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Autologous hematopoietic stem cell transplantation conditioning regimens and chimeric antigen receptor T cell therapy in various diseases

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World Journal of Transplantation 2024年第1期14卷 32-41页

作者： shahzaib Maqbool Maryam Farhan Baloch Muhammad Abdul Khaliq khan Azeem Khalid Kiran Naimat Department of Medicine Holy Family HospitalRawalpindi 46000Pakistan Department of Community Medicine Allama Iqbal Medical CollegeLahore 45000Pakistan Department of Community Dentistry Baqai Medical UniversityKarachi 43000Pakistan Department of Medicine Allama lqbal Medical CollegeLahore 45000Pakistan Department of MedicineLiaquat University of Medical and Health sciences Karachi 43000Pakistan

Conditioning regimens employed in autologous stem cell transplantation have been proven useful in various hematological disorders and underlying malignancies;however,despite being efficacious in various instances,negative consequences have also been *** conditioning regimens were extracted from various literature searches from databases like PubMed,Google scholar,EMBAsE,and *** regimens for each disease were compared by using various end points such as overall survival(Os),progression free survival(PFs),and leukemia free survival(LFs).Variables were presented on graphs and analyzed to conclude a more efficacious conditioning *** multiple myeloma,the most effective regimen was high dose melphalan(MEL)given at a dose of 200/mg/*** comparative results of acute myeloid leukemia were presented and the regimens that proved to be at an admirable position were busulfan(BU)+MEL regarding Os and BU+VP16 regarding *** case of acute lymphoblastic leukemia(ALL),BU,fludarabine,and etoposide(BuFluVP)conferred good disease control not only with a paramount improvement in survival rate but also low risk of ***,for ALL,chimeric antigen receptor(CAR)T cell therapy was preferred in the context of better Os and *** respect to Hodgkin’s lymphoma,mitoxantrone(MITO)/MEL overtook carmustine,VP16,cytarabine,and MEL in view of PFs and vice versa regarding ***-Hodgkin’s lymphoma patients were administered MITO(60 mg/m2)and MEL(180 mg/m2)which showed promising ***,amyloidosis was considered,and the regimen that proved to be competent was MEL 200(200 mg/m2).This review article demonstrates a comparison between various conditioning regimens employed in different diseases.

关键词： Conditioning regimens Multiple myeloma Lymphoma Hodgkin Non-Hodgkin Acute leukemia

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Privacy-Preserving Information Fusion Technique for Device to server-Enabled Communication in the Internet of Things:A Hybrid Approach

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Computers, Materials & Continua 2024年第7期80卷 1305-1323页

作者： Amal Al-Rasheed Rahim khan Tahani Alsaed Mahwish Kundi Mohamad Hanif Md.saad Mahidur R.sarker Department of Information systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer science AbdulWali Khan University MardanMardan23200Pakistan Faculty of Computing and Informatics University Malaysia SabahKota KinabaluSabah88400Malaysia Applied College Taibah UniversityMadinah41477Saudi Arabia Maynooth International Engineering College Maynooth UniversityCo KildareW23 X021Irland Department of Mechanical Engineering Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaBangiSelangor43600Malaysia Institute of Visual Informatics Universiti Kebangsaan MalaysiaBangiSelangor43600Malaysia University of Design Innovation and Technology(UDIT)Av.Alfonso XIII97Madrid28016Spain

Due to the overwhelming characteristics of the Internet of Things(IoT)and its adoption in approximately every aspect of our lives,the concept of individual devices’privacy has gained prominent attention from both customers,i.e.,people,and industries as wearable devices collect sensitive information about patients(both admitted and outdoor)in smart healthcare *** addition to privacy,outliers or noise are among the crucial issues,which are directly correlated with IoT infrastructures,as most member devices are resource-limited and could generate or transmit false data that is required to be refined before processing,i.e.,***,the development of privacy-preserving information fusion techniques is highly encouraged,especially those designed for smart IoT-enabled *** this paper,we are going to present an effective hybrid approach that can refine raw data values captured by the respectivemember device before transmission while preserving its privacy through the utilization of the differential privacy technique in IoT *** window,i.e.,δi based dynamic programming methodology,is implemented at the device level to ensure precise and accurate detection of outliers or noisy data,and refine it prior to activation of the respective transmission ***,an appropriate privacy budget has been selected,which is enough to ensure the privacy of every individualmodule,i.e.,a wearable device such as a smartwatch attached to the patient’s *** contrast,the end module,i.e.,the server in this case,can extract important information with approximately the maximum level of ***,refined data has been processed by adding an appropriate nose through the Laplace mechanism to make it useless or meaningless for the adversary modules in the *** proposed hybrid approach is trusted from both the device’s privacy and the integrity of the transmitted information *** and analytical results ha

关键词： Internet of things information fusion differential privacy dynamic programming Laplace function

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Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： souvik Kar Andrea Perrelli Kiran Kumar Bali Raffaella Mastrocola Arpita Kar Bushra khan Luis Gand Arnab Nayak Christian Hartmann Wolfram sKunz Amir samii Helmut Bertalanffy saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and Biological sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-street-10B Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

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Astrophysical s-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezerashvili N.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate school and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh National University 050040 AlmatyKazakhstan

We study radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)N(p,γ0)16O process with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances is elucidated.A comparison of our calculation for the s-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances in reference to the CNO Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model CNO-cycle

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Nonmetric Traits in Permanent Teeth as Clues to Ethnicity in Vidarbha subpopulation to Aid Forensic Profiling:Pilot study

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Journal of Forensic science and Medicine 2024年第1期10卷 11-19页

作者： Vaishali Amarlal sadhwani Nilima Prakash GLPradeep Rekha Patil shubhechha Anand Khivsara sabiha Mokashi khan MGV’s KBH Dental College NashikMaharashtraIndia Oral Cancer screening and Awareness in Cancer screening Vertical Indian Cancer SocietyMumbaiMaharashtraIndia

Introduction:Nonmetric dental traits have a crucial role in ethnic classification of populations that help in forensic racial *** studies have demonstrated the differences in the expression and frequency of dental traits between various ethnic groups for ancestry determination in the context of forensic dental *** present study is an attempt to assess the frequency and variation in nonmetric traits for establishing ethnicity in the Vidarbha ***:The aim of the study was to assess the frequency and variation of nonmetric traits in permanent teeth for establishing ethnicity in the Vidarbha *** and Methods:Participants of the Vidarbha subpopulation were selected by random sampling ***,premolars,and incisors were evaluated for frequency of nonmetric traits,and variations were graded according to Dentoanthropological system of state University of Arizona *** statistics,Chi-square test,and student’s t-test were used for analysis of ***:The most common occlusal morphology in mandibular first and second molar was 5 cusp and 4 cusp,respectively,with the“+”groove *** 3 and cusp 4 were observed frequently in the maxillary *** lingual cusp was most commonly seen in mandibular premolars show while incisors showed faint ***:Our study concludes that nonmetric traits were present and showed variation in permanent maxillary and mandibular teeth among the Vidarbha *** 5 and Cusp 4 in first and second mandibular molars,respectively,groove pattern“+”and grade 1 protostylid were the most frequent grades observed in permanent mandibular *** lingual cusp was most commonly seen in mandibular premolars and faint shoveling was a notable feature in incisors of this population.

关键词： Cusp number ethnicity forensic anthropology molar protostylid

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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey sinforiano Posadas María E.Quiros-Ortega Zafar U.khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGs14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGs14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGs14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGs14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGs14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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Probing the Efficiency of PPMG-Based Composite Electrolytes for Applications of Proton Exchange Membrane Fuel Cell

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Transactions of Tianjin University 2024年第3期30卷 262-283页

作者： shakeel Ahmed Faizah Altaf safyan Akram khan sumaira Manzoor Aziz Ahmad Muhammad Mansha shahid Ali Ata-ur-Rehman Karl Jacob school of Material science and Engineering Henan International Joint Laboratory of Nano-Photoelectric Magnetic MaterialsHenan University of TechnologyZhengzhou 450001China Interdisciplinary Research Center for Hydrogen Technologies and Carbon Management King Fahd University of Petroleum and Minerals31261 DhahranSaudi Arabia school of Materials science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

PPMG-based composite electrolytes were fabricated via the solution method using the polyvinyl alcohol and polyvinylpyrrolidone blend reinforced with various contents of sulfonated inorganic *** acid was employed as the sulfonating agent to functionalize the external surface of the inorganic filler,i.e.,graphene *** proton conductivities of the newly prepared proton exchange membranes(PEMs)were increased by increasing the temperature and content of sulfonated graphene oxide(sGO),i.e.,ranging from 0.025 s/cm to 0.060 s/*** induction of the optimum level of sGO is determined to be an excellent route to enhance ionic *** single-cell performance test was conducted by sandwiching the newly prepared PEMs between an anode(0.2 mg/cm^(2) Pt/Ru)and a cathode(0.2 mg/cm^(2) Pt)to prepare membrane electrode assemblies,followed by hot pressing under a pressure of approximately 100 kg/cm^(2) at 60℃for 5–10 *** highest power densities achieved with PPMG PEMs were 14.9 and 35.60 mW/cm^(2) at 25℃and 70℃,respectively,at ambient pressure with 100%relative *** showed that the newly prepared PEMs exhibit good electrochemical *** results indicated that the prepared composite membrane with 6 wt%filler can be used as an alternative membrane for applications of high-performance proton exchange membrane fuel cell.

关键词： Proton exchange membrane fuel cell sulfonated graphene oxide Polyvinylpyrrolidone solution casting Membrane electrode assembly Fuel cell performance

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The Ca^(2+)-sensing receptor and the pocketome:comparing nature's complexity with human intervention in receptor modulation

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signal Transduction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda s.F.Matthees Carsten Hoffmann Institut fur Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany Friedrich-schiller-Universitat Jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper published in Nature,the relatively understudied Ca^(2+)-sensing,receptor(CasR)within the Gprotein-coupled receptor(GPCR)family C,gained attention due to pioneering research led by Georgios skiniotis ... 详细信息

关键词： stanford gained skin

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Reimagining critical care:Trends and shifts in 21st century medicine

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World Journal of Critical Care Medicine 2024年第3期13卷 5-10页

作者： sai Doppalapudi Bilal khan Muhammad Adrish Division of Pulmonary and Critical Care Medicine Department of MedicineBronxCare Health System/Icahn School of Medicine at Mount SinaiBronxNY 10467United States Pulmonary William P.Clements High SchoolSugar LandTX 77479United States section of Pulmonary and Critical Care Medicine Ben Taub Hospital/Baylor College of MedicineHoustonTX 77030United States

primarily driven by advancements in technology,changes in healthcare delivery,and a deeper understanding of disease *** in technology have revolutionized patient monitoring,diagnosis,and treatment in the critical care *** minimally invasive procedures to advances imaging techniques,clinicians now have access to a wide array of tools to assess and manage critically ill patients more *** this editorial we comment on the review article published by Padte s et al wherein they concisely describe the latest developments in critical care medicine.

关键词： Artificintelligenceial Ventilators Extracorporeal organ support Telemedicine Critical care

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Malaysia-China Relations:Exemplary Model for AsEAN

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China Report AsEAN 2024年第6期9卷 48-51页

作者： Dato'Abdul Majid Ahmad khan Malaysia-China Friendship Association

Five Decades(1974-2024)of Harmonious and Mutually Beneficial Partnership Fifty years ago in May 1974,the second Prime Minister of Malaysia,Tun Abdul Razak,journeyed to Beijing,China,to start a new and strategic chapter in Malaysia-China *** was a visionary and courageous initiative by Malaysia that commenced resetting Malaysia's foreign policy towards non-alignment and building mutual trust with China.

关键词： Malaysia mutual policy

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