检索结果-南通市图书馆

Predictors.of the placebo res.onse in a nutraceutical randomized controlled trial for depress.on

Journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jenifer Murphy-smith Chee h.ng David Mischoulon Gerard J.Byrne Chad A.Bousman Con s.ough Michael Berk Jerome sarris Profes.orial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depress.on Clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments.of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psychiatry the University of MelbourneMelbourne 3052Australia Centre for human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physical health and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence in Youth Mental health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental health the University of MelbourneParkville 3052Australia NICM health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

objective The placebo res.onse in depress.on studies is the ch.nge in symptoms amongst those who receive an inactive *** well-designed randomized controlled trials(RCTs.of depress.on have a high proportion of placebo res.onders,with little understanding as to *** present study assesses characteristics as.ociated with the placebo res.onse in a nutraceutical trial with a large proportion of placebo *** This is a secondary analysis.of a nutraceutical depress.on RCT which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their as.ociation with the placebo *** genetic polymorphisms were also *** res.onse was measured based on ch.nge in Montgomery-Asberg Depress.on Rating scale *** as.ociation of these hypothesis-driven variables.of interest and the placebo res.onse was examined using linear mixed effects *** Greater levels.of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were as.ociated with greater placebo *** increased placebo res.onse was not found in those recruited via social media nor in those with concomitant antidepressant *** nucleotide polymorphisms from the tryptophan hydroxylase 1(TPh1)gene(A779C and A218C)were weakly as.ociated with greater placebo res.onse,although the evidence was attenuated after accounting for multiple *** This is,to our knowledge,the first study within nutraceutical research for depress.on to assess the as.ociation between participant characteristics and variation in the placebo *** variables appeared to predict the placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depress.on Nutraceutical Psychiatry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mechanisms

引用

Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： h.T.Jeong s.W.Lee W.J.kim Department of Materials science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The superplastic behavior and as.ociated deformation mechanisms.of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain size of 3.2μm,primarily composed of the BCCβphase and a small amount of the hCPαphase,were examined in a temperature range of 473 K to 623 *** microstructural refinement of this alloy was achieved by employing high-ratio differential speed *** best superplasticity was achieved at 523 K and at strain rates.of 10^(-4)-5×10^(-4)s^(-1),where tensile elongations.of 550±600%were *** the heating and holding stage of the tensile samples prior to tensile loading,a significant increase in grain size was.observed at temperatures above 573 ***,it was important to consider this effect when analyzing and understanding the superplastic deformation behavior and *** the investigated strain rate range,the superplastic flow at low strain rates was governed by lattice diffus.on-controlled grain boundary sliding,while at high strain rates,lattice diffus.on-controlled dis.ocation climb creep was the rate-controlling deformation *** was concluded that solute drag creep is unlikely to *** the late stages.of deformation at 523 K,it was.observed that grain boundary sliding led to the agglomeration of theαphase,resulting in significant strain *** mechanism maps were constructed forβ-Mg-Li alloys in the form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using the constitutive equations for various deformation mechanisms derived based on the data of the current tests.

关键词： Magnesium-lithium alloy superplasticity severe plastic deformation Grain size Grain growth

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Jetting-based bioprinting:process,dispense physics,and applications

引用

Bio-Design and Manufacturing 2024年第5期7卷 771-799页

作者： Wei Long ng Viktor shkolnikov singapore Centre for 3D Printing(sC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore 639798Singapore hP Inc. Palo AltoCA 94304USA

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells,growth factors,drugs,and biomaterials in a highly automated layer-by-layer fabrication *** to its immense versatility,jetting-based bioprinting has been used for various applications,including tissue engineering and regenerative medicine,wound healing,and drug development.A lack of in-depth understanding exists in the processes that occur during jetting-based *** review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based *** first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting,laser-induced forward transfer bioprinting,electrohydrodynamic jet bioprinting,acoustic bioprinting and microvalve ***,we provide an in-depth discuss.on of various considerations for bioink formulation relating to cell deposition,print chamber design,droplet formation and droplet ***,we highlight recent accomplishments in jetting-based *** present the advantages and challenges.of each method,discuss considerations relating to cell viability and protein stability,and conclude by providing insights into future directions.of jetting-based bioprinting.

关键词： 3D bioprinting Biofabrication Jetting-based Dispense physics Machine learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dysfunction of synaptic endocytic trafficking in Parkinson's disease

引用

Neural Regeneration Research 2024年第12期19卷 2649-2660页

作者： Xin Yi ng Mian Cao Programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of Phys.ology National University of SingaporeSingaporeSingapore

Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely *** investigations have identified over 20 causative PARK genes and 90 genomic risk loci as.ociated with both familial and s.oradic Parkinson's ***,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis *** suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss.of dopamine cell bodies in the midbrain via a"dying back"***,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively *** models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models.of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(sYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic ***,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,sAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide as.ociation studies,in Parkinson's disease *** will also explore the direct or indirect roles.of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK

关键词： autophagy auxilin/PARK19 clathrin-mediated endocytosis dopamine neurons neurodegeneration nigrostriatal pathway Parkinson's disease synaptic vesicle recycling synaptojanin1/PARK20

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of radiative loss mechanisms.on FIR thermometric parameters.of Nd^(3+)-doped lithium tellurite glasses

引用

Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.L silva L.A.o.Nunes s.M.Lima L.h.C.Andrade optical and Photothermal spectros.opy Group(GEoF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics.of s.o Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as.optical reabsorption and cross-relaxation can affect the Nd^(3+)emiss.on,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters.on the Nd^(3+)concentration,due to ch.nges in the emiss.on band profiles caused by optical reabsorption of the Nd^(3+)emiss.ons and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is.observed for samples doped with higher amounts.of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio optical thermometry Judd-ofelt Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inclusive quasielastic neutrino-nucleus scattering with energy density functional nuclear models

引用

Chinese Physics C 2024年第8期48卷 153-158页

作者： K.s.kim s.onchul Choi hana Gil Ch.ng ho hyun school of liberal arts and science korea aerospace universitygoyang 10540korea Center for exotic nuclear studies institute for basic sciencedaejeon 34126korea Center for extreme nuclear matters korea universityseoul 02841korea Department of physics education daegu universitygyeongsan 38453korea

In this study,we calculated the inclusive charged-current neutrino-nucleus scattering from ^(40)Ar in the quasielastic *** explore the effect of uncertainties stemming from the nuclear structure,we used the KIDs(Korea-IBs-Daegu-sKKU)nuclear energy density functional and skyrme force models,namely sLy4,skI3,and *** models were selected to have distinct behavior in terms.of the density dependence of the symmetry energy and the effective mass.of the *** the charged-current neutrino scattering,the single-and double-differential cross sections were calculated for various *** cross sections are reported as a function of the incident neutrino *** theoretical cross sections were compared with experimental data,and the roles.of the effective mass and symmetry energy were investigated in terms.of charged-current neutrino-nucleus scattering.

关键词： energy density functional neutrino-nucleus scattering symmetry energy effective mass.of the nucleon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

optimizing Average Electric Power During the Charging of Lithium-Ion Batteries Through the Taguchi Method

引用

Transactions.of Tianjin University 2024年第2期30卷 152-166页

作者： Mohd h.s.Alrashdan Department of Electrical Engineering Al-Hussein Bin Talal UniversityMaan 71110Jordan

In recent times, lithium-ion batteries have been widely used owing to their high energy density, extended cycle lifespan, and minimal self-discharge rate. The design of high-speed rechargeable lithium-ion batteries faces a significant challenge owing to the need to increase average electric power during charging. This challenge results from the direct influence of the power level on the rate of chemical reactions.occurring in the battery electrodes. In this study, the Taguchi optimization method was used to enhance the average electric power during the charging process.of lithium-ion batteries. The Taguchi technique is a statistical strategy that facilitates the systematic and efficient evaluation of numerous experimental variables. The proposed method involved varying seven input factors, including positive electrode thickness, positive electrode material, positive electrode active material volume fraction, negative electrode active material volume fraction, separator thickness, positive current collector thickness, and negative current collector thickness. Three levels were assigned to each control factor to identify the optimal conditions and maximize the average electric power during charging. Moreover, a variance assessment analysis was conducted to validate the results.obtained from the Taguchi analysis. The results revealed that the Taguchi method was an eff ective approach for optimizing the average electric power during the charging of lithium-ion batteries. This indicates that the positive electrode material, followed by the separator thickness and the negative electrode active material volume fraction, was key factors significantly infl uencing the average electric power during the charging of lithium-ion batteries res.onse. The identification of optimal conditions resulted in the improved performance of lithium-ion batteries, extending their potential in various applications. Particularly, lithium-ion batteries with average electric power of 16 W and 17

关键词： Lithium-ion batteries Average electric power during charging Taguchi method CoMsoL Multiphysics software C rate L27 orthogonal array

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Boosted Lithium-Ion Trans.ort Kinetics in n-Type siloxene Anodes Enabled by selective Nucleophilic substitution of Phosphorus

引用

Nano-Micro Letters 2024年第10期16卷 618-637页

作者： se In kim Woong-Ju kim Jin Gu Kang Dong-Wan kim school of Civil Environmental and Architectural EngineeringKorea University02841 SeoulSouth Korea Nanophotonics Research Center Korea Institute of Science and Technology02792 SeoulSouth Korea

Doped two-dimens.onal(2D)materials hold significant promise for advancing many technologies,such as microelectronics.optoelectronics,and energy ***,n-type 2D oxidized si nanosheets,namely n-type siloxene(n-sX),are employed as Li-ion battery *** thermal evaporation of sodium hypophosphite at 275℃,P atoms are effectively incorporated into siloxene(sX)without compromising its 2D layered morphology and unique Kautsky-type crystal ***,selective nucleophilic substitution occurs,with only si atoms being replaced by P atoms in the o_(3)≡si-h *** resulting n-sX possesses two delocalized electrons arising from the presence of two electron donor types:(i)P atoms residing in si sites and(ii)h *** doping concentrations are varied by controlling the amount of precursors.or their mean free *** at 2000 mA g^(-1),the n-sX electrode with the optimized doping concentration(6.7×10^(19) atoms cm^(-3))delivers a capacity of 594 mAh g^(-1) with a 73%capacity retention after 500 *** improvements.originate from the enhanced kinetics.of charge trans.ort processes,including electronic conduction,charge transfer,and solid-state *** approach proposed herein offers an unprecedented route for engineering sX anodes to boost Li-ion s.orage.

关键词： Li-ion battery Two-dimens.onal N-type siloxene Doping mechanism Kinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Three-year field study on grass growth and soil hydrological properties in biochar-amended soil

引用

Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2764-2774页

作者： haowen Guo Charles Wang Wai ng Junjun Ni Qi Zh.ng Yuchen Wang Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina school of Trans.ortation Southeast UniversityNanjingChina

Field monitoring was conducted to investigate and quantify the long-term effects.of peanut shell biochar on soil-grass interaction over three *** 10 m5 m grassed plots were constructed in completely decomposed granitic *** of them were amended,respectively,with 5%and 10%biochar contents(m^(3)/m^(3))for grass growth,while the third was without biochar *** the threeyear monitoring,plant characteristics,saturated water permeability(k_(s))of grassed soil and soil suction were *** monitored results s.ow that the grass leaf area index(LAI)and root length density(RLD)with biochar amendment were improved by 38%and 200%,*** the grassed plot without biochar,a thres.old RLD existed with a value of 1.7 cm/cm^(3),beyond which k_(s) raised *** thres.old RLD increased by 52%when biochar content increased from 0%to 10%.This implies that biochar may restrict the increase in k_(s) of grassed soil due to the rise in the thres.old *** presence of biochar and grass can retain over 100%higher suction after heavy rainfalls,while 54%lower peak suction under evapotranspiration(ET)compared with the non-amended *** can alleviate the negative effects.on hydraulic properties caused by plant growth and reduce ET-induced excessive water loss.A 5%peanut shell biochar content is recommended for the long-term management of vegetated earthen infrastructures.

关键词： soil-grass interaction Biochar Long-term Water infiltration soil drying

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dragonfly Interaction Algorithm for optimization of Queuing Delay in Industrial Wireless Networks

引用

Journal of Bionic Engineering 2024年第1期21卷 447-485页

作者： sanjay Bhardwaj Da-hye kim Dong-s.ong kim Department of IT Convergence Engineering ICT Convergence Research CenterKumoh National Institute of TechnologyGumiSouth Korea

In industrial wireless networks,data transmitted from source to destination are highly *** often leads to the queuing of the data,and poor management of the queued data results in excessive delays,increased energy consumption,and packet ***,a nature-inspired-based Dragonfly Interaction optimization Algorithm(DMoA)is proposed for optimization of the queue delay in industrial wireless *** term“interaction”herein used is the characterization of the“flying movement”of the dragonfly towards damselflies(female dragonflies)for *** a result,interaction is represented as the flow of transmitted data packets.or traffic,from the source to the base *** includes each and every feature of dragonfly movement as well as awareness.of the rival dragonflies,predators,and damselflies for the desired optimization of the queue *** features are juxtaposed as noise and interference,which are further used in the calculation of industrial wireless metrics:latency,error rate(reliability),throughput,energy efficiency,and fairness for the optimization of the queue *** analysis,convergence analysis,the Wilcoxon test,the Friedman test,and the classical as well as the 2014 IEEE Congress.of Evolutionary Computation(CEC)on the benchmark functions are also used for the evaluation of DMoA in terms.of its robustness and *** results demonstrate the robustness.of the proposed algorithm for both classical and benchmarking functions.of the IEEE CEC ***,the accuracy and efficacy of DMoA were demonstrated by means.of the convergence rate,Wilcoxon testing,and ***,fairness using Jain’s index in queue delay optimization in terms.of throughput and latency,along with computational complexity,is also evaluated and compared with other *** results s.ow that DMoA exceeds.other bio-inspired optimization algorithms in terms.of fairness in queue delay management and average packet *** proposed a

关键词： Dragonfly Damselfly Interaction Queuing delay optimization Industrial wireless networks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：