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Features of Ciguatera Fish Poisoning Cases in Hong Kong 2004-2007

Biomedical and Environmental sciences 2008年第6期21卷 521-527页

作者： CHUN-KWAN WOng PATRICIA HUng KELLIE L. H. lee TINA MOK THOMAs CHUng KAI-MAN KAM Biotoxin Laboratory Public Health Laboratory Services Branch Centre for Health Protection Department of Health Shek Kip Mei Kowloon Food and Environmental Hygiene Department Queensway Government Offices

Ohjective To review the clinical features and laboratory investigations of ciguatera patients in Hong Kong between 2004 and 2007 in order to show the timely sampling of implicated fish from ciguatera victims and application of validated mouse bioassay for confirming suspected clinical cases of ciguatera. Methods Diagnosis of the ciguatera victims was based on history of coral fish consumption and clinical presentations stated in official guidelines for clinical diagnosis of ciguatera fish poisoning in Hong Kong. Food remnants of coral fish samples were collected swiftly from ciguatera victims between 2004 and 2007 for ciguatoxins （CTXs） analysis. Results Major clinical symptoms in ciguatera patients included gastrointestinal and neurological effects including limb numbness and diarrhoea, which developed at 0.5 to 15 hours after consumption of fish. In most cases, neurological symptoms were more common than gastrointestinal symptoms. A broad range of attack rate （10%-100%） was observed in each ciguatera outbreak. Validated mouse bioassay on ether extracts of the food remnant samples confirmed that all were CTXs-positive （〈0.5 - 4.3 MU/20 mg ether extract） and directly linked to the corresponding ciguatera cases. Conclusion Consistency between clinical and laboratory analysis for ciguatera poisoning illustrates the application of laboratory mouse bioassay in a timely fashion for confirming ciguatera poisoning cases and implementing effective public health measures. With further improvement in laboratory techniques, features of ciguatera fish poisoning cases can be better defined, Further studies are needed to determine the risk of each class of CTXs （Pacific-, Indian- and Caribbean-CTXs） in Hong Kong.

关键词： Ciguatera poisoning Ciguatoxin Food remnants Hong Kong Mouse bioassay

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Quantification of HBsAg:Basic virology for clinical practice

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World Journal of Gastroenterology 2011年第3期17卷 283-289页

作者： Jung Min lee s.ng Hoon Ahn Department of Internal Medicine Yonsei University College of Medicine Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine Liver Cirrhosis Clinical Research Center

Hepatitis B surface antigen (HBsAg) is produced and secreted through a complex mechanism that is still not fully understood. In clinical fields, HBsAg has long served as a qualitative diagnostic marker for hepatitis B virus infection. Notably, advances have been made in the development of quantitative HBsAg assays, which have allowed viral replication monitoring, and there is an opportunity to make maximal use of quantitative HBsAg to elucidate its role in clinical fields. Yet, it needs to be underscored that a further understanding of HBsAg, not only from clinical point of view but also from a virologic point of view, would enable us to deepen our insights, so that we could more widely expand and apply its utility. It is also important to be familiar with HBsAg variants and their clinical consequences in terms of immune escape mutants, issues resulting from overlap with corresponding mutation in the P gene, and detection problems for the HBsAg variants. In this article, we review current concepts and issues on the quantification of HBsAg titers with respect to their biologic nature, method principles, and clinically relevant topics.

关键词： Hepatitis B virus Hepatitis B surface antigen Quantitative assay Virology

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Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/sTAMP2/FsP27

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Bone Research 2018年第3期6卷 238-251页

作者： s.ng Won lee Jee Hyun Rho s.ng Yeob lee Won Tae Chung Yoo Jin Oh Jung Ha Kim seung Hee Yoo Woo Young Kwon Ju Yong Bae su Young seo Hokeun sun Hye Young Kim Young Hyun Yoo Department of Rheumatology Dong-A University College of Medicine Department of Anatomy and Cell Biology Dong-A University College of Medicine and Mitochondria Hub Regulation Center Department of Microbiology Dong-A University College of Medicine Department of statistics Pusan National University

Free fatty acids(FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet(LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Us.ng high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2(PKCK2)—six-transmembrane protein of prostate 2(sTAMP2)—and fat-specific protein 27(FsP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/sTAMP2/FsP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/sTAMP2/FsP27 should be considered for interventions against metabolic OA.

关键词： osteoarthritis remains articular chondrocytes

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Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury

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Neural Regeneration Research 2015年第1期10卷 10-16页

作者： Corinne A.lee-Kubli Paul Lu Department of Neurosciences University of California Veterans Administration Medical Center

The greatest challenge to successful treatment of spinal cord injury is the limited regenerative capacity of the central nervous system and its inability to replace lost neurons and severed axons following injury. Neural stem cell grafts derived from fetal central nervous system tissue or embryonic stem cells have shown therapeutic promise by differentiation into neurons and glia that have the potential to form functional neuronal relays across injured spinal cord segments. However, implementation of fetal-derived or embryonic stem cell-derived neural stem cell ther- apies for patients with spinal cord injury raises ethical concerns. Induced pluripotent stem cells can be generated from adult somatic cells and differentiated into neural stem cells suitable for therapeutic use, thereby providing an ethical source of implantable cells that can be made in an autologous fashion to avoid problems of immune rejection. This review discusses the therapeutic potential of human induced pluripotent stem cell-derived neural stem cell transplantation for treatment of spinal cord injury, as well as address.ng potential mechanisms, future perspectives and challenges.

关键词： transplantation axonal growth axonal regeneration neuroprotection remyelination differentiation neuronal relay human astrocytes neurons oligodendrocytes secondary degeneration

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The Effectiveness of a Preferred Music Implementation Program on Nurs.ng Home staff and Older People with Dementia

The Effectiveness of a Preferred Music Implementation Progra...

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The 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics

作者： s.ng,H.C. Abbey,J. lee,M.s

＜正＞This project was a quasi-experimental study which evaluated the implementation of a preferred music intervention delivered by nurs.ng home staff on agitation and anxiety of institutionalized elders with dementia

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sensitivity of snowfall Characteristics to Meteorological Conditions in the Yeongdong Region of Korea

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Advances in Atmospheric sciences 2021年第3期38卷 413-429页

作者： Yoo-Jun KIM so-Ra IN Hae-Min KIM Jin-Hwa lee Kyu Rang KIM seungbum KIM Byung-Gon KIM High Impact Weather Research Department National Institute of Meteorological SciencesGangneung 25457Korea Operational systems Development Department National Institute of Meteorological SciencesSeogwipo 63568Korea Department of Atmospheric Environmental sciences Gangneung-Wonju National UniversityGangneung 25457Korea

This study investigates the characteristics of cold clouds and snowfall in both the Yeongdong coastal and mountainous regions under different meteorological conditions based on the integration of numerical modeling and three-hourly rawinsonde observations with snow crystal photographs for a snowfall event that occurred on 29−30 January *** found that rimed particles predominantly observed turned into dendrite particles in the latter period of the episode when the 850 hPa temperature decreased at the coastal site,whereas the snow crystal habits at the mountainous site were largely needle or rimed *** soundings showed a well-defined,two-layered cloud structure along with distinctive wind-directional shear,and an inversion in the equivalent potential temperature above the low-level cloud *** first experiment with a decrease in lower-layer temperature showed that the low-level cloud thickness was reduced to less than 1.5 km,and the accumulated precipitation was decreased by 87%compared with the control *** difference in precipitation amount between the s.ngle-layered experiment and control experiment(two-layered)was not so significant to attribute it to the effect of the seeder−feeder *** precipitation in the last experiment by weakening winddirectional shear was increased by 1.4 times greater than the control experiment specifically at the coastal site,with graupel particles accounting for the highest proportion(~62%).The current results would improve snowfall forecasts in complicated geographical environments such as Yeongdong in terms of snow crystal habit as well as snowfall amount in both time and space domains.

关键词： Yeongdong snow crystal rawinsonde cloud-resolving model

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Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increas.ng doublecortin and tyrosine kinase A in the dorsal root ganglion

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Neural Regeneration Research 2020年第1期15卷 162-168页

作者： Hyun-Kee Cho Woosuk Kim Kwon-Young lee Jin-Ok Ahn Jung Hoon Choi In Koo Hwang Jin-Young Chung Department of Veterinary Internal Medicine and Institute of Veterinary science College of Veterinary MedicineKangwon National UniversityChuncheonKangwon-doSouth Korea Department of Anatomy and Cell Biology College of Veterinary MedicineResearch Institute for Veterinary ScienceSeoul National UniversitySeoulSouth Korea Department of Anatomy College of Veterinary MedicineKangwon National UniversityChuncheonKangwon-doSouth Korea

Beta-nerve growth factor(β-ngF) is known to be a major leading cause of neuronal plasticity. To identify the possible action mechanisms of β-ngF gene therapy for sciatic nerve recovery, experimental dogs were randomly divided into control, pyridoxine, and pyridoxine + β-ngF groups. We observed chronological changes of morphology in the dorsal root ganglia in response to pyridoxine toxicity based on cresyl violet staining. The number of large neurons positive for cresyl violet was dramatically decreased after pyridoxine intoxication for 7 days in the dorsal root ganglia and the neuron number was gradually increased after pyridoxine withdrawal. In addition, we also investigated the effects of β-ngF gene therapy on neuronal plasticity in pyridoxine-induced neuropathic dogs. To accomplish this, tyrosine kinase receptor A(TrkA), βIII-tubulin and doublecortin(DCX) immunohistochemical staining was performed at 3 days after the last pyridoxine treatment. TrkA-immunoreactive neurons were dramatically decreased in the pyridoxine group compared to the control group, but strong TrkA immunoreactivity was observed in the small-sized dorsal root ganglia in this group. TrkA immunoreactivity in the dorsal root ganglia was similar between β-ngF and control groups. The numbers of βIII-tubulin-and DCX-immunoreactive cells decreased significantly in the pyridoxine group compared to the control group. However, the reduction of βIII-tubulin-and DCX-immunoreactive cells in the dorsal root ganglia in the β-ngF group was significantly ameliorated than that in the pyridoxine group. These results indicate that β-ngF gene therapy is a powerful treatment of pyridoxine-induced neuropathic damage by increas.ng the TrkA and DCX levels in the dorsal root ganglia. The experimental protocol was approved by the Institutional Animal Care and Use Committee(IACUC) of seoul National University, south Korea(approval No. sNU-060623-1, sNU-091009-1) on June 23, 2006 and October 9, 2009, respectively.

关键词： β-nerve growth factor βIII-tubulin doublecortin gene therapy neuron-glial antigen 2 neuropathy pyridoxine

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Management of distal humeral coronal shear fractures

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World Journal of Clinical Cases 2015年第5期3卷 405-417页

作者： shahram s Yari Nathan L Bowers Miguel A Craig lee M Reichel Baylor College of Medicine Medical School One Baylor Plaza Houston TX 77030 United States Baylor College of Medicine Department of Orthopedic Surgery Ben Taub General Hospital Houston TX 77030 United States

Coronal shear fractures of the distal humerus are rare,complex fractures that can be technically challenging to manage. They usually result from a low-energy fall and direct compression of the distal humerus by the radial head in a hyper-extended or semi-flexed elbow or from spontaneous reduction of a posterolateral subluxation or dislocation. Due to the small number of soft tissue attachments at this site, almost all of these fractures are displaced. The incidence of distal humeral coronal shear fractures is higher among women because of the higher rate of osteoporosis in women and the difference in carrying angle between men and women. Distal humeral coronal shear fractures may occur in isolation, may be part of a complex elbow injury, or may be associated with injuries proximal or distal to the elbow. An associated lateral collateral ligament injury is seen in up to 40% and an associated radial head fracture is seen in up to 30% of these fractures. Given the complex nature of distal humeral coronal shear fractures, there is preference for operative management. Operative fixation leads to stable anatomic reduction, restores articular congruity, and allows initiation of early range-of-motion movements in the majority of cases. several surgical exposure and fixation techniques are available to reconstruct the articular surface fol owing distal humeral coronal shear fractures. The lateral extensile approach and fixation with countersunk headless compression screws placed in an anterior-to-posterior fashion are commonly used. We have found a two-incision approach(direct anterior and lateral) that results in less soft tissue dissection and better outcomes than the lateral extensile approach in our experience. stiffness, pain, articular incongruity, arthritis, and ulnohumeral instability may result if reduction is non-anatomic or if fixation fails.

关键词： Coronal shear Fractures Distal Humerus Management Approach Two-incision

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垂直排水法中非织造布土工袋和机织土工袋的比较研究

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产业用纺织品 2000年第11期18卷 14-17,22页

作者： M.Chung s.D.Cho s.H.lee J.M.Koh 韩国建筑技术研究院韩国铁路研究院阳光土工管线公司

传统的网袋排水法是先将套管在可压缩土壤中打入一定深度以形成排水道 ,然后将圆筒状鱼网机织袋放置入套管中 ,并用砂填充网袋 ,最后将套管取出。通过对 4种不同规格的机织袋和非织造布袋进行现场试验 ,研究其在施工中的性能。采用砂石... 详细信息

传统的网袋排水法是先将套管在可压缩土壤中打入一定深度以形成排水道 ,然后将圆筒状鱼网机织袋放置入套管中 ,并用砂填充网袋 ,最后将套管取出。通过对 4种不同规格的机织袋和非织造布袋进行现场试验 ,研究其在施工中的性能。采用砂石、轮胎碎料、石屑和煤灰作填充材料。文章探讨了不同网袋的适用性 ,介绍了一种旨在防止网袋在套管中发生扭曲并保证排水道畅通的革新技术。这种方法的特点是采用专门设计的导板和直接接触套管管壁的抗扭曲杆 ,最后通过与传统网袋排水法的比较来验证其有效性。

关键词：非织造布土工袋机织土工袋垂直排水法排水道比较研究施工

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Fast preparation of photopolymerized monolithic columns for capillary electrochromatography

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Journal of Central south University of Technology 2008年第2期15卷 176-182页

作者：龚文君许光日张毅军张裕平 CHOI seong-ho lee Kwang-pill Henan Institute of science and Technology Department of Chemistry Hannam UniversityDaejonSouth Korea Department of Chemistry Graduate SchoolKyungpook National UniversityDaegu702-701South Korea

Photopolymerized sol-gel(PsG) columns were prepared us.ng methacryloxypropyltrimethoxysilane as the monomer,toluene as the porogen and hydrochloric acid as the *** different photoinitiators such as benzoin methyl ether,Irgacure 819,Irgacure 1700 and Irgacure 1800 were comparatively used in the reaction solution in the presence and absence of sodium dodecyl *** above eight solutions were respectively irradiated at 365 nm for 5?10 min in each capillary(75 μm inside diameter) to prepare the porous monolithic sol-gel column by a one-step,in situ,*** chromatographic behavior of the eight PsG columns were comparatively studied,all of which exhibit reversed-phase *** these columns,several neutral compounds,namely thiourea,benzene,toluene,ethyl benzene,biphenyl and naphthalene can be separated from mixtures with a largest column efficiency of 74 470 plate/column for *** of sodium dodecyl sulfate in the polymerization process has a significant influence on the morphology and migration time.

关键词： electrochromatography monolithic columns photopolymerized sol-gel aromatic hydrocarbons

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