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Response Evaluation Us.ng Contrast-Enhanced Ultrasound for Unresectable Advanced Hepatocellular Carcinoma Treated With Ty.os.ne k.nase Inhibitors Plus Anti-PD-1 Antibody.Therapy

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Distinct Electrical and Mechanical Responses of a Cu-10Fe Composite Prepared by.Hot-Pressed s.ntering and Post Treatment

Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zhao C.-k. Guan X. Pu y.-y. Zhou B.-y. Wang L.-F. s.n y.-k. y.n H.-H. Xia H.-s. Wang X. Han H. Xu H.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China shanghai Institute of Medical Imaging Shanghai China Central Laboratory.and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: The aim of the work.described here was to evaluate the role of contrast-enhanced ultrasound (CEUs) in response evaluation for unresectable advanced hepatocellular carcinoma (HCC) treated with ty.os.ne k.nase inhibitors (Tk.s) plus anti-programmed cell death protein-1 (PD-1) antibody.therapy. Methods: A prospective cohort of consecutive patients with HCC who received combined Tk./anti-PD-1 antibody.treatment for unresectable HCC between January.2022 and October 2022 was included in this study. The patients underwent unenhanced ultrasound (Us) and CEUs examinations before treatment and at follow-up. Changes in the largest diameters of the target tumor on unenhanced Us and the largest diameters of the enhancing target tumors on CEUs were evaluated. Response Evaluation Criteria in solid Tumors (RECIsT) version 1.1 with unenhanced Us and magnetic res.nance imaging/computed tomography.(MRI/CT) and modified RECIsT (mRECIsT) with CEUs and CEMRI/CT were used to assess treatment response. Results: A total of 24 HCC patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y. Barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrahepatic target tumors) were studied. Calculations of degree of necrosis in the target tumors revealed no significant differences between CEUs and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for the differentiation of responders from non-responders, the agreement between RECIsT version 1.1 of unenhanced Us and mRECIsT-CEUs was poor (κ coefficient = 0.233). Meanwhile, there was a high degree of concordance between mRECIsT-CEUs and mRECIsT-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUs proved to be superior to baseline Us and is comparable to CEMRI/CT in defining treatment outcome for combined Tk./anti-PD-1 antibody.therapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic therapy Anti-PD-1 antibody Contrast-enhanced ultrasound Hepatocellular carcinoma

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Acta Metallurgica s.nica(English Letters) 2024年第2期37卷 255-265页

作者： X.y.y.e s.y.Peng X.Zhang C.n.He y.Z.Tian k.y.Laboratory.for Anisotropy.and Texture of Materials(Ministry.of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China school of Materials science and Engineering and Tianjin k.y.Laboratory.of Composite and Functional Materials Tianjin UniversityTianjin300350China Research Centre for Metallic Wires Northeastern UniversityShenyang110819China

A Cu-10wt%Fe composite was prepared through hot-pressed s.ntering,and the material was subsequently.solution *** hot-pressed s.ntered and solution treated materials were rolled and *** precipitation behavior and performance changes were sy.tematically.studied by.us.ng scanning electron microscopy.and transmission electron *** contrast to the hot-pressed s.ntered specimen,the solution treatment significantly.affects the thermal stability.and properties of the Cu-10wt%Fe *** Cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 k.for 1 h,and it obtained excellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity.of 51.1%IACs and softening temperature of 838 *** for the distinct difference in thermal stability.and properties between hot-pressed s.ntered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance Cu-based in-situ composites by.post treatment.

关键词： Cu-Fe composite Hot-pressed s.ntering Thermal stability strength Electrical conductivity

Ren-integrable and ren-sy.metric integrable sy.tems

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Communications in Theoretical Phy.ics 2024年第3期76卷 62-69页

作者： s y.Lou school of Phy.ical science and Technology Ningbo UniversityNingbo315211China

A new ty.e of sy.metry.ren-sy.metry.describing any.n phy.ics and corresponding topological phy.ics,is ***-sy.metry.is a generalization of super-sy.metry.which is widely.applied in super-sy.metric phy.ics such as super-sy.metric quantum mechanics,super-sy.metric gravity.super-sy.metric string theory.super-sy.metric integrable sy.tems and so *** and Grassmann numbers are,in some s.nse,dual conceptions,and it turns out that these conceptions coincide for the ren situation,that is,a similar conception of ren-number(R-number)is devised for *** particular,some basic results of the R-number and ren-sy.metry.are exposed which allow one to derive,in principle,some new ty.es of integrable sy.tems including ren-integrable models and ren-sy.metric integrable *** examples of ren-integrable k.V-ty.e sy.tems and ren-sy.metric k.V equations are explicitly.given.

关键词： sy.metries integrable sy.tems any.n phy.ics extended supersy.metry ren-sy.metry

Optimum Profiles of Endwall Contouring for Enhanced net Heat Flux Reduction and Aerody.amic Performance

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Journal of Harbin Institute of Technology.new series) 2024年第2期31卷 80-92页

作者： Arjun k.s Tide P s Biju n Division of Mechanical Engineering School of EngineeringCochin University of Science&TechnologyKalamassery 682022India

successfully.utilized non-axisy.metric endwalls to enhance turbine efficiencies(aerody.amic and turbine inlet temperatures)by.controlling the characteristics of the secondary.flow in a blade *** is accomplished by.steady.state numerical hy.rody.amics and deep k.owledge of the field of *** of the interaction between mainstream and purge flow contributing supplementary.losses in the stage,non-axisy.metric endwalls are highly.susceptible to the inception of purge flow exit compared to the flat and any.advantage rapidly.*** conclusions reveal that the supreme endwall pattern could y.eld a lowering of the gross pressure loss at the design stage and is related to the size of the top-loss location being productively.*** has led to diminished global thermal exchange lowered in the passage of the vane *** reverse flow adjacent to the suction side corner of the endwall is migrated farther from the vane surface,as the deviated pressure spread on the endwall accelerates the flow and progresses the reverse flow core still *** depleted association between the tornado-lik. vortex and the corner vortex adjacent to the suction side corner of the endwall is the dominant mechanism of control in the contoured end *** this publication,we show that the non-axisy.metric endwall contouring by.selective numerical shape change method at most prominent locations is advantageous in lowering the thermal load in turbines to augment the net heat flux reduction as well as the aerody.amic performance us.ng multi-objective optimization.

关键词： endwall contouring turbine vane heat transfer phantom cooling coolant injection net heat flux reduction aerody.amic performance

Turbine Passage secondary.Flow Dy.amics and Endwall Heat Transfer Under Different Inflow Turbulence

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Journal of Harbin Institute of Technology.new series) 2024年第3期31卷 51-62页

作者： Arjun k.s Tide P s Biju n Division of Mechanical Engineering School of EngineeringCochin University of Science&TechnologyKalamassery 682022India

This study.pres.nts endwall hy.rody.amics and heat transfer in a linear turbine cascade at Re 5×105 at low and high intensities of *** are numerically.predicted us.ng the standard ssT model and Reθ-γtransition model as well as us.ng the high-resolution LEs *** major secondary.flow components,compris.ng the horseshoe,corner,and passage vortices are recognized and the impact on heat or mass transfer is *** complicated behavior of turbine passage secondary.flow generation and establishment are impacted by.the perspective of boundary.lay.r attributes and inflow *** passage vortex concerning the latest big leading-edge vane is generated by.the enlargement of the circulation developed at the first instance adjacent to the pressure side becomes powerful and mixes with other vortex sy.tems during its migration towards the suction *** study.conclusions reveal that substantial enhancements are attained on the endwall surface,for the entire spanwise blade extension on the pressure surface,and in the highly.3-D region close to the endwall on the suction *** forecasted suction surface thermal exchange depicts great conformity.with the measurement values and precisely.reproduces the enhanced thermal exchange owing to the development and lateral distribution of the secondary.flows along the midspan of the blade passage *** impacts of the different secondary.flow structures on the endwall thermal exchange are described in depth.

关键词： turbine vane heat transfer endwall turbulence secondary.flow

Effect of Eu3+,Bi3+,and Li+ doping on luminescent property.of GdnbO4

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Journal of Rare Earths 2024年第1期42卷 66-75页

作者： s.W.Wi y.s.Lee Department of Phy.ics and Integrative Institute of Basic sciences Soongsil University

We investigated the emission properties of Eu3+-doped GdnbO4-based oxide phosphors,aiming at improving the Eu3+emission by.codoping of Bi3+and Li+.Eu3+s.ngly.doped,Eu3+and Bi3+doubly.doped,and Eu3+,Bi3+,and Li+triply.doped GdnbO4were prepared us.ng a high-temperature solid-state reaction *** red-orange emissions from Eu3+in the s.ngly.doped samples are significantly.improved by.the codoping of Bi3+,mainly.due to the energy.transfer from Bi3+to Eu3+.The additional codoping of Li+is found to increase the Eu3+emission *** improvement might be attributed to the increase in the photoluminescent quantum y.eld originating from larger grain sizes and better cry.tallinity.A detailed analy.is of the X-ray.diffraction pattern and the asy.metric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu3+in GdnbO4does.not change significantly.with the codoping of Bi3+and Li+.Our results indicate that Li+doping is a promis.ng way.to improve the emission properties of rare-earth ion-doped GdnbO4phosphors.

关键词： Eu 3+ GdnbO 4 Codoping of Li + Photoluminescence s.nsitizer Rare earths

Compression properties of cost-efficient porous expanded clay.reinforced AA7075 s.ntactic foams fabricated by.industrial-oriented die casting technology

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China Foundry 2024年第1期21卷 60-70页

作者： İsmail Cem Ak.ün Çağın Bolat Ali Gök.enli Faculty.of Mechanical Engineering Istanbul Technical University34437İstanbulTurkey Faculty.of Engineering Samsun University55420SamsunTurkey

In today.s manufacturing industries,hard competition between rival firms mak.s it compulsory.for researchers to design lighter and cheaper machine components due to the megatrends of cost-effectiveness and *** this point,aluminum s.ntactic foams(AsFs)are new-generation engineering composites and come into the upfront as a *** to their features lik. low density.sufficient elongation,and perfect energy.absorption ability.these advanced foams have been considerably.seductive for many.industrial sectors *** this study.an industrial-oriented automatic die casting technology.was used for the first time to manufacture the combination of AA7075/porous expanded clay.PEC).Micro evaluations(optical and FEsEM)reveal that there is a homogenous particle distribution in the foam samples,and inspections are compatible with the other AsF ***,T6 aging heat treatment was operated on one half of the produced foams to explore the probable impact of aging on the compressive *** results show that PEC particles can be an alternative to expensive hollow spheres used in the previous ***,a favorable relationship is ascertained between the aging treatment and mechanical properties such as compression strength and plateau strength.

关键词： die casting porous materials metal matrix sy.anctic foams expanded clay compressive deformation

Decomposition solutions and Bäck.und transformations of the B-ty.e and C-ty.e k.domtsev-Petviashvili equations

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Communications in Theoretical Phy.ics 2024年第6期76卷 34-44页

作者： Xiazhi Hao s y.Lou College of science Zhejiang University of TechnologyHangzhou 310014China school of Phy.ical science and Technology Ningbo UniversityNingbo 315211China

This paper introduces a modified formal variable separation approach,showcas.ng a sy.tematic and notably.straightforward methodology.for analy.ing the B-ty.e k.domtsev-Petviashvili(Bk.)*** the application of this approach,we successfully.ascertain decomposition solutions,Bäck.und transformations,the Lax pair,and the linear superposition solution associated with the aforementioned ***,we expand the utilization of this technique to the C-ty.e k.domtsev-Petviashvili(Ck.)equation,leading to the derivation of decomposition solutions,Bäck.und transformations,and the Lax pair specific to this *** results obtained not only.underscore the efficacy.of the proposed approach,but also highlight its potential in offering a profound comprehension of integrable behaviors in nonlinear ***,this approach demonstrates an efficient framework.for establishing interrelations between diverse sy.tems.

关键词： decomposition solution Back.und transformation Lax pair linear superposition solution

supposition of graphene stack. to estimate the contact resistance and conductivity.of nanocomposites

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 663-676页

作者： y.ZARE M.T.MUnIR G.J.WEnG k.y.RHEE Biomaterials and Tissue Engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait Department of Mechanical and Aerospace Engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Department of Mechanical Engineering(Bk.1 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study.the effects of stack.d nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity.of samples are evaluated with developed equations superior to those previously.*** contact resistance and nanocomposite conductivity.are modeled by.several influencing factors,including stack.properties,interphase depth,tunneling size,and contact *** developed model's accuracy.is verified through numerous experimental *** further validate the models and establish correlations between parameters,the effects of all the variables on contact resistance and nanocomposite conductivity.are ***,the contact resistance is primarily.dependent on the poly.er tunnel resistivity.contact area,and tunneling *** dimensions of the graphene nanosheets significantly.influence the conductivity.which ranges from 0 s/m to90 s/*** increased number of nanosheets in stack. and a larger gap between them enhance the nanocomposite's ***,the thick.r interphase and smaller tunneling size can lead to higher sample conductivity.due to their optimistic effects on the percolation threshold and network.efficacy.

关键词： graphene poly.er composite stack.d nanosheet tunneling conductivity contact resistance interphase