Ir(Ⅲ) complexes with high quantum yields for triplet excited-state formation, long triplet lifetimes, and bright luminescence are potential theranostic photodynamic therapy(PDT) reagents. More importantly, the tr...
详细信息
Ir(Ⅲ) complexes with high quantum yields for triplet excited-state formation, long triplet lifetimes, and bright luminescence are potential theranostic photodynamic therapy(PDT) reagents. More importantly, the triplet excited-state characteristics of these complexes are readily tuned via alternation of the ligands However, most of the currently studied Ir(Ⅲ) complex photosensitizers mainly absorb in the UV and blue spectral region, which is not suitable for potential clinical applications. To red-shift the ground-state absorption and meanwhile to retain the desired triplet excited-state characteristics, we synthesized severa series of cationic or neutral Ir(Ⅲ) complexes that have strong absorption in the visible to the red spectra region and are emissive in the red/NIR region. Their photophysical properties and in vitro/in vivo theranostic PDT effects were systematically evaluated. Alternation of the different types of ligands dramatically impacted the natures and energies of the lowest singlet and triplet excited states of these complexes. Many of the complexes can efficiently generate singlet oxygen in solutions and other reactive oxygen species in vitro, and exhibited strong PDT effects upon visible or red light activation. One of the complexes showed the largest phototherapeutic index(>1600) for the reported Ir(Ⅲ) complexes toward the sKMEL28 cells upon white light activation. These complexes also produce strong intracellular luminescence which highlights their potential as theranostic PDT agents.
Copper-zinc-nickel(Cu-Zn-Ni) ferrite nanoparticles are used for wastewater treatment ***,low degradation efficiency and stability are two main issues that make them unsuitable for actual production *** this paper,th...
详细信息
Copper-zinc-nickel(Cu-Zn-Ni) ferrite nanoparticles are used for wastewater treatment ***,low degradation efficiency and stability are two main issues that make them unsuitable for actual production *** this paper,the citrate-nitrate auto-combustion method was applied for the formation of Cu0.5Zn0.25Ni0.25LaxFe2-xO4;(0≤x≤0.1;step 0.02)(CZNL) *** the substitution process entails the replacement of a small ion with a larger one,the lattice constant and crystallite size does not exhibit a consistent incremental *** behavior is justified and *** size of all the CZNL ferrite nanoparticles is in the range of 8-12 nm,and the lattice constant is in the range of 8.6230 to 8.4865 *** morphological analysis conducted using field emission-scanning electron microscopy(FE-sEM) reveals that the CZNL exhibits agglomerated spherical *** energy dispersive X-ray spectrameter(EDAX) analysis was employed to confirm the elemental composition of CZNL *** the process entails the substitution of Fe3+magnetic ions with nonmagnetic ions La3+,the magnetic parameters of CZNL nanoferrites show a general decreasing trend as *** 20 K,saturation magnetization Ms shows an overall drop in its values from 59.302 emu/g at x=0.0-41.295 emu/g at x=0.1,the smallest value of 37.87 emu/g is recorded at x=*** highest coercivity(Hc=125.9 Oe) and remanence(Mr=13.32 emu/g) are recorded for x=0.08 and x=0.04 nanoferrite,*** band gap of all the CZNL nanoferrites was determined using the Kubelka-Munk function and Tauc plot for direct permitted *** doping modifies the band gap(within 1.86-1.75 eV),increases light absorption,induces efficient e/h separation and charge migration to *** nanoferrite Cu0.5Zn0.25Ni0.25La0.06Fe1.94O4achieves a degradation efficiency of 97.3% for methylene blue(MB) dye removal after just 60 *** five recycling processes,the nanoc
Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, thisstudy ...
详细信息
Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.
Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by ...
详细信息
Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.
stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approac...
详细信息
stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.
In the realm of nonlinear integrable systems, the presence of decompositions facilitates the establishment of linear superposition solutions and the derivation of novel coupled systems exhibiting nonlinear integrabili...
详细信息
In the realm of nonlinear integrable systems, the presence of decompositions facilitates the establishment of linear superposition solutions and the derivation of novel coupled systems exhibiting nonlinear integrability. By focusing on single-component decompositions within the potential BKP hierarchy, it has been observed that specific linear superpositions of decomposition solutions remain consistent with the underlying equations. Moreover, through the implementation of multi-component decompositions within the potential BKP hierarchy,successful endeavors have been undertaken to formulate linear superposition solutions and novel coupled Kd V-type systems that resist decoupling via alterations in dependent variables.
Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ...
详细信息
Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes of TBI,a neuroinflammatory response is triggered,driven by intricate molecular and cellular inflammatory processes.
γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...
详细信息
γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations
Rare earth-based Bi_(0.85)La_(0.15)FeO_(3)(BLFO)and NdMnO_(3)(NMO)particles were synthesised using the solidstate route,and their roles affecting structural,electrical,magnetic properties along with hydroelectric appl...
详细信息
Rare earth-based Bi_(0.85)La_(0.15)FeO_(3)(BLFO)and NdMnO_(3)(NMO)particles were synthesised using the solidstate route,and their roles affecting structural,electrical,magnetic properties along with hydroelectric application in different concentrations i.e.,(1-x)BLFO:xNMO(where x=0,0.10,0.20,0.30 and 1.0)ceramics composites were investigated.X-ray diffraction analyses confirm the pure-phase formation of BLFO:NMO composites,featuring micrometer-scale crystallite *** transform infrared(FT-IR)spectra of BLFO:NMO composites reveal peak shifts with rising NMO content,indicating composite *** composites exhibit robust Maxwell-Wagner polarization and a pronounced composition-dependent *** addition of NMO to BLFO results in a rise in dielectric permittivity at lower frequencies,confirming relaxor behavior and indicating success in achieving the transition *** spectroscopy facilitates a clearer understanding of how charge carriers contribute to these composites and the impact of grain/grain *** saturation magnetization maximum value(i.e.,0.807 emu/g)was attained in *** coercivity decreases with the addition of NMO in *** results suggest the composite's enhanced suitability for microelectronics and hydropower cells,showing improved hydroelectric cell performance with increased NMO in BLFO,highlighting a notable ion diffusion mechanism.
Luminescent materials for application in temperature sensing have caught a lot of interest in recent *** erbium(Er3+)-doped fluoride-based materials(EFM),which are readily accessible by near-infrared(NIR) excitati...
详细信息
Luminescent materials for application in temperature sensing have caught a lot of interest in recent *** erbium(Er3+)-doped fluoride-based materials(EFM),which are readily accessible by near-infrared(NIR) excitation to produce efficient photon *** has been established that ytterbium(Yb3+) may improve the performance of EFMs in both bulk and nanostructured forms by energy transfer channels among rare-earth ions in interstitial *** this work,a comprehensive analysis of the Er3+:Yb3+:CaF2crystalline structure,photoluminescence,and energy transfer from Yb3+to Er3+is presented for powders prepared by combustion *** Er3+:Yb3+:CaF2powders display exceptional photon down-shift and up-conversion when exposed to NIR light(λ=975 nm).The luminescence spectral change of the NIR emission around 1.5 μm,which corresponds to the Er3+electronic transition4I13/2→4I15/2,was investigated in a temperature range of 298-423 K for application in temperature sensing of biological systems exploring the third biological *** luminescence intensity ratio technique was applied to the thermally coupled stark sublevels of states4I13/2and4I15/2with the highest estimated temperature relative sensitivity being around 0.4 %/K at 298 K.
暂无评论