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Impact of Proteinuria on Liver Enzyme Levels

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 759-760页

作者： David Yardeni Asif Hitawala Lilian Howard Theo heller Meryl Waldman Department of Gastroenterology and Liver Diseases Soroka University Medical CenterBeer-ShevaIsrael Liver Diseases Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Kidney Diseases Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA

Dear Editors,We read with great interest the recently published article“subnormal serum Liver Enzyme Levels:A Review of Pathophysiology and Clinical significance”by Youssef and colleagues.1 While much attention is given to elevations of liver enzymes,the authors highlight clinically important,often unrecognized reasons leading to low liver enzyme *** example,chronic kidney disease was cited as a cause of low serum aspartate aminotransferase(AsT)proportional to the progression of the disease,but the cause(s)are not well *** is known about the possible influence of nephrotic syndrome(Ns)on liver enzymes.

关键词： Impact Liver Levels

LIU TUNGsHENG's PALAEOMAGNETIC LOEss REsEARCH IN sWITZERLAND

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第四纪研究 2009年第5期29卷 847-850页

作者： Friedrich heller Institut für Geophysik ETH-Zentrum CH-8092 Zürich

11月22日是刘东生先生的生日,在先生离开我们的一年多时间里,我们时刻在怀念他。这里我们刊登了刘先生的密友之一、瑞士的heller教授的短文,怀念与刘先生一起研究黄土磁学的点点滴滴。本文是heller教授为刘先生的纪念文集撰写的,但因故... 详细信息

11月22日是刘东生先生的生日,在先生离开我们的一年多时间里,我们时刻在怀念他。这里我们刊登了刘先生的密友之一、瑞士的heller教授的短文,怀念与刘先生一起研究黄土磁学的点点滴滴。本文是heller教授为刘先生的纪念文集撰写的,但因故未及在文集中刊出。现在本刊补登,除了表示对先生的深切怀念,也表示对heller教授的感谢和歉意。

关键词：黄土磁学研究刘东

Modeling of IPMC Cantilever＇s Displacements and Blocking Forces

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Journal of Bionic Engineering 2015年第1期12卷 142-151页

作者： David Vokoun Qingsong He Ludek heller Min Yu Zhendong Dai Institute of Physics of the AsCR Prague 182 21 Czech Republic Institute of Bio-lnspired structure and surface Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The motion of an Ionic Polymer Metal Composite （IPMC） cantilever under a periodic voltage control is modeled. In our finite element 3D model, we follow both the free tip displacements and the blocking forces for various thicknesses and elastic constants of the ionomer membrane. It turns out that the maximum displacement of the free tip strongly depends on the value of the Young＇s modulus of the electrodes. Furthermore, the maximum blocking force, Fmax, increases with the thickness of the ionomer membrane. At constant values of Young＇s moduli of the electrodes and ionomer membrane thickness, if the Young＇s modulus of the ionomer membrane varies within the range from 0.2 MPa to 1 GPa, the change of Fmax is less than 10 %. The simulated maximal displacements, blocking forces and electrical currents are compared with the corresponding sets of ex- perimental data, respectively. Qualitative agreement between the simulated and the respective measured data profiles is ob- tained. Furthermore, it is found that the assumption of electrostatic interactions in the cation depleted region of the ionomer membrane has a negligible effect. The advantage of the model consists in its simplicity.

关键词： ionic polymer metal composite actuator blocking force finite element method

Towards Understanding Paleosols in southern Levantine Eolianites:Integration of Micromorphology,Environmental Magnetism and Mineralogy

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Journal of Mountain science 2009年第2期6卷 113-124页

作者： Alexander Tsatskin Tatyana s.Gendler Friedrich heller Igal Dekman Gitti L.Frey Laboratory of Geology Zinman Institute of Archaeology University of HaifaHaifa 31905 Israel United Institute of Physics of the Earth RAS Bolshaya Gruzinskaya 10Moscow 123810 Russia Institut für Geophysik ETH ZürichCH-8092 Zürich Switzerland Department of Materials Engineering Technion Haifa 32000 Israel

The paper addresses the controversial question of the role of clay-sized dust in the formation of paleosols in coastal eolianites, Israel. At the Habonim type section, the pedocomplex dated by archaeology and luminescence to 45-135 ka ago shows at least three paleosols, not separated by non-soil sediments. The oldest reddish paleosol （apparently related to MIs 5） is magnetically enhanced, leached from carbonates, with signs of bioturbation and strongly aged clay coatings. The reddening is due to very fine, -20 nm, poorly crystallized, superparamagnetic （sP） hematite, as determined by Mossbauer studies. In subsoil, lithorelics of eolianite are found. Over time, the soil surface aggraded due to accelerated fine dust accumulation alongside local slope wash. On younger materials formed magnetically depleted vertisols, dominated by smectite-type expandable paramagnetic clays. In thin sections, vertisols exhibit strong stipple-speckled and striated b-fabric due to shrink-swell processes, impregnative calcite nodules and Fe-Mn redistribution. The uppermost hydric vertisol shows the strongest expression of juxtaposed features of recurrent calcite and Fe precipitation. This paleosol developed on colluvial soil materials, as evidenced by mixing of clay coated and uncoated grains of quartz and calcite allochems. M6ssbauer spectra show high amounts of Fe（III） incorporated in the clay structure, low amounts of sP goethite and absence of sP hematite. Whilst magnetic susceptibility drops in vertisols to minimal values, increase. The latter along ferrimagnetie grain sizes with differences in the hierarchy of microfabric features is taken as indication for lithologic discontinuities which may have resulted from continuous, albeit variable and low-intensity, input of eolian clay from both remote saharan and local sources, roughly dated to the earlier to middle part of the Last Glacial.

关键词： Coastal sand loess deposition microfabrie hierarchy magnetic enhancement paramagnetic phyllosilicates Msssbauer effect

Preface to A study of Agnes heller’s Thoughts on Aesthetic Modernity by Fu Qilin

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Comparative Literature:East & West 2007年第1期 57-59页

作者： Agnes heller New school for social Research in New York

本文是阿格妮丝·赫勒为书稿《阿格妮丝·赫勒审美现代性思想研究》所写的序,肯定了此书从美学现代性角度考察其著述的新颖性与合法性,有助于帮助读者理解她的现代性理论、伦理学与历史哲学。赫勒在文中重新阐释了从现代美学起源到当代... 详细信息

本文是阿格妮丝·赫勒为书稿《阿格妮丝·赫勒审美现代性思想研究》所写的序,肯定了此书从美学现代性角度考察其著述的新颖性与合法性,有助于帮助读者理解她的现代性理论、伦理学与历史哲学。赫勒在文中重新阐释了从现代美学起源到当代的某些重要问题,也谈及其近年的美学与艺术转向。

关键词：赫勒现代美学现代性理论 heller 历史哲学审美现代性 favorite familiar

CNEReg Interprets Ruminant-specific Conserved Non-coding Elements by Developmental Gene Regulatory Network

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Genomics, Proteomics & Bioinformatics 2023年第3期21卷 632-648页

作者： Xiangyu Pan Zhaoxia Ma Xinqi sun Hui Li Tingting Zhang Chen Zhao Nini Wang Rasmus heller Wing Hung Wong Wen Wang Yu Jiang Yong Wang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Academy of Mathematics and systems science Chinese Academy of SciencesBeijing 100190China school of Mathematics University of Chinese Academy of SciencesBeijing 100049China state Key Laboratory for Conservation and Utilization of subtropical Agro-Bioresources College of Animal Science and TechnologyGuangxi UniversityNanning 530005China section for Computational and RNA Biology Department of BiologyUniversity of CopenhagenCopenhagen DK-2100Denmark Department of statistics Department of Biomedical Data ScienceBio-X ProgramStanford UniversityStanfordCA 94305USA Center for Ecological and Environmental sciences Northwestern Polytechnical UniversityXi’an 710072China state Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Key Laboratory of systems Health science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

The genetic information coded in DNA leads to trait innovation via a gene regulatory network(GRN)in ***,we developed a conserved non-coding element interpretation method to integrate multi-omics data into gene regulatory network(CNEReg)to investigate the ruminant multi-chambered stomach *** generated paired expression and chromatin accessibility data during rumen and esophagus development in sheep,and revealed 1601 active ruminantspecific conserved non-coding elements(active-RsCNEs).To interpret the function of these activeRsCNEs,we defined toolkit transcription factors(TTFs)and modeled their regulation on rumenspecific genes via batteries of active-RsCNEs during *** developmental GRN revealed 18 TTFs and 313 active-RsCNEs regulating 7 rumen functional ***,6 TTFs(OTX1,sOX21,HOXC8,sOX2,TP63,and PPARG),as well as 16 active-RsCNEs,functionally distinguished the rumen from the *** study provides a systematic approach to understanding how gene regulation evolves and shapes complex traits by putting evo-devo concepts into practice with developmental multi-omics data.

关键词： Trait innovation Gene regulatory network Conserved non-coding element Toolkit transcription factor Ruminant

女性致密乳腺实质型研究以及年龄变化对筛查结果的影响:观察结果源于英国筛查项目

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国际医学放射学杂志 2019年第1期 119-120页

作者： L.Ward s.heller s.Hudson L.Wilkinson 周健 Department of Radiology St George’s University Hospitals NHS Foundation Trust

摘要目的评估在乳腺钼靶X线影像检查中表现致密的女性乳腺的实质组织类型,同时回顾性分析年龄增长将如何影响癌症的评估及诊断。方法收集2013年4月—2015

关键词：筛查结果实质型

The response to vedolizumab in chronic granulomatous disease-related inflammatory bowel disease

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Gastroenterology Report 2020年第5期8卷 404-406,I0003页

作者： Natasha Kamal Beatriz Marciano Bryan Curtin Anna strongin suk see DeRavin Athos Bousvaros Christopher Koh Harry L.Malech steven M.Holland Christa Zerbe Theo heller Digestive Disease Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Laboratory of Host Defenses National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMDUSA Division of Gastroenterology Hepatology and NutritionBoston Children’s HospitalBostonMAUSA Liver Disease Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Laboratory of Clinical Immunology and Microbiology National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMDUSA

Introduction Chronic granulomatous disease(CGD)is a rare immunodeficiency affecting approximately 1 in 200,000 people[1].Patients with CGD are unable to produce normal amounts of neutrophil superoxide and other phagocyte reactive oxygen *** a result,phagocytes have decreased microbicidal activity and patients develop recurrent bacterial and fungal infections.

关键词：慢性肉芽肿单抗治疗炎症性肠病 immunodeficiency

2006年4月17日北京降尘的粒度分布与磁学特征

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第四纪研究 2008年第2期28卷 354-362页

作者：张崧 F．heller 靳春胜刘平秦小光刘东生中国科学院地质与地球物理研究所北京100029 Institute of Geophysics ETH ZurichSwitzerland

对2006年4月17日北京降尘的粒度和磁学性质进行深入分析，提出降尘磁化率相对黄土样品较高是现代降尘磁化率的特点，源区表土磁化率普遍较高是本次降尘磁化率值高的主要原因，污染产生的磁性物质对其也有一定的影响。同时通过对比几次... 详细信息

对2006年4月17日北京降尘的粒度和磁学性质进行深入分析，提出降尘磁化率相对黄土样品较高是现代降尘磁化率的特点，源区表土磁化率普遍较高是本次降尘磁化率值高的主要原因，污染产生的磁性物质对其也有一定的影响。同时通过对比几次降尘的粒度特征和传输方式提出粒度可以有效地指示源区的变化。结合降尘的粒度、磁化率分析与沙尘暴的监测信息和卫星云图，认为此次降尘粒度为0．8～20．0μm的组分可能是来自内蒙古西部的物质；20～70μm与〉70μm的组分可能是来自距离北京较近的河北北部和内蒙古中部发生强烈沙尘暴的地区。

关键词：降尘粒度磁化率磁学特征