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study on improving hematopoietic function of rats with blood deficiency syndrome by shengxuebao mixture

Traditional Medicine Research 2024年第8期9卷 35-46页

作者： Yan shu Hong-na Liu Yang Zhao Jin-Yi Cao Yue Chen Yi Qiao Hui Guo Zhi-Fu Yang College of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Tsing Hua De Ren Xi’an Happiness Pharmaceutical Co. Ltd.Xi’an 710400China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710000China state Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Engineering Research Center for Dental Materials and Advanced ManufactureDepartment of PharmacySchool of Stomatologythe Fourth Military Medical UniversityXi’an 710000China

Background:shengxuebao mixture(sXBM)is a novel herbal drug approved by China state Food and Drug Administration for the treatment of Leukopenia and iron deficiency anemia caused by radiotherapy and ***:To explore the mechanism of sXBM in treating blood deficiency syndrome(BDs).Firstly,network pharmacology and in vivo experiments were used to screen candidate targets and important signaling pathways of sXBM,GO functional enrichment and KEGG pathway analysis were ***,a BDs rat model was established to verify the results of the analysis of network pharmacological *** and routine peripheral blood examination were *** expressions of tumor necrosis factor-α,interleukin(IL)-6,HIF-1αand NF-κB were detected by Western blot,and the expressions of IL-6,IL-1βwere detected by ***:62 bioactive components,66 potential targets and 131 signaling pathways of BDs were successfully identified by network *** docking simulation techniques showed that key targets tumor necrosis factor-α,IL-6,IL-1βcan dock well with crucial components,and the BDs-related signaling pathways HIF-1 and JAK-sTAT play a vital *** combined model experiment of acetylphenylhydrazine and cyclophosphamide showed that the model group had obvious blood deficiency,and the histopathology and blood routine were effectively restored after *** findings indicate that sXBM’s therapeutic effect on BDs primarily involves the mediation of the HIF-1α/NF-κB signaling pathway and the regulation of hematopoietic factor ***:This study not only affirmed the protective properties of sXBM against BDs but also provided insights into a potential mechanism for blood replenishment in the treatment of BDs using sXBM.

关键词： network pharmacology molecular docking technology blood deficiency syndrome hematopoietic factors HIF-1α/NF-κB

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Clinical analysis of colistin sulfate in the treatment of pneumonia caused by carbapenem-resistant Gram-negative bacteria

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World Journal of Clinical Cases 2024年第13期12卷 2173-2181页

作者： Hai-Chang Xu Yan Cui Xue-Ying Wang Hai-Bo Wu Wei Li Dan Wang na Lin Lin Lin Ying-Hui Zhang Department of Intensive Care Medicine The General Hospital of the Northern Theater Command of the People's Liberation Army of ChinaShenyang 110016Liaoning ProvinceChina

BACKGROUND Multidrug-resistant Gram-negative bacteria,exacerbated by excessive use of antimicrobials and immunosuppressants,are a major health *** To study the clinical efficacy and safety of colistin sulfate in the treatment of carbapenem-resistant Gram-negative bacilli-induced pneumonia,and to provide theoretical reference for clinical diagnosis and *** This retrospective analysis involved 54 patients with Gram-negative bacilli pneumonia admitted to intensive care unit of The General Hospital of the Northern Theater Command of the People's Liberation Army of China from August 2020 to June *** bacteriological culture,the patients'airway secretions were collected to confirm the presence of Gram-negative *** patients were divided into the experimental and control groups according to the medication *** research group consisted of 28 patients who received polymyxin sulfate combined with other drugs through intravenous,nebulization,or intravenous combined with nebulization,with a daily dosage of 1.5–3.0 million *** control group consisted of 26 patients who received standard dosages of other antibiotics(including sulbactam sodium for injection,cefoperazone sodium sulbactam for injection,tigecycline,meropenem,or vaborbactam).REsULTs Of the 28 patients included in the research group,26 patients showed improvement,treatment was ineffective for two patients,and one patient died,with the treatment efficacy rate of 92.82%.Of the 26 patients in the control group,18 patients improved,treatment was ineffective for eight patients,and two patients died,with the treatment efficacy rate of 54.9%;significant difference was observed between the two groups(Ps of white blood cell(WBC),procalcitonin(PCT),and C-reactive protein(CRP)in both groups were significantly lower after treatment than before treatment(Ps of WBC,PCT,and CRP in the research group were significantly lower than those in the control group

关键词： Colistin sulfate Extensively drug-resistant Pneumonia Intravenous combined with nebulization sepsis Nephrotoxicity Neurotoxicity

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Robust Timing Constraints for Granitic Magmatism and Hydrothermal Mineralization in the Tieshanlong W-sn Ore Field,Eastern nanling Range,south China

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Acta Geologica sinica(English Edition) 2024年第5期98卷 1255-1269页

作者： LI Wei TANG Juxing GUO na LANG Xinghai sONG shiwei WU Zhongru PENG Linlin FANG Xiang CHEN Binfeng LIAN Dunmei LU Jie The seventh Geological Brigade of Jiangxi Bureau of Geology Key Laboratory of Ionic Rare Earth Resources and EnvironmentGanzhouJiangxi 341000China College of Earth and Planetary sciences Chengdu University of TechnologyChengdu 610059China Jiangxi Province Key Laboratory of Exploration and Development of Critical Mineral Resources Nanchang 330036China MNR Key Laboratory of Metallogeny and Mineral Resource Assessment Institute of Mineral ResourcesCAGSBeijing 100037China Institute of Earth sciences China University of GeosciencesBeijing 100083China Jiangxi Geological Bureau Nanchang 330036China Chinese Academy of Geological sciences Beijing 100037China

The Tieshanlong ore field is an important part of the nanling Range,which is famous worldwide for its W-sn ***,the mineralization age of the Tieshanlong ore field is not well constrained,and our field investigation reveals that granitic emplacement occurred at different ***,previous studies have not distinguished these multiple stages of *** Tieshanlong granite complex is closely related to the Huangsha quartz vein-type W-sn deposit and Tongling skarn-type Cu-W-sn deposit in this *** field investigations and isotopic age analyses,this work studies the relationship between multistage magmatic activity and mineralization in the Tieshanlong ore ***-ICP-Ms zircon U-Pb isotope analyses revealed that the first-and second-staged granites formed at 154.2±0.6 Ma(MsDW=1.4)and 151.2±0.4 Ma(MsDW=1.5),with zirconε_(Hf)(t)values ranging from-13.1 to-10.5 and from-14.7 to-11.1,*** data suggest that the Tieshanlong granite complex was derived from the partial melting of ancient crustal ***-ICP-Ms U-Pb dating of wolframite and cassiterite reveals that W-sn mineralization occurred at 160-150 Ma,which agrees well with the U-Pb dating results of the second-staged granite within analytical *** magmatic activity in this ore field can be divided into three stages:175-154 Ma,154-150 Ma and 150-145 *** quartz vein-and skarn-type W-sn mineralization is closely related to second-staged fine-grained twomica granite,and formed earlier than skarn-type *** study establishes a metallogenic model for the Tieshanlong ore field,and this model has important practical significance for identifying concealed W-sn(-Cu)deposits around other granitic complexes in the nanling Range.

关键词： zircon U-Pb-Hf isotopes wolframite U-Pb ages cassiterite U-Pb ages metallogenic model Tieshanlong ore field nanling Range

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从小床位到大福祉:家庭养老床位模式的发展与优化

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西南金融 2024年第5期 27-38页

作者：张娜厦门大学公共事务学院福建厦门361005

作为一种新型嵌入式居家养老服务模式,家庭养老床位模式的发展与优化对于助力民众增进福祉意义重大。家庭养老床位模式以满足养老现实需求为前提、以信息化手段为抓手、以多元主体资源整合为基础、以经济福利性激发动能而得以生发,融合... 详细信息

作为一种新型嵌入式居家养老服务模式,家庭养老床位模式的发展与优化对于助力民众增进福祉意义重大。家庭养老床位模式以满足养老现实需求为前提、以信息化手段为抓手、以多元主体资源整合为基础、以经济福利性激发动能而得以生发,融合了家庭养老与机构养老的优势,为我国居家养老服务体系优化升级提供了新路径。基于协同治理理论分析发现,参与主体目标不一瓦解凝聚力、信息共享机制尚待健全动摇合作力、服务资源未能有效整合降低支持力、发展成本较高减弱引动力,使“家庭”“养老”“床位”“制度”等资源未能实现有效整合,影响家庭养老床位模式持续健康发展。基于家庭养老床位模式发展实际、借鉴国际经验,文章认为有必要优“通”助“统”、以“享”增“效”、促“整”提“质”、完善制度设计,促进“四力”融合,使家庭养老床位模式切实服务民众养老福祉水平的提升。

关键词：养老服务居家养老社区养老家庭养老床位医养结合长期护理人口老龄化养老经济

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确立人工智能法律主体地位的再思考

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法学论坛 2024年第5期39卷 112-121页

作者：孙那西安交通大学法学院陕西西安710049

随着生成式人工智能逐步迈向通用人工智能,其涌现出的独特的思维和理解能力、打通虚拟与现实边界的可交互性以及向人脑规模发展的模型参数量等特征使其在法律层面上应被赋予相应的独立法律主体资格。目前学者们提出的否定说、代理说、... 详细信息

随着生成式人工智能逐步迈向通用人工智能,其涌现出的独特的思维和理解能力、打通虚拟与现实边界的可交互性以及向人脑规模发展的模型参数量等特征使其在法律层面上应被赋予相应的独立法律主体资格。目前学者们提出的否定说、代理说、限制说等理论无法在逻辑上实现自洽,也未关注到目前人工智能发展的本质特征所应被赋予的法律意义。从理论探索的角度出发,将人工智能行为体运用法律拟制的方式设定为民法上的限制民事行为能力人,运用监护理论中监护人和被监护人之间的权利义务关系来处理人工智能行为体与其他多方主体之间的法律关系,可以从根本上化解新兴权利主体对多法域带来的制度冲击,为我国人工智能产业的发展探索提供前瞻立法制度构建,为全球范围内处理人工智能相关法律问题提供新思路。

关键词：人工智能法律主体地位法律拟制监护理论

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美国全球水资源安全战略分析

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亚太安全与海洋研究 2024年第2期 72-88,I0003,I0004页

作者：任娜中国社会科学院亚太与全球战略研究院北京100007

由于相对实力下降,美国的霸权正面临“碎片化”与“议题化”转型。在众多涉及安全的议题中,水资源议题因为自身的敏感性,成为美国国家安全的重要组成部分。2022年美国相继发布《全球水安全行动计划》和第二个《美国全球水战略》文件,明... 详细信息

由于相对实力下降,美国的霸权正面临“碎片化”与“议题化”转型。在众多涉及安全的议题中,水资源议题因为自身的敏感性,成为美国国家安全的重要组成部分。2022年美国相继发布《全球水安全行动计划》和第二个《美国全球水战略》文件,明确了未来一段时期美国在全球水资源领域的战略目标、原则、优先方向、实施路径以及项目规划。其在优先方向、重点地区以及实施路径等方面的新变化,不但会对中美在水资源领域的竞争产生重要影响,更可能干扰中国与周边国家在水资源领域的合作。中国需加强跟踪研判和科学谋划,不断调整和优化与周边国家开展水资源合作及治理的政策和路径,化解美国对华开展水资源竞争所带来的风险。

关键词：美国水资源水资源合作中美博弈安全战略国家安全

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Effects of Dietary Changes on the Gut Microbiota of Cynops orientalis

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Asian Herpetological Research 2024年第2期15卷 63-72页

作者： Yuting WANG Yuning XIE siyu WU Wenwen ZHANG Xiner CHENG Zixuan LI Fangfei HAN Jiayi sHI Yingying sHI Zhirong HE Chunna ZHANG Yixin JIANG na ZHAO Jiaqi LI supen WANG College of Life sciences Anhui Normal UniversityWuhu 241000AnhuiChina nanjing Institute of Environmental sciences Ministry of Ecology and Environment of ChinaNanjing 210042JiangsuChina school of Ecology and Environment Anhui Normal UniversityWuhu 241002AnhuiChina Key Laboratory of Zoological systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The gut microbiota plays a pivotal role in the maintenance of health for amphibians,and it has been fully recognized,but the effectiveness of various influencing factors has not yet been fully *** this association should be considered while the amphibian order Caudata is facing a severe situation of population decline and extinction,there is little understanding of the association between diets and the diversity of gut microbiota in the amphibian order ***,we conducted an extensive analysis of the gut microbiota of Cynops orientalis fed different diets using functional prediction and 16s rRna amplicon sequencing ***,we found that wild individuals had greater gut microbial diversity and richness in comparison to captive ***,we identified the bacterial taxa associated with diets and observed differences in the relative abundance of gut microbiota among people on various ***,we have a predictive comprehension of the selection and adaptative significance of shared core AsVs in the gut microbiota in maintaining the healthy survival of *** in a large-scale spatiotemporal *** study emphasizes how diets alter the gut microbiota of Caudata and offers fresh perspectives on the conservation and captive management of species in Caudata.

关键词： 16s rRna Caudata core microbiota diet gut microbiota

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澳大利亚支柱二立法进程及立法技术经验

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国际税收 2024年第10期 37-42页

作者：李娜华东政法大学国际法学院

澳大利亚在完成影响评估、公开征询意见、修改会计准则等准备工作后,于2024年3月公布支柱二立法草案,正式启动支柱二国内立法程序。澳大利亚支柱二立法草案引入收入纳入规则、低税支付规则和国内补足税规则,并采取分段实施方式,即从2024... 详细信息

澳大利亚在完成影响评估、公开征询意见、修改会计准则等准备工作后,于2024年3月公布支柱二立法草案,正式启动支柱二国内立法程序。澳大利亚支柱二立法草案引入收入纳入规则、低税支付规则和国内补足税规则,并采取分段实施方式,即从2024年1月1日开始实施收入纳入规则和国内补足税规则,从2025年1月1日开始实施低税支付规则。该支柱二立法草案不仅涵盖支柱二规则与国内规则的衔接、与税收协定的衔接等问题,还详细规定了新规则相应征管措施,以期尽可能地降低实施过程中跨国企业的税收遵从成本。本文详细介绍了澳大利亚支柱二立法进程、立法草案架构和内容,并总结具有借鉴价值的立法技术经验。

关键词：支柱二全球反税基侵蚀规则收入纳入规则低税支付规则国内补足税规则

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A study on How Urban Rail Operators Can secure New Growth Engines for the Future Approach: The Case of Underground Urban Logistics system

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Journal of Traffic and Transportation Engineering 2024年第3期12卷 130-140页

作者： su Min Hong Oek s.ok Jeon Young soo na Metro Research Institute Seoul MetroSeoul 04806Korea Department of Transportation Engineering University of SeoulSeoul 02504Korea

seoul Metro is seoul’s leading metro company, transporting up to 3 billion people annually. However, future ridership is expected to plummet due to an aging and shrinking population with one of the fastest declining total fertility rates in the world. The COVID-19 pandemic in 2019 accelerated this phenomenon. On the contrary, the e-commerce and home delivery industries have developed significantly since COVID-19. seoul’s current logistics infrastructure cannot handle it. Under the inflection point of declining passenger transportation demand and increasing urban logistics demand, urban rail operators need new growth engines. Therefore, it is necessary to consider the introduction of an UULs (underground urban logistics system) that transports parcels instead of passengers through urban railways. If the UULs becomes a reality, it can be expected to secure scarce logistics land in cities, protect the environment and prevent traffic congestion by operating eco-friendly mass urban transportation, and acquire new revenue sources for urban rail operators. The UULs’s B/C ratio is 1.32. The sensitivity analysis shows that the ratio is above 1 in most cases where the unit cost of transportation is not significantly reduced.

关键词： UULs metro new growth engines COVID-19 traffic congestion environment.

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Effect of psychological nursing intervention on anxiety level and quality of life in patients with gastrointestinal peptic ulcer

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World Journal of Gastrointestinal surgery 2024年第9期16卷 2953-2960页

作者： Xiao-Rong Zhang Yan-song Li Ya-na Xu Department of Neurology Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina Department of Nursing Bengbu Railway Police CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND Peptic ulcer is a common gastrointestinal disease,and psychological intervention has an important influence on its occurrence and *** To investigate the effect of psychological nursing intervention on the anxiety level and quality of life of patients with gastrointestinal peptic *** Two groups of patients with peptic ulcer were selected from January to December 2012,with 60 cases in each group,and psychological nursing intervention and routine treatment were respectively *** nursing interven-tions include cognitive behavioral therapy,psychological support and relaxation ***-rating anxiety scale(sAs)and quality of life questionnaire were used to evaluate the anxiety level and quality of life of patients before,during and after *** The sAs scores of the experimental group significantly decreased over the course of treatment,from 52.3 before treatment to 30.5 after treatment,while sAs scores of the control group did not change ***,the experimental group's quality of life score(sF-36)significantly improved over the course of treatment,from 65.2 to 85.2,while the control group remained *** analysis showed that sex and age had no significant influence on the effect of *** men and women,young and old,showed similar trends in anxiety relief and improved quality of life after *** Psychological nursing-based intervention program has a positive effect on the anxiety level and quality of life of patients with gastrointestinal peptic ulcer.

关键词： Gastrointestinal peptic ulcer Psychological nursing Anxiety level Quality of life Cognitive behavioral therapy

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