lateral friction from the karstic dissolution zone in its failure *** insights offer a valuable reference for mitigating risks and preventing disasters related to obliquely inclined bedding landslides.

关键词： Landslide steep obliquely inclined bedding slope Failure mode Failure mechanism Apparent dip creep-buckling Lateral friction 3DEC model Landslide numerical model Geological hazards survey engineering

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Effect of La on the Corrosion Behavior and Mechanism of 3Ni Weathering steel in a simulated Marine Atmospheric Environment

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Acta Metallurgica sinica(English Letters) 2024年第2期37卷 308-324页

作者： Gang Niu Rui Yuan R.D.K.Misra na Gong Zhi-Hui Zhang Hao-Xiu Chen Hui-Bin Wu Cheng-Jia shang Xin-Ping Mao Collaborative Innovation Center of steel Technology University of Science and Technology BeijingBeijing100083China Laboratory for Excellence in Advanced steel Research Department of MetallurgicalMaterials and Biomedical EngineeringUniversity of Texas at El PasoEl PasoTX79968USA Institute of Materials Research and Engineering Agency for ScienceTechnologyand ResearchSingapore138634Singapore Department of Materials science and Engineering University of TorontoTorontoONM5S 3E4Canada

The corrosion behavior and mechanism of 3Ni weathering steel in a simulated oceanic atmospheric environment are investigated in order to comprehend the impacts of La,as determined through electrochemical analysis and rust layer *** results of this study demonstrate that the addition of La enhances the corrosion resistance of 3Ni weathering steel in the marine atmospheric environment,thereby reducing the corrosion rate and improving the protection of the rust *** influence of La on corrosion resistance can be attributed to two primary ***,La functions as a grain refiner,minimizing the potential difference of the micro-regions on the substrate surface,thereby significantly reducing the corrosion of bare steel in the marine ***,La inhibits the process of Fe_(3)O_(4) oxidation back toγ-FeOOH during corrosion at the local site,thus decreasing the formation ofγ-FeOOH and enhancing the charge transfer *** research work may serve as a reference for expanding the application of rare earth elements in the field of weathering steel.

关键词： Weathering steel Rare earth Rust layer Corrosion behavior Corrosion resistance

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Innovative Techniques Unveiled in Advanced sheet Pile Curtain Design

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Open Journal of Civil Engineering 2024年第1期14卷 1-37页

作者： Peace sèna Hounkpe Guy Oyéniran Adéoti Patrick Oniakitan Mondoté Éric Adéchina Alamou Department of Civil Engineering Higher National School of Public Works (ENSTP) Abomey Benin Laboratory of Testing and studies in Civil Engineering (L2EGC) National University of Science Technology Engineering and Mathematics (UNSTIM) Abomey Benin

This thorough review explores the complexities of geotechnical engineering, emphasizing soil-structure interaction (ssI). The investigation centers on sheet pile design, examining two primary methodologies: Limit Equilibrium Methods (LEM) and soil-structure Interaction Methods (ssIM). While LEM methods, grounded in classical principles, provide valuable insights for preliminary design considerations, they may encounter limitations in addressing real-world complexities. In contrast, ssIM methods, including the ssI-sR approach, introduce precision and depth to the field. By employing numerical techniques such as Finite Element (FE) and Finite Difference (FD) analyses, these methods enable engineers to navigate the dynamics of soil-structure interaction. The exploration extends to ssI-FE, highlighting its essential role in civil engineering. By integrating Finite Element analysis with considerations for soil-structure interaction, the ssI-FE method offers a holistic understanding of how structures dynamically interact with their geotechnical environment. Throughout this exploration, the study dissects critical components governing ssIM methods, providing engineers with tools to navigate the intricate landscape of geotechnical design. The study acknowledges the significance of the Mohr-Coulomb constitutive model while recognizing its limitations, and guiding practitioners toward informed decision-making in geotechnical analyses. As the article concludes, it underscores the importance of continuous learning and innovation for the future of geotechnical engineering. With advancing technology and an evolving understanding of soil-structure interaction, the study remains committed to ensuring the safety, stability, and efficiency of geotechnical structures through cutting-edge design and analysis techniques.

关键词： sheet Pile Curtain Design soil-structure Interaction Geotechnical Engineering Advanced Design Techniques Finite Element Analysis Innovative Geotechnical Methods

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Metabolic and microbial changes in light-vented bulbul during recent northward range expansion

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Current Zoology 2024年第1期70卷 24-33页

作者： Yun Wu Ying Xiong Yanzhu Ji Yalin Cheng Qianghui Zhu Xiaolu Jiao Yongbin Chang na Zhao Jing Yang Fumin Lei Gang song Key Laboratory of Zoological systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China College of Life science University of Chinese Academy of SciencesBeijing 100049China Department of Zoology College of Life scienceSichuan Agricultural UniversityYa'an 625099SichuanChina Henan Engineering Research Center of Bird-Related Outage Zhengzhou Normal UniversityZhengzhou 450044China school of Ecology and Environment Anhui Normal UniversityWuhu 241002AnhuiChina school of Environmental science and Engineering Shaanxi University of Science and TechnologyXian 710021China Centerfor Excellence inanimal Evolutionand Genetics Chinese Academy of SciencesKunming 650223China

Endotherms recently expanding to cold environments generally exhibit strong physiological acclimation to sustain high body *** this process,gut microbes likely play a considerable role in host physiological functions,including digestion and *** light-vented bulbul Pycnonotus sinensis represents one such *** used to be restricted to the Oriental realm but expanded its distribution range north to the Palearctic areas during the past few ***,we explored the seasonal dynamics of the resting metabolic rate(RMR)and microbiota for local and newly colonized populations of the *** results showed that the mass-adjusted RMR and body mass were pos-itively correlated with latitude variations in both ***,the gut microbiota showed a corresponding variation to the northern cold *** the two northern populations,the alpha diversity decreased compared with those of the two southern *** differences were detected in dominant phyla,such as Firmicutes,Bacteroidetes,Proteobacteria,and Desulfobacterota in both *** core microbiota showed geographic differences in the winter,including the elevated relative abundance of 5 species in northern ***,to explore the link between microbial communities and host metabolic thermogenesis,we conducted a correlation analysis between microbiota and mass-adjusted *** found that more genera were significantly correlated with mass-adjusted RMR in the wintering season compared to the breeding season(71 vs.23).These results suggest that microbiota of the lighted-vented bulbul linked with thermogenesis in diversity and abundance under northward expansion.

关键词： bird body mass gutmicrobiota RMR season

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Progress of Clinical Research on the Treatment of spinal Disorders by the Tongdu Method

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Yangtze Medicine 2024年第1期8卷 20-28页

作者： na Li Yuefang Li Huimin Lv Graduate school of Qinghai University Xining China Acupuncture and Moxibustion Department Qinghai Provincial Hospital of Traditional Chinese Medicine Xining China

spinal disorders are diseases caused by congenital, degenerative, postural errors, trauma, and external evils that result in lesions of bones, discs, ligaments, and muscles, thus compressing the nerves. spine-related diseases include scoliosis, intervertebral disc herniation, intervertebral stenosis, spinal fracture, ankylosing spondylitis, spinal cord injury, spinal tumour, etc., which seriously affect people’s daily life. This paper summarises the relevant studies on the treatment of spinal diseases by Tongzhu therapy. The mechanism of action of Tongzhu therapy in treating spinal diseases is closely related to the control of inflammatory factors, the improvement of local microcirculation, analgesia, and the promotion of nerve repair. This paper describes the application and modern mechanism of Tongzhu therapy in the treatment of spinal diseases, which will provide a direction for future research on Tongzhu therapy.

关键词： Tongdu spine Mechanism Clinical Application

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Advanced sheet Pile Curtain Design: Case study of Cotonou East Corniche

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Open Journal of Civil Engineering 2024年第1期14卷 38-64页

This paper delves into the critical aspects of sheet pile walls in civil engineering, highlighting their versatility in soil protection, retention, and waterproofing, all while emphasizing sustainability and efficient construction practices. The paper explores two fundamental approaches to sheet pile design: limit equilibrium methods and numerical techniques, with a particular focus on finite element analysis. Utilizing the robust PLAXIs 2016 calculation code based on the finite element method and employing a simplified elastoplastic model (Mohr-Coulomb), this study meticulously models the interaction between sheet pile walls and surrounding soil. The research offers valuable insights into settlement and deformation patterns that adjacent buildings may experience during various construction phases. The central objective of this paper is to present the study’s findings and recommend potential mitigation measures for settlement effects on nearby structures. By unraveling the intricate interplay between sheet pile wall construction and neighboring buildings, the paper equips engineers and practitioners to make informed decisions that ensure the safety and integrity of the built environment. In the context of the Cotonou East Corniche development, the study addresses the limitations of existing software, such as RIDO, in predicting settlements and deformations affecting nearby buildings due to the substantial load supported by sheet pile walls. This information gap necessitates a comprehensive study to assess potential impacts on adjacent structures and propose suitable mitigation measures. The research underscores the intricate dynamics between sheet pile wall construction and its influence on the local environment. It emphasizes the critical importance of proactive engineering and vigilant monitoring in managing and mitigating potential hazards to nearby buildings. To mitigate these risks, the paper recommends measures such as deep foundations, ground improvement tech

关键词： sheet Pile Walls and structural Analysis soil-structure Interaction Modeling structural sustainability Cotonou East Corniche sustainable Construction Plaxis Calculation Code settlement Mitigation

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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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